|Institutional Source||Beutler Lab|
|Gene Name||hyperpolarization-activated, cyclic nucleotide-gated K+ 3|
|Is this an essential gene?||Possibly non essential (E-score: 0.373)|
|Stock #||R6909 (G1)|
|Chromosomal Location||89146074-89160196 bp(-) (GRCm38)|
|Type of Mutation||critical splice donor site (2 bp from exon)|
|DNA Base Change (assembly)||A to G at 89152629 bp|
|Amino Acid Change|
|Ref Sequence||ENSEMBL: ENSMUSP00000029686 (fasta)|
|Gene Model||predicted gene model for transcript(s): [ENSMUST00000029686]|
|Predicted Effect||probably null
|Coding Region Coverage||
FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes a multi-pass membrane protein that functions as a voltage gated cation channel. The encoded protein is a member of a family of closely related cyclic adenosine monophosphate-binding channel proteins. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2012]
PHENOTYPE: Mice homozygous for a knock-out allele exhibit abnormal ventricular action potential waveform. [provided by MGI curators]
|Allele List at MGI|
|Other mutations in this stock||
|Other mutations in Hcn3||
(F):5'- AAGTGTTTGCCATAGCTCTGTAC -3'
(R):5'- CACCTGGTTCCTGGTTGATCTG -3'
(F):5'- GCCATAGCTCTGTACCCCAC -3'
(R):5'- GGTTCCTGGTTGATCTGATCTCC -3'