Incidental Mutation 'R6907:Or10ad1c'
ID 538840
Institutional Source Beutler Lab
Gene Symbol Or10ad1c
Ensembl Gene ENSMUSG00000075427
Gene Name olfactory receptor family 10 subfamily AD member 1C
Synonyms MOR286-3P, GA_x6K02T2NBG7-5568919-5569857, Olfr288
MMRRC Submission 044999-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.080) question?
Stock # R6907 (G1)
Quality Score 225.009
Status Validated
Chromosome 15
Chromosomal Location 98083894-98093423 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to C at 98085649 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Asparagine to Aspartic acid at position 10 (N10D)
Ref Sequence ENSEMBL: ENSMUSP00000132237 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000142443] [ENSMUST00000165379]
AlphaFold no structure available at present
Predicted Effect probably damaging
Transcript: ENSMUST00000142443
AA Change: N10D

PolyPhen 2 Score 0.998 (Sensitivity: 0.27; Specificity: 0.99)
SMART Domains Protein: ENSMUSP00000119026
Gene: ENSMUSG00000075427
AA Change: N10D

DomainStartEndE-ValueType
low complexity region 19 34 N/A INTRINSIC
Pfam:7tm_1 38 287 1.2e-32 PFAM
Pfam:7tm_4 136 280 3.9e-34 PFAM
Predicted Effect probably damaging
Transcript: ENSMUST00000142443
AA Change: N10D

PolyPhen 2 Score 0.998 (Sensitivity: 0.27; Specificity: 0.99)
Predicted Effect probably damaging
Transcript: ENSMUST00000165379
AA Change: N10D

PolyPhen 2 Score 0.998 (Sensitivity: 0.27; Specificity: 0.99)
SMART Domains Protein: ENSMUSP00000132237
Gene: ENSMUSG00000075427
AA Change: N10D

DomainStartEndE-ValueType
Pfam:7tm_4 38 314 2.7e-48 PFAM
Pfam:7tm_1 48 297 5.9e-24 PFAM
Meta Mutation Damage Score 0.3574 question?
Coding Region Coverage
  • 1x: 100.0%
  • 3x: 99.9%
  • 10x: 99.4%
  • 20x: 98.0%
Validation Efficiency 97% (38/39)
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 38 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Adat1 T C 8: 112,698,793 (GRCm39) I344V probably benign Het
Bmper A T 9: 23,310,868 (GRCm39) Q434L probably damaging Het
Cabyr A G 18: 12,883,969 (GRCm39) Y152C probably benign Het
Cactin G A 10: 81,159,278 (GRCm39) probably null Het
Cadps2 T C 6: 23,599,505 (GRCm39) D238G probably damaging Het
Card10 T C 15: 78,671,671 (GRCm39) T598A possibly damaging Het
Ctr9 C T 7: 110,629,449 (GRCm39) P25L probably damaging Het
Entpd5 T C 12: 84,424,127 (GRCm39) T409A probably benign Het
Exd1 A G 2: 119,363,957 (GRCm39) V137A probably damaging Het
Fcgbp G A 7: 27,784,443 (GRCm39) G168R probably damaging Het
Ift88 A G 14: 57,683,067 (GRCm39) N248S probably benign Het
Kntc1 T A 5: 123,939,888 (GRCm39) Y1561N probably damaging Het
Mef2c A G 13: 83,802,730 (GRCm39) D227G probably benign Het
Myh2 C T 11: 67,084,567 (GRCm39) T1702M probably damaging Het
Myo1e T A 9: 70,234,437 (GRCm39) N263K probably benign Het
Nfe2l1 A G 11: 96,710,636 (GRCm39) L373P probably damaging Het
Nob1 C T 8: 108,142,860 (GRCm39) V274M possibly damaging Het
Ntng2 A G 2: 29,118,218 (GRCm39) C77R probably damaging Het
Nynrin T G 14: 56,101,335 (GRCm39) S335A probably benign Het
Or5p55 T C 7: 107,567,459 (GRCm39) L285P probably damaging Het
Pcdh7 T A 5: 57,876,471 (GRCm39) W9R possibly damaging Het
Pcdha1 A G 18: 37,064,124 (GRCm39) T263A probably benign Het
Per3 C T 4: 151,128,015 (GRCm39) probably null Het
Pgbd5 A G 8: 125,107,021 (GRCm39) F265L probably damaging Het
Ppm1k T G 6: 57,487,755 (GRCm39) E356A probably benign Het
Ptgfr G T 3: 151,540,938 (GRCm39) T190K possibly damaging Het
Sec24a A G 11: 51,603,103 (GRCm39) Y782H probably damaging Het
Setd1b T C 5: 123,301,295 (GRCm39) probably benign Het
Sfpq GCCGCCGCAGCAGCCTCCGCCGCAGCAGCC GCCGCCGCAGCAGCC 4: 126,915,419 (GRCm39) probably benign Het
Slc19a2 C T 1: 164,090,323 (GRCm39) T253I possibly damaging Het
Tcf4 C T 18: 69,785,484 (GRCm39) T207M probably damaging Het
Thada T C 17: 84,700,897 (GRCm39) N1203S probably damaging Het
Tln2 A T 9: 67,304,917 (GRCm39) S5T probably damaging Het
Traf4 C T 11: 78,051,268 (GRCm39) R296Q probably benign Het
Ttbk2 A G 2: 120,655,751 (GRCm39) S38P probably benign Het
Vrk1 G T 12: 106,041,291 (GRCm39) Q395H possibly damaging Het
Vwa3a G T 7: 120,391,804 (GRCm39) probably benign Het
Wdsub1 C T 2: 59,692,028 (GRCm39) V335I possibly damaging Het
Other mutations in Or10ad1c
AlleleSourceChrCoordTypePredicted EffectPPH Score
R1936:Or10ad1c UTSW 15 98,085,462 (GRCm39) missense probably benign 0.02
R2047:Or10ad1c UTSW 15 98,084,920 (GRCm39) missense probably damaging 1.00
R2219:Or10ad1c UTSW 15 98,084,848 (GRCm39) nonsense probably null
R4697:Or10ad1c UTSW 15 98,084,749 (GRCm39) missense probably damaging 1.00
R7601:Or10ad1c UTSW 15 98,084,860 (GRCm39) missense probably damaging 1.00
R8101:Or10ad1c UTSW 15 98,084,839 (GRCm39) missense probably benign 0.00
R9385:Or10ad1c UTSW 15 98,085,486 (GRCm39) missense probably damaging 1.00
Predicted Primers PCR Primer
(F):5'- GTACATGGGGCTGTTGAGC -3'
(R):5'- ATTCCAAAACTTTCCCTATCACTGGG -3'

Sequencing Primer
(F):5'- CCTGGGGTCAGTCCATGTG -3'
(R):5'- AGCATGTATCATCCCATGTCGAG -3'
Posted On 2018-11-06