Mutagenetix > Incidental Mutation

Incidental Mutation 'R6895:Tas2r123'

538281

Institutional Source

Beutler Lab

Gene Symbol

Tas2r123

Ensembl Gene

ENSMUSG00000057381

Gene Name

taste receptor, type 2, member 123

Synonyms

mt2r55, mGR23, STC 9-2, T2R23, Tas2r23

MMRRC Submission

044989-MU

Accession Numbers

Essential gene?

Probably non essential (E-score: 0.055) question?

Stock #

R6895 (G1)

Quality Score

225.009

Status

Validated

Chromosome

Chromosomal Location

132824105-132825106 bp(+) (GRCm39)

Type of Mutation

missense

DNA Base Change (assembly)

A to T at 132824133 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Histidine to Leucine at position 10 (H10L)

Ref Sequence

ENSEMBL: ENSMUSP00000071615 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000071696]

AlphaFold

P59528

Predicted Effect

probably benign
Transcript: ENSMUST00000071696
AA Change: H10L

PolyPhen 2 Score 0.000 (Sensitivity: 1.00; Specificity: 0.00)

SMART Domains

Protein: ENSMUSP00000071615
Gene: ENSMUSG00000057381
AA Change: H10L

Domain	Start	End	E-Value	Type
Pfam:TAS2R	7	322	4.6e-79	PFAM

Coding Region Coverage

1x: 100.0%
3x: 99.9%
10x: 99.3%
20x: 97.7%

Validation Efficiency

100% (45/45)

Allele List at MGI

Other mutations in this stock

Total: 43 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Ankrd29	A	G	18: 12,394,046 (GRCm39)	V256A	probably benign	Het
Arid4a	A	G	12: 71,110,076 (GRCm39)	D139G	probably benign	Het
AU040320	T	C	4: 126,685,723 (GRCm39)	W100R	probably damaging	Het
C4bp	T	C	1: 130,563,943 (GRCm39)	*470W	probably null	Het
Capn8	C	A	1: 182,456,234 (GRCm39)	D661E	possibly damaging	Het
Car14	T	C	3: 95,805,472 (GRCm39)	T334A	probably benign	Het
Cfhr4	G	A	1: 139,668,210 (GRCm39)	P308S	possibly damaging	Het
Chd6	T	A	2: 160,830,260 (GRCm39)	T1012S	probably damaging	Het
Csmd3	T	C	15: 47,529,910 (GRCm39)		probably null	Het
Dnaaf2	A	G	12: 69,244,437 (GRCm39)	V208A	probably benign	Het
Dnah11	A	G	12: 117,958,926 (GRCm39)	W2986R	probably damaging	Het
Epb42	G	A	2: 120,867,104 (GRCm39)		probably benign	Het
Fam120a	A	G	13: 49,045,497 (GRCm39)	F780L	probably benign	Het
Gpt2	G	A	8: 86,244,681 (GRCm39)	E325K	probably benign	Het
Grid2	T	C	6: 64,372,283 (GRCm39)	F655S	probably damaging	Het
Homer3	T	C	8: 70,737,955 (GRCm39)	S2P	probably damaging	Het
Hydin	T	C	8: 111,038,883 (GRCm39)	V207A	probably benign	Het
Inpp5j	T	C	11: 3,445,557 (GRCm39)		probably null	Het
Jak1	C	T	4: 101,011,734 (GRCm39)		probably null	Het
Jmjd1c	A	G	10: 67,052,869 (GRCm39)	I220V	probably benign	Het
Kat6a	T	G	8: 23,425,799 (GRCm39)	S1115A	possibly damaging	Het
Larp4	T	G	15: 99,905,611 (GRCm39)		probably null	Het
Lrrc72	T	G	12: 36,259,717 (GRCm39)	D43A	probably damaging	Het
Mptx2	A	C	1: 173,105,252 (GRCm39)	V13G	probably benign	Het
Nmbr	A	T	10: 14,645,704 (GRCm39)	*258Y	probably null	Het
Nup210l	C	T	3: 90,067,231 (GRCm39)	A757V	probably damaging	Het
Nup62	A	G	7: 44,479,157 (GRCm39)	K391E	possibly damaging	Het
Nup93	T	A	8: 94,970,314 (GRCm39)	I71K	probably damaging	Het
Or14a256	A	T	7: 86,265,323 (GRCm39)	C177S	probably damaging	Het
Or8b51	A	C	9: 38,569,385 (GRCm39)	L101R	probably damaging	Het
Pik3cg	A	G	12: 32,254,346 (GRCm39)	M547T	possibly damaging	Het
Ropn1	A	T	16: 34,497,668 (GRCm39)	I187F	possibly damaging	Het
Rtp3	T	C	9: 110,816,264 (GRCm39)	R96G	possibly damaging	Het
Sfrp5	A	T	19: 42,188,227 (GRCm39)	S197R	probably damaging	Het
Slc12a6	A	G	2: 112,185,440 (GRCm39)	H903R	probably damaging	Het
Slc26a3	G	T	12: 31,513,523 (GRCm39)	A482S	probably damaging	Het
Slc2a12	G	T	10: 22,568,084 (GRCm39)	A504S	probably damaging	Het
Slitrk5	C	A	14: 111,919,085 (GRCm39)	P903Q	probably damaging	Het
Tex46	T	C	4: 136,340,212 (GRCm39)	V99A	probably benign	Het
Top2b	T	C	14: 16,413,604 (GRCm38)	V1024A	probably benign	Het
Ugt2b36	G	A	5: 87,240,157 (GRCm39)	T76I	probably benign	Het
Usp31	G	T	7: 121,252,399 (GRCm39)	T747K	probably benign	Het
Vmn2r111	T	C	17: 22,778,032 (GRCm39)	N549S	possibly damaging	Het

Other mutations in Tas2r123

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL01021:Tas2r123	APN	6	132,824,369 (GRCm39)	missense	probably benign	0.01
IGL01547:Tas2r123	APN	6	132,824,421 (GRCm39)	missense	probably damaging	1.00
IGL02576:Tas2r123	APN	6	132,824,703 (GRCm39)	missense	possibly damaging	0.96
IGL03303:Tas2r123	APN	6	132,824,401 (GRCm39)	missense	probably damaging	1.00
G1patch:Tas2r123	UTSW	6	132,824,801 (GRCm39)	missense	probably damaging	0.97
R0068:Tas2r123	UTSW	6	132,824,955 (GRCm39)	missense	possibly damaging	0.66
R0068:Tas2r123	UTSW	6	132,824,955 (GRCm39)	missense	possibly damaging	0.66
R0110:Tas2r123	UTSW	6	132,824,295 (GRCm39)	missense	probably benign	0.01
R0364:Tas2r123	UTSW	6	132,824,644 (GRCm39)	missense	probably benign
R0415:Tas2r123	UTSW	6	132,824,801 (GRCm39)	missense	probably damaging	0.97
R0469:Tas2r123	UTSW	6	132,824,295 (GRCm39)	missense	probably benign	0.01
R1791:Tas2r123	UTSW	6	132,824,528 (GRCm39)	missense	probably damaging	1.00
R1976:Tas2r123	UTSW	6	132,824,295 (GRCm39)	missense	probably damaging	0.96
R2328:Tas2r123	UTSW	6	132,824,279 (GRCm39)	missense	probably benign	0.02
R4282:Tas2r123	UTSW	6	132,825,008 (GRCm39)	missense	possibly damaging	0.75
R4283:Tas2r123	UTSW	6	132,825,008 (GRCm39)	missense	possibly damaging	0.75
R4939:Tas2r123	UTSW	6	132,824,808 (GRCm39)	missense	probably benign	0.32
R5079:Tas2r123	UTSW	6	132,824,681 (GRCm39)	missense	probably benign	0.01
R5241:Tas2r123	UTSW	6	132,824,181 (GRCm39)	missense	probably benign	0.06
R5288:Tas2r123	UTSW	6	132,824,190 (GRCm39)	missense	probably benign	0.17
R5851:Tas2r123	UTSW	6	132,824,271 (GRCm39)	missense	probably damaging	1.00
R6725:Tas2r123	UTSW	6	132,824,801 (GRCm39)	missense	probably damaging	0.97
R7017:Tas2r123	UTSW	6	132,824,513 (GRCm39)	missense	probably benign	0.00
R7183:Tas2r123	UTSW	6	132,824,661 (GRCm39)	missense	possibly damaging	0.95
R8972:Tas2r123	UTSW	6	132,824,333 (GRCm39)	missense	probably benign	0.30
R9321:Tas2r123	UTSW	6	132,825,095 (GRCm39)	missense	probably benign

Predicted Primers

PCR Primer
(F):5'- AACAAACCCAAGATTTTCATGGAGG -3'
(R):5'- TAGGCAAATGTGGGCACAGC -3'

Sequencing Primer
(F):5'- CCCAAGATTTTCATGGAGGAATTATG -3'
(R):5'- TGGGCACAGCATGAATAACAATATGC -3'

Posted On

2018-11-06