Incidental Mutation 'R6909:Olfr1155'
ID538906
Institutional Source Beutler Lab
Gene Symbol Olfr1155
Ensembl Gene ENSMUSG00000075145
Gene Nameolfactory receptor 1155
SynonymsGA_x6K02T2Q125-49426894-49425950, MOR174-10
MMRRC Submission
Accession Numbers

Genbank: NM_146643; MGI: 3030989

Is this an essential gene? Probably non essential (E-score: 0.074) question?
Stock #R6909 (G1)
Quality Score225.009
Status Not validated
Chromosome2
Chromosomal Location87941645-87945137 bp(-) (GRCm38)
Type of Mutationmissense
DNA Base Change (assembly) A to G at 87942690 bp
ZygosityHeterozygous
Amino Acid Change Serine to Proline at position 313 (S313P)
Ref Sequence ENSEMBL: ENSMUSP00000149428 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000099843] [ENSMUST00000214641] [ENSMUST00000215903] [ENSMUST00000216191] [ENSMUST00000216726]
Predicted Effect probably benign
Transcript: ENSMUST00000099843
AA Change: S313P

PolyPhen 2 Score 0.267 (Sensitivity: 0.91; Specificity: 0.88)
SMART Domains Protein: ENSMUSP00000097431
Gene: ENSMUSG00000075145
AA Change: S313P

DomainStartEndE-ValueType
Pfam:7tm_4 33 310 2.7e-44 PFAM
Pfam:7tm_1 43 292 5.3e-16 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000214641
AA Change: S313P

PolyPhen 2 Score 0.267 (Sensitivity: 0.91; Specificity: 0.88)
Predicted Effect probably benign
Transcript: ENSMUST00000215903
AA Change: S313P

PolyPhen 2 Score 0.267 (Sensitivity: 0.91; Specificity: 0.88)
Predicted Effect probably benign
Transcript: ENSMUST00000216191
Predicted Effect probably benign
Transcript: ENSMUST00000216726
Coding Region Coverage
  • 1x: 100.0%
  • 3x: 99.9%
  • 10x: 99.1%
  • 20x: 97.1%
Validation Efficiency
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 59 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Abca9 G T 11: 110,115,497 Q1261K probably benign Het
Acpp T C 9: 104,300,965 Y329C probably damaging Het
Agrn G T 4: 156,177,007 H585N possibly damaging Het
Ano1 G A 7: 144,655,731 T211M probably damaging Het
Atic T G 1: 71,576,846 probably null Het
Catsperd T A 17: 56,650,781 S229R probably damaging Het
Ccdc173 A T 2: 69,781,848 probably null Het
Cmya5 T C 13: 93,091,252 T2443A probably benign Het
Dysf A T 6: 84,192,938 E1772V probably damaging Het
Eps8l1 T A 7: 4,469,900 L107* probably null Het
Fam92a T C 4: 12,168,309 T97A probably benign Het
Fpr3 T A 17: 17,971,167 F233L probably benign Het
Gjc2 A T 11: 59,177,092 V188E unknown Het
Gm45861 T A 8: 27,527,081 Y690N unknown Het
Gm8251 C T 1: 44,059,775 R721Q possibly damaging Het
Gsdma2 T A 11: 98,652,557 C224* probably null Het
Gucy2d T A 7: 98,467,625 Y881N probably damaging Het
Hcn3 A G 3: 89,152,629 probably null Het
Hectd1 G T 12: 51,764,162 probably null Het
Ifitm5 A G 7: 140,949,259 F146L probably benign Het
Impg2 T C 16: 56,204,584 F18S probably damaging Het
Ino80c T A 18: 24,108,755 probably benign Het
Itga10 A G 3: 96,662,599 H1109R probably benign Het
Kdm3b T A 18: 34,827,328 probably null Het
Klra8 T G 6: 130,125,160 N104T probably benign Het
Llgl2 G A 11: 115,850,799 C585Y probably damaging Het
Lmod2 T A 6: 24,604,158 D377E probably benign Het
Lrat G A 3: 82,903,654 S20F probably damaging Het
Lrrc43 T A 5: 123,500,419 H363Q probably benign Het
Lyst T G 13: 13,743,375 I3340S probably damaging Het
Magi1 C A 6: 93,697,320 G948W probably damaging Het
Map3k4 A C 17: 12,270,985 F520V probably damaging Het
Mcm4 A T 16: 15,628,697 N607K probably damaging Het
Mta3 T C 17: 83,766,551 V216A possibly damaging Het
Ncor1 C A 11: 62,329,486 G2131V probably damaging Het
Olfr1123 A G 2: 87,418,615 H189R probably damaging Het
Olfr373 T A 8: 72,100,528 V256E possibly damaging Het
Olfr827 T A 10: 130,210,753 I126L probably benign Het
Pramef8 T C 4: 143,417,909 L275P probably damaging Het
Ptpn2 A T 18: 67,675,971 probably null Het
Scn10a A G 9: 119,609,790 I1671T probably damaging Het
Scyl2 A T 10: 89,645,742 S622T probably benign Het
Sim1 C T 10: 50,909,410 R192C possibly damaging Het
Skor2 A G 18: 76,860,557 H658R possibly damaging Het
Slc10a5 A G 3: 10,335,595 S2P possibly damaging Het
Slc37a4 A T 9: 44,400,034 K207N possibly damaging Het
Syne2 G T 12: 76,064,195 V5768L probably benign Het
Tdpoz3 T A 3: 93,826,465 V149E probably damaging Het
Tekt5 T C 16: 10,358,301 N460S probably damaging Het
Tk2 G T 8: 104,236,810 Y142* probably null Het
Tkfc T A 19: 10,596,266 Q236L probably benign Het
Tln2 G A 9: 67,392,532 T148I probably damaging Het
Trim62 A G 4: 128,884,228 D20G probably damaging Het
Tspan14 A C 14: 40,913,441 V166G probably benign Het
Ttn A T 2: 76,881,721 probably benign Het
Vmn1r217 T A 13: 23,113,938 M265L probably benign Het
Vmn2r117 C G 17: 23,479,505 Q31H possibly damaging Het
Wdr66 A G 5: 123,287,752 Y418C probably damaging Het
Zfp72 T C 13: 74,371,742 T406A possibly damaging Het
Other mutations in Olfr1155
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL02507:Olfr1155 APN 2 87942918 nonsense probably null
IGL03245:Olfr1155 APN 2 87942742 missense possibly damaging 0.75
B5639:Olfr1155 UTSW 2 87943598 missense probably benign 0.03
PIT4531001:Olfr1155 UTSW 2 87943227 missense probably damaging 1.00
R0212:Olfr1155 UTSW 2 87943091 missense probably damaging 1.00
R0393:Olfr1155 UTSW 2 87943565 missense possibly damaging 0.62
R1178:Olfr1155 UTSW 2 87943146 missense probably benign 0.02
R1180:Olfr1155 UTSW 2 87943146 missense probably benign 0.02
R1181:Olfr1155 UTSW 2 87943146 missense probably benign 0.02
R1266:Olfr1155 UTSW 2 87943533 missense probably benign 0.01
R1847:Olfr1155 UTSW 2 87942721 splice site probably null
R1998:Olfr1155 UTSW 2 87943146 missense probably benign 0.02
R2000:Olfr1155 UTSW 2 87943146 missense probably benign 0.02
R4119:Olfr1155 UTSW 2 87943443 missense probably damaging 1.00
R4213:Olfr1155 UTSW 2 87943121 missense probably benign 0.00
R5157:Olfr1155 UTSW 2 87942888 missense probably benign
R5688:Olfr1155 UTSW 2 87943208 missense probably benign 0.02
R5731:Olfr1155 UTSW 2 87943427 missense possibly damaging 0.89
R6064:Olfr1155 UTSW 2 87943484 missense probably benign 0.00
R6372:Olfr1155 UTSW 2 87942975 missense probably benign 0.00
R6505:Olfr1155 UTSW 2 87943174 nonsense probably null
R6555:Olfr1155 UTSW 2 87943288 missense probably damaging 1.00
R7257:Olfr1155 UTSW 2 87943571 missense probably damaging 1.00
R8037:Olfr1155 UTSW 2 87942975 missense probably benign 0.00
R8367:Olfr1155 UTSW 2 87943097 missense possibly damaging 0.75
Z1088:Olfr1155 UTSW 2 87943448 missense probably damaging 1.00
Z1176:Olfr1155 UTSW 2 87943209 missense possibly damaging 0.57
Z1176:Olfr1155 UTSW 2 87943467 missense probably damaging 1.00
Predicted Primers PCR Primer
(F):5'- CCTAACACAGTATCATCTTTTGGTC -3'
(R):5'- GCTTCCCATATGACAGCCATC -3'

Sequencing Primer
(F):5'- ATGCCCAGTTCATTCACT -3'
(R):5'- ATGACAGCCATCACTATCTTCCATGG -3'
Posted On2018-11-06