Incidental Mutation 'R6902:Gpr132'
ID 538608
Institutional Source Beutler Lab
Gene Symbol Gpr132
Ensembl Gene ENSMUSG00000021298
Gene Name G protein-coupled receptor 132
Synonyms G2a, G2 accumulation
MMRRC Submission 045032-MU
Accession Numbers
Essential gene? Non essential (E-score: 0.000) question?
Stock # R6902 (G1)
Quality Score 225.009
Status Validated
Chromosome 12
Chromosomal Location 112814493-112831848 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to A at 112815830 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Tyrosine to Phenylalanine at position 332 (Y332F)
Ref Sequence ENSEMBL: ENSMUSP00000021729 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000021729] [ENSMUST00000222776]
AlphaFold Q9Z282
Predicted Effect probably benign
Transcript: ENSMUST00000021729
AA Change: Y332F

PolyPhen 2 Score 0.392 (Sensitivity: 0.90; Specificity: 0.89)
SMART Domains Protein: ENSMUSP00000021729
Gene: ENSMUSG00000021298
AA Change: Y332F

DomainStartEndE-ValueType
low complexity region 33 52 N/A INTRINSIC
Pfam:7tm_1 56 306 6.1e-33 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000222776
Meta Mutation Damage Score 0.0898 question?
Coding Region Coverage
  • 1x: 100.0%
  • 3x: 99.9%
  • 10x: 99.2%
  • 20x: 97.6%
Validation Efficiency 98% (50/51)
MGI Phenotype FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes a member of the guanine nucleotide-binding protein (G protein)-coupled receptor (GPCR) superfamily. The receptors are seven-pass transmembrane proteins that respond to extracellular cues and activate intracellular signal transduction pathways. This protein was reported to be a receptor for lysophosphatidylcholine action, but PubMedID: 15653487 retracts this finding and instead suggests this protein to be an effector of lysophosphatidylcholine action. This protein may have proton-sensing activity and may be a receptor for oxidized free fatty acids. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2013]
PHENOTYPE: Mice homozygous for disruptions in this gene display a generally normal phenotype but eventually develop a "late onset lymphoproliferative autoimmune syndrome" [provided by MGI curators]
Allele List at MGI
Other mutations in this stock
Total: 53 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
3110070M22Rik C G 13: 119,624,680 (GRCm39) probably benign Het
Abcc9 T A 6: 142,624,953 (GRCm39) S481C probably damaging Het
Adgrl3 C A 5: 81,837,434 (GRCm39) S773R probably damaging Het
Alkbh5 G A 11: 60,429,381 (GRCm39) A45T probably benign Het
Ankrd6 C A 4: 32,806,419 (GRCm39) Q576H probably damaging Het
Ankrd6 T A 4: 32,806,420 (GRCm39) Q576L probably damaging Het
Carmil1 T C 13: 24,299,528 (GRCm39) N332S possibly damaging Het
Cc2d2b A G 19: 40,804,733 (GRCm39) Q1250R possibly damaging Het
Chd9 A C 8: 91,769,579 (GRCm39) N2539T probably damaging Het
Clec4b2 C T 6: 123,177,987 (GRCm39) Q101* probably null Het
Clstn2 A T 9: 97,351,875 (GRCm39) F517I probably damaging Het
Cog2 A G 8: 125,273,430 (GRCm39) K590E probably damaging Het
Coq9 G A 8: 95,577,180 (GRCm39) E182K probably benign Het
Fcgbpl1 C T 7: 27,836,638 (GRCm39) R186C probably damaging Het
Focad C T 4: 88,148,713 (GRCm39) R477C unknown Het
Gja10 G T 4: 32,601,905 (GRCm39) H160N probably damaging Het
Herc2 A G 7: 55,785,234 (GRCm39) T1495A probably benign Het
Hivep3 T A 4: 119,953,192 (GRCm39) S503T possibly damaging Het
Ifi44 A T 3: 151,451,536 (GRCm39) I190N possibly damaging Het
Igf1r T A 7: 67,653,911 (GRCm39) C150S probably damaging Het
Ighv1-42 T A 12: 114,901,155 (GRCm39) N4Y possibly damaging Het
Klra9 T A 6: 130,156,003 (GRCm39) I251F probably benign Het
Krt79 T C 15: 101,840,314 (GRCm39) N294S probably benign Het
Lama2 T G 10: 26,857,625 (GRCm39) T3075P probably damaging Het
Lrfn1 T G 7: 28,159,238 (GRCm39) C386G probably benign Het
Lrp2 T C 2: 69,289,847 (GRCm39) D3664G probably damaging Het
Mfsd3 T A 15: 76,587,349 (GRCm39) M344K probably damaging Het
Mier2 C A 10: 79,376,673 (GRCm39) probably benign Het
Mmp2 G A 8: 93,563,545 (GRCm39) V340M probably damaging Het
Mrgprb3 T A 7: 48,293,447 (GRCm39) I35F probably benign Het
Myo5b A T 18: 74,809,756 (GRCm39) I613F possibly damaging Het
Nicol1 G A 5: 34,140,923 (GRCm39) probably benign Het
Or14c43 T A 7: 86,114,995 (GRCm39) C125* probably null Het
Or51f1e A T 7: 102,747,562 (GRCm39) I205F probably benign Het
Or7d11 A T 9: 19,966,670 (GRCm39) L30M possibly damaging Het
Or8g30 C A 9: 39,230,315 (GRCm39) L198F probably damaging Het
Pan2 A G 10: 128,151,506 (GRCm39) T867A probably benign Het
Papolb T A 5: 142,513,906 (GRCm39) H579L probably benign Het
Pcf11 C A 7: 92,307,507 (GRCm39) G887V probably damaging Het
Pdzd8 A G 19: 59,289,829 (GRCm39) S524P possibly damaging Het
Pole3 T C 4: 62,442,300 (GRCm39) probably benign Het
Prdm14 C T 1: 13,192,645 (GRCm39) V365I probably benign Het
Shank1 T A 7: 44,006,239 (GRCm39) F1985L probably benign Het
Slc13a1 T C 6: 24,097,665 (GRCm39) I421V possibly damaging Het
Slc2a6 C T 2: 26,913,172 (GRCm39) V374M probably benign Het
Spata1 A T 3: 146,181,078 (GRCm39) N293K possibly damaging Het
Stk40 T A 4: 126,031,605 (GRCm39) D366E probably benign Het
Tas2r117 T C 6: 132,780,288 (GRCm39) L142S probably damaging Het
Tomm70a T C 16: 56,958,444 (GRCm39) S266P probably damaging Het
Trgv1 T C 13: 19,524,190 (GRCm39) L2P probably benign Het
Vipr2 A T 12: 116,102,819 (GRCm39) T310S possibly damaging Het
Vti1a A T 19: 55,487,673 (GRCm39) probably null Het
Zfp961 A G 8: 72,722,522 (GRCm39) K345R probably damaging Het
Other mutations in Gpr132
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL02349:Gpr132 APN 12 112,816,475 (GRCm39) missense probably damaging 1.00
R1454:Gpr132 UTSW 12 112,815,860 (GRCm39) missense possibly damaging 0.78
R1785:Gpr132 UTSW 12 112,816,023 (GRCm39) missense probably damaging 1.00
R1786:Gpr132 UTSW 12 112,816,023 (GRCm39) missense probably damaging 1.00
R2133:Gpr132 UTSW 12 112,816,023 (GRCm39) missense probably damaging 1.00
R3899:Gpr132 UTSW 12 112,815,728 (GRCm39) missense probably benign 0.05
R3913:Gpr132 UTSW 12 112,816,640 (GRCm39) missense probably benign 0.03
R5226:Gpr132 UTSW 12 112,815,768 (GRCm39) missense probably benign 0.00
R5662:Gpr132 UTSW 12 112,816,416 (GRCm39) missense probably damaging 1.00
R5665:Gpr132 UTSW 12 112,816,416 (GRCm39) missense probably damaging 1.00
R5805:Gpr132 UTSW 12 112,816,416 (GRCm39) missense probably damaging 1.00
R5807:Gpr132 UTSW 12 112,816,416 (GRCm39) missense probably damaging 1.00
R5907:Gpr132 UTSW 12 112,815,717 (GRCm39) missense probably benign
R6946:Gpr132 UTSW 12 112,815,830 (GRCm39) missense probably benign 0.39
R7218:Gpr132 UTSW 12 112,816,049 (GRCm39) missense probably damaging 1.00
R7543:Gpr132 UTSW 12 112,815,822 (GRCm39) missense probably benign 0.00
R8742:Gpr132 UTSW 12 112,819,517 (GRCm39) start gained probably benign
Predicted Primers PCR Primer
(F):5'- ATCTATAGTGCTGTGGACACCCC -3'
(R):5'- CCGTGTGTGCCTTTGAAAGC -3'

Sequencing Primer
(F):5'- CTCAGAGGACCAGGTATGTGTGAC -3'
(R):5'- GTGCCTTTGAAAGCAGACTGTACAC -3'
Posted On 2018-11-06