Incidental Mutation 'R6897:Zfp735'
ID |
538411 |
Institutional Source |
Beutler Lab
|
Gene Symbol |
Zfp735
|
Ensembl Gene |
ENSMUSG00000060630 |
Gene Name |
zinc finger protein 735 |
Synonyms |
1700012C15Rik |
MMRRC Submission |
044991-MU
|
Accession Numbers |
|
Essential gene? |
Probably non essential
(E-score: 0.074)
|
Stock # |
R6897 (G1)
|
Quality Score |
225.009 |
Status
|
Validated
|
Chromosome |
11 |
Chromosomal Location |
73579604-73604624 bp(+) (GRCm39) |
Type of Mutation |
missense |
DNA Base Change (assembly) |
A to C
at 73601880 bp (GRCm39)
|
Zygosity |
Heterozygous |
Amino Acid Change |
Isoleucine to Leucine
at position 275
(I275L)
|
Ref Sequence |
ENSEMBL: ENSMUSP00000079269
(fasta)
|
Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000080407]
|
AlphaFold |
B1ARH2 |
Predicted Effect |
probably benign
Transcript: ENSMUST00000080407
AA Change: I275L
PolyPhen 2
Score 0.083 (Sensitivity: 0.93; Specificity: 0.85)
|
SMART Domains |
Protein: ENSMUSP00000079269 Gene: ENSMUSG00000060630 AA Change: I275L
Domain | Start | End | E-Value | Type |
KRAB
|
8 |
68 |
2.2e-34 |
SMART |
ZnF_C2H2
|
483 |
505 |
4.38e1 |
SMART |
ZnF_C2H2
|
511 |
533 |
2.67e-1 |
SMART |
ZnF_C2H2
|
539 |
561 |
1.81e1 |
SMART |
ZnF_C2H2
|
567 |
589 |
1.5e-4 |
SMART |
ZnF_C2H2
|
595 |
617 |
4.87e-4 |
SMART |
ZnF_C2H2
|
623 |
645 |
4.24e-4 |
SMART |
ZnF_C2H2
|
651 |
673 |
2.27e-4 |
SMART |
ZnF_C2H2
|
679 |
701 |
7.49e-5 |
SMART |
ZnF_C2H2
|
707 |
729 |
4.87e-4 |
SMART |
|
Coding Region Coverage |
- 1x: 100.0%
- 3x: 99.9%
- 10x: 99.3%
- 20x: 97.7%
|
Validation Efficiency |
97% (72/74) |
Allele List at MGI |
|
Other mutations in this stock |
Total: 72 list
Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
4930579F01Rik |
T |
C |
3: 137,889,534 (GRCm39) |
I28V |
possibly damaging |
Het |
Adamts2 |
A |
T |
11: 50,627,991 (GRCm39) |
|
probably null |
Het |
Adgrg1 |
T |
C |
8: 95,729,126 (GRCm39) |
F17L |
probably benign |
Het |
Aldob |
A |
G |
4: 49,539,789 (GRCm39) |
L183P |
probably damaging |
Het |
Alg5 |
T |
C |
3: 54,656,063 (GRCm39) |
C270R |
probably benign |
Het |
Anxa4 |
T |
A |
6: 86,720,160 (GRCm39) |
|
probably null |
Het |
Armc2 |
C |
A |
10: 41,869,225 (GRCm39) |
|
probably null |
Het |
Atrnl1 |
A |
G |
19: 58,030,800 (GRCm39) |
N1314S |
probably benign |
Het |
Bbs7 |
T |
A |
3: 36,652,460 (GRCm39) |
E331V |
probably benign |
Het |
Bmper |
T |
A |
9: 23,285,225 (GRCm39) |
V258E |
probably benign |
Het |
Catspere2 |
A |
T |
1: 177,939,139 (GRCm39) |
I671F |
possibly damaging |
Het |
Cd101 |
A |
G |
3: 100,920,376 (GRCm39) |
S508P |
probably damaging |
Het |
Cd177 |
C |
T |
7: 24,444,499 (GRCm39) |
R694H |
probably benign |
Het |
Clptm1 |
C |
A |
7: 19,369,751 (GRCm39) |
Q386H |
possibly damaging |
Het |
Cnrip1 |
A |
G |
11: 17,004,705 (GRCm39) |
Y85C |
probably damaging |
Het |
Dclk2 |
A |
T |
3: 86,739,070 (GRCm39) |
F310I |
probably benign |
Het |
Dmxl1 |
A |
G |
18: 49,984,562 (GRCm39) |
K186R |
probably null |
Het |
Dmxl1 |
C |
A |
18: 49,996,124 (GRCm39) |
Q417K |
possibly damaging |
Het |
Eloa |
T |
C |
4: 135,740,220 (GRCm39) |
D67G |
possibly damaging |
Het |
Elovl4 |
T |
C |
9: 83,665,278 (GRCm39) |
I103V |
probably benign |
Het |
Gabpa |
C |
G |
16: 84,657,361 (GRCm39) |
A412G |
probably benign |
Het |
Gldn |
T |
A |
9: 54,242,158 (GRCm39) |
|
probably null |
Het |
Ino80d |
A |
T |
1: 63,104,993 (GRCm39) |
I361N |
probably damaging |
Het |
Kalrn |
G |
A |
16: 33,796,073 (GRCm39) |
T1234M |
probably damaging |
Het |
Kcnk13 |
T |
A |
12: 100,028,026 (GRCm39) |
M367K |
probably benign |
Het |
Klrd1 |
G |
A |
6: 129,570,468 (GRCm39) |
R8Q |
possibly damaging |
Het |
Kmt2a |
T |
C |
9: 44,758,942 (GRCm39) |
N969S |
probably benign |
Het |
Lgi4 |
A |
G |
7: 30,768,315 (GRCm39) |
D438G |
probably benign |
Het |
Lig1 |
T |
C |
7: 13,039,840 (GRCm39) |
L684P |
probably damaging |
Het |
Lrp2 |
T |
C |
2: 69,340,846 (GRCm39) |
M1010V |
probably benign |
Het |
Magi3 |
C |
A |
3: 103,996,873 (GRCm39) |
R224I |
probably damaging |
Het |
Mier2 |
T |
C |
10: 79,380,573 (GRCm39) |
N277S |
probably damaging |
Het |
Morn1 |
A |
G |
4: 155,171,112 (GRCm39) |
H17R |
probably benign |
Het |
Nf2 |
A |
T |
11: 4,749,878 (GRCm39) |
S265T |
probably damaging |
Het |
Or5m11b |
A |
G |
2: 85,805,700 (GRCm39) |
T38A |
possibly damaging |
Het |
Or8k24 |
G |
A |
2: 86,216,024 (GRCm39) |
T246I |
possibly damaging |
Het |
Palb2 |
A |
G |
7: 121,726,270 (GRCm39) |
|
probably null |
Het |
Pdzd2 |
C |
T |
15: 12,385,951 (GRCm39) |
V940M |
probably damaging |
Het |
Phldb2 |
T |
C |
16: 45,598,138 (GRCm39) |
K850E |
probably damaging |
Het |
Pitx1 |
G |
A |
13: 55,976,335 (GRCm39) |
T108M |
probably damaging |
Het |
Polr2a |
C |
T |
11: 69,626,787 (GRCm39) |
A1516T |
probably benign |
Het |
Pomp |
T |
A |
5: 147,812,313 (GRCm39) |
M133K |
possibly damaging |
Het |
Prex1 |
T |
C |
2: 166,423,913 (GRCm39) |
E993G |
probably damaging |
Het |
Prrc2c |
C |
A |
1: 162,533,075 (GRCm39) |
|
probably benign |
Het |
Pwp2 |
C |
A |
10: 78,007,917 (GRCm39) |
Q879H |
probably damaging |
Het |
Rab26 |
G |
A |
17: 24,748,766 (GRCm39) |
T245I |
probably damaging |
Het |
Rapgef1 |
A |
G |
2: 29,592,514 (GRCm39) |
D502G |
probably damaging |
Het |
Rsf1 |
GGCG |
GGCGACGGCCGCG |
7: 97,229,113 (GRCm39) |
|
probably benign |
Het |
Sema5a |
T |
A |
15: 32,550,421 (GRCm39) |
D153E |
probably benign |
Het |
Sez6 |
C |
G |
11: 77,844,385 (GRCm39) |
H69Q |
probably damaging |
Het |
Sgsm3 |
A |
T |
15: 80,893,095 (GRCm39) |
T391S |
probably benign |
Het |
Sh3rf2 |
T |
C |
18: 42,234,670 (GRCm39) |
V151A |
possibly damaging |
Het |
Socs1 |
G |
T |
16: 10,602,266 (GRCm39) |
A157E |
probably benign |
Het |
Spmip4 |
T |
A |
6: 50,566,145 (GRCm39) |
Q110L |
possibly damaging |
Het |
Sptbn4 |
C |
A |
7: 27,071,375 (GRCm39) |
V346L |
possibly damaging |
Het |
Srgap1 |
T |
A |
10: 121,621,523 (GRCm39) |
H990L |
probably damaging |
Het |
Tbc1d9 |
G |
T |
8: 83,892,809 (GRCm39) |
G36W |
probably damaging |
Het |
Tbk1 |
T |
C |
10: 121,395,782 (GRCm39) |
E437G |
probably benign |
Het |
Tns3 |
A |
G |
11: 8,481,743 (GRCm39) |
L203P |
probably damaging |
Het |
Tspoap1 |
A |
T |
11: 87,656,638 (GRCm39) |
K283M |
probably damaging |
Het |
Ttyh1 |
C |
T |
7: 4,127,649 (GRCm39) |
|
probably benign |
Het |
Ufd1 |
T |
A |
16: 18,645,850 (GRCm39) |
I254N |
probably benign |
Het |
Ugdh |
T |
G |
5: 65,584,776 (GRCm39) |
T49P |
probably benign |
Het |
Vav3 |
T |
C |
3: 109,434,810 (GRCm39) |
L447P |
probably damaging |
Het |
Vmn1r216 |
A |
T |
13: 23,283,445 (GRCm39) |
K43* |
probably null |
Het |
Vmn2r111 |
T |
C |
17: 22,778,032 (GRCm39) |
N549S |
possibly damaging |
Het |
Vmn2r13 |
A |
G |
5: 109,306,015 (GRCm39) |
I521T |
possibly damaging |
Het |
Wdfy3 |
T |
C |
5: 101,991,932 (GRCm39) |
T3470A |
probably benign |
Het |
Wdhd1 |
T |
A |
14: 47,485,587 (GRCm39) |
K791N |
probably damaging |
Het |
Xirp2 |
A |
G |
2: 67,338,911 (GRCm39) |
D384G |
probably damaging |
Het |
Zfp512b |
C |
T |
2: 181,232,273 (GRCm39) |
R86Q |
probably damaging |
Het |
Zfp957 |
A |
T |
14: 79,451,344 (GRCm39) |
S152T |
probably damaging |
Het |
|
Other mutations in Zfp735 |
Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
IGL00492:Zfp735
|
APN |
11 |
73,602,192 (GRCm39) |
missense |
possibly damaging |
0.86 |
IGL00798:Zfp735
|
APN |
11 |
73,602,386 (GRCm39) |
missense |
possibly damaging |
0.72 |
IGL01642:Zfp735
|
APN |
11 |
73,601,305 (GRCm39) |
missense |
possibly damaging |
0.73 |
IGL01684:Zfp735
|
APN |
11 |
73,581,191 (GRCm39) |
missense |
possibly damaging |
0.86 |
IGL02096:Zfp735
|
APN |
11 |
73,602,254 (GRCm39) |
missense |
probably benign |
0.01 |
IGL02238:Zfp735
|
APN |
11 |
73,601,319 (GRCm39) |
missense |
probably benign |
0.00 |
IGL02505:Zfp735
|
APN |
11 |
73,580,626 (GRCm39) |
missense |
probably benign |
0.03 |
IGL02740:Zfp735
|
APN |
11 |
73,601,412 (GRCm39) |
missense |
possibly damaging |
0.53 |
IGL02957:Zfp735
|
APN |
11 |
73,601,755 (GRCm39) |
missense |
probably benign |
0.00 |
bananaquit
|
UTSW |
11 |
73,601,412 (GRCm39) |
nonsense |
probably null |
|
bescher
|
UTSW |
11 |
73,602,979 (GRCm39) |
missense |
possibly damaging |
0.93 |
Galvanic
|
UTSW |
11 |
73,602,504 (GRCm39) |
nonsense |
probably null |
|
grassquit
|
UTSW |
11 |
73,603,029 (GRCm39) |
missense |
possibly damaging |
0.66 |
R0114:Zfp735
|
UTSW |
11 |
73,601,488 (GRCm39) |
missense |
probably benign |
0.33 |
R0217:Zfp735
|
UTSW |
11 |
73,602,112 (GRCm39) |
missense |
possibly damaging |
0.73 |
R0943:Zfp735
|
UTSW |
11 |
73,602,909 (GRCm39) |
missense |
probably benign |
0.04 |
R1421:Zfp735
|
UTSW |
11 |
73,601,523 (GRCm39) |
missense |
probably benign |
|
R1460:Zfp735
|
UTSW |
11 |
73,603,159 (GRCm39) |
missense |
possibly damaging |
0.73 |
R1493:Zfp735
|
UTSW |
11 |
73,601,305 (GRCm39) |
missense |
possibly damaging |
0.73 |
R1517:Zfp735
|
UTSW |
11 |
73,601,470 (GRCm39) |
missense |
probably benign |
|
R1676:Zfp735
|
UTSW |
11 |
73,602,301 (GRCm39) |
missense |
possibly damaging |
0.53 |
R1709:Zfp735
|
UTSW |
11 |
73,602,589 (GRCm39) |
missense |
probably benign |
0.01 |
R1871:Zfp735
|
UTSW |
11 |
73,601,412 (GRCm39) |
nonsense |
probably null |
|
R1931:Zfp735
|
UTSW |
11 |
73,602,677 (GRCm39) |
missense |
possibly damaging |
0.69 |
R2219:Zfp735
|
UTSW |
11 |
73,601,851 (GRCm39) |
missense |
possibly damaging |
0.53 |
R2227:Zfp735
|
UTSW |
11 |
73,602,223 (GRCm39) |
nonsense |
probably null |
|
R2227:Zfp735
|
UTSW |
11 |
73,602,222 (GRCm39) |
missense |
possibly damaging |
0.53 |
R3552:Zfp735
|
UTSW |
11 |
73,602,067 (GRCm39) |
nonsense |
probably null |
|
R3856:Zfp735
|
UTSW |
11 |
73,602,282 (GRCm39) |
missense |
probably benign |
0.01 |
R3925:Zfp735
|
UTSW |
11 |
73,601,950 (GRCm39) |
missense |
probably benign |
0.33 |
R4572:Zfp735
|
UTSW |
11 |
73,580,611 (GRCm39) |
missense |
probably benign |
0.02 |
R4585:Zfp735
|
UTSW |
11 |
73,580,550 (GRCm39) |
missense |
possibly damaging |
0.51 |
R4586:Zfp735
|
UTSW |
11 |
73,580,550 (GRCm39) |
missense |
possibly damaging |
0.51 |
R4619:Zfp735
|
UTSW |
11 |
73,602,031 (GRCm39) |
missense |
probably damaging |
0.98 |
R4687:Zfp735
|
UTSW |
11 |
73,602,682 (GRCm39) |
missense |
probably damaging |
0.98 |
R4687:Zfp735
|
UTSW |
11 |
73,602,681 (GRCm39) |
missense |
probably damaging |
0.98 |
R5435:Zfp735
|
UTSW |
11 |
73,602,939 (GRCm39) |
missense |
possibly damaging |
0.72 |
R5489:Zfp735
|
UTSW |
11 |
73,601,419 (GRCm39) |
nonsense |
probably null |
|
R5516:Zfp735
|
UTSW |
11 |
73,601,640 (GRCm39) |
missense |
probably benign |
|
R5654:Zfp735
|
UTSW |
11 |
73,602,964 (GRCm39) |
missense |
possibly damaging |
0.71 |
R5990:Zfp735
|
UTSW |
11 |
73,581,174 (GRCm39) |
missense |
possibly damaging |
0.70 |
R6332:Zfp735
|
UTSW |
11 |
73,602,504 (GRCm39) |
nonsense |
probably null |
|
R6427:Zfp735
|
UTSW |
11 |
73,581,140 (GRCm39) |
missense |
possibly damaging |
0.73 |
R6460:Zfp735
|
UTSW |
11 |
73,602,478 (GRCm39) |
missense |
probably benign |
0.33 |
R6820:Zfp735
|
UTSW |
11 |
73,579,783 (GRCm39) |
start codon destroyed |
probably null |
0.01 |
R6831:Zfp735
|
UTSW |
11 |
73,601,434 (GRCm39) |
missense |
probably damaging |
1.00 |
R6833:Zfp735
|
UTSW |
11 |
73,601,434 (GRCm39) |
missense |
probably damaging |
1.00 |
R6834:Zfp735
|
UTSW |
11 |
73,601,434 (GRCm39) |
missense |
probably damaging |
1.00 |
R6941:Zfp735
|
UTSW |
11 |
73,581,159 (GRCm39) |
missense |
probably benign |
0.33 |
R7335:Zfp735
|
UTSW |
11 |
73,602,379 (GRCm39) |
missense |
possibly damaging |
0.47 |
R7366:Zfp735
|
UTSW |
11 |
73,602,979 (GRCm39) |
missense |
possibly damaging |
0.93 |
R7474:Zfp735
|
UTSW |
11 |
73,602,002 (GRCm39) |
missense |
possibly damaging |
0.72 |
R7487:Zfp735
|
UTSW |
11 |
73,581,154 (GRCm39) |
missense |
possibly damaging |
0.53 |
R7583:Zfp735
|
UTSW |
11 |
73,601,933 (GRCm39) |
missense |
possibly damaging |
0.86 |
R7866:Zfp735
|
UTSW |
11 |
73,601,629 (GRCm39) |
missense |
probably benign |
0.00 |
R8005:Zfp735
|
UTSW |
11 |
73,603,140 (GRCm39) |
nonsense |
probably null |
|
R8500:Zfp735
|
UTSW |
11 |
73,601,811 (GRCm39) |
missense |
possibly damaging |
0.53 |
R8551:Zfp735
|
UTSW |
11 |
73,603,122 (GRCm39) |
missense |
probably benign |
0.06 |
R8754:Zfp735
|
UTSW |
11 |
73,603,000 (GRCm39) |
missense |
possibly damaging |
0.85 |
R8769:Zfp735
|
UTSW |
11 |
73,581,127 (GRCm39) |
missense |
possibly damaging |
0.53 |
R8794:Zfp735
|
UTSW |
11 |
73,603,029 (GRCm39) |
missense |
possibly damaging |
0.66 |
R8835:Zfp735
|
UTSW |
11 |
73,601,692 (GRCm39) |
missense |
possibly damaging |
0.53 |
R8869:Zfp735
|
UTSW |
11 |
73,602,510 (GRCm39) |
missense |
possibly damaging |
0.53 |
R8969:Zfp735
|
UTSW |
11 |
73,602,699 (GRCm39) |
missense |
possibly damaging |
0.83 |
R9072:Zfp735
|
UTSW |
11 |
73,603,060 (GRCm39) |
missense |
probably benign |
0.21 |
R9073:Zfp735
|
UTSW |
11 |
73,603,060 (GRCm39) |
missense |
probably benign |
0.21 |
R9193:Zfp735
|
UTSW |
11 |
73,580,600 (GRCm39) |
missense |
possibly damaging |
0.71 |
R9355:Zfp735
|
UTSW |
11 |
73,602,362 (GRCm39) |
missense |
probably benign |
0.01 |
R9414:Zfp735
|
UTSW |
11 |
73,602,023 (GRCm39) |
nonsense |
probably null |
|
R9456:Zfp735
|
UTSW |
11 |
73,602,403 (GRCm39) |
missense |
possibly damaging |
0.53 |
R9573:Zfp735
|
UTSW |
11 |
73,602,936 (GRCm39) |
missense |
possibly damaging |
0.67 |
R9647:Zfp735
|
UTSW |
11 |
73,580,600 (GRCm39) |
missense |
probably damaging |
0.98 |
R9710:Zfp735
|
UTSW |
11 |
73,601,806 (GRCm39) |
missense |
possibly damaging |
0.86 |
Z1176:Zfp735
|
UTSW |
11 |
73,601,641 (GRCm39) |
missense |
probably benign |
0.02 |
|
Predicted Primers |
PCR Primer
(F):5'- GGGTGAATAAACACACTTCTCTG -3'
(R):5'- TAGACCTAGCCTGTCTACTATCATG -3'
Sequencing Primer
(F):5'- ACACACTTCTCTGAAGCATTTAC -3'
(R):5'- GAATTGTTTCATGATGAGAATC -3'
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Posted On |
2018-11-06 |