Incidental Mutation 'R6902:Zfp961'
ID 538596
Institutional Source Beutler Lab
Gene Symbol Zfp961
Ensembl Gene ENSMUSG00000052446
Gene Name zinc finger protein 961
Synonyms A230105L22Rik, BC049349
MMRRC Submission 045032-MU
Accession Numbers
Essential gene? Non essential (E-score: 0.000) question?
Stock # R6902 (G1)
Quality Score 225.009
Status Validated
Chromosome 8
Chromosomal Location 72704910-72724177 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to G at 72722522 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Lysine to Arginine at position 345 (K345R)
Ref Sequence ENSEMBL: ENSMUSP00000105623 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000109997] [ENSMUST00000131237] [ENSMUST00000132848] [ENSMUST00000136516] [ENSMUST00000138304] [ENSMUST00000145256]
AlphaFold E9Q4R5
Predicted Effect probably damaging
Transcript: ENSMUST00000109997
AA Change: K345R

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
SMART Domains Protein: ENSMUSP00000105623
Gene: ENSMUSG00000052446
AA Change: K345R

DomainStartEndE-ValueType
KRAB 25 82 1.14e-18 SMART
ZnF_C2H2 144 166 1.69e-3 SMART
ZnF_C2H2 172 194 3.07e-1 SMART
ZnF_C2H2 199 221 1.36e-2 SMART
ZnF_C2H2 226 248 3.29e-1 SMART
ZnF_C2H2 254 276 3.34e-2 SMART
ZnF_C2H2 282 304 9.58e-3 SMART
ZnF_C2H2 310 332 2.17e-1 SMART
ZnF_C2H2 338 360 1.04e-3 SMART
ZnF_C2H2 366 388 2.24e-3 SMART
ZnF_C2H2 394 416 2.24e-3 SMART
ZnF_C2H2 421 443 4.61e-5 SMART
Predicted Effect possibly damaging
Transcript: ENSMUST00000131237
AA Change: K326R

PolyPhen 2 Score 0.707 (Sensitivity: 0.86; Specificity: 0.92)
SMART Domains Protein: ENSMUSP00000122942
Gene: ENSMUSG00000052446
AA Change: K326R

DomainStartEndE-ValueType
KRAB 6 63 1.14e-18 SMART
ZnF_C2H2 125 147 1.69e-3 SMART
ZnF_C2H2 153 175 3.07e-1 SMART
ZnF_C2H2 180 202 1.36e-2 SMART
ZnF_C2H2 207 229 3.29e-1 SMART
ZnF_C2H2 235 257 3.34e-2 SMART
ZnF_C2H2 263 285 9.58e-3 SMART
ZnF_C2H2 291 313 2.17e-1 SMART
ZnF_C2H2 319 341 1.04e-3 SMART
ZnF_C2H2 347 369 2.24e-3 SMART
ZnF_C2H2 375 397 2.24e-3 SMART
ZnF_C2H2 402 424 4.61e-5 SMART
Predicted Effect probably benign
Transcript: ENSMUST00000132848
SMART Domains Protein: ENSMUSP00000114730
Gene: ENSMUSG00000052446

DomainStartEndE-ValueType
KRAB 25 82 1.14e-18 SMART
ZnF_C2H2 144 166 1.69e-3 SMART
Predicted Effect probably benign
Transcript: ENSMUST00000136516
SMART Domains Protein: ENSMUSP00000122589
Gene: ENSMUSG00000052446

DomainStartEndE-ValueType
KRAB 25 82 1.14e-18 SMART
ZnF_C2H2 144 166 1.69e-3 SMART
ZnF_C2H2 172 194 3.07e-1 SMART
ZnF_C2H2 199 221 1.36e-2 SMART
Predicted Effect probably benign
Transcript: ENSMUST00000138304
Predicted Effect probably benign
Transcript: ENSMUST00000145256
Meta Mutation Damage Score 0.6467 question?
Coding Region Coverage
  • 1x: 100.0%
  • 3x: 99.9%
  • 10x: 99.2%
  • 20x: 97.6%
Validation Efficiency 98% (50/51)
Allele List at MGI
Other mutations in this stock
Total: 53 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
3110070M22Rik C G 13: 119,624,680 (GRCm39) probably benign Het
Abcc9 T A 6: 142,624,953 (GRCm39) S481C probably damaging Het
Adgrl3 C A 5: 81,837,434 (GRCm39) S773R probably damaging Het
Alkbh5 G A 11: 60,429,381 (GRCm39) A45T probably benign Het
Ankrd6 C A 4: 32,806,419 (GRCm39) Q576H probably damaging Het
Ankrd6 T A 4: 32,806,420 (GRCm39) Q576L probably damaging Het
Carmil1 T C 13: 24,299,528 (GRCm39) N332S possibly damaging Het
Cc2d2b A G 19: 40,804,733 (GRCm39) Q1250R possibly damaging Het
Chd9 A C 8: 91,769,579 (GRCm39) N2539T probably damaging Het
Clec4b2 C T 6: 123,177,987 (GRCm39) Q101* probably null Het
Clstn2 A T 9: 97,351,875 (GRCm39) F517I probably damaging Het
Cog2 A G 8: 125,273,430 (GRCm39) K590E probably damaging Het
Coq9 G A 8: 95,577,180 (GRCm39) E182K probably benign Het
Fcgbpl1 C T 7: 27,836,638 (GRCm39) R186C probably damaging Het
Focad C T 4: 88,148,713 (GRCm39) R477C unknown Het
Gja10 G T 4: 32,601,905 (GRCm39) H160N probably damaging Het
Gpr132 T A 12: 112,815,830 (GRCm39) Y332F probably benign Het
Herc2 A G 7: 55,785,234 (GRCm39) T1495A probably benign Het
Hivep3 T A 4: 119,953,192 (GRCm39) S503T possibly damaging Het
Ifi44 A T 3: 151,451,536 (GRCm39) I190N possibly damaging Het
Igf1r T A 7: 67,653,911 (GRCm39) C150S probably damaging Het
Ighv1-42 T A 12: 114,901,155 (GRCm39) N4Y possibly damaging Het
Klra9 T A 6: 130,156,003 (GRCm39) I251F probably benign Het
Krt79 T C 15: 101,840,314 (GRCm39) N294S probably benign Het
Lama2 T G 10: 26,857,625 (GRCm39) T3075P probably damaging Het
Lrfn1 T G 7: 28,159,238 (GRCm39) C386G probably benign Het
Lrp2 T C 2: 69,289,847 (GRCm39) D3664G probably damaging Het
Mfsd3 T A 15: 76,587,349 (GRCm39) M344K probably damaging Het
Mier2 C A 10: 79,376,673 (GRCm39) probably benign Het
Mmp2 G A 8: 93,563,545 (GRCm39) V340M probably damaging Het
Mrgprb3 T A 7: 48,293,447 (GRCm39) I35F probably benign Het
Myo5b A T 18: 74,809,756 (GRCm39) I613F possibly damaging Het
Nicol1 G A 5: 34,140,923 (GRCm39) probably benign Het
Or14c43 T A 7: 86,114,995 (GRCm39) C125* probably null Het
Or51f1e A T 7: 102,747,562 (GRCm39) I205F probably benign Het
Or7d11 A T 9: 19,966,670 (GRCm39) L30M possibly damaging Het
Or8g30 C A 9: 39,230,315 (GRCm39) L198F probably damaging Het
Pan2 A G 10: 128,151,506 (GRCm39) T867A probably benign Het
Papolb T A 5: 142,513,906 (GRCm39) H579L probably benign Het
Pcf11 C A 7: 92,307,507 (GRCm39) G887V probably damaging Het
Pdzd8 A G 19: 59,289,829 (GRCm39) S524P possibly damaging Het
Pole3 T C 4: 62,442,300 (GRCm39) probably benign Het
Prdm14 C T 1: 13,192,645 (GRCm39) V365I probably benign Het
Shank1 T A 7: 44,006,239 (GRCm39) F1985L probably benign Het
Slc13a1 T C 6: 24,097,665 (GRCm39) I421V possibly damaging Het
Slc2a6 C T 2: 26,913,172 (GRCm39) V374M probably benign Het
Spata1 A T 3: 146,181,078 (GRCm39) N293K possibly damaging Het
Stk40 T A 4: 126,031,605 (GRCm39) D366E probably benign Het
Tas2r117 T C 6: 132,780,288 (GRCm39) L142S probably damaging Het
Tomm70a T C 16: 56,958,444 (GRCm39) S266P probably damaging Het
Trgv1 T C 13: 19,524,190 (GRCm39) L2P probably benign Het
Vipr2 A T 12: 116,102,819 (GRCm39) T310S possibly damaging Het
Vti1a A T 19: 55,487,673 (GRCm39) probably null Het
Other mutations in Zfp961
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00595:Zfp961 APN 8 72,722,272 (GRCm39) missense probably damaging 1.00
IGL00801:Zfp961 APN 8 72,719,732 (GRCm39) missense probably damaging 1.00
IGL00825:Zfp961 APN 8 72,721,888 (GRCm39) missense possibly damaging 0.91
IGL01405:Zfp961 APN 8 72,721,778 (GRCm39) missense possibly damaging 0.53
IGL03100:Zfp961 APN 8 72,721,754 (GRCm39) makesense probably null
R0969:Zfp961 UTSW 8 72,722,139 (GRCm39) missense probably damaging 1.00
R4851:Zfp961 UTSW 8 72,722,847 (GRCm39) unclassified probably benign
R5502:Zfp961 UTSW 8 72,721,903 (GRCm39) missense probably damaging 0.99
R5813:Zfp961 UTSW 8 72,722,070 (GRCm39) missense probably damaging 1.00
R6762:Zfp961 UTSW 8 72,719,958 (GRCm39) missense possibly damaging 0.53
R7858:Zfp961 UTSW 8 72,704,949 (GRCm39) missense unknown
R8749:Zfp961 UTSW 8 72,719,686 (GRCm39) missense probably damaging 1.00
R9718:Zfp961 UTSW 8 72,721,933 (GRCm39) missense possibly damaging 0.81
X0027:Zfp961 UTSW 8 72,721,793 (GRCm39) missense possibly damaging 0.89
Predicted Primers PCR Primer
(F):5'- TGTAGAGAAGCGTTCCCTAATG -3'
(R):5'- GGAGCTAGAATGTGTAGAGCTC -3'

Sequencing Primer
(F):5'- CTCACACTGGGGAGAAACCTTTTG -3'
(R):5'- GTAACTGGAACAACTAAAGGCTTTCC -3'
Posted On 2018-11-06