Mutagenetix > Incidental Mutation

Incidental Mutation 'R6893:Vmn2r111'

538180

Institutional Source

Beutler Lab

Gene Symbol

Vmn2r111

Ensembl Gene

ENSMUSG00000095093

Gene Name

vomeronasal 2, receptor 111

Synonyms

EG210876

MMRRC Submission

044987-MU

Accession Numbers

Essential gene?

Probably non essential (E-score: 0.080) question?

Stock #

R6893 (G1)

Quality Score

148.008

Status

Validated

Chromosome

Chromosomal Location

22547941-22573273 bp(-) (GRCm38)

Type of Mutation

missense

DNA Base Change (assembly)

T to C at 22559051 bp (GRCm38)

Zygosity

Heterozygous

Amino Acid Change

Asparagine to Serine at position 549 (N549S)

Ref Sequence

ENSEMBL: ENSMUSP00000090148 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000092491]

AlphaFold

K7N674

Predicted Effect

possibly damaging
Transcript: ENSMUST00000092491
AA Change: N549S

PolyPhen 2 Score 0.502 (Sensitivity: 0.88; Specificity: 0.90)

SMART Domains

Protein: ENSMUSP00000090148
Gene: ENSMUSG00000095093
AA Change: N549S

Domain	Start	End	E-Value	Type
signal peptide	1	18	N/A	INTRINSIC
Pfam:ANF_receptor	73	469	2.5e-29	PFAM
Pfam:NCD3G	512	565	1.1e-20	PFAM
Pfam:7tm_3	595	833	5.6e-54	PFAM

Meta Mutation Damage Score

0.1795

Coding Region Coverage

1x: 99.9%
3x: 99.8%
10x: 98.7%
20x: 95.2%

Validation Efficiency

100% (49/49)

Allele List at MGI

Other mutations in this stock

Total: 48 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Adam32	T	A	8: 24,878,754 (GRCm38)	D538V	probably damaging	Het
Akap9	T	C	5: 3,961,709 (GRCm38)	I804T	probably benign	Het
Amy1	T	C	3: 113,563,632 (GRCm38)	E186G	probably benign	Het
Best1	A	G	19: 9,997,082 (GRCm38)	Y33H	probably damaging	Het
Cacna1s	C	A	1: 136,077,693 (GRCm38)	N405K	probably benign	Het
Casp7	T	C	19: 56,433,309 (GRCm38)	Y60H	probably damaging	Het
Ccdc61	T	C	7: 18,892,563 (GRCm38)	N367S	possibly damaging	Het
Cnksr3	A	T	10: 7,135,129 (GRCm38)		probably null	Het
Col14a1	A	C	15: 55,444,648 (GRCm38)		probably benign	Het
Cyp3a57	A	T	5: 145,386,974 (GRCm38)	K424*	probably null	Het
Dnai3	T	C	3: 146,080,429 (GRCm38)	E366G	probably damaging	Het
Dpep3	T	C	8: 105,973,842 (GRCm38)	K411E	probably benign	Het
Ebf2	T	A	14: 67,237,559 (GRCm38)	V81E	probably benign	Het
Ehbp1	G	T	11: 22,014,945 (GRCm38)	T1084K	probably damaging	Het
Fastkd2	C	T	1: 63,731,794 (GRCm38)	A103V	possibly damaging	Het
Gm13762	A	G	2: 88,973,799 (GRCm38)	F31L	probably benign	Het
Gtf3c2	T	C	5: 31,166,378 (GRCm38)	K525E	probably benign	Het
Hdac2	A	G	10: 36,997,007 (GRCm38)	E287G	probably damaging	Het
Ifi207	T	A	1: 173,727,642 (GRCm38)	T832S	possibly damaging	Het
Igf1	G	C	10: 87,864,860 (GRCm38)	V49L	probably damaging	Het
Lef1	A	G	3: 131,115,500 (GRCm38)	D55G	possibly damaging	Het
Lipo2	G	T	19: 33,721,007 (GRCm38)	Y323*	probably null	Het
Mettl24	C	T	10: 40,737,798 (GRCm38)	R178C	probably damaging	Het
Naa80	A	G	9: 107,583,026 (GRCm38)	E40G	probably damaging	Het
Ndrg4	C	A	8: 95,706,601 (GRCm38)	C66*	probably null	Het
Nemf	A	G	12: 69,352,336 (GRCm38)	V140A	probably benign	Het
Nid2	T	A	14: 19,789,787 (GRCm38)	F815I	probably benign	Het
Or5b106	A	C	19: 13,145,742 (GRCm38)	S306A	probably benign	Het
Or8b12c	A	C	9: 37,804,845 (GRCm38)	*311C	probably null	Het
Or8b3b	A	T	9: 38,673,059 (GRCm38)	N141K	possibly damaging	Het
Or8k30	A	G	2: 86,508,792 (GRCm38)	E111G	probably damaging	Het
Pcdhga3	T	C	18: 37,676,545 (GRCm38)	S684P	probably benign	Het
Plch1	A	T	3: 63,753,141 (GRCm38)	C352*	probably null	Het
Plscr2	G	A	9: 92,290,704 (GRCm38)	V139I	probably benign	Het
Ppa1	T	A	10: 61,672,403 (GRCm38)	C270S	probably benign	Het
Ryr2	T	A	13: 11,829,654 (GRCm38)	M399L	possibly damaging	Het
Scn3a	A	G	2: 65,525,754 (GRCm38)	V212A	possibly damaging	Het
Serpina3b	A	G	12: 104,133,026 (GRCm38)	K267E	probably benign	Het
Shroom3	A	G	5: 92,942,204 (GRCm38)	T938A	probably damaging	Het
Specc1	A	C	11: 62,132,453 (GRCm38)	S115R	probably benign	Het
Stim2	C	T	5: 54,053,445 (GRCm38)	T74I	probably benign	Het
Sult6b2	T	A	6: 142,804,299 (GRCm38)	D31V	possibly damaging	Het
Tbc1d24	A	T	17: 24,182,518 (GRCm38)	W406R	probably damaging	Het
Tmprss11b	A	G	5: 86,663,386 (GRCm38)		probably null	Het
Trappc9	A	G	15: 72,925,650 (GRCm38)	Y575H	possibly damaging	Het
Trim63	C	T	4: 134,323,101 (GRCm38)	T232M	probably damaging	Het
Ttn	A	T	2: 76,767,836 (GRCm38)	S19578T	probably damaging	Het
Xpo4	T	A	14: 57,582,310 (GRCm38)	E1139D	probably benign	Het

Other mutations in Vmn2r111

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL00932:Vmn2r111	APN	17	22,548,753 (GRCm38)	missense	probably benign	0.00
IGL01306:Vmn2r111	APN	17	22,568,984 (GRCm38)	missense	probably damaging	0.99
IGL01309:Vmn2r111	APN	17	22,569,016 (GRCm38)	missense	possibly damaging	0.51
IGL01457:Vmn2r111	APN	17	22,571,985 (GRCm38)	nonsense	probably null
IGL01465:Vmn2r111	APN	17	22,548,737 (GRCm38)	missense	probably benign	0.00
IGL01505:Vmn2r111	APN	17	22,548,572 (GRCm38)	missense	probably benign	0.00
IGL01571:Vmn2r111	APN	17	22,571,392 (GRCm38)	missense	probably damaging	0.99
IGL01715:Vmn2r111	APN	17	22,569,073 (GRCm38)	splice site	probably benign
IGL01962:Vmn2r111	APN	17	22,548,284 (GRCm38)	missense	possibly damaging	0.90
IGL02190:Vmn2r111	APN	17	22,570,773 (GRCm38)	missense	probably benign	0.00
IGL02496:Vmn2r111	APN	17	22,568,856 (GRCm38)	missense	probably benign
IGL02519:Vmn2r111	APN	17	22,548,339 (GRCm38)	missense	possibly damaging	0.80
IGL02616:Vmn2r111	APN	17	22,571,050 (GRCm38)	missense	possibly damaging	0.67
IGL02641:Vmn2r111	APN	17	22,573,224 (GRCm38)	missense	possibly damaging	0.82
IGL02690:Vmn2r111	APN	17	22,559,042 (GRCm38)	critical splice donor site	probably null
IGL02698:Vmn2r111	APN	17	22,571,245 (GRCm38)	missense	probably damaging	1.00
IGL03017:Vmn2r111	APN	17	22,570,858 (GRCm38)	missense	probably damaging	1.00
R0046:Vmn2r111	UTSW	17	22,548,009 (GRCm38)	missense	probably benign
R0064:Vmn2r111	UTSW	17	22,572,072 (GRCm38)	missense	probably benign	0.00
R0519:Vmn2r111	UTSW	17	22,573,121 (GRCm38)	missense	probably benign	0.02
R1439:Vmn2r111	UTSW	17	22,571,116 (GRCm38)	missense	probably benign	0.00
R1467:Vmn2r111	UTSW	17	22,571,047 (GRCm38)	missense	probably damaging	0.99
R1467:Vmn2r111	UTSW	17	22,571,047 (GRCm38)	missense	probably damaging	0.99
R1636:Vmn2r111	UTSW	17	22,571,399 (GRCm38)	missense	probably damaging	1.00
R1647:Vmn2r111	UTSW	17	22,569,061 (GRCm38)	missense	probably benign	0.03
R1648:Vmn2r111	UTSW	17	22,569,061 (GRCm38)	missense	probably benign	0.03
R1697:Vmn2r111	UTSW	17	22,548,060 (GRCm38)	missense	probably benign	0.26
R1996:Vmn2r111	UTSW	17	22,548,081 (GRCm38)	missense	probably benign	0.21
R2040:Vmn2r111	UTSW	17	22,548,414 (GRCm38)	missense	probably damaging	1.00
R2075:Vmn2r111	UTSW	17	22,559,062 (GRCm38)	missense	probably damaging	1.00
R2134:Vmn2r111	UTSW	17	22,573,104 (GRCm38)	missense	possibly damaging	0.68
R2357:Vmn2r111	UTSW	17	22,559,170 (GRCm38)	splice site	probably benign
R3700:Vmn2r111	UTSW	17	22,571,161 (GRCm38)	nonsense	probably null
R3782:Vmn2r111	UTSW	17	22,571,320 (GRCm38)	missense	possibly damaging	0.89
R4085:Vmn2r111	UTSW	17	22,559,115 (GRCm38)	missense	probably benign	0.00
R4323:Vmn2r111	UTSW	17	22,573,178 (GRCm38)	missense	probably benign	0.02
R4900:Vmn2r111	UTSW	17	22,548,656 (GRCm38)	missense	possibly damaging	0.94
R5072:Vmn2r111	UTSW	17	22,548,041 (GRCm38)	missense	probably damaging	0.99
R5123:Vmn2r111	UTSW	17	22,571,143 (GRCm38)	missense	possibly damaging	0.82
R5181:Vmn2r111	UTSW	17	22,571,020 (GRCm38)	missense	possibly damaging	0.56
R5357:Vmn2r111	UTSW	17	22,548,102 (GRCm38)	nonsense	probably null
R5398:Vmn2r111	UTSW	17	22,573,271 (GRCm38)	start codon destroyed	probably null	0.88
R5434:Vmn2r111	UTSW	17	22,548,489 (GRCm38)	missense	probably damaging	0.99
R5462:Vmn2r111	UTSW	17	22,548,257 (GRCm38)	missense	probably damaging	1.00
R6149:Vmn2r111	UTSW	17	22,559,051 (GRCm38)	missense	possibly damaging	0.50
R6149:Vmn2r111	UTSW	17	22,548,815 (GRCm38)	missense	probably benign	0.00
R6207:Vmn2r111	UTSW	17	22,559,051 (GRCm38)	missense	possibly damaging	0.50
R6281:Vmn2r111	UTSW	17	22,559,051 (GRCm38)	missense	possibly damaging	0.50
R6282:Vmn2r111	UTSW	17	22,559,051 (GRCm38)	missense	possibly damaging	0.50
R6283:Vmn2r111	UTSW	17	22,559,051 (GRCm38)	missense	possibly damaging	0.50
R6307:Vmn2r111	UTSW	17	22,573,089 (GRCm38)	missense	probably benign	0.00
R6323:Vmn2r111	UTSW	17	22,559,051 (GRCm38)	missense	possibly damaging	0.50
R6325:Vmn2r111	UTSW	17	22,559,051 (GRCm38)	missense	possibly damaging	0.50
R6367:Vmn2r111	UTSW	17	22,559,051 (GRCm38)	missense	possibly damaging	0.50
R6368:Vmn2r111	UTSW	17	22,571,908 (GRCm38)	missense	probably benign	0.38
R6369:Vmn2r111	UTSW	17	22,548,602 (GRCm38)	missense	probably damaging	1.00
R6489:Vmn2r111	UTSW	17	22,559,051 (GRCm38)	missense	possibly damaging	0.50
R6490:Vmn2r111	UTSW	17	22,559,051 (GRCm38)	missense	possibly damaging	0.50
R6546:Vmn2r111	UTSW	17	22,559,051 (GRCm38)	missense	possibly damaging	0.50
R6547:Vmn2r111	UTSW	17	22,559,051 (GRCm38)	missense	possibly damaging	0.50
R6557:Vmn2r111	UTSW	17	22,559,051 (GRCm38)	missense	possibly damaging	0.50
R6654:Vmn2r111	UTSW	17	22,559,051 (GRCm38)	missense	possibly damaging	0.50
R6655:Vmn2r111	UTSW	17	22,559,051 (GRCm38)	missense	possibly damaging	0.50
R6657:Vmn2r111	UTSW	17	22,559,051 (GRCm38)	missense	possibly damaging	0.50
R6659:Vmn2r111	UTSW	17	22,559,051 (GRCm38)	missense	possibly damaging	0.50
R6660:Vmn2r111	UTSW	17	22,559,051 (GRCm38)	missense	possibly damaging	0.50
R6664:Vmn2r111	UTSW	17	22,559,051 (GRCm38)	missense	possibly damaging	0.50
R6798:Vmn2r111	UTSW	17	22,559,051 (GRCm38)	missense	possibly damaging	0.50
R6799:Vmn2r111	UTSW	17	22,559,051 (GRCm38)	missense	possibly damaging	0.50
R6801:Vmn2r111	UTSW	17	22,559,051 (GRCm38)	missense	possibly damaging	0.50
R6895:Vmn2r111	UTSW	17	22,559,051 (GRCm38)	missense	possibly damaging	0.50
R6897:Vmn2r111	UTSW	17	22,559,051 (GRCm38)	missense	possibly damaging	0.50
R6922:Vmn2r111	UTSW	17	22,559,051 (GRCm38)	missense	possibly damaging	0.50
R6923:Vmn2r111	UTSW	17	22,559,051 (GRCm38)	missense	possibly damaging	0.50
R6944:Vmn2r111	UTSW	17	22,559,051 (GRCm38)	missense	possibly damaging	0.50
R6945:Vmn2r111	UTSW	17	22,559,051 (GRCm38)	missense	possibly damaging	0.50
R7017:Vmn2r111	UTSW	17	22,559,051 (GRCm38)	missense	possibly damaging	0.50
R7018:Vmn2r111	UTSW	17	22,559,051 (GRCm38)	missense	possibly damaging	0.50
R7024:Vmn2r111	UTSW	17	22,559,051 (GRCm38)	missense	possibly damaging	0.50
R7031:Vmn2r111	UTSW	17	22,571,245 (GRCm38)	missense	probably damaging	1.00
R7039:Vmn2r111	UTSW	17	22,548,184 (GRCm38)	missense	probably damaging	1.00
R7053:Vmn2r111	UTSW	17	22,559,051 (GRCm38)	missense	possibly damaging	0.50
R7054:Vmn2r111	UTSW	17	22,559,051 (GRCm38)	missense	possibly damaging	0.50
R7055:Vmn2r111	UTSW	17	22,559,051 (GRCm38)	missense	possibly damaging	0.50
R7056:Vmn2r111	UTSW	17	22,559,051 (GRCm38)	missense	possibly damaging	0.50
R7145:Vmn2r111	UTSW	17	22,559,051 (GRCm38)	missense	possibly damaging	0.50
R7146:Vmn2r111	UTSW	17	22,559,051 (GRCm38)	missense	possibly damaging	0.50
R7246:Vmn2r111	UTSW	17	22,548,714 (GRCm38)	missense	probably damaging	1.00
R7259:Vmn2r111	UTSW	17	22,559,051 (GRCm38)	missense	possibly damaging	0.50
R7260:Vmn2r111	UTSW	17	22,559,051 (GRCm38)	missense	possibly damaging	0.50
R7327:Vmn2r111	UTSW	17	22,559,051 (GRCm38)	missense	possibly damaging	0.50
R7401:Vmn2r111	UTSW	17	22,571,086 (GRCm38)	missense	possibly damaging	0.93
R7514:Vmn2r111	UTSW	17	22,548,399 (GRCm38)	missense	probably benign	0.05
R7651:Vmn2r111	UTSW	17	22,559,051 (GRCm38)	missense	possibly damaging	0.50
R7781:Vmn2r111	UTSW	17	22,570,733 (GRCm38)	missense	probably benign	0.17
R7816:Vmn2r111	UTSW	17	22,573,102 (GRCm38)	missense	probably damaging	0.97
R7821:Vmn2r111	UTSW	17	22,559,051 (GRCm38)	missense	possibly damaging	0.50
R7838:Vmn2r111	UTSW	17	22,559,051 (GRCm38)	missense	possibly damaging	0.50
R8078:Vmn2r111	UTSW	17	22,559,051 (GRCm38)	missense	possibly damaging	0.50
R8080:Vmn2r111	UTSW	17	22,559,051 (GRCm38)	missense	possibly damaging	0.50
R8117:Vmn2r111	UTSW	17	22,571,488 (GRCm38)	missense	probably benign	0.12
R8171:Vmn2r111	UTSW	17	22,573,092 (GRCm38)	missense	probably benign	0.10
R8195:Vmn2r111	UTSW	17	22,559,051 (GRCm38)	missense	possibly damaging	0.50
R8197:Vmn2r111	UTSW	17	22,559,051 (GRCm38)	missense	possibly damaging	0.50
R8411:Vmn2r111	UTSW	17	22,548,581 (GRCm38)	missense	probably benign	0.03
R8539:Vmn2r111	UTSW	17	22,571,293 (GRCm38)	missense	probably benign	0.23
R8540:Vmn2r111	UTSW	17	22,559,043 (GRCm38)	missense	probably damaging	1.00
R8540:Vmn2r111	UTSW	17	22,559,042 (GRCm38)	critical splice donor site	probably null
R8557:Vmn2r111	UTSW	17	22,571,929 (GRCm38)	nonsense	probably null
R8720:Vmn2r111	UTSW	17	22,573,213 (GRCm38)	missense	possibly damaging	0.88
R8729:Vmn2r111	UTSW	17	22,548,258 (GRCm38)	missense	probably damaging	1.00
R8843:Vmn2r111	UTSW	17	22,548,030 (GRCm38)	missense	probably benign	0.00
R9184:Vmn2r111	UTSW	17	22,571,841 (GRCm38)	missense	probably benign
R9374:Vmn2r111	UTSW	17	22,568,878 (GRCm38)	missense	probably benign	0.17
R9452:Vmn2r111	UTSW	17	22,559,151 (GRCm38)	missense	probably damaging	1.00
X0026:Vmn2r111	UTSW	17	22,548,695 (GRCm38)	missense	probably damaging	0.98

Predicted Primers

PCR Primer
(F):5'- GTAAAAGATGCAGCCCAATTTCTAC -3'
(R):5'- TCAAGGAGTTGGGAAACAATTCAAC -3'

Sequencing Primer
(F):5'- TGAGTAACTTAGGACAGAGAT -3'
(R):5'- ACAATGCACTAAATAAGGTCTGC -3'

Posted On

2018-11-06