Mutagenetix > Incidental Mutation

Incidental Mutation 'R6897:Morn1'

538379

Institutional Source

Beutler Lab

Gene Symbol

Morn1

Ensembl Gene

ENSMUSG00000029049

Gene Name

MORN repeat containing 1

Synonyms

4930417P05Rik, 2900057D20Rik

MMRRC Submission

044991-MU

Accession Numbers

Essential gene?

Non essential (E-score: 0.000) question?

Stock #

R6897 (G1)

Quality Score

180.009

Status

Validated

Chromosome

Chromosomal Location

155171034-155229962 bp(+) (GRCm39)

Type of Mutation

missense

DNA Base Change (assembly)

A to G at 155171112 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Histidine to Arginine at position 17 (H17R)

Ref Sequence

ENSEMBL: ENSMUSP00000116690 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000030914] [ENSMUST00000030915] [ENSMUST00000127457] [ENSMUST00000132367] [ENSMUST00000155775]

AlphaFold

A2RTS7

Predicted Effect

probably benign
Transcript: ENSMUST00000030914

SMART Domains

Protein: ENSMUSP00000030914
Gene: ENSMUSG00000029048

Domain	Start	End	E-Value	Type
Pfam:Rer1	20	185	4.1e-82	PFAM

Predicted Effect

probably benign
Transcript: ENSMUST00000030915
AA Change: H17R

PolyPhen 2 Score 0.000 (Sensitivity: 1.00; Specificity: 0.00)

SMART Domains

Protein: ENSMUSP00000030915
Gene: ENSMUSG00000029049
AA Change: H17R

Domain	Start	End	E-Value	Type
Pfam:MORN	23	35	1.4e-3	PFAM
MORN	37	58	4.11e-6	SMART
MORN	60	81	2.41e-1	SMART
MORN	84	105	1.43e-1	SMART
MORN	107	128	8.05e0	SMART
MORN	130	151	2.06e-6	SMART
MORN	153	174	7.56e-5	SMART
MORN	176	197	1.2e0	SMART

Predicted Effect

probably benign
Transcript: ENSMUST00000127457
AA Change: H17R

PolyPhen 2 Score 0.057 (Sensitivity: 0.94; Specificity: 0.84)

SMART Domains

Protein: ENSMUSP00000116690
Gene: ENSMUSG00000029049
AA Change: H17R

Domain	Start	End	E-Value	Type
Pfam:MORN	23	35	5.5e-4	PFAM
MORN	37	58	4.11e-6	SMART
MORN	60	81	2.41e-1	SMART
MORN	84	105	1.43e-1	SMART
MORN	107	128	8.05e0	SMART
MORN	130	151	2.06e-6	SMART
MORN	153	174	7.56e-5	SMART

Predicted Effect

probably benign
Transcript: ENSMUST00000132367
AA Change: H17R

PolyPhen 2 Score 0.000 (Sensitivity: 1.00; Specificity: 0.00)

SMART Domains

Protein: ENSMUSP00000116794
Gene: ENSMUSG00000029049
AA Change: H17R

Domain	Start	End	E-Value	Type
Pfam:MORN	23	35	6.8e-4	PFAM
MORN	37	58	4.11e-6	SMART
MORN	60	81	2.41e-1	SMART
MORN	84	105	1.43e-1	SMART
MORN	107	128	8.05e0	SMART
MORN	130	151	2.06e-6	SMART
MORN	153	174	7.56e-5	SMART
MORN	176	197	1.2e0	SMART

Predicted Effect

probably benign
Transcript: ENSMUST00000155775
AA Change: H17R

PolyPhen 2 Score 0.000 (Sensitivity: 1.00; Specificity: 0.00)

SMART Domains

Protein: ENSMUSP00000123207
Gene: ENSMUSG00000029049
AA Change: H17R

Domain	Start	End	E-Value	Type
Pfam:MORN	23	35	2.7e-4	PFAM
MORN	37	58	4.11e-6	SMART
MORN	60	81	2.41e-1	SMART
MORN	93	114	2.06e-6	SMART

Meta Mutation Damage Score

0.0898

Coding Region Coverage

1x: 100.0%
3x: 99.9%
10x: 99.3%
20x: 97.7%

Validation Efficiency

97% (72/74)

Allele List at MGI

Other mutations in this stock

Total: 72 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
4930579F01Rik	T	C	3: 137,889,534 (GRCm39)	I28V	possibly damaging	Het
Adamts2	A	T	11: 50,627,991 (GRCm39)		probably null	Het
Adgrg1	T	C	8: 95,729,126 (GRCm39)	F17L	probably benign	Het
Aldob	A	G	4: 49,539,789 (GRCm39)	L183P	probably damaging	Het
Alg5	T	C	3: 54,656,063 (GRCm39)	C270R	probably benign	Het
Anxa4	T	A	6: 86,720,160 (GRCm39)		probably null	Het
Armc2	C	A	10: 41,869,225 (GRCm39)		probably null	Het
Atrnl1	A	G	19: 58,030,800 (GRCm39)	N1314S	probably benign	Het
Bbs7	T	A	3: 36,652,460 (GRCm39)	E331V	probably benign	Het
Bmper	T	A	9: 23,285,225 (GRCm39)	V258E	probably benign	Het
Catspere2	A	T	1: 177,939,139 (GRCm39)	I671F	possibly damaging	Het
Cd101	A	G	3: 100,920,376 (GRCm39)	S508P	probably damaging	Het
Cd177	C	T	7: 24,444,499 (GRCm39)	R694H	probably benign	Het
Clptm1	C	A	7: 19,369,751 (GRCm39)	Q386H	possibly damaging	Het
Cnrip1	A	G	11: 17,004,705 (GRCm39)	Y85C	probably damaging	Het
Dclk2	A	T	3: 86,739,070 (GRCm39)	F310I	probably benign	Het
Dmxl1	A	G	18: 49,984,562 (GRCm39)	K186R	probably null	Het
Dmxl1	C	A	18: 49,996,124 (GRCm39)	Q417K	possibly damaging	Het
Eloa	T	C	4: 135,740,220 (GRCm39)	D67G	possibly damaging	Het
Elovl4	T	C	9: 83,665,278 (GRCm39)	I103V	probably benign	Het
Gabpa	C	G	16: 84,657,361 (GRCm39)	A412G	probably benign	Het
Gldn	T	A	9: 54,242,158 (GRCm39)		probably null	Het
Ino80d	A	T	1: 63,104,993 (GRCm39)	I361N	probably damaging	Het
Kalrn	G	A	16: 33,796,073 (GRCm39)	T1234M	probably damaging	Het
Kcnk13	T	A	12: 100,028,026 (GRCm39)	M367K	probably benign	Het
Klrd1	G	A	6: 129,570,468 (GRCm39)	R8Q	possibly damaging	Het
Kmt2a	T	C	9: 44,758,942 (GRCm39)	N969S	probably benign	Het
Lgi4	A	G	7: 30,768,315 (GRCm39)	D438G	probably benign	Het
Lig1	T	C	7: 13,039,840 (GRCm39)	L684P	probably damaging	Het
Lrp2	T	C	2: 69,340,846 (GRCm39)	M1010V	probably benign	Het
Magi3	C	A	3: 103,996,873 (GRCm39)	R224I	probably damaging	Het
Mier2	T	C	10: 79,380,573 (GRCm39)	N277S	probably damaging	Het
Nf2	A	T	11: 4,749,878 (GRCm39)	S265T	probably damaging	Het
Or5m11b	A	G	2: 85,805,700 (GRCm39)	T38A	possibly damaging	Het
Or8k24	G	A	2: 86,216,024 (GRCm39)	T246I	possibly damaging	Het
Palb2	A	G	7: 121,726,270 (GRCm39)		probably null	Het
Pdzd2	C	T	15: 12,385,951 (GRCm39)	V940M	probably damaging	Het
Phldb2	T	C	16: 45,598,138 (GRCm39)	K850E	probably damaging	Het
Pitx1	G	A	13: 55,976,335 (GRCm39)	T108M	probably damaging	Het
Polr2a	C	T	11: 69,626,787 (GRCm39)	A1516T	probably benign	Het
Pomp	T	A	5: 147,812,313 (GRCm39)	M133K	possibly damaging	Het
Prex1	T	C	2: 166,423,913 (GRCm39)	E993G	probably damaging	Het
Prrc2c	C	A	1: 162,533,075 (GRCm39)		probably benign	Het
Pwp2	C	A	10: 78,007,917 (GRCm39)	Q879H	probably damaging	Het
Rab26	G	A	17: 24,748,766 (GRCm39)	T245I	probably damaging	Het
Rapgef1	A	G	2: 29,592,514 (GRCm39)	D502G	probably damaging	Het
Rsf1	GGCG	GGCGACGGCCGCG	7: 97,229,113 (GRCm39)		probably benign	Het
Sema5a	T	A	15: 32,550,421 (GRCm39)	D153E	probably benign	Het
Sez6	C	G	11: 77,844,385 (GRCm39)	H69Q	probably damaging	Het
Sgsm3	A	T	15: 80,893,095 (GRCm39)	T391S	probably benign	Het
Sh3rf2	T	C	18: 42,234,670 (GRCm39)	V151A	possibly damaging	Het
Socs1	G	T	16: 10,602,266 (GRCm39)	A157E	probably benign	Het
Spmip4	T	A	6: 50,566,145 (GRCm39)	Q110L	possibly damaging	Het
Sptbn4	C	A	7: 27,071,375 (GRCm39)	V346L	possibly damaging	Het
Srgap1	T	A	10: 121,621,523 (GRCm39)	H990L	probably damaging	Het
Tbc1d9	G	T	8: 83,892,809 (GRCm39)	G36W	probably damaging	Het
Tbk1	T	C	10: 121,395,782 (GRCm39)	E437G	probably benign	Het
Tns3	A	G	11: 8,481,743 (GRCm39)	L203P	probably damaging	Het
Tspoap1	A	T	11: 87,656,638 (GRCm39)	K283M	probably damaging	Het
Ttyh1	C	T	7: 4,127,649 (GRCm39)		probably benign	Het
Ufd1	T	A	16: 18,645,850 (GRCm39)	I254N	probably benign	Het
Ugdh	T	G	5: 65,584,776 (GRCm39)	T49P	probably benign	Het
Vav3	T	C	3: 109,434,810 (GRCm39)	L447P	probably damaging	Het
Vmn1r216	A	T	13: 23,283,445 (GRCm39)	K43*	probably null	Het
Vmn2r111	T	C	17: 22,778,032 (GRCm39)	N549S	possibly damaging	Het
Vmn2r13	A	G	5: 109,306,015 (GRCm39)	I521T	possibly damaging	Het
Wdfy3	T	C	5: 101,991,932 (GRCm39)	T3470A	probably benign	Het
Wdhd1	T	A	14: 47,485,587 (GRCm39)	K791N	probably damaging	Het
Xirp2	A	G	2: 67,338,911 (GRCm39)	D384G	probably damaging	Het
Zfp512b	C	T	2: 181,232,273 (GRCm39)	R86Q	probably damaging	Het
Zfp735	A	C	11: 73,601,880 (GRCm39)	I275L	probably benign	Het
Zfp957	A	T	14: 79,451,344 (GRCm39)	S152T	probably damaging	Het

Other mutations in Morn1

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL00471:Morn1	APN	4	155,176,785 (GRCm39)	missense	possibly damaging	0.81
IGL01143:Morn1	APN	4	155,176,761 (GRCm39)	missense	probably damaging	1.00
IGL02214:Morn1	APN	4	155,176,776 (GRCm39)	missense	probably damaging	1.00
IGL03112:Morn1	APN	4	155,177,601 (GRCm39)	missense	probably damaging	1.00
R0091:Morn1	UTSW	4	155,229,629 (GRCm39)	missense	probably damaging	1.00
R0573:Morn1	UTSW	4	155,195,473 (GRCm39)	missense	possibly damaging	0.87
R0639:Morn1	UTSW	4	155,173,960 (GRCm39)	missense	possibly damaging	0.92
R0918:Morn1	UTSW	4	155,171,928 (GRCm39)	missense	probably damaging	1.00
R2041:Morn1	UTSW	4	155,175,399 (GRCm39)	missense	probably damaging	1.00
R2360:Morn1	UTSW	4	155,176,770 (GRCm39)	missense	probably damaging	0.98
R5831:Morn1	UTSW	4	155,185,733 (GRCm39)	missense	probably benign	0.02
R8178:Morn1	UTSW	4	155,213,160 (GRCm39)	missense	probably benign	0.00
R8505:Morn1	UTSW	4	155,177,792 (GRCm39)	missense	unknown

Predicted Primers

PCR Primer
(F):5'- ATTGACGTCCTCAGGCTCCG -3'
(R):5'- GACTCTGACCTCATATCGATCC -3'

Sequencing Primer
(F):5'- TCCTCAGGCTCCGGATCC -3'
(R):5'- TCATCAGACTGCATTGGGC -3'

Posted On

2018-11-06