Mutagenetix > Incidental Mutation

Incidental Mutation 'IGL01019:Taar3'

53834

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Taar3

Ensembl Gene

ENSMUSG00000069708

Gene Name

trace amine-associated receptor 3

Synonyms

Accession Numbers

Is this an essential gene?

Probably non essential (E-score: 0.197) question?

Stock #

IGL01019

Quality Score

Status

Chromosome

Chromosomal Location

23949558-23950589 bp(+) (GRCm38)

Type of Mutation

missense

DNA Base Change (assembly)

A to T at 23950432 bp (GRCm38)

Zygosity

Heterozygous

Amino Acid Change

Aspartic acid to Valine at position 292 (D292V)

Ref Sequence

ENSEMBL: ENSMUSP00000036817 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000045152]

AlphaFold

Q5QD16

Predicted Effect

probably damaging
Transcript: ENSMUST00000045152
AA Change: D292V

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)

SMART Domains

Protein: ENSMUSP00000036817
Gene: ENSMUSG00000069708
AA Change: D292V

Domain	Start	End	E-Value	Type
Pfam:7TM_GPCR_Srsx	42	320	1.8e-13	PFAM
Pfam:7tm_1	48	309	1.4e-53	PFAM

Coding Region Coverage

Validation Efficiency

Allele List at MGI

Other mutations in this stock

Total: 50 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
4932438A13Rik	G	T	3: 37,006,984		probably null	Het
9930022D16Rik	T	C	11: 109,417,911		probably benign	Het
Aatk	T	C	11: 120,012,275	S375G	probably benign	Het
Abcg8	T	C	17: 84,691,995	M173T	probably benign	Het
B3galt2	A	C	1: 143,646,757	R210S	probably benign	Het
Capn5	C	T	7: 98,135,764	A168T	probably damaging	Het
Cbx7	C	T	15: 79,930,628	G24D	probably damaging	Het
Ccdc7a	A	T	8: 129,061,618	S77T	probably benign	Het
Cd200r2	T	A	16: 44,909,469		probably benign	Het
Cdh11	T	C	8: 102,679,745	H32R	probably benign	Het
Chdh	A	T	14: 30,031,332	N66I	probably benign	Het
Clca3a2	G	A	3: 144,813,627	Q263*	probably null	Het
Dcc	T	C	18: 71,809,090	I319V	probably benign	Het
Depdc5	G	T	5: 32,893,401	M170I	probably damaging	Het
Dopey2	T	A	16: 93,810,229	L2140Q	probably benign	Het
Frem3	G	A	8: 80,615,134	G1352E	probably benign	Het
Fsd1l	T	A	4: 53,694,742	C389S	probably damaging	Het
Grin2c	C	T	11: 115,258,110	A221T	possibly damaging	Het
Gstz1	C	A	12: 87,163,801	P153T	probably damaging	Het
Itgb2	T	C	10: 77,542,403	S22P	possibly damaging	Het
Krt87	G	T	15: 101,438,431	Q114K	possibly damaging	Het
Krtap5-4	A	C	7: 142,303,910	S106R	unknown	Het
Lats1	T	C	10: 7,705,671	V740A	probably damaging	Het
Mcm9	C	A	10: 53,629,945	G78C	probably damaging	Het
Mn1	G	A	5: 111,421,547	E1128K	possibly damaging	Het
Myo1f	G	A	17: 33,593,003	R592H	possibly damaging	Het
Nfat5	G	T	8: 107,367,514	A277S	probably damaging	Het
Nfkbia	T	A	12: 55,490,542	Y254F	probably damaging	Het
Nr3c2	A	T	8: 76,909,214	N315Y	probably damaging	Het
Otof	T	C	5: 30,405,216	M258V	probably benign	Het
Panx3	C	T	9: 37,661,471	C261Y	probably damaging	Het
Pdia2	C	A	17: 26,198,922	G38W	probably damaging	Het
Psg19	G	T	7: 18,794,046	Y257*	probably null	Het
Ptpre	A	T	7: 135,678,325	K586*	probably null	Het
Reps1	A	G	10: 18,124,895	R752G	probably damaging	Het
Rpgrip1	T	A	14: 52,131,176	D277E	possibly damaging	Het
Rpl21-ps6	A	G	17: 55,915,671		noncoding transcript	Het
Serpinf2	T	A	11: 75,436,507	E198V	possibly damaging	Het
Sh3tc1	A	G	5: 35,703,375	L1046P	probably damaging	Het
Snw1	T	C	12: 87,450,941	E426G	probably benign	Het
Sord	T	A	2: 122,264,083	N317K	probably benign	Het
Tdrd3	C	A	14: 87,472,182	T94K	probably damaging	Het
Ttn	C	A	2: 76,856,821	E736*	probably null	Het
Usp32	A	G	11: 85,039,265	V562A	probably damaging	Het
Vmn1r169	T	G	7: 23,577,186	M1R	probably null	Het
Vmn2r3	C	T	3: 64,259,883	C609Y	probably damaging	Het
Vmn2r69	T	C	7: 85,406,531	T800A	probably benign	Het
Vmn2r72	G	A	7: 85,738,334	T674I	probably benign	Het
Zfp160	T	A	17: 21,020,826	M52K	possibly damaging	Het
Zfp607a	T	A	7: 27,878,617	C371S	probably damaging	Het

Other mutations in Taar3

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL01777:Taar3	APN	10	23950005	missense	probably benign	0.39
IGL01940:Taar3	APN	10	23949957	missense	probably damaging	1.00
IGL02120:Taar3	APN	10	23950167	missense	probably benign	0.33
PIT4445001:Taar3	UTSW	10	23949688	missense	possibly damaging	0.85
R0582:Taar3	UTSW	10	23949817	missense	probably damaging	1.00
R1925:Taar3	UTSW	10	23950585	missense	probably benign	0.22
R2261:Taar3	UTSW	10	23950155	missense	probably benign	0.00
R4088:Taar3	UTSW	10	23949859	missense	possibly damaging	0.46
R4504:Taar3	UTSW	10	23949573	missense	possibly damaging	0.84
R4505:Taar3	UTSW	10	23949573	missense	possibly damaging	0.84
R4507:Taar3	UTSW	10	23949573	missense	possibly damaging	0.84
R4925:Taar3	UTSW	10	23950543	missense	probably damaging	0.99
R6221:Taar3	UTSW	10	23950072	missense	possibly damaging	0.92
R6451:Taar3	UTSW	10	23949807	missense	possibly damaging	0.96
R7290:Taar3	UTSW	10	23950400	nonsense	probably null
R7414:Taar3	UTSW	10	23949817	missense	probably damaging	1.00
R8432:Taar3	UTSW	10	23950155	missense	probably benign	0.11
X0057:Taar3	UTSW	10	23949646	missense	probably benign	0.13

Posted On

2013-06-28