Mutagenetix > Incidental Mutation

Incidental Mutation 'R6897:Dmxl1'

538431

Institutional Source

Beutler Lab

Gene Symbol

Dmxl1

Ensembl Gene

ENSMUSG00000037416

Gene Name

Dmx-like 1

Synonyms

C630007L23Rik

MMRRC Submission

044991-MU

Accession Numbers

Essential gene?

Probably essential (E-score: 0.956) question?

Stock #

R6897 (G1)

Quality Score

225.009

Status

Validated

Chromosome

Chromosomal Location

49965737-50098540 bp(+) (GRCm39)

Type of Mutation

missense

DNA Base Change (assembly)

C to A at 49996124 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Glutamine to Lysine at position 417 (Q417K)

Ref Sequence

ENSEMBL: ENSMUSP00000137871 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000041772] [ENSMUST00000180611]

AlphaFold

no structure available at present

Predicted Effect

probably benign
Transcript: ENSMUST00000041772
AA Change: Q417K

PolyPhen 2 Score 0.304 (Sensitivity: 0.90; Specificity: 0.89)

SMART Domains

Protein: ENSMUSP00000045559
Gene: ENSMUSG00000037416
AA Change: Q417K

Domain	Start	End	E-Value	Type
WD40	100	136	8.22e1	SMART
WD40	156	195	2.88e-1	SMART
WD40	218	266	8.29e-1	SMART
low complexity region	367	378	N/A	INTRINSIC
WD40	464	505	1.53e2	SMART
Blast:WD40	719	772	1e-25	BLAST
WD40	957	999	1.1e1	SMART
Pfam:Rav1p_C	1102	1877	4.3e-84	PFAM
low complexity region	1922	1942	N/A	INTRINSIC
low complexity region	1966	1975	N/A	INTRINSIC
low complexity region	1993	2007	N/A	INTRINSIC
low complexity region	2147	2158	N/A	INTRINSIC
low complexity region	2371	2385	N/A	INTRINSIC
low complexity region	2397	2410	N/A	INTRINSIC
low complexity region	2449	2466	N/A	INTRINSIC
WD40	2735	2770	1.07e1	SMART
WD40	2773	2813	3.7e0	SMART
WD40	2825	2867	1.07e0	SMART
WD40	2873	2912	1.05e-2	SMART
WD40	2915	2954	4.51e-7	SMART
Blast:WD40	2957	3005	9e-26	BLAST

Predicted Effect

possibly damaging
Transcript: ENSMUST00000180611
AA Change: Q417K

PolyPhen 2 Score 0.514 (Sensitivity: 0.88; Specificity: 0.90)

SMART Domains

Protein: ENSMUSP00000137871
Gene: ENSMUSG00000037416
AA Change: Q417K

Domain	Start	End	E-Value	Type
WD40	100	136	8.22e1	SMART
WD40	156	195	2.88e-1	SMART
WD40	218	266	8.29e-1	SMART
low complexity region	367	378	N/A	INTRINSIC
WD40	464	505	1.53e2	SMART
Blast:WD40	719	772	1e-25	BLAST
WD40	957	999	1.1e1	SMART
low complexity region	1195	1206	N/A	INTRINSIC
low complexity region	1258	1271	N/A	INTRINSIC
Pfam:Rav1p_C	1287	1876	9.4e-72	PFAM
low complexity region	1922	1942	N/A	INTRINSIC
low complexity region	1966	1975	N/A	INTRINSIC
low complexity region	1993	2007	N/A	INTRINSIC
low complexity region	2147	2158	N/A	INTRINSIC
low complexity region	2385	2398	N/A	INTRINSIC
low complexity region	2437	2454	N/A	INTRINSIC
WD40	2723	2758	1.07e1	SMART
WD40	2761	2801	3.7e0	SMART
WD40	2813	2855	1.07e0	SMART
WD40	2861	2900	1.05e-2	SMART
WD40	2903	2942	4.51e-7	SMART
Blast:WD40	2945	2993	9e-26	BLAST

Coding Region Coverage

1x: 100.0%
3x: 99.9%
10x: 99.3%
20x: 97.7%

Validation Efficiency

97% (72/74)

MGI Phenotype

FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] The protein encoded by this gene is a member of the WD repeat superfamily of proteins, which have regulatory functions. This gene is expressed in many tissue types including several types of eye tissue, and it has been associated with ocular phenotypes. In addition, it is upregulated in cultured cells that overexpress growth factor independence 1B, a transcription factor that is essential for hematopoietic cell development. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Nov 2014]

Allele List at MGI

Other mutations in this stock

Total: 71 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
4930579F01Rik	T	C	3: 137,889,534 (GRCm39)	I28V	possibly damaging	Het
Adamts2	A	T	11: 50,627,991 (GRCm39)		probably null	Het
Adgrg1	T	C	8: 95,729,126 (GRCm39)	F17L	probably benign	Het
Aldob	A	G	4: 49,539,789 (GRCm39)	L183P	probably damaging	Het
Alg5	T	C	3: 54,656,063 (GRCm39)	C270R	probably benign	Het
Anxa4	T	A	6: 86,720,160 (GRCm39)		probably null	Het
Armc2	C	A	10: 41,869,225 (GRCm39)		probably null	Het
Atrnl1	A	G	19: 58,030,800 (GRCm39)	N1314S	probably benign	Het
Bbs7	T	A	3: 36,652,460 (GRCm39)	E331V	probably benign	Het
Bmper	T	A	9: 23,285,225 (GRCm39)	V258E	probably benign	Het
Catspere2	A	T	1: 177,939,139 (GRCm39)	I671F	possibly damaging	Het
Cd101	A	G	3: 100,920,376 (GRCm39)	S508P	probably damaging	Het
Cd177	C	T	7: 24,444,499 (GRCm39)	R694H	probably benign	Het
Clptm1	C	A	7: 19,369,751 (GRCm39)	Q386H	possibly damaging	Het
Cnrip1	A	G	11: 17,004,705 (GRCm39)	Y85C	probably damaging	Het
Dclk2	A	T	3: 86,739,070 (GRCm39)	F310I	probably benign	Het
Eloa	T	C	4: 135,740,220 (GRCm39)	D67G	possibly damaging	Het
Elovl4	T	C	9: 83,665,278 (GRCm39)	I103V	probably benign	Het
Gabpa	C	G	16: 84,657,361 (GRCm39)	A412G	probably benign	Het
Gldn	T	A	9: 54,242,158 (GRCm39)		probably null	Het
Ino80d	A	T	1: 63,104,993 (GRCm39)	I361N	probably damaging	Het
Kalrn	G	A	16: 33,796,073 (GRCm39)	T1234M	probably damaging	Het
Kcnk13	T	A	12: 100,028,026 (GRCm39)	M367K	probably benign	Het
Klrd1	G	A	6: 129,570,468 (GRCm39)	R8Q	possibly damaging	Het
Kmt2a	T	C	9: 44,758,942 (GRCm39)	N969S	probably benign	Het
Lgi4	A	G	7: 30,768,315 (GRCm39)	D438G	probably benign	Het
Lig1	T	C	7: 13,039,840 (GRCm39)	L684P	probably damaging	Het
Lrp2	T	C	2: 69,340,846 (GRCm39)	M1010V	probably benign	Het
Magi3	C	A	3: 103,996,873 (GRCm39)	R224I	probably damaging	Het
Mier2	T	C	10: 79,380,573 (GRCm39)	N277S	probably damaging	Het
Morn1	A	G	4: 155,171,112 (GRCm39)	H17R	probably benign	Het
Nf2	A	T	11: 4,749,878 (GRCm39)	S265T	probably damaging	Het
Or5m11b	A	G	2: 85,805,700 (GRCm39)	T38A	possibly damaging	Het
Or8k24	G	A	2: 86,216,024 (GRCm39)	T246I	possibly damaging	Het
Palb2	A	G	7: 121,726,270 (GRCm39)		probably null	Het
Pdzd2	C	T	15: 12,385,951 (GRCm39)	V940M	probably damaging	Het
Phldb2	T	C	16: 45,598,138 (GRCm39)	K850E	probably damaging	Het
Pitx1	G	A	13: 55,976,335 (GRCm39)	T108M	probably damaging	Het
Polr2a	C	T	11: 69,626,787 (GRCm39)	A1516T	probably benign	Het
Pomp	T	A	5: 147,812,313 (GRCm39)	M133K	possibly damaging	Het
Prex1	T	C	2: 166,423,913 (GRCm39)	E993G	probably damaging	Het
Prrc2c	C	A	1: 162,533,075 (GRCm39)		probably benign	Het
Pwp2	C	A	10: 78,007,917 (GRCm39)	Q879H	probably damaging	Het
Rab26	G	A	17: 24,748,766 (GRCm39)	T245I	probably damaging	Het
Rapgef1	A	G	2: 29,592,514 (GRCm39)	D502G	probably damaging	Het
Rsf1	GGCG	GGCGACGGCCGCG	7: 97,229,113 (GRCm39)		probably benign	Het
Sema5a	T	A	15: 32,550,421 (GRCm39)	D153E	probably benign	Het
Sez6	C	G	11: 77,844,385 (GRCm39)	H69Q	probably damaging	Het
Sgsm3	A	T	15: 80,893,095 (GRCm39)	T391S	probably benign	Het
Sh3rf2	T	C	18: 42,234,670 (GRCm39)	V151A	possibly damaging	Het
Socs1	G	T	16: 10,602,266 (GRCm39)	A157E	probably benign	Het
Spmip4	T	A	6: 50,566,145 (GRCm39)	Q110L	possibly damaging	Het
Sptbn4	C	A	7: 27,071,375 (GRCm39)	V346L	possibly damaging	Het
Srgap1	T	A	10: 121,621,523 (GRCm39)	H990L	probably damaging	Het
Tbc1d9	G	T	8: 83,892,809 (GRCm39)	G36W	probably damaging	Het
Tbk1	T	C	10: 121,395,782 (GRCm39)	E437G	probably benign	Het
Tns3	A	G	11: 8,481,743 (GRCm39)	L203P	probably damaging	Het
Tspoap1	A	T	11: 87,656,638 (GRCm39)	K283M	probably damaging	Het
Ttyh1	C	T	7: 4,127,649 (GRCm39)		probably benign	Het
Ufd1	T	A	16: 18,645,850 (GRCm39)	I254N	probably benign	Het
Ugdh	T	G	5: 65,584,776 (GRCm39)	T49P	probably benign	Het
Vav3	T	C	3: 109,434,810 (GRCm39)	L447P	probably damaging	Het
Vmn1r216	A	T	13: 23,283,445 (GRCm39)	K43*	probably null	Het
Vmn2r111	T	C	17: 22,778,032 (GRCm39)	N549S	possibly damaging	Het
Vmn2r13	A	G	5: 109,306,015 (GRCm39)	I521T	possibly damaging	Het
Wdfy3	T	C	5: 101,991,932 (GRCm39)	T3470A	probably benign	Het
Wdhd1	T	A	14: 47,485,587 (GRCm39)	K791N	probably damaging	Het
Xirp2	A	G	2: 67,338,911 (GRCm39)	D384G	probably damaging	Het
Zfp512b	C	T	2: 181,232,273 (GRCm39)	R86Q	probably damaging	Het
Zfp735	A	C	11: 73,601,880 (GRCm39)	I275L	probably benign	Het
Zfp957	A	T	14: 79,451,344 (GRCm39)	S152T	probably damaging	Het

Other mutations in Dmxl1

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL00163:Dmxl1	APN	18	49,984,534 (GRCm39)	missense	probably damaging	1.00
IGL00668:Dmxl1	APN	18	50,072,620 (GRCm39)	missense	possibly damaging	0.64
IGL00740:Dmxl1	APN	18	50,050,735 (GRCm39)	missense	probably benign	0.00
IGL00969:Dmxl1	APN	18	50,045,792 (GRCm39)	missense	probably benign	0.02
IGL01113:Dmxl1	APN	18	50,045,818 (GRCm39)	missense	probably benign	0.01
IGL01384:Dmxl1	APN	18	49,990,401 (GRCm39)	missense	probably benign
IGL01475:Dmxl1	APN	18	50,004,781 (GRCm39)	missense	probably damaging	1.00
IGL01559:Dmxl1	APN	18	50,054,005 (GRCm39)	missense	probably damaging	0.99
IGL01578:Dmxl1	APN	18	50,095,272 (GRCm39)	missense	probably damaging	1.00
IGL01632:Dmxl1	APN	18	49,996,092 (GRCm39)	missense	probably damaging	0.99
IGL01814:Dmxl1	APN	18	49,997,935 (GRCm39)	missense	probably damaging	1.00
IGL01843:Dmxl1	APN	18	50,011,449 (GRCm39)	nonsense	probably null
IGL01933:Dmxl1	APN	18	50,010,852 (GRCm39)	missense	probably benign	0.17
IGL01952:Dmxl1	APN	18	50,023,721 (GRCm39)	missense	probably benign	0.11
IGL02120:Dmxl1	APN	18	50,027,245 (GRCm39)	missense	possibly damaging	0.83
IGL02162:Dmxl1	APN	18	50,094,230 (GRCm39)	missense	probably benign	0.00
IGL02213:Dmxl1	APN	18	50,010,741 (GRCm39)	splice site	probably benign
IGL02261:Dmxl1	APN	18	49,973,566 (GRCm39)	missense	possibly damaging	0.85
IGL02689:Dmxl1	APN	18	49,997,962 (GRCm39)	missense	probably damaging	1.00
IGL02892:Dmxl1	APN	18	49,992,187 (GRCm39)	missense	probably damaging	0.96
IGL03232:Dmxl1	APN	18	50,011,247 (GRCm39)	missense	probably benign	0.01
IGL03258:Dmxl1	APN	18	50,053,960 (GRCm39)	missense	probably damaging	1.00
IGL03298:Dmxl1	APN	18	49,997,885 (GRCm39)	missense	probably benign
capture	UTSW	18	50,095,328 (GRCm39)	missense	probably damaging	1.00
carnivora	UTSW	18	49,997,450 (GRCm39)	missense	probably damaging	0.99
digestion	UTSW	18	50,011,326 (GRCm39)	missense	probably damaging	1.00
drowning	UTSW	18	50,011,292 (GRCm39)	missense	possibly damaging	0.55
hibiscus	UTSW	18	50,022,534 (GRCm39)	missense	probably damaging	1.00
impound	UTSW	18	50,026,316 (GRCm39)	missense	probably benign
pitcher	UTSW	18	49,997,215 (GRCm39)	missense	probably damaging	1.00
PIT4810001:Dmxl1	UTSW	18	50,065,030 (GRCm39)	missense	probably damaging	1.00
R0001:Dmxl1	UTSW	18	50,021,964 (GRCm39)	splice site	probably benign
R0027:Dmxl1	UTSW	18	50,090,362 (GRCm39)	splice site	probably benign
R0042:Dmxl1	UTSW	18	49,997,102 (GRCm39)	missense	probably benign	0.03
R0042:Dmxl1	UTSW	18	49,997,102 (GRCm39)	missense	probably benign	0.03
R0046:Dmxl1	UTSW	18	50,011,149 (GRCm39)	missense	probably benign	0.22
R0046:Dmxl1	UTSW	18	50,011,149 (GRCm39)	missense	probably benign	0.22
R0257:Dmxl1	UTSW	18	50,088,870 (GRCm39)	splice site	probably benign
R0349:Dmxl1	UTSW	18	50,012,349 (GRCm39)	missense	probably damaging	0.99
R0390:Dmxl1	UTSW	18	50,012,429 (GRCm39)	missense	probably benign	0.14
R0511:Dmxl1	UTSW	18	50,024,534 (GRCm39)	nonsense	probably null
R0539:Dmxl1	UTSW	18	49,990,497 (GRCm39)	splice site	probably benign
R0542:Dmxl1	UTSW	18	50,026,761 (GRCm39)	missense	probably benign	0.05
R0587:Dmxl1	UTSW	18	50,068,374 (GRCm39)	missense	probably benign	0.39
R0635:Dmxl1	UTSW	18	49,984,490 (GRCm39)	splice site	probably benign
R0744:Dmxl1	UTSW	18	49,966,215 (GRCm39)	missense	probably damaging	1.00
R0836:Dmxl1	UTSW	18	49,966,215 (GRCm39)	missense	probably damaging	1.00
R0845:Dmxl1	UTSW	18	50,026,469 (GRCm39)	missense	probably damaging	1.00
R1218:Dmxl1	UTSW	18	50,026,678 (GRCm39)	missense	probably damaging	1.00
R1278:Dmxl1	UTSW	18	50,026,292 (GRCm39)	missense	probably benign
R1313:Dmxl1	UTSW	18	50,011,550 (GRCm39)	missense	probably damaging	1.00
R1313:Dmxl1	UTSW	18	50,011,550 (GRCm39)	missense	probably damaging	1.00
R1349:Dmxl1	UTSW	18	50,021,920 (GRCm39)	missense	probably damaging	1.00
R1453:Dmxl1	UTSW	18	49,990,316 (GRCm39)	missense	probably benign	0.05
R1522:Dmxl1	UTSW	18	49,985,434 (GRCm39)	missense	probably benign	0.05
R1629:Dmxl1	UTSW	18	49,992,353 (GRCm39)	critical splice donor site	probably null
R1638:Dmxl1	UTSW	18	50,023,834 (GRCm39)	nonsense	probably null
R1646:Dmxl1	UTSW	18	50,095,328 (GRCm39)	missense	probably damaging	1.00
R1719:Dmxl1	UTSW	18	50,067,704 (GRCm39)	missense	probably damaging	1.00
R1732:Dmxl1	UTSW	18	50,036,055 (GRCm39)	missense	probably benign
R1732:Dmxl1	UTSW	18	50,026,511 (GRCm39)	nonsense	probably null
R1886:Dmxl1	UTSW	18	49,992,202 (GRCm39)	missense	probably benign	0.09
R1887:Dmxl1	UTSW	18	49,992,202 (GRCm39)	missense	probably benign	0.09
R1895:Dmxl1	UTSW	18	50,088,981 (GRCm39)	splice site	probably null
R1911:Dmxl1	UTSW	18	50,011,230 (GRCm39)	missense	probably benign	0.00
R2020:Dmxl1	UTSW	18	50,022,625 (GRCm39)	nonsense	probably null
R2116:Dmxl1	UTSW	18	50,011,884 (GRCm39)	missense	probably damaging	1.00
R2196:Dmxl1	UTSW	18	50,050,698 (GRCm39)	missense	probably benign	0.00
R2206:Dmxl1	UTSW	18	50,027,161 (GRCm39)	missense	probably benign	0.12
R2216:Dmxl1	UTSW	18	50,026,990 (GRCm39)	missense	probably benign	0.00
R2255:Dmxl1	UTSW	18	49,979,706 (GRCm39)	missense	probably benign	0.34
R2333:Dmxl1	UTSW	18	50,053,043 (GRCm39)	splice site	probably null
R2343:Dmxl1	UTSW	18	50,023,745 (GRCm39)	missense	probably damaging	1.00
R2496:Dmxl1	UTSW	18	50,013,858 (GRCm39)	missense	possibly damaging	0.51
R3757:Dmxl1	UTSW	18	50,068,384 (GRCm39)	missense	probably damaging	0.98
R3758:Dmxl1	UTSW	18	50,068,384 (GRCm39)	missense	probably damaging	0.98
R3783:Dmxl1	UTSW	18	49,998,189 (GRCm39)	missense	probably damaging	1.00
R3786:Dmxl1	UTSW	18	49,998,189 (GRCm39)	missense	probably damaging	1.00
R3787:Dmxl1	UTSW	18	49,998,189 (GRCm39)	missense	probably damaging	1.00
R3885:Dmxl1	UTSW	18	50,011,326 (GRCm39)	missense	probably damaging	1.00
R3886:Dmxl1	UTSW	18	50,011,326 (GRCm39)	missense	probably damaging	1.00
R3887:Dmxl1	UTSW	18	50,011,326 (GRCm39)	missense	probably damaging	1.00
R3888:Dmxl1	UTSW	18	50,011,326 (GRCm39)	missense	probably damaging	1.00
R3889:Dmxl1	UTSW	18	50,011,326 (GRCm39)	missense	probably damaging	1.00
R4014:Dmxl1	UTSW	18	49,997,029 (GRCm39)	missense	probably benign
R4033:Dmxl1	UTSW	18	49,984,498 (GRCm39)	missense	possibly damaging	0.95
R4096:Dmxl1	UTSW	18	50,094,264 (GRCm39)	missense	probably damaging	1.00
R4366:Dmxl1	UTSW	18	50,011,084 (GRCm39)	nonsense	probably null
R4406:Dmxl1	UTSW	18	50,022,620 (GRCm39)	missense	probably damaging	1.00
R4412:Dmxl1	UTSW	18	49,981,828 (GRCm39)	missense	probably benign
R4454:Dmxl1	UTSW	18	50,026,399 (GRCm39)	missense	probably benign	0.01
R4459:Dmxl1	UTSW	18	50,094,283 (GRCm39)	missense	possibly damaging	0.80
R4569:Dmxl1	UTSW	18	49,985,427 (GRCm39)	missense	probably damaging	1.00
R4570:Dmxl1	UTSW	18	49,985,427 (GRCm39)	missense	probably damaging	1.00
R4606:Dmxl1	UTSW	18	50,095,248 (GRCm39)	missense	probably damaging	0.98
R4649:Dmxl1	UTSW	18	50,011,698 (GRCm39)	missense	probably damaging	0.99
R4683:Dmxl1	UTSW	18	50,011,088 (GRCm39)	missense	probably damaging	1.00
R4782:Dmxl1	UTSW	18	49,996,059 (GRCm39)	missense	probably damaging	1.00
R4878:Dmxl1	UTSW	18	49,984,543 (GRCm39)	missense	probably damaging	1.00
R4879:Dmxl1	UTSW	18	50,022,534 (GRCm39)	missense	probably damaging	1.00
R4881:Dmxl1	UTSW	18	50,090,348 (GRCm39)	intron	probably benign
R4885:Dmxl1	UTSW	18	50,011,862 (GRCm39)	missense	probably damaging	0.99
R4916:Dmxl1	UTSW	18	50,010,764 (GRCm39)	missense	probably damaging	1.00
R5022:Dmxl1	UTSW	18	50,028,194 (GRCm39)	missense	probably damaging	0.99
R5056:Dmxl1	UTSW	18	50,003,990 (GRCm39)	missense	probably benign	0.00
R5177:Dmxl1	UTSW	18	50,026,651 (GRCm39)	missense	probably damaging	0.99
R5342:Dmxl1	UTSW	18	50,084,302 (GRCm39)	missense	probably damaging	0.96
R5421:Dmxl1	UTSW	18	49,996,186 (GRCm39)	critical splice donor site	probably null
R5433:Dmxl1	UTSW	18	50,000,966 (GRCm39)	splice site	probably null
R5484:Dmxl1	UTSW	18	50,022,531 (GRCm39)	missense	probably damaging	1.00
R5598:Dmxl1	UTSW	18	49,997,545 (GRCm39)	missense	probably benign	0.04
R5633:Dmxl1	UTSW	18	50,010,764 (GRCm39)	missense	probably damaging	1.00
R5638:Dmxl1	UTSW	18	50,024,693 (GRCm39)	missense	possibly damaging	0.95
R5694:Dmxl1	UTSW	18	50,027,324 (GRCm39)	missense	probably damaging	1.00
R5696:Dmxl1	UTSW	18	50,065,008 (GRCm39)	nonsense	probably null
R5706:Dmxl1	UTSW	18	50,090,462 (GRCm39)	critical splice donor site	probably null
R5745:Dmxl1	UTSW	18	49,979,653 (GRCm39)	missense	probably benign
R5876:Dmxl1	UTSW	18	50,004,051 (GRCm39)	missense	possibly damaging	0.70
R6054:Dmxl1	UTSW	18	49,990,453 (GRCm39)	missense	probably benign	0.00
R6145:Dmxl1	UTSW	18	50,045,833 (GRCm39)	missense	possibly damaging	0.90
R6189:Dmxl1	UTSW	18	50,026,402 (GRCm39)	missense	probably benign	0.33
R6213:Dmxl1	UTSW	18	49,996,082 (GRCm39)	missense	possibly damaging	0.93
R6219:Dmxl1	UTSW	18	50,035,434 (GRCm39)	missense	probably damaging	0.99
R6221:Dmxl1	UTSW	18	50,004,799 (GRCm39)	missense	probably damaging	0.96
R6276:Dmxl1	UTSW	18	49,979,653 (GRCm39)	missense	probably benign
R6319:Dmxl1	UTSW	18	49,985,367 (GRCm39)	missense	probably benign	0.00
R6426:Dmxl1	UTSW	18	49,997,645 (GRCm39)	missense	probably damaging	0.99
R6567:Dmxl1	UTSW	18	49,992,246 (GRCm39)	missense	probably damaging	0.99
R6739:Dmxl1	UTSW	18	50,011,313 (GRCm39)	missense	probably benign	0.03
R6743:Dmxl1	UTSW	18	50,013,847 (GRCm39)	missense	possibly damaging	0.95
R6776:Dmxl1	UTSW	18	50,027,041 (GRCm39)	missense	probably damaging	1.00
R6827:Dmxl1	UTSW	18	50,054,091 (GRCm39)	missense	probably damaging	1.00
R6828:Dmxl1	UTSW	18	50,054,091 (GRCm39)	missense	probably damaging	1.00
R6829:Dmxl1	UTSW	18	50,054,091 (GRCm39)	missense	probably damaging	1.00
R6830:Dmxl1	UTSW	18	50,054,091 (GRCm39)	missense	probably damaging	1.00
R6833:Dmxl1	UTSW	18	50,088,890 (GRCm39)	missense	probably damaging	0.99
R6834:Dmxl1	UTSW	18	50,088,890 (GRCm39)	missense	probably damaging	0.99
R6856:Dmxl1	UTSW	18	49,985,355 (GRCm39)	nonsense	probably null
R6857:Dmxl1	UTSW	18	49,997,902 (GRCm39)	missense	probably damaging	0.99
R6881:Dmxl1	UTSW	18	50,068,372 (GRCm39)	missense	probably benign	0.00
R6882:Dmxl1	UTSW	18	49,976,851 (GRCm39)	critical splice acceptor site	probably null
R6892:Dmxl1	UTSW	18	50,053,969 (GRCm39)	missense	probably damaging	0.98
R6897:Dmxl1	UTSW	18	49,984,562 (GRCm39)	missense	probably null	0.99
R6917:Dmxl1	UTSW	18	49,997,215 (GRCm39)	missense	probably damaging	1.00
R7192:Dmxl1	UTSW	18	50,088,920 (GRCm39)	missense	probably damaging	0.99
R7447:Dmxl1	UTSW	18	49,997,681 (GRCm39)	missense	probably damaging	0.99
R7460:Dmxl1	UTSW	18	50,011,679 (GRCm39)	missense	probably benign	0.00
R7570:Dmxl1	UTSW	18	50,027,024 (GRCm39)	missense	possibly damaging	0.82
R7626:Dmxl1	UTSW	18	50,035,861 (GRCm39)	missense	probably benign
R7629:Dmxl1	UTSW	18	49,992,337 (GRCm39)	missense	probably damaging	1.00
R7644:Dmxl1	UTSW	18	50,026,619 (GRCm39)	missense	probably benign
R7688:Dmxl1	UTSW	18	50,088,938 (GRCm39)	missense	probably benign	0.03
R7689:Dmxl1	UTSW	18	49,979,685 (GRCm39)	missense	probably benign	0.00
R7712:Dmxl1	UTSW	18	50,026,528 (GRCm39)	missense	probably damaging	0.99
R7808:Dmxl1	UTSW	18	50,011,382 (GRCm39)	missense	probably benign	0.00
R7834:Dmxl1	UTSW	18	50,054,044 (GRCm39)	missense	probably damaging	1.00
R7848:Dmxl1	UTSW	18	49,973,557 (GRCm39)	missense	possibly damaging	0.88
R7849:Dmxl1	UTSW	18	50,094,214 (GRCm39)	missense	probably benign	0.00
R7881:Dmxl1	UTSW	18	49,997,450 (GRCm39)	missense	probably damaging	0.99
R7884:Dmxl1	UTSW	18	50,026,474 (GRCm39)	missense	possibly damaging	0.65
R8073:Dmxl1	UTSW	18	50,011,500 (GRCm39)	missense	probably damaging	1.00
R8089:Dmxl1	UTSW	18	50,021,897 (GRCm39)	missense	probably damaging	0.99
R8266:Dmxl1	UTSW	18	49,976,878 (GRCm39)	missense	probably benign	0.17
R8371:Dmxl1	UTSW	18	50,031,781 (GRCm39)	missense	probably benign	0.08
R8402:Dmxl1	UTSW	18	50,011,409 (GRCm39)	missense	probably benign
R8402:Dmxl1	UTSW	18	50,011,393 (GRCm39)	nonsense	probably null
R8402:Dmxl1	UTSW	18	50,011,394 (GRCm39)	missense	probably benign	0.09
R8423:Dmxl1	UTSW	18	49,998,183 (GRCm39)	missense	probably damaging	1.00
R8678:Dmxl1	UTSW	18	50,004,759 (GRCm39)	nonsense	probably null
R8702:Dmxl1	UTSW	18	49,992,202 (GRCm39)	missense	probably benign	0.09
R8749:Dmxl1	UTSW	18	50,088,937 (GRCm39)	missense	probably damaging	1.00
R8813:Dmxl1	UTSW	18	50,090,406 (GRCm39)	missense	probably damaging	0.99
R8877:Dmxl1	UTSW	18	50,011,292 (GRCm39)	missense	possibly damaging	0.55
R8945:Dmxl1	UTSW	18	50,072,639 (GRCm39)	missense	probably damaging	1.00
R8971:Dmxl1	UTSW	18	50,026,741 (GRCm39)	missense	probably damaging	1.00
R8971:Dmxl1	UTSW	18	49,997,575 (GRCm39)	missense	possibly damaging	0.96
R8978:Dmxl1	UTSW	18	50,055,679 (GRCm39)	missense	probably benign	0.37
R8987:Dmxl1	UTSW	18	50,026,919 (GRCm39)	missense
R9011:Dmxl1	UTSW	18	49,997,240 (GRCm39)	missense	probably damaging	1.00
R9124:Dmxl1	UTSW	18	50,072,639 (GRCm39)	missense	probably damaging	1.00
R9131:Dmxl1	UTSW	18	50,072,639 (GRCm39)	missense	probably damaging	1.00
R9132:Dmxl1	UTSW	18	50,072,639 (GRCm39)	missense	probably damaging	1.00
R9156:Dmxl1	UTSW	18	50,072,639 (GRCm39)	missense	probably damaging	1.00
R9165:Dmxl1	UTSW	18	50,011,992 (GRCm39)	missense	probably damaging	1.00
R9244:Dmxl1	UTSW	18	50,026,316 (GRCm39)	missense	probably benign
R9254:Dmxl1	UTSW	18	50,024,567 (GRCm39)	missense	possibly damaging	0.67
R9262:Dmxl1	UTSW	18	49,976,919 (GRCm39)	missense	probably benign	0.03
R9335:Dmxl1	UTSW	18	49,992,187 (GRCm39)	missense	probably damaging	0.96
R9375:Dmxl1	UTSW	18	50,091,477 (GRCm39)	missense	probably damaging	1.00
R9379:Dmxl1	UTSW	18	50,024,567 (GRCm39)	missense	possibly damaging	0.67
R9434:Dmxl1	UTSW	18	50,010,788 (GRCm39)	missense	probably damaging	0.98
R9470:Dmxl1	UTSW	18	50,026,777 (GRCm39)	missense	possibly damaging	0.69
R9500:Dmxl1	UTSW	18	50,011,271 (GRCm39)	missense	probably damaging	1.00
R9507:Dmxl1	UTSW	18	50,024,567 (GRCm39)	missense	possibly damaging	0.94
R9617:Dmxl1	UTSW	18	49,998,228 (GRCm39)	missense	probably damaging	1.00
R9642:Dmxl1	UTSW	18	50,013,825 (GRCm39)	missense	probably damaging	1.00
RF009:Dmxl1	UTSW	18	50,026,461 (GRCm39)	missense	probably damaging	0.96
X0025:Dmxl1	UTSW	18	49,997,435 (GRCm39)	missense	probably damaging	0.98
X0066:Dmxl1	UTSW	18	50,052,966 (GRCm39)	missense	probably damaging	1.00
Z1088:Dmxl1	UTSW	18	50,054,032 (GRCm39)	missense	probably benign
Z1188:Dmxl1	UTSW	18	50,001,070 (GRCm39)	missense	probably damaging	0.96
Z1189:Dmxl1	UTSW	18	50,001,070 (GRCm39)	missense	probably damaging	0.96

Predicted Primers

PCR Primer
(F):5'- TGTGTATGCTATGTTATAGAGGTTCA -3'
(R):5'- AAGCTAGTCCATATTACATTATGCCA -3'

Sequencing Primer
(F):5'- GAGAAATGTGGACCTTTTGTG -3'
(R):5'- TTATGCCACAATGACCATGGG -3'

Posted On

2018-11-06