Incidental Mutation 'R6894:Tnrc18'
ID 538204
Institutional Source Beutler Lab
Gene Symbol Tnrc18
Ensembl Gene ENSMUSG00000039477
Gene Name trinucleotide repeat containing 18
Synonyms EG381742, Zfp469
MMRRC Submission 044988-MU
Accession Numbers
Essential gene? Probably essential (E-score: 0.820) question?
Stock # R6894 (G1)
Quality Score 225.009
Status Not validated
Chromosome 5
Chromosomal Location 142710416-142803417 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to T at 142745804 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Methionine to Lysine at position 1323 (M1323K)
Ref Sequence ENSEMBL: ENSMUSP00000117651 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000151477] [ENSMUST00000152247]
AlphaFold no structure available at present
Predicted Effect unknown
Transcript: ENSMUST00000151477
AA Change: M1548K
SMART Domains Protein: ENSMUSP00000114769
Gene: ENSMUSG00000039477
AA Change: M1548K

DomainStartEndE-ValueType
low complexity region 38 50 N/A INTRINSIC
low complexity region 83 98 N/A INTRINSIC
low complexity region 240 287 N/A INTRINSIC
low complexity region 369 390 N/A INTRINSIC
low complexity region 457 475 N/A INTRINSIC
low complexity region 623 634 N/A INTRINSIC
coiled coil region 843 876 N/A INTRINSIC
low complexity region 916 930 N/A INTRINSIC
low complexity region 951 970 N/A INTRINSIC
low complexity region 980 993 N/A INTRINSIC
low complexity region 1093 1112 N/A INTRINSIC
low complexity region 1269 1289 N/A INTRINSIC
coiled coil region 1411 1443 N/A INTRINSIC
low complexity region 1477 1493 N/A INTRINSIC
low complexity region 1581 1593 N/A INTRINSIC
low complexity region 1608 1619 N/A INTRINSIC
low complexity region 1735 1752 N/A INTRINSIC
Predicted Effect unknown
Transcript: ENSMUST00000152247
AA Change: M1323K
SMART Domains Protein: ENSMUSP00000117651
Gene: ENSMUSG00000039477
AA Change: M1323K

DomainStartEndE-ValueType
low complexity region 57 104 N/A INTRINSIC
low complexity region 186 207 N/A INTRINSIC
low complexity region 274 292 N/A INTRINSIC
low complexity region 440 451 N/A INTRINSIC
coiled coil region 660 693 N/A INTRINSIC
low complexity region 733 747 N/A INTRINSIC
low complexity region 768 787 N/A INTRINSIC
low complexity region 797 810 N/A INTRINSIC
low complexity region 910 929 N/A INTRINSIC
low complexity region 1086 1106 N/A INTRINSIC
coiled coil region 1228 1260 N/A INTRINSIC
low complexity region 1294 1310 N/A INTRINSIC
low complexity region 1398 1410 N/A INTRINSIC
low complexity region 1425 1436 N/A INTRINSIC
coiled coil region 1570 1592 N/A INTRINSIC
low complexity region 1606 1618 N/A INTRINSIC
low complexity region 1622 1640 N/A INTRINSIC
low complexity region 1641 1653 N/A INTRINSIC
Coding Region Coverage
  • 1x: 100.0%
  • 3x: 99.9%
  • 10x: 99.2%
  • 20x: 97.5%
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 79 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
4921509C19Rik C A 2: 151,315,227 (GRCm39) L150F probably damaging Het
4930449I24Rik G A 5: 146,441,542 (GRCm39) E230K possibly damaging Het
4930449I24Rik A T 5: 146,441,543 (GRCm39) E230V probably benign Het
9430038I01Rik A G 7: 136,989,117 (GRCm39) C93R possibly damaging Het
Aoc1l2 G A 6: 48,907,596 (GRCm39) A199T probably damaging Het
Apobec1 T C 6: 122,568,201 (GRCm39) probably benign Het
Arl4c T A 1: 88,629,097 (GRCm39) D97V probably damaging Het
Ash1l A G 3: 88,890,298 (GRCm39) T726A probably benign Het
Asz1 A C 6: 18,055,520 (GRCm39) F359V probably damaging Het
Atr T A 9: 95,809,250 (GRCm39) L1970H probably damaging Het
Baz2a G T 10: 127,959,450 (GRCm39) A1322S possibly damaging Het
Cd209e T A 8: 3,903,569 (GRCm39) I37F possibly damaging Het
Cd209f T C 8: 4,155,477 (GRCm39) K37R probably benign Het
Cd5 G C 19: 10,716,203 (GRCm39) S3C possibly damaging Het
Clec16a A T 16: 10,462,718 (GRCm39) I260F probably damaging Het
Cltc A T 11: 86,603,428 (GRCm39) Y799* probably null Het
Cplane1 T C 15: 8,216,852 (GRCm39) L690P probably damaging Het
Csde1 G A 3: 102,951,972 (GRCm39) V258I possibly damaging Het
Dennd5a G T 7: 109,500,325 (GRCm39) H909Q probably damaging Het
Dnah12 A G 14: 26,456,904 (GRCm39) D890G probably damaging Het
Dnah2 A T 11: 69,375,086 (GRCm39) M1379K probably benign Het
Dpp10 A T 1: 123,264,593 (GRCm39) I743N probably damaging Het
Dpp9 T A 17: 56,495,321 (GRCm39) T815S probably damaging Het
Ears2 T C 7: 121,647,447 (GRCm39) N279S probably damaging Het
Ect2l A G 10: 18,045,128 (GRCm39) probably null Het
Eomes C G 9: 118,310,353 (GRCm39) P288A probably damaging Het
Fat3 T C 9: 15,909,072 (GRCm39) D2310G probably damaging Het
Fignl2 T C 15: 100,951,854 (GRCm39) T143A probably benign Het
Gdf9 A G 11: 53,327,646 (GRCm39) K201E possibly damaging Het
Gfra3 C T 18: 34,828,710 (GRCm39) R228Q probably damaging Het
Grin1 A T 2: 25,185,829 (GRCm39) V876E probably damaging Het
Igkv12-41 A C 6: 69,835,635 (GRCm39) V39G probably damaging Het
Kat7 A T 11: 95,174,910 (GRCm39) M367K possibly damaging Het
Ly6d T C 15: 74,634,654 (GRCm39) K33E possibly damaging Het
Lztfl1 T C 9: 123,529,998 (GRCm39) N273S possibly damaging Het
Macf1 T A 4: 123,377,480 (GRCm39) I1485F possibly damaging Het
Marchf10 G T 11: 105,287,787 (GRCm39) L172I possibly damaging Het
Mdn1 T G 4: 32,748,614 (GRCm39) S4220A possibly damaging Het
Muc16 A G 9: 18,406,872 (GRCm39) V8460A possibly damaging Het
Myh14 A G 7: 44,282,936 (GRCm39) F769L probably damaging Het
Myl10 G C 5: 136,726,825 (GRCm39) V70L probably benign Het
Mylk4 A G 13: 32,905,998 (GRCm39) L395P probably damaging Het
Nat8f6 A T 6: 85,785,504 (GRCm39) L215* probably null Het
Nell2 T C 15: 95,244,768 (GRCm39) D443G probably damaging Het
Nkx6-3 A G 8: 23,647,632 (GRCm39) K197R probably benign Het
Nt5c3 A T 6: 56,859,958 (GRCm39) L293* probably null Het
Ntrk1 A T 3: 87,690,109 (GRCm39) V429D probably damaging Het
Obscn A G 11: 59,023,508 (GRCm39) V623A probably benign Het
Or2o1 T C 11: 49,051,186 (GRCm39) F115S probably benign Het
Or4c1 A G 2: 89,133,837 (GRCm39) L33S probably damaging Het
Or5ac21 A G 16: 59,124,142 (GRCm39) T209A probably damaging Het
Or5p5 C T 7: 107,414,271 (GRCm39) T160I probably benign Het
Or6c74 T C 10: 129,870,178 (GRCm39) S228P probably damaging Het
Or8k22 A T 2: 86,163,295 (GRCm39) I135N probably damaging Het
Pate3 T A 9: 35,557,969 (GRCm39) D33V probably damaging Het
Pcnx1 T A 12: 82,034,747 (GRCm39) I1843N probably damaging Het
Pla2g4f A T 2: 120,134,077 (GRCm39) I503N probably benign Het
Prkg1 C A 19: 30,602,174 (GRCm39) E361* probably null Het
Proca1 A G 11: 78,085,613 (GRCm39) probably benign Het
Prss38 G T 11: 59,263,850 (GRCm39) H287Q probably benign Het
Ptpdc1 T C 13: 48,744,114 (GRCm39) E169G probably benign Het
Ptpn21 T C 12: 98,681,440 (GRCm39) S65G probably damaging Het
Rfx6 A T 10: 51,592,135 (GRCm39) H177L probably damaging Het
Slc20a2 G A 8: 23,050,609 (GRCm39) G276D possibly damaging Het
Spag6l A T 16: 16,601,802 (GRCm39) L159I probably damaging Het
Spata31f1a G A 4: 42,850,291 (GRCm39) P622S probably benign Het
St3gal1 A G 15: 66,983,195 (GRCm39) V187A possibly damaging Het
Stk33 T A 7: 108,935,269 (GRCm39) E174D possibly damaging Het
Stxbp5 A T 10: 9,660,105 (GRCm39) V730E probably benign Het
Tmprss15 A T 16: 78,872,702 (GRCm39) L168* probably null Het
Tpr T C 1: 150,312,598 (GRCm39) V1932A probably benign Het
Trak2 A G 1: 58,950,892 (GRCm39) S432P probably damaging Het
Ttn A T 2: 76,738,534 (GRCm39) F4002I probably benign Het
Txndc11 G A 16: 10,906,009 (GRCm39) T507I probably damaging Het
Usp12 G A 5: 146,691,349 (GRCm39) T135I possibly damaging Het
Vit T A 17: 78,934,187 (GRCm39) Y596* probably null Het
Vmn1r32 A T 6: 66,530,345 (GRCm39) Y144N possibly damaging Het
Vmn2r80 G T 10: 79,005,438 (GRCm39) L358F probably benign Het
Zfp382 T G 7: 29,825,261 (GRCm39) S38A probably benign Het
Other mutations in Tnrc18
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00568:Tnrc18 APN 5 142,748,792 (GRCm39) missense unknown
IGL01732:Tnrc18 APN 5 142,757,816 (GRCm39) missense unknown
IGL01796:Tnrc18 APN 5 142,750,642 (GRCm39) missense possibly damaging 0.88
IGL01868:Tnrc18 APN 5 142,757,567 (GRCm39) missense unknown
IGL02010:Tnrc18 APN 5 142,773,049 (GRCm39) missense unknown
IGL02566:Tnrc18 APN 5 142,758,068 (GRCm39) splice site probably benign
IGL02688:Tnrc18 APN 5 142,775,927 (GRCm39) missense probably damaging 0.96
IGL03052:Tnrc18 UTSW 5 142,760,974 (GRCm39) missense unknown
R0129:Tnrc18 UTSW 5 142,750,800 (GRCm39) splice site probably benign
R0617:Tnrc18 UTSW 5 142,762,494 (GRCm39) missense unknown
R0894:Tnrc18 UTSW 5 142,800,869 (GRCm39) missense probably benign 0.37
R1056:Tnrc18 UTSW 5 142,759,614 (GRCm39) nonsense probably null
R1084:Tnrc18 UTSW 5 142,750,522 (GRCm39) critical splice donor site probably null
R1131:Tnrc18 UTSW 5 142,772,963 (GRCm39) missense unknown
R1411:Tnrc18 UTSW 5 142,751,702 (GRCm39) missense unknown
R1443:Tnrc18 UTSW 5 142,757,288 (GRCm39) missense unknown
R1681:Tnrc18 UTSW 5 142,759,572 (GRCm39) missense unknown
R1698:Tnrc18 UTSW 5 142,774,458 (GRCm39) missense possibly damaging 0.83
R1795:Tnrc18 UTSW 5 142,800,869 (GRCm39) missense probably benign 0.37
R1903:Tnrc18 UTSW 5 142,800,895 (GRCm39) missense probably damaging 0.99
R1930:Tnrc18 UTSW 5 142,762,079 (GRCm39) missense unknown
R1931:Tnrc18 UTSW 5 142,762,079 (GRCm39) missense unknown
R1941:Tnrc18 UTSW 5 142,800,905 (GRCm39) missense probably damaging 1.00
R2069:Tnrc18 UTSW 5 142,751,842 (GRCm39) missense unknown
R2074:Tnrc18 UTSW 5 142,745,461 (GRCm39) splice site probably null
R2089:Tnrc18 UTSW 5 142,759,396 (GRCm39) missense unknown
R2091:Tnrc18 UTSW 5 142,759,396 (GRCm39) missense unknown
R2091:Tnrc18 UTSW 5 142,759,396 (GRCm39) missense unknown
R2182:Tnrc18 UTSW 5 142,745,816 (GRCm39) missense unknown
R2190:Tnrc18 UTSW 5 142,761,644 (GRCm39) missense unknown
R2310:Tnrc18 UTSW 5 142,774,308 (GRCm39) missense probably damaging 0.96
R2372:Tnrc18 UTSW 5 142,745,459 (GRCm39) splice site probably benign
R2445:Tnrc18 UTSW 5 142,757,870 (GRCm39) missense unknown
R3806:Tnrc18 UTSW 5 142,773,029 (GRCm39) missense unknown
R4097:Tnrc18 UTSW 5 142,759,561 (GRCm39) small deletion probably benign
R4153:Tnrc18 UTSW 5 142,751,747 (GRCm39) missense possibly damaging 0.89
R4274:Tnrc18 UTSW 5 142,729,405 (GRCm39) missense unknown
R4520:Tnrc18 UTSW 5 142,717,905 (GRCm39) missense unknown
R4627:Tnrc18 UTSW 5 142,725,883 (GRCm39) missense unknown
R4852:Tnrc18 UTSW 5 142,717,095 (GRCm39) missense probably damaging 0.98
R4873:Tnrc18 UTSW 5 142,750,932 (GRCm39) missense unknown
R4875:Tnrc18 UTSW 5 142,750,932 (GRCm39) missense unknown
R4876:Tnrc18 UTSW 5 142,717,380 (GRCm39) missense unknown
R4936:Tnrc18 UTSW 5 142,751,732 (GRCm39) nonsense probably null
R4942:Tnrc18 UTSW 5 142,773,737 (GRCm39) missense unknown
R4962:Tnrc18 UTSW 5 142,725,248 (GRCm39) missense unknown
R5373:Tnrc18 UTSW 5 142,725,911 (GRCm39) missense unknown
R5374:Tnrc18 UTSW 5 142,725,911 (GRCm39) missense unknown
R5454:Tnrc18 UTSW 5 142,757,446 (GRCm39) missense unknown
R5678:Tnrc18 UTSW 5 142,719,319 (GRCm39) missense unknown
R5826:Tnrc18 UTSW 5 142,759,502 (GRCm39) missense unknown
R5891:Tnrc18 UTSW 5 142,800,926 (GRCm39) missense probably damaging 0.99
R6195:Tnrc18 UTSW 5 142,750,928 (GRCm39) missense unknown
R6296:Tnrc18 UTSW 5 142,719,331 (GRCm39) missense unknown
R6358:Tnrc18 UTSW 5 142,713,736 (GRCm39) missense probably damaging 0.99
R6452:Tnrc18 UTSW 5 142,712,767 (GRCm39) missense probably damaging 1.00
R6498:Tnrc18 UTSW 5 142,717,923 (GRCm39) missense unknown
R6711:Tnrc18 UTSW 5 142,773,545 (GRCm39) missense unknown
R6782:Tnrc18 UTSW 5 142,773,063 (GRCm39) missense unknown
R6863:Tnrc18 UTSW 5 142,800,952 (GRCm39) missense probably damaging 1.00
R6970:Tnrc18 UTSW 5 142,713,744 (GRCm39) missense probably damaging 0.99
R7053:Tnrc18 UTSW 5 142,772,984 (GRCm39) missense unknown
R7135:Tnrc18 UTSW 5 142,773,572 (GRCm39) missense
R7756:Tnrc18 UTSW 5 142,772,907 (GRCm39) missense
R7902:Tnrc18 UTSW 5 142,757,902 (GRCm39) missense
R8039:Tnrc18 UTSW 5 142,717,807 (GRCm39) missense unknown
R8053:Tnrc18 UTSW 5 142,736,385 (GRCm39) missense unknown
R8322:Tnrc18 UTSW 5 142,711,767 (GRCm39) missense probably damaging 1.00
R8379:Tnrc18 UTSW 5 142,774,157 (GRCm39) missense
R8745:Tnrc18 UTSW 5 142,773,202 (GRCm39) missense
R8837:Tnrc18 UTSW 5 142,778,811 (GRCm39) missense possibly damaging 0.94
R8894:Tnrc18 UTSW 5 142,725,212 (GRCm39) missense unknown
R8909:Tnrc18 UTSW 5 142,762,131 (GRCm39) missense
R9030:Tnrc18 UTSW 5 142,711,818 (GRCm39) missense probably damaging 1.00
R9186:Tnrc18 UTSW 5 142,773,488 (GRCm39) missense
R9189:Tnrc18 UTSW 5 142,717,107 (GRCm39) missense probably damaging 1.00
R9192:Tnrc18 UTSW 5 142,773,602 (GRCm39) missense
R9227:Tnrc18 UTSW 5 142,773,392 (GRCm39) missense
R9230:Tnrc18 UTSW 5 142,773,392 (GRCm39) missense
R9582:Tnrc18 UTSW 5 142,757,128 (GRCm39) missense
RF022:Tnrc18 UTSW 5 142,759,385 (GRCm39) missense
Z1177:Tnrc18 UTSW 5 142,759,643 (GRCm39) missense
Predicted Primers PCR Primer
(F):5'- TTCAGAGACAAGCCGAGTCC -3'
(R):5'- CAGACACAGCCCCATTTTAGATG -3'

Sequencing Primer
(F):5'- AGACAAGCCGAGTCCTTTGG -3'
(R):5'- CATTTTAGATGGAAGGGCTGAGGAC -3'
Posted On 2018-11-06