Mutagenetix > Incidental Mutation

Incidental Mutation 'R6897:Lrp2'

538365

Institutional Source

Beutler Lab

Gene Symbol

Lrp2

Ensembl Gene

ENSMUSG00000027070

Gene Name

low density lipoprotein receptor-related protein 2

Synonyms

Gp330, D230004K18Rik, b2b1625.2Clo, Megalin

MMRRC Submission

044991-MU

Accession Numbers

Essential gene?

Essential (E-score: 1.000) question?

Stock #

R6897 (G1)

Quality Score

225.009

Status

Validated

Chromosome

Chromosomal Location

69424340-69586065 bp(-) (GRCm38)

Type of Mutation

missense

DNA Base Change (assembly)

T to C at 69510502 bp (GRCm38)

Zygosity

Heterozygous

Amino Acid Change

Methionine to Valine at position 1010 (M1010V)

Ref Sequence

ENSEMBL: ENSMUSP00000097628 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000080953] [ENSMUST00000100051]

AlphaFold

no structure available at present

Predicted Effect

probably benign
Transcript: ENSMUST00000080953
AA Change: M1010V

PolyPhen 2 Score 0.000 (Sensitivity: 1.00; Specificity: 0.00)

SMART Domains

Protein: ENSMUSP00000079752
Gene: ENSMUSG00000027070
AA Change: M1010V

Domain	Start	End	E-Value	Type
low complexity region	5	21	N/A	INTRINSIC
LDLa	27	64	5.63e-13	SMART
LDLa	66	105	2.25e-12	SMART
EGF	107	143	2.59e1	SMART
LDLa	107	144	9.29e-14	SMART
LDLa	146	181	6.18e-10	SMART
LDLa	182	219	1.08e-14	SMART
LDLa	221	258	1.05e-12	SMART
LDLa	264	302	1.66e-10	SMART
EGF	310	346	3.23e0	SMART
EGF	350	385	2.32e-1	SMART
LY	414	457	3.88e-3	SMART
LY	458	500	1.17e-6	SMART
LY	501	547	5.96e-13	SMART
LY	548	590	1.94e-12	SMART
LY	591	634	2.66e0	SMART
EGF	661	704	7.76e-3	SMART
LY	732	774	1.76e0	SMART
LY	775	817	3.64e-8	SMART
LY	818	860	1.11e-3	SMART
LY	861	903	2.11e-13	SMART
LY	905	946	9.33e-1	SMART
EGF	972	1013	1.73e0	SMART
LDLa	1024	1061	1.05e-12	SMART
LDLa	1065	1103	4.65e-14	SMART
LDLa	1109	1146	3.63e-16	SMART
LDLa	1149	1186	5.5e-16	SMART
LDLa	1187	1225	1.43e-14	SMART
LDLa	1230	1269	2.1e-12	SMART
LDLa	1271	1308	3.63e-16	SMART
LDLa	1312	1351	4.69e-10	SMART
EGF	1353	1390	9.7e-4	SMART
EGF_CA	1391	1430	6.54e-10	SMART
LY	1457	1501	1.43e-1	SMART
LY	1502	1544	2e-14	SMART
LY	1545	1590	3.03e-14	SMART
LY	1591	1633	5.48e-12	SMART
LY	1635	1677	1.18e-2	SMART
EGF	1704	1742	5.2e-4	SMART
LY	1771	1812	1.68e1	SMART
LY	1813	1856	1.91e-2	SMART
LY	1859	1911	1.88e-10	SMART
LY	1912	1954	7.69e-7	SMART
LY	1955	1994	3e1	SMART
EGF	2022	2060	1.18e-2	SMART
LY	2088	2135	1.14e1	SMART
LY	2136	2182	2.11e-4	SMART
LY	2183	2226	2.22e-12	SMART
LY	2227	2269	1.24e-10	SMART
EGF	2346	2384	2.07e1	SMART
LY	2459	2501	9.91e-10	SMART
LY	2503	2543	1.48e-8	SMART
LY	2544	2586	6.85e-13	SMART
LY	2587	2627	8.13e-1	SMART
EGF_like	2655	2694	3.5e1	SMART
LDLa	2700	2739	2.86e-14	SMART
LDLa	2741	2778	8.09e-14	SMART
LDLa	2780	2820	3.19e-12	SMART
LDLa	2822	2862	6.94e-13	SMART
LDLa	2864	2903	9.29e-14	SMART
LDLa	2907	2947	4.79e-16	SMART
LDLa	2949	2992	8.41e-12	SMART
LDLa	2994	3031	1.08e-14	SMART
LDLa	3033	3072	1.83e-12	SMART
LDLa	3076	3113	1.16e-14	SMART
EGF	3115	3153	8.57e-5	SMART
EGF_CA	3154	3194	3.56e-11	SMART
LY	3221	3263	9.77e-9	SMART
LY	3264	3306	1.22e-9	SMART
LY	3312	3358	5.44e-7	SMART
LY	3359	3401	1.83e-13	SMART
LY	3402	3443	1.41e-5	SMART
EGF	3470	3511	8.91e-3	SMART
LDLa	3513	3552	1.79e-15	SMART
LDLa	3554	3593	9.89e-9	SMART
LDLa	3595	3634	3.07e-14	SMART
LDLa	3636	3675	3.34e-15	SMART
LDLa	3679	3718	1.39e-12	SMART
LDLa	3720	3758	3.83e-15	SMART
LDLa	3760	3797	7.15e-15	SMART
LDLa	3799	3836	2.86e-14	SMART
LDLa	3843	3882	2.38e-11	SMART
LDLa	3884	3924	3.66e-12	SMART
LDLa	3929	3966	1.93e-11	SMART
EGF	3971	4008	6.3e-3	SMART
EGF_CA	4009	4050	1.36e-7	SMART
low complexity region	4072	4084	N/A	INTRINSIC
LY	4136	4178	6.2e-11	SMART
LY	4179	4222	4.32e-10	SMART
LY	4223	4266	3.78e-15	SMART
LY	4267	4306	4.53e1	SMART
EGF	4335	4367	3.46e0	SMART
EGF	4368	4413	1.53e-1	SMART
transmembrane domain	4425	4447	N/A	INTRINSIC
low complexity region	4454	4472	N/A	INTRINSIC
low complexity region	4616	4636	N/A	INTRINSIC

Predicted Effect

probably benign
Transcript: ENSMUST00000100051
AA Change: M1010V

PolyPhen 2 Score 0.000 (Sensitivity: 1.00; Specificity: 0.00)

SMART Domains

Protein: ENSMUSP00000097628
Gene: ENSMUSG00000027070
AA Change: M1010V

Domain	Start	End	E-Value	Type
signal peptide	1	25	N/A	INTRINSIC
LDLa	27	64	5.63e-13	SMART
LDLa	66	105	2.25e-12	SMART
EGF	107	143	2.59e1	SMART
LDLa	107	144	9.29e-14	SMART
LDLa	146	181	6.18e-10	SMART
LDLa	182	219	1.08e-14	SMART
LDLa	221	258	1.05e-12	SMART
LDLa	264	302	1.66e-10	SMART
EGF	310	346	3.23e0	SMART
EGF	350	385	2.32e-1	SMART
LY	414	457	3.88e-3	SMART
LY	458	500	1.17e-6	SMART
LY	501	547	5.96e-13	SMART
LY	548	590	1.94e-12	SMART
LY	591	634	2.66e0	SMART
EGF	661	704	7.76e-3	SMART
LY	732	774	1.76e0	SMART
LY	775	817	3.64e-8	SMART
LY	818	860	1.11e-3	SMART
LY	861	903	2.11e-13	SMART
LY	905	946	9.33e-1	SMART
EGF	972	1013	1.73e0	SMART
LDLa	1024	1061	1.05e-12	SMART
LDLa	1065	1103	4.65e-14	SMART
LDLa	1109	1146	3.63e-16	SMART
LDLa	1149	1186	5.5e-16	SMART
LDLa	1187	1225	1.43e-14	SMART
LDLa	1230	1269	2.1e-12	SMART
LDLa	1271	1308	3.63e-16	SMART
LDLa	1312	1351	6.18e-10	SMART

Coding Region Coverage

1x: 100.0%
3x: 99.9%
10x: 99.3%
20x: 97.7%

Validation Efficiency

97% (72/74)

MGI Phenotype

FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] The protein encoded by this gene, low density lipoprotein-related protein 2 (LRP2) or megalin, is a multi-ligand endocytic receptor that is expressed in many different tissues but primarily in absorptive epithilial tissues such as the kidney. This glycoprotein has a large amino-terminal extracellular domain, a single transmembrane domain, and a short carboxy-terminal cytoplasmic tail. The extracellular ligand-binding-domains bind diverse macromolecules including albumin, apolipoproteins B and E, and lipoprotein lipase. The LRP2 protein is critical for the reuptake of numerous ligands, including lipoproteins, sterols, vitamin-binding proteins, and hormones. This protein also has a role in cell-signaling; extracellular ligands include parathyroid horomones and the morphogen sonic hedgehog while cytosolic ligands include MAP kinase scaffold proteins and JNK interacting proteins. Recycling of this membrane receptor is regulated by phosphorylation of its cytoplasmic domain. Mutations in this gene cause Donnai-Barrow syndrome (DBS) and facio-oculoacoustico-renal syndrome (FOAR).[provided by RefSeq, Aug 2009]
PHENOTYPE: Homozygotes for a targeted null mutation exhibit lung and kidney epithelial defects, impaired B12 uptake, reduced proliferation of the neuroepithelium resulting in lack of olfactory bulbs, forebrain fusions, ventricular defects, and perinatal lethality. [provided by MGI curators]

Allele List at MGI

Other mutations in this stock

Total: 72 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
4921507P07Rik	T	A	6: 50,589,165 (GRCm38)	Q110L	possibly damaging	Het
4930579F01Rik	T	C	3: 138,183,773 (GRCm38)	I28V	possibly damaging	Het
Adamts2	A	T	11: 50,737,164 (GRCm38)		probably null	Het
Adgrg1	T	C	8: 95,002,498 (GRCm38)	F17L	probably benign	Het
Aldob	A	G	4: 49,539,789 (GRCm38)	L183P	probably damaging	Het
Alg5	T	C	3: 54,748,642 (GRCm38)	C270R	probably benign	Het
Anxa4	T	A	6: 86,743,178 (GRCm38)		probably null	Het
Armc2	C	A	10: 41,993,229 (GRCm38)		probably null	Het
Atrnl1	A	G	19: 58,042,368 (GRCm38)	N1314S	probably benign	Het
Bbs7	T	A	3: 36,598,311 (GRCm38)	E331V	probably benign	Het
Bmper	T	A	9: 23,373,929 (GRCm38)	V258E	probably benign	Het
Catspere2	A	T	1: 178,111,573 (GRCm38)	I671F	possibly damaging	Het
Cd101	A	G	3: 101,013,060 (GRCm38)	S508P	probably damaging	Het
Cd177	C	T	7: 24,745,074 (GRCm38)	R694H	probably benign	Het
Clptm1	C	A	7: 19,635,826 (GRCm38)	Q386H	possibly damaging	Het
Cnrip1	A	G	11: 17,054,705 (GRCm38)	Y85C	probably damaging	Het
Dclk2	A	T	3: 86,831,763 (GRCm38)	F310I	probably benign	Het
Dmxl1	C	A	18: 49,863,057 (GRCm38)	Q417K	possibly damaging	Het
Dmxl1	A	G	18: 49,851,495 (GRCm38)	K186R	probably null	Het
Eloa	T	C	4: 136,012,909 (GRCm38)	D67G	possibly damaging	Het
Elovl4	T	C	9: 83,783,225 (GRCm38)	I103V	probably benign	Het
Gabpa	C	G	16: 84,860,473 (GRCm38)	A412G	probably benign	Het
Gldn	T	A	9: 54,334,874 (GRCm38)		probably null	Het
Ino80d	A	T	1: 63,065,834 (GRCm38)	I361N	probably damaging	Het
Kalrn	G	A	16: 33,975,703 (GRCm38)	T1234M	probably damaging	Het
Kcnk13	T	A	12: 100,061,767 (GRCm38)	M367K	probably benign	Het
Klrd1	G	A	6: 129,593,505 (GRCm38)	R8Q	possibly damaging	Het
Kmt2a	T	C	9: 44,847,645 (GRCm38)	N969S	probably benign	Het
Lgi4	A	G	7: 31,068,890 (GRCm38)	D438G	probably benign	Het
Lig1	T	C	7: 13,305,914 (GRCm38)	L684P	probably damaging	Het
Magi3	C	A	3: 104,089,557 (GRCm38)	R224I	probably damaging	Het
Mier2	T	C	10: 79,544,739 (GRCm38)	N277S	probably damaging	Het
Morn1	A	G	4: 155,086,655 (GRCm38)	H17R	probably benign	Het
Nf2	A	T	11: 4,799,878 (GRCm38)	S265T	probably damaging	Het
Olfr1029	A	G	2: 85,975,356 (GRCm38)	T38A	possibly damaging	Het
Olfr1058	G	A	2: 86,385,680 (GRCm38)	T246I	possibly damaging	Het
Palb2	A	G	7: 122,127,047 (GRCm38)		probably null	Het
Pdzd2	C	T	15: 12,385,865 (GRCm38)	V940M	probably damaging	Het
Phldb2	T	C	16: 45,777,775 (GRCm38)	K850E	probably damaging	Het
Pitx1	G	A	13: 55,828,522 (GRCm38)	T108M	probably damaging	Het
Polr2a	C	T	11: 69,735,961 (GRCm38)	A1516T	probably benign	Het
Pomp	T	A	5: 147,875,503 (GRCm38)	M133K	possibly damaging	Het
Prex1	T	C	2: 166,581,993 (GRCm38)	E993G	probably damaging	Het
Prrc2c	C	A	1: 162,705,506 (GRCm38)		probably benign	Het
Pwp2	C	A	10: 78,172,083 (GRCm38)	Q879H	probably damaging	Het
Rab26	G	A	17: 24,529,792 (GRCm38)	T245I	probably damaging	Het
Rapgef1	A	G	2: 29,702,502 (GRCm38)	D502G	probably damaging	Het
Rsf1	GGCG	GGCGACGGCCGCG	7: 97,579,906 (GRCm38)		probably benign	Het
Sema5a	T	A	15: 32,550,275 (GRCm38)	D153E	probably benign	Het
Sez6	C	G	11: 77,953,559 (GRCm38)	H69Q	probably damaging	Het
Sgsm3	A	T	15: 81,008,894 (GRCm38)	T391S	probably benign	Het
Sh3rf2	T	C	18: 42,101,605 (GRCm38)	V151A	possibly damaging	Het
Socs1	G	T	16: 10,784,402 (GRCm38)	A157E	probably benign	Het
Sptbn4	C	A	7: 27,371,950 (GRCm38)	V346L	possibly damaging	Het
Srgap1	T	A	10: 121,785,618 (GRCm38)	H990L	probably damaging	Het
Tbc1d9	G	T	8: 83,166,180 (GRCm38)	G36W	probably damaging	Het
Tbk1	T	C	10: 121,559,877 (GRCm38)	E437G	probably benign	Het
Tns3	A	G	11: 8,531,743 (GRCm38)	L203P	probably damaging	Het
Tspoap1	A	T	11: 87,765,812 (GRCm38)	K283M	probably damaging	Het
Ttyh1	C	T	7: 4,124,650 (GRCm38)		probably benign	Het
Ufd1	T	A	16: 18,827,100 (GRCm38)	I254N	probably benign	Het
Ugdh	T	G	5: 65,427,433 (GRCm38)	T49P	probably benign	Het
Vav3	T	C	3: 109,527,494 (GRCm38)	L447P	probably damaging	Het
Vmn1r216	A	T	13: 23,099,275 (GRCm38)	K43*	probably null	Het
Vmn2r111	T	C	17: 22,559,051 (GRCm38)	N549S	possibly damaging	Het
Vmn2r13	A	G	5: 109,158,149 (GRCm38)	I521T	possibly damaging	Het
Wdfy3	T	C	5: 101,844,066 (GRCm38)	T3470A	probably benign	Het
Wdhd1	T	A	14: 47,248,130 (GRCm38)	K791N	probably damaging	Het
Xirp2	A	G	2: 67,508,567 (GRCm38)	D384G	probably damaging	Het
Zfp512b	C	T	2: 181,590,480 (GRCm38)	R86Q	probably damaging	Het
Zfp735	A	C	11: 73,711,054 (GRCm38)	I275L	probably benign	Het
Zfp957	A	T	14: 79,213,904 (GRCm38)	S152T	probably damaging	Het

Other mutations in Lrp2

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL00094:Lrp2	APN	2	69,507,779 (GRCm38)	missense	probably damaging	1.00
IGL00594:Lrp2	APN	2	69,486,280 (GRCm38)	missense	probably benign	0.00
IGL00782:Lrp2	APN	2	69,501,645 (GRCm38)	missense	probably benign	0.14
IGL00821:Lrp2	APN	2	69,459,516 (GRCm38)	missense	probably damaging	1.00
IGL00897:Lrp2	APN	2	69,521,881 (GRCm38)	missense	possibly damaging	0.86
IGL01065:Lrp2	APN	2	69,469,436 (GRCm38)	missense	possibly damaging	0.94
IGL01087:Lrp2	APN	2	69,524,073 (GRCm38)	missense	probably damaging	1.00
IGL01095:Lrp2	APN	2	69,492,432 (GRCm38)	nonsense	probably null
IGL01131:Lrp2	APN	2	69,499,239 (GRCm38)	missense	probably damaging	1.00
IGL01350:Lrp2	APN	2	69,510,984 (GRCm38)	missense	probably damaging	0.96
IGL01352:Lrp2	APN	2	69,503,526 (GRCm38)	missense	possibly damaging	0.77
IGL01358:Lrp2	APN	2	69,552,470 (GRCm38)	splice site	probably benign
IGL01375:Lrp2	APN	2	69,478,566 (GRCm38)	splice site	probably benign
IGL01384:Lrp2	APN	2	69,483,502 (GRCm38)	missense	probably damaging	1.00
IGL01384:Lrp2	APN	2	69,453,812 (GRCm38)	missense	probably null	1.00
IGL01411:Lrp2	APN	2	69,482,267 (GRCm38)	missense	probably damaging	1.00
IGL01418:Lrp2	APN	2	69,525,286 (GRCm38)	missense	probably benign
IGL01444:Lrp2	APN	2	69,443,716 (GRCm38)	missense	possibly damaging	0.94
IGL01464:Lrp2	APN	2	69,472,439 (GRCm38)	missense	probably damaging	0.98
IGL01528:Lrp2	APN	2	69,492,460 (GRCm38)	missense	probably damaging	1.00
IGL01663:Lrp2	APN	2	69,428,706 (GRCm38)	missense	probably benign
IGL01761:Lrp2	APN	2	69,481,235 (GRCm38)	missense	possibly damaging	0.85
IGL01780:Lrp2	APN	2	69,486,184 (GRCm38)	missense	possibly damaging	0.66
IGL01994:Lrp2	APN	2	69,483,601 (GRCm38)	missense	probably benign	0.08
IGL02015:Lrp2	APN	2	69,527,578 (GRCm38)	missense	probably benign	0.00
IGL02104:Lrp2	APN	2	69,510,418 (GRCm38)	missense	probably damaging	1.00
IGL02132:Lrp2	APN	2	69,537,616 (GRCm38)	missense	probably benign	0.01
IGL02134:Lrp2	APN	2	69,513,379 (GRCm38)	critical splice acceptor site	probably null
IGL02197:Lrp2	APN	2	69,466,880 (GRCm38)	missense	probably benign	0.01
IGL02212:Lrp2	APN	2	69,451,264 (GRCm38)	missense	probably benign	0.00
IGL02240:Lrp2	APN	2	69,535,046 (GRCm38)	missense	probably benign
IGL02248:Lrp2	APN	2	69,482,808 (GRCm38)	missense	probably damaging	1.00
IGL02369:Lrp2	APN	2	69,464,636 (GRCm38)	missense	probably damaging	1.00
IGL02416:Lrp2	APN	2	69,469,633 (GRCm38)	missense	probably damaging	1.00
IGL02417:Lrp2	APN	2	69,461,305 (GRCm38)	missense	probably damaging	1.00
IGL02458:Lrp2	APN	2	69,521,773 (GRCm38)	missense	probably damaging	0.97
IGL02479:Lrp2	APN	2	69,464,801 (GRCm38)	splice site	probably benign
IGL02508:Lrp2	APN	2	69,503,430 (GRCm38)	missense	probably benign	0.04
IGL02751:Lrp2	APN	2	69,533,462 (GRCm38)	missense	possibly damaging	0.56
IGL02814:Lrp2	APN	2	69,506,736 (GRCm38)	missense	probably damaging	1.00
IGL02867:Lrp2	APN	2	69,552,450 (GRCm38)	missense	possibly damaging	0.67
IGL02889:Lrp2	APN	2	69,552,450 (GRCm38)	missense	possibly damaging	0.67
IGL02943:Lrp2	APN	2	69,455,510 (GRCm38)	missense	possibly damaging	0.86
IGL02948:Lrp2	APN	2	69,487,837 (GRCm38)	missense	probably damaging	1.00
IGL02960:Lrp2	APN	2	69,455,453 (GRCm38)	splice site	probably benign
IGL02990:Lrp2	APN	2	69,441,396 (GRCm38)	missense	possibly damaging	0.56
IGL03027:Lrp2	APN	2	69,537,553 (GRCm38)	missense	probably benign	0.43
IGL03038:Lrp2	APN	2	69,475,464 (GRCm38)	missense	probably damaging	0.99
IGL03064:Lrp2	APN	2	69,483,133 (GRCm38)	missense	probably damaging	0.98
IGL03107:Lrp2	APN	2	69,454,833 (GRCm38)	missense	probably damaging	1.00
IGL03141:Lrp2	APN	2	69,477,026 (GRCm38)	missense	probably damaging	0.99
IGL03154:Lrp2	APN	2	69,549,042 (GRCm38)	missense	probably damaging	1.00
IGL03155:Lrp2	APN	2	69,455,452 (GRCm38)	splice site	probably benign
IGL03163:Lrp2	APN	2	69,501,526 (GRCm38)	nonsense	probably null
IGL03164:Lrp2	APN	2	69,464,699 (GRCm38)	missense	probably damaging	1.00
IGL03169:Lrp2	APN	2	69,523,194 (GRCm38)	missense	probably damaging	1.00
IGL03174:Lrp2	APN	2	69,466,265 (GRCm38)	missense	probably damaging	1.00
IGL03189:Lrp2	APN	2	69,438,478 (GRCm38)	splice site	probably benign
IGL03288:Lrp2	APN	2	69,426,039 (GRCm38)	missense	probably benign	0.02
IGL03350:Lrp2	APN	2	69,438,453 (GRCm38)	missense	probably damaging	1.00
IGL03378:Lrp2	APN	2	69,431,152 (GRCm38)	missense	probably damaging	1.00
casual	UTSW	2	69,499,263 (GRCm38)	missense	probably benign
nonchalant	UTSW	2	69,489,329 (GRCm38)	missense	probably damaging	1.00
Presto	UTSW	2	69,459,531 (GRCm38)	nonsense	probably null
relaxed	UTSW	2	69,535,005 (GRCm38)	missense	probably damaging	1.00
unguarded	UTSW	2	69,465,758 (GRCm38)	missense	probably benign	0.00
Unintended	UTSW	2	69,518,443 (GRCm38)	missense	probably damaging	1.00
BB009:Lrp2	UTSW	2	69,426,027 (GRCm38)	missense	probably benign	0.00
BB019:Lrp2	UTSW	2	69,426,027 (GRCm38)	missense	probably benign	0.00
IGL02835:Lrp2	UTSW	2	69,505,304 (GRCm38)	missense	probably damaging	1.00
IGL03055:Lrp2	UTSW	2	69,458,448 (GRCm38)	missense	probably damaging	1.00
PIT4362001:Lrp2	UTSW	2	69,537,538 (GRCm38)	missense	probably damaging	1.00
PIT4504001:Lrp2	UTSW	2	69,475,403 (GRCm38)	missense	probably damaging	1.00
R0008:Lrp2	UTSW	2	69,516,551 (GRCm38)	missense	probably benign	0.42
R0008:Lrp2	UTSW	2	69,516,551 (GRCm38)	missense	probably benign	0.42
R0044:Lrp2	UTSW	2	69,527,555 (GRCm38)	missense	probably benign	0.01
R0044:Lrp2	UTSW	2	69,527,555 (GRCm38)	missense	probably damaging	0.96
R0048:Lrp2	UTSW	2	69,465,627 (GRCm38)	missense	probably damaging	1.00
R0098:Lrp2	UTSW	2	69,475,412 (GRCm38)	missense	probably damaging	1.00
R0098:Lrp2	UTSW	2	69,475,412 (GRCm38)	missense	probably damaging	1.00
R0103:Lrp2	UTSW	2	69,477,040 (GRCm38)	missense	probably benign
R0167:Lrp2	UTSW	2	69,425,658 (GRCm38)	missense	possibly damaging	0.95
R0226:Lrp2	UTSW	2	69,537,563 (GRCm38)	missense	probably null	1.00
R0243:Lrp2	UTSW	2	69,428,630 (GRCm38)	missense	probably benign	0.00
R0308:Lrp2	UTSW	2	69,482,982 (GRCm38)	splice site	probably benign
R0323:Lrp2	UTSW	2	69,469,639 (GRCm38)	missense	probably damaging	1.00
R0372:Lrp2	UTSW	2	69,535,043 (GRCm38)	missense	probably benign	0.10
R0374:Lrp2	UTSW	2	69,430,307 (GRCm38)	missense	probably damaging	1.00
R0391:Lrp2	UTSW	2	69,460,337 (GRCm38)	splice site	probably benign
R0391:Lrp2	UTSW	2	69,456,858 (GRCm38)	missense	probably damaging	0.99
R0395:Lrp2	UTSW	2	69,433,077 (GRCm38)	missense	possibly damaging	0.89
R0401:Lrp2	UTSW	2	69,479,148 (GRCm38)	missense	probably damaging	0.98
R0471:Lrp2	UTSW	2	69,525,234 (GRCm38)	missense	probably damaging	0.97
R0483:Lrp2	UTSW	2	69,507,801 (GRCm38)	missense	probably damaging	0.99
R0502:Lrp2	UTSW	2	69,511,017 (GRCm38)	missense	probably damaging	1.00
R0542:Lrp2	UTSW	2	69,428,654 (GRCm38)	missense	probably benign	0.00
R0544:Lrp2	UTSW	2	69,491,931 (GRCm38)	missense	probably benign	0.18
R0548:Lrp2	UTSW	2	69,537,638 (GRCm38)	splice site	probably benign
R0593:Lrp2	UTSW	2	69,467,006 (GRCm38)	missense	probably benign
R0608:Lrp2	UTSW	2	69,486,243 (GRCm38)	missense	probably benign	0.02
R0633:Lrp2	UTSW	2	69,448,120 (GRCm38)	missense	probably damaging	1.00
R0691:Lrp2	UTSW	2	69,451,380 (GRCm38)	missense	probably benign	0.19
R0718:Lrp2	UTSW	2	69,510,948 (GRCm38)	missense	probably damaging	1.00
R0737:Lrp2	UTSW	2	69,448,169 (GRCm38)	missense	probably damaging	0.96
R0771:Lrp2	UTSW	2	69,507,990 (GRCm38)	missense	probably damaging	1.00
R0784:Lrp2	UTSW	2	69,518,365 (GRCm38)	missense	probably benign	0.32
R0885:Lrp2	UTSW	2	69,482,353 (GRCm38)	missense	possibly damaging	0.75
R0947:Lrp2	UTSW	2	69,487,838 (GRCm38)	missense	probably damaging	1.00
R1235:Lrp2	UTSW	2	69,524,036 (GRCm38)	missense	probably damaging	1.00
R1293:Lrp2	UTSW	2	69,523,302 (GRCm38)	splice site	probably null
R1301:Lrp2	UTSW	2	69,428,604 (GRCm38)	missense	probably damaging	0.98
R1387:Lrp2	UTSW	2	69,456,918 (GRCm38)	missense	probably damaging	1.00
R1459:Lrp2	UTSW	2	69,483,394 (GRCm38)	missense	probably damaging	0.99
R1459:Lrp2	UTSW	2	69,460,477 (GRCm38)	missense	probably damaging	1.00
R1529:Lrp2	UTSW	2	69,523,182 (GRCm38)	missense	probably damaging	1.00
R1543:Lrp2	UTSW	2	69,500,730 (GRCm38)	missense	probably damaging	1.00
R1546:Lrp2	UTSW	2	69,502,610 (GRCm38)	missense	probably damaging	1.00
R1550:Lrp2	UTSW	2	69,502,661 (GRCm38)	missense	possibly damaging	0.74
R1590:Lrp2	UTSW	2	69,466,763 (GRCm38)	critical splice donor site	probably null
R1689:Lrp2	UTSW	2	69,503,529 (GRCm38)	missense	probably benign	0.09
R1693:Lrp2	UTSW	2	69,510,418 (GRCm38)	missense	probably damaging	1.00
R1753:Lrp2	UTSW	2	69,496,489 (GRCm38)	missense	possibly damaging	0.87
R1799:Lrp2	UTSW	2	69,503,530 (GRCm38)	missense	probably benign	0.04
R1834:Lrp2	UTSW	2	69,466,880 (GRCm38)	missense	probably benign	0.01
R1921:Lrp2	UTSW	2	69,523,287 (GRCm38)	missense	probably damaging	1.00
R2000:Lrp2	UTSW	2	69,467,090 (GRCm38)	missense	probably damaging	1.00
R2077:Lrp2	UTSW	2	69,507,843 (GRCm38)	missense	probably damaging	1.00
R2092:Lrp2	UTSW	2	69,536,021 (GRCm38)	missense	probably benign	0.25
R2093:Lrp2	UTSW	2	69,536,021 (GRCm38)	missense	probably benign	0.25
R2108:Lrp2	UTSW	2	69,506,624 (GRCm38)	missense	possibly damaging	0.75
R2117:Lrp2	UTSW	2	69,483,385 (GRCm38)	missense	probably benign	0.05
R2122:Lrp2	UTSW	2	69,483,707 (GRCm38)	missense	probably damaging	1.00
R2134:Lrp2	UTSW	2	69,511,067 (GRCm38)	missense	probably damaging	1.00
R2207:Lrp2	UTSW	2	69,467,028 (GRCm38)	missense	possibly damaging	0.94
R2248:Lrp2	UTSW	2	69,511,010 (GRCm38)	missense	probably damaging	1.00
R2264:Lrp2	UTSW	2	69,482,366 (GRCm38)	missense	possibly damaging	0.88
R2316:Lrp2	UTSW	2	69,491,847 (GRCm38)	missense	possibly damaging	0.75
R2513:Lrp2	UTSW	2	69,506,374 (GRCm38)	splice site	probably null
R2984:Lrp2	UTSW	2	69,425,814 (GRCm38)	splice site	probably null
R3085:Lrp2	UTSW	2	69,467,135 (GRCm38)	missense	probably benign	0.05
R3103:Lrp2	UTSW	2	69,431,984 (GRCm38)	missense	probably benign	0.00
R3727:Lrp2	UTSW	2	69,510,429 (GRCm38)	missense	probably damaging	1.00
R3730:Lrp2	UTSW	2	69,464,579 (GRCm38)	missense	probably damaging	0.99
R3730:Lrp2	UTSW	2	69,534,907 (GRCm38)	critical splice donor site	probably null
R3731:Lrp2	UTSW	2	69,464,579 (GRCm38)	missense	probably damaging	0.99
R3731:Lrp2	UTSW	2	69,534,907 (GRCm38)	critical splice donor site	probably null
R3764:Lrp2	UTSW	2	69,496,336 (GRCm38)	missense	probably damaging	1.00
R3768:Lrp2	UTSW	2	69,505,105 (GRCm38)	missense	probably benign	0.34
R3778:Lrp2	UTSW	2	69,509,204 (GRCm38)	missense	probably benign	0.00
R3808:Lrp2	UTSW	2	69,501,548 (GRCm38)	missense	probably damaging	1.00
R3809:Lrp2	UTSW	2	69,501,548 (GRCm38)	missense	probably damaging	1.00
R3813:Lrp2	UTSW	2	69,464,579 (GRCm38)	missense	probably damaging	0.99
R3828:Lrp2	UTSW	2	69,426,012 (GRCm38)	missense	probably benign	0.03
R3852:Lrp2	UTSW	2	69,537,565 (GRCm38)	missense	probably damaging	0.96
R3877:Lrp2	UTSW	2	69,459,472 (GRCm38)	critical splice donor site	probably null
R3877:Lrp2	UTSW	2	69,549,047 (GRCm38)	missense	probably damaging	1.00
R3922:Lrp2	UTSW	2	69,506,376 (GRCm38)	missense	probably benign
R4081:Lrp2	UTSW	2	69,513,273 (GRCm38)	missense	probably damaging	0.98
R4082:Lrp2	UTSW	2	69,513,273 (GRCm38)	missense	probably damaging	0.98
R4118:Lrp2	UTSW	2	69,430,262 (GRCm38)	critical splice donor site	probably null
R4193:Lrp2	UTSW	2	69,467,143 (GRCm38)	missense	probably damaging	1.00
R4284:Lrp2	UTSW	2	69,480,094 (GRCm38)	missense	possibly damaging	0.95
R4322:Lrp2	UTSW	2	69,425,991 (GRCm38)	nonsense	probably null
R4352:Lrp2	UTSW	2	69,432,182 (GRCm38)	critical splice donor site	probably null
R4407:Lrp2	UTSW	2	69,502,517 (GRCm38)	missense	probably damaging	1.00
R4408:Lrp2	UTSW	2	69,467,169 (GRCm38)	missense	probably benign	0.09
R4416:Lrp2	UTSW	2	69,527,231 (GRCm38)	missense	probably benign	0.18
R4426:Lrp2	UTSW	2	69,506,348 (GRCm38)	missense	probably benign	0.00
R4510:Lrp2	UTSW	2	69,480,062 (GRCm38)	missense	possibly damaging	0.58
R4511:Lrp2	UTSW	2	69,480,062 (GRCm38)	missense	possibly damaging	0.58
R4553:Lrp2	UTSW	2	69,513,285 (GRCm38)	missense	probably benign	0.13
R4591:Lrp2	UTSW	2	69,536,075 (GRCm38)	missense	probably damaging	1.00
R4612:Lrp2	UTSW	2	69,458,427 (GRCm38)	nonsense	probably null
R4622:Lrp2	UTSW	2	69,460,349 (GRCm38)	missense	possibly damaging	0.87
R4632:Lrp2	UTSW	2	69,489,129 (GRCm38)	splice site	probably null
R4633:Lrp2	UTSW	2	69,461,417 (GRCm38)	missense	probably benign	0.16
R4636:Lrp2	UTSW	2	69,436,639 (GRCm38)	missense	possibly damaging	0.93
R4657:Lrp2	UTSW	2	69,466,993 (GRCm38)	missense	probably damaging	1.00
R4667:Lrp2	UTSW	2	69,489,298 (GRCm38)	missense	probably benign	0.02
R4712:Lrp2	UTSW	2	69,506,551 (GRCm38)	missense	probably damaging	1.00
R4713:Lrp2	UTSW	2	69,487,966 (GRCm38)	missense	probably damaging	1.00
R4720:Lrp2	UTSW	2	69,481,173 (GRCm38)	missense	probably damaging	0.99
R4732:Lrp2	UTSW	2	69,533,555 (GRCm38)	missense	probably benign
R4733:Lrp2	UTSW	2	69,533,555 (GRCm38)	missense	probably benign
R4777:Lrp2	UTSW	2	69,482,264 (GRCm38)	missense	probably damaging	1.00
R4779:Lrp2	UTSW	2	69,459,715 (GRCm38)	missense	possibly damaging	0.75
R4786:Lrp2	UTSW	2	69,537,956 (GRCm38)	missense	probably damaging	1.00
R4842:Lrp2	UTSW	2	69,469,411 (GRCm38)	missense	probably benign	0.06
R4845:Lrp2	UTSW	2	69,509,241 (GRCm38)	missense	possibly damaging	0.71
R4846:Lrp2	UTSW	2	69,479,113 (GRCm38)	missense	probably damaging	1.00
R4938:Lrp2	UTSW	2	69,472,368 (GRCm38)	missense	probably damaging	0.98
R4951:Lrp2	UTSW	2	69,535,988 (GRCm38)	missense	probably damaging	1.00
R4990:Lrp2	UTSW	2	69,481,388 (GRCm38)	missense	probably benign	0.01
R5075:Lrp2	UTSW	2	69,465,758 (GRCm38)	missense	probably benign	0.00
R5078:Lrp2	UTSW	2	69,501,530 (GRCm38)	missense	possibly damaging	0.93
R5102:Lrp2	UTSW	2	69,489,158 (GRCm38)	missense	probably damaging	0.98
R5124:Lrp2	UTSW	2	69,501,490 (GRCm38)	missense	probably damaging	0.97
R5131:Lrp2	UTSW	2	69,430,342 (GRCm38)	missense	possibly damaging	0.74
R5141:Lrp2	UTSW	2	69,552,349 (GRCm38)	splice site	probably null
R5223:Lrp2	UTSW	2	69,524,053 (GRCm38)	missense	probably damaging	0.99
R5236:Lrp2	UTSW	2	69,456,819 (GRCm38)	splice site	probably null
R5267:Lrp2	UTSW	2	69,548,978 (GRCm38)	missense	possibly damaging	0.83
R5290:Lrp2	UTSW	2	69,513,354 (GRCm38)	missense	probably damaging	1.00
R5333:Lrp2	UTSW	2	69,525,228 (GRCm38)	missense	probably benign	0.01
R5355:Lrp2	UTSW	2	69,454,838 (GRCm38)	nonsense	probably null
R5356:Lrp2	UTSW	2	69,464,708 (GRCm38)	missense	possibly damaging	0.74
R5369:Lrp2	UTSW	2	69,459,560 (GRCm38)	missense	probably benign	0.04
R5486:Lrp2	UTSW	2	69,437,465 (GRCm38)	missense	probably benign	0.04
R5554:Lrp2	UTSW	2	69,552,424 (GRCm38)	missense	possibly damaging	0.92
R5584:Lrp2	UTSW	2	69,451,288 (GRCm38)	missense	probably damaging	1.00
R5585:Lrp2	UTSW	2	69,464,624 (GRCm38)	missense	possibly damaging	0.77
R5587:Lrp2	UTSW	2	69,499,263 (GRCm38)	missense	probably benign
R5605:Lrp2	UTSW	2	69,523,299 (GRCm38)	missense	probably damaging	1.00
R5637:Lrp2	UTSW	2	69,472,418 (GRCm38)	missense	probably damaging	1.00
R5647:Lrp2	UTSW	2	69,519,914 (GRCm38)	missense	probably null	0.80
R5686:Lrp2	UTSW	2	69,511,061 (GRCm38)	missense	possibly damaging	0.88
R5691:Lrp2	UTSW	2	69,502,553 (GRCm38)	missense	probably damaging	1.00
R5724:Lrp2	UTSW	2	69,451,382 (GRCm38)	missense	probably damaging	0.99
R5726:Lrp2	UTSW	2	69,509,147 (GRCm38)	missense	probably damaging	1.00
R5743:Lrp2	UTSW	2	69,466,877 (GRCm38)	missense	probably damaging	1.00
R5777:Lrp2	UTSW	2	69,455,525 (GRCm38)	missense	probably damaging	1.00
R5841:Lrp2	UTSW	2	69,480,153 (GRCm38)	missense	probably benign	0.00
R5892:Lrp2	UTSW	2	69,442,776 (GRCm38)	missense	probably benign
R5951:Lrp2	UTSW	2	69,496,323 (GRCm38)	splice site	probably null
R5974:Lrp2	UTSW	2	69,459,548 (GRCm38)	missense	probably damaging	1.00
R5980:Lrp2	UTSW	2	69,535,005 (GRCm38)	missense	probably damaging	1.00
R6046:Lrp2	UTSW	2	69,506,754 (GRCm38)	missense	probably damaging	1.00
R6113:Lrp2	UTSW	2	69,483,557 (GRCm38)	missense	possibly damaging	0.76
R6146:Lrp2	UTSW	2	69,511,001 (GRCm38)	missense	probably benign	0.00
R6177:Lrp2	UTSW	2	69,510,419 (GRCm38)	frame shift	probably null
R6180:Lrp2	UTSW	2	69,503,524 (GRCm38)	missense	possibly damaging	0.85
R6219:Lrp2	UTSW	2	69,469,478 (GRCm38)	missense	probably damaging	1.00
R6228:Lrp2	UTSW	2	69,482,366 (GRCm38)	missense	possibly damaging	0.88
R6265:Lrp2	UTSW	2	69,466,340 (GRCm38)	missense	probably damaging	1.00
R6312:Lrp2	UTSW	2	69,436,681 (GRCm38)	missense	probably damaging	1.00
R6337:Lrp2	UTSW	2	69,438,467 (GRCm38)	missense	probably damaging	1.00
R6376:Lrp2	UTSW	2	69,483,443 (GRCm38)	missense	probably benign	0.02
R6385:Lrp2	UTSW	2	69,495,784 (GRCm38)	missense	probably benign	0.22
R6429:Lrp2	UTSW	2	69,461,287 (GRCm38)	missense	probably damaging	1.00
R6458:Lrp2	UTSW	2	69,505,156 (GRCm38)	missense	probably benign	0.00
R6524:Lrp2	UTSW	2	69,436,639 (GRCm38)	missense	possibly damaging	0.93
R6555:Lrp2	UTSW	2	69,509,303 (GRCm38)	missense	probably benign	0.00
R6594:Lrp2	UTSW	2	69,439,923 (GRCm38)	missense	possibly damaging	0.58
R6599:Lrp2	UTSW	2	69,469,405 (GRCm38)	missense	probably damaging	1.00
R6655:Lrp2	UTSW	2	69,453,858 (GRCm38)	missense	probably benign	0.01
R6718:Lrp2	UTSW	2	69,483,780 (GRCm38)	missense	probably benign	0.09
R6736:Lrp2	UTSW	2	69,448,211 (GRCm38)	missense	probably benign	0.02
R6738:Lrp2	UTSW	2	69,458,488 (GRCm38)	missense	probably damaging	0.97
R6799:Lrp2	UTSW	2	69,483,904 (GRCm38)	missense	probably damaging	1.00
R6846:Lrp2	UTSW	2	69,518,443 (GRCm38)	missense	probably damaging	1.00
R6856:Lrp2	UTSW	2	69,513,268 (GRCm38)	missense	probably damaging	1.00
R6861:Lrp2	UTSW	2	69,513,377 (GRCm38)	missense	possibly damaging	0.77
R6888:Lrp2	UTSW	2	69,524,141 (GRCm38)	missense	probably damaging	0.98
R6902:Lrp2	UTSW	2	69,459,503 (GRCm38)	missense	probably damaging	1.00
R6908:Lrp2	UTSW	2	69,472,365 (GRCm38)	missense	probably damaging	1.00
R6918:Lrp2	UTSW	2	69,489,305 (GRCm38)	missense	probably damaging	1.00
R6989:Lrp2	UTSW	2	69,472,455 (GRCm38)	missense	probably damaging	1.00
R7022:Lrp2	UTSW	2	69,483,208 (GRCm38)	missense	probably damaging	1.00
R7025:Lrp2	UTSW	2	69,483,028 (GRCm38)	missense	possibly damaging	0.90
R7026:Lrp2	UTSW	2	69,521,787 (GRCm38)	missense	probably damaging	0.97
R7138:Lrp2	UTSW	2	69,465,745 (GRCm38)	missense	possibly damaging	0.94
R7145:Lrp2	UTSW	2	69,454,808 (GRCm38)	critical splice donor site	probably null
R7150:Lrp2	UTSW	2	69,488,051 (GRCm38)	missense	probably damaging	0.99
R7165:Lrp2	UTSW	2	69,506,573 (GRCm38)	missense	probably damaging	0.99
R7174:Lrp2	UTSW	2	69,433,072 (GRCm38)	missense	probably benign	0.11
R7204:Lrp2	UTSW	2	69,472,533 (GRCm38)	missense	probably benign	0.25
R7275:Lrp2	UTSW	2	69,459,531 (GRCm38)	nonsense	probably null
R7278:Lrp2	UTSW	2	69,486,352 (GRCm38)	missense	probably damaging	1.00
R7296:Lrp2	UTSW	2	69,482,381 (GRCm38)	missense	probably benign	0.04
R7315:Lrp2	UTSW	2	69,491,822 (GRCm38)	missense	probably damaging	0.98
R7342:Lrp2	UTSW	2	69,479,290 (GRCm38)	missense	possibly damaging	0.95
R7351:Lrp2	UTSW	2	69,448,142 (GRCm38)	missense	probably damaging	1.00
R7352:Lrp2	UTSW	2	69,472,397 (GRCm38)	missense	probably benign	0.04
R7366:Lrp2	UTSW	2	69,483,806 (GRCm38)	missense	probably damaging	1.00
R7373:Lrp2	UTSW	2	69,500,692 (GRCm38)	missense	probably damaging	1.00
R7446:Lrp2	UTSW	2	69,459,674 (GRCm38)	missense	probably damaging	0.99
R7446:Lrp2	UTSW	2	69,432,213 (GRCm38)	missense	probably damaging	1.00
R7451:Lrp2	UTSW	2	69,513,333 (GRCm38)	missense	probably damaging	1.00
R7492:Lrp2	UTSW	2	69,537,581 (GRCm38)	missense	probably damaging	0.99
R7571:Lrp2	UTSW	2	69,516,403 (GRCm38)	missense	probably damaging	1.00
R7638:Lrp2	UTSW	2	69,477,008 (GRCm38)	critical splice donor site	probably null
R7664:Lrp2	UTSW	2	69,506,732 (GRCm38)	missense	probably damaging	1.00
R7686:Lrp2	UTSW	2	69,489,237 (GRCm38)	missense	probably damaging	1.00
R7711:Lrp2	UTSW	2	69,479,343 (GRCm38)	critical splice acceptor site	probably null
R7737:Lrp2	UTSW	2	69,496,438 (GRCm38)	missense	possibly damaging	0.77
R7763:Lrp2	UTSW	2	69,503,388 (GRCm38)	missense	probably damaging	0.99
R7775:Lrp2	UTSW	2	69,501,539 (GRCm38)	missense	possibly damaging	0.74
R7824:Lrp2	UTSW	2	69,501,539 (GRCm38)	missense	possibly damaging	0.74
R7840:Lrp2	UTSW	2	69,464,784 (GRCm38)	missense	probably damaging	0.98
R7878:Lrp2	UTSW	2	69,507,809 (GRCm38)	missense	probably damaging	1.00
R7878:Lrp2	UTSW	2	69,507,810 (GRCm38)	missense	probably damaging	1.00
R7895:Lrp2	UTSW	2	69,458,479 (GRCm38)	missense	probably damaging	0.97
R7898:Lrp2	UTSW	2	69,441,366 (GRCm38)	missense	probably benign	0.00
R7912:Lrp2	UTSW	2	69,428,672 (GRCm38)	missense	probably benign	0.03
R7923:Lrp2	UTSW	2	69,438,388 (GRCm38)	missense	possibly damaging	0.75
R7932:Lrp2	UTSW	2	69,426,027 (GRCm38)	missense	probably benign	0.00
R7940:Lrp2	UTSW	2	69,432,197 (GRCm38)	missense	possibly damaging	0.91
R7954:Lrp2	UTSW	2	69,503,523 (GRCm38)	missense	possibly damaging	0.61
R8007:Lrp2	UTSW	2	69,506,505 (GRCm38)	missense	probably benign	0.02
R8084:Lrp2	UTSW	2	69,509,369 (GRCm38)	missense	probably damaging	0.97
R8087:Lrp2	UTSW	2	69,448,129 (GRCm38)	missense	probably damaging	1.00
R8090:Lrp2	UTSW	2	69,464,745 (GRCm38)	missense	possibly damaging	0.94
R8110:Lrp2	UTSW	2	69,506,453 (GRCm38)	missense	probably benign
R8129:Lrp2	UTSW	2	69,430,280 (GRCm38)	missense	possibly damaging	0.75
R8155:Lrp2	UTSW	2	69,482,998 (GRCm38)	missense	possibly damaging	0.74
R8182:Lrp2	UTSW	2	69,489,329 (GRCm38)	missense	probably damaging	1.00
R8239:Lrp2	UTSW	2	69,481,267 (GRCm38)	nonsense	probably null
R8247:Lrp2	UTSW	2	69,431,087 (GRCm38)	missense	possibly damaging	0.76
R8327:Lrp2	UTSW	2	69,491,924 (GRCm38)	missense	probably damaging	1.00
R8355:Lrp2	UTSW	2	69,516,484 (GRCm38)	missense	probably damaging	0.99
R8404:Lrp2	UTSW	2	69,514,241 (GRCm38)	nonsense	probably null
R8427:Lrp2	UTSW	2	69,451,297 (GRCm38)	missense	probably damaging	0.97
R8463:Lrp2	UTSW	2	69,491,906 (GRCm38)	missense	probably damaging	1.00
R8502:Lrp2	UTSW	2	69,514,241 (GRCm38)	nonsense	probably null
R8529:Lrp2	UTSW	2	69,500,642 (GRCm38)	missense	probably damaging	0.96
R8673:Lrp2	UTSW	2	69,472,460 (GRCm38)	missense	probably damaging	1.00
R8698:Lrp2	UTSW	2	69,458,423 (GRCm38)	missense	probably benign	0.37
R8698:Lrp2	UTSW	2	69,448,239 (GRCm38)	missense	probably benign	0.39
R8708:Lrp2	UTSW	2	69,459,613 (GRCm38)	missense	probably damaging	1.00
R8716:Lrp2	UTSW	2	69,443,794 (GRCm38)	missense	probably benign	0.04
R8723:Lrp2	UTSW	2	69,486,304 (GRCm38)	missense	probably damaging	1.00
R8787:Lrp2	UTSW	2	69,552,401 (GRCm38)	missense	probably damaging	1.00
R8903:Lrp2	UTSW	2	69,549,038 (GRCm38)	missense	possibly damaging	0.68
R8944:Lrp2	UTSW	2	69,511,004 (GRCm38)	missense	probably damaging	1.00
R9069:Lrp2	UTSW	2	69,501,652 (GRCm38)	missense	probably damaging	1.00
R9076:Lrp2	UTSW	2	69,519,916 (GRCm38)	missense	probably benign	0.01
R9155:Lrp2	UTSW	2	69,461,369 (GRCm38)	nonsense	probably null
R9173:Lrp2	UTSW	2	69,469,387 (GRCm38)	missense	probably damaging	1.00
R9254:Lrp2	UTSW	2	69,503,547 (GRCm38)	missense	probably benign	0.09
R9256:Lrp2	UTSW	2	69,510,959 (GRCm38)	missense	probably benign	0.03
R9291:Lrp2	UTSW	2	69,480,035 (GRCm38)	missense	probably damaging	1.00
R9335:Lrp2	UTSW	2	69,428,639 (GRCm38)	missense	probably benign	0.01
R9357:Lrp2	UTSW	2	69,506,573 (GRCm38)	missense	probably damaging	0.99
R9368:Lrp2	UTSW	2	69,527,635 (GRCm38)	missense	probably damaging	0.99
R9453:Lrp2	UTSW	2	69,458,488 (GRCm38)	missense	probably damaging	1.00
R9546:Lrp2	UTSW	2	69,456,821 (GRCm38)	critical splice donor site	probably null
R9554:Lrp2	UTSW	2	69,431,153 (GRCm38)	missense	probably damaging	1.00
R9597:Lrp2	UTSW	2	69,430,359 (GRCm38)	missense	probably benign	0.02
R9601:Lrp2	UTSW	2	69,459,584 (GRCm38)	missense	probably damaging	1.00
R9623:Lrp2	UTSW	2	69,477,079 (GRCm38)	missense	probably benign	0.09
RF016:Lrp2	UTSW	2	69,509,205 (GRCm38)	missense	probably benign
X0011:Lrp2	UTSW	2	69,519,998 (GRCm38)	missense	probably damaging	1.00
X0023:Lrp2	UTSW	2	69,436,600 (GRCm38)	missense	probably damaging	0.99
Z1176:Lrp2	UTSW	2	69,507,881 (GRCm38)	missense	possibly damaging	0.88
Z1176:Lrp2	UTSW	2	69,480,042 (GRCm38)	missense	possibly damaging	0.66
Z1177:Lrp2	UTSW	2	69,496,468 (GRCm38)	missense	probably damaging	1.00
Z1177:Lrp2	UTSW	2	69,472,453 (GRCm38)	missense	probably benign	0.03
Z1177:Lrp2	UTSW	2	69,451,280 (GRCm38)	missense	probably damaging	1.00
Z1177:Lrp2	UTSW	2	69,509,289 (GRCm38)	missense	probably benign	0.00
Z1177:Lrp2	UTSW	2	69,501,641 (GRCm38)	missense	probably damaging	1.00

Predicted Primers

PCR Primer
(F):5'- GCACAGATACTTACTAAGTGCCC -3'
(R):5'- AACCGAATGCTGTCTTTGGTG -3'

Sequencing Primer
(F):5'- CCACACTGATGCTCATCACTG -3'
(R):5'- TGCTTCCCAGTTCCAAAC -3'

Posted On

2018-11-06