Incidental Mutation 'R6436:Pdcd4'
ID 538068
Institutional Source Beutler Lab
Gene Symbol Pdcd4
Ensembl Gene ENSMUSG00000024975
Gene Name programmed cell death 4
Synonyms MA-3, TIS, D19Ucla1
MMRRC Submission 044574-MU
Accession Numbers
Essential gene? Possibly non essential (E-score: 0.252) question?
Stock # R6436 (G1)
Quality Score 57.0073
Status Validated
Chromosome 19
Chromosomal Location 53880662-53918291 bp(+) (GRCm39)
Type of Mutation splice site
DNA Base Change (assembly) A to G at 53915362 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change
Ref Sequence ENSEMBL: ENSMUSP00000133135 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000025931] [ENSMUST00000074371] [ENSMUST00000165617]
AlphaFold Q61823
Predicted Effect probably null
Transcript: ENSMUST00000025931
SMART Domains Protein: ENSMUSP00000025931
Gene: ENSMUSG00000024975

DomainStartEndE-ValueType
low complexity region 66 82 N/A INTRINSIC
low complexity region 96 122 N/A INTRINSIC
MA3 164 275 3.68e-41 SMART
MA3 327 440 5.01e-43 SMART
Predicted Effect probably null
Transcript: ENSMUST00000074371
SMART Domains Protein: ENSMUSP00000073975
Gene: ENSMUSG00000024975

DomainStartEndE-ValueType
low complexity region 66 82 N/A INTRINSIC
low complexity region 96 122 N/A INTRINSIC
MA3 164 275 3.68e-41 SMART
MA3 327 440 5.01e-43 SMART
Predicted Effect probably null
Transcript: ENSMUST00000165617
SMART Domains Protein: ENSMUSP00000133135
Gene: ENSMUSG00000024975

DomainStartEndE-ValueType
low complexity region 66 82 N/A INTRINSIC
low complexity region 96 122 N/A INTRINSIC
MA3 164 275 3.68e-41 SMART
MA3 327 440 5.01e-43 SMART
Coding Region Coverage
  • 1x: 100.0%
  • 3x: 99.7%
  • 10x: 98.1%
  • 20x: 93.5%
Validation Efficiency 100% (33/33)
MGI Phenotype FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene is a tumor suppressor and encodes a protein that binds to the eukaryotic translation initiation factor 4A1 and inhibits its function by preventing RNA binding. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2010]
PHENOTYPE: Mice homozygous for a null allele have a higher prevalence of B cell derived lymphomas, multi-organ cysts and decreased susceptibility to experimentally induced autoimmune encephalomyelitis and type 1 diabetes. [provided by MGI curators]
Allele List at MGI
Other mutations in this stock
Total: 32 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Arc C A 15: 74,544,098 (GRCm39) V42L possibly damaging Het
Clip1 C T 5: 123,779,848 (GRCm39) E433K probably damaging Het
Cmya5 T C 13: 93,225,723 (GRCm39) T3122A probably damaging Het
Ctf2 G T 7: 127,318,603 (GRCm39) A92E probably damaging Het
Ctsw G T 19: 5,516,322 (GRCm39) R184S possibly damaging Het
D130043K22Rik A G 13: 25,061,918 (GRCm39) E629G probably damaging Het
Dmbt1 T C 7: 130,718,370 (GRCm39) V1523A probably benign Het
Eml2 G A 7: 18,935,088 (GRCm39) V432I probably damaging Het
Fanci T C 7: 79,090,446 (GRCm39) I982T probably benign Het
Fnbp1 T C 2: 30,986,139 (GRCm39) D3G probably damaging Het
Gm10770 G A 2: 150,020,830 (GRCm39) T229I probably benign Het
Gm35315 G A 5: 110,226,578 (GRCm39) T287I probably benign Het
Itgb3 T A 11: 104,524,318 (GRCm39) D151E probably damaging Het
Lcn8 A T 2: 25,544,990 (GRCm39) probably null Het
Ninl A G 2: 150,808,098 (GRCm39) L310P probably damaging Het
Nop2 A G 6: 125,114,274 (GRCm39) D215G probably benign Het
Or4d10c T C 19: 12,065,299 (GRCm39) T286A probably benign Het
Or6c3 A G 10: 129,308,773 (GRCm39) T71A probably damaging Het
Parg T C 14: 31,993,634 (GRCm39) W289R probably damaging Het
Plk2 G T 13: 110,532,570 (GRCm39) E95* probably null Het
Pold1 G A 7: 44,188,202 (GRCm39) R559C probably damaging Het
Ptprc T C 1: 138,011,377 (GRCm39) D560G possibly damaging Het
Rasal3 T C 17: 32,616,478 (GRCm39) Y290C probably damaging Het
Rcsd1 T A 1: 165,485,184 (GRCm39) S90C probably damaging Het
Rttn T C 18: 89,128,853 (GRCm39) L1935P probably damaging Het
Smc1b C T 15: 84,976,232 (GRCm39) R825Q probably benign Het
Srsf11 C T 3: 157,728,981 (GRCm39) probably benign Homo
Tmc3 T C 7: 83,247,695 (GRCm39) Y230H probably damaging Het
Tnfrsf25 A T 4: 152,204,084 (GRCm39) probably null Het
Ubl7 T C 9: 57,827,793 (GRCm39) L160P probably damaging Het
Vmn2r106 C T 17: 20,488,725 (GRCm39) C558Y probably damaging Het
Zfp646 T A 7: 127,479,113 (GRCm39) V430E probably benign Het
Other mutations in Pdcd4
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01563:Pdcd4 APN 19 53,917,552 (GRCm39) missense probably benign
IGL02608:Pdcd4 APN 19 53,915,638 (GRCm39) splice site probably null
seventh UTSW 19 53,910,564 (GRCm39) critical splice donor site probably null
Uccidere UTSW 19 53,899,379 (GRCm39) missense probably damaging 1.00
R0893:Pdcd4 UTSW 19 53,917,525 (GRCm39) missense probably damaging 1.00
R1437:Pdcd4 UTSW 19 53,897,674 (GRCm39) missense probably damaging 0.99
R1836:Pdcd4 UTSW 19 53,914,650 (GRCm39) missense probably damaging 1.00
R4298:Pdcd4 UTSW 19 53,908,092 (GRCm39) missense probably damaging 1.00
R6365:Pdcd4 UTSW 19 53,910,564 (GRCm39) critical splice donor site probably null
R7523:Pdcd4 UTSW 19 53,899,379 (GRCm39) missense probably damaging 1.00
R8244:Pdcd4 UTSW 19 53,895,965 (GRCm39) missense probably benign
R8739:Pdcd4 UTSW 19 53,899,405 (GRCm39) nonsense probably null
Predicted Primers PCR Primer
(F):5'- AAGGTCTATGCCTCCTTTAGC -3'
(R):5'- GTGCAACCTGGCAAAACAAGTC -3'

Sequencing Primer
(F):5'- TGCCTCCTTTAGCTATATAAGAGTTG -3'
(R):5'- CAACCTGGCAAAACAAGTCATATTTG -3'
Posted On 2018-10-19