Incidental Mutation 'R6909:Or2z9'
ID 538927
Institutional Source Beutler Lab
Gene Symbol Or2z9
Ensembl Gene ENSMUSG00000061561
Gene Name olfactory receptor family 2 subfamily Z member 9
Synonyms MOR282-1, GA_x6K02T2NUPS-231686-232630, Olfr373, MOR282-2
MMRRC Submission 045001-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.187) question?
Stock # R6909 (G1)
Quality Score 225.009
Status Not validated
Chromosome 8
Chromosomal Location 72853606-72854550 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to A at 72854372 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Valine to Glutamic Acid at position 256 (V256E)
Ref Sequence ENSEMBL: ENSMUSP00000149452 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000074540] [ENSMUST00000213940] [ENSMUST00000215198]
AlphaFold E9Q4J3
Predicted Effect possibly damaging
Transcript: ENSMUST00000074540
AA Change: V256E

PolyPhen 2 Score 0.948 (Sensitivity: 0.79; Specificity: 0.95)
SMART Domains Protein: ENSMUSP00000074128
Gene: ENSMUSG00000061561
AA Change: V256E

DomainStartEndE-ValueType
Pfam:7tm_4 31 307 6.1e-57 PFAM
Pfam:7TM_GPCR_Srsx 35 253 6.5e-8 PFAM
Pfam:7tm_1 41 290 4.9e-25 PFAM
Predicted Effect possibly damaging
Transcript: ENSMUST00000213940
AA Change: V256E

PolyPhen 2 Score 0.948 (Sensitivity: 0.79; Specificity: 0.95)
Predicted Effect possibly damaging
Transcript: ENSMUST00000215198
AA Change: V256E

PolyPhen 2 Score 0.948 (Sensitivity: 0.79; Specificity: 0.95)
Meta Mutation Damage Score 0.3825 question?
Coding Region Coverage
  • 1x: 100.0%
  • 3x: 99.9%
  • 10x: 99.1%
  • 20x: 97.1%
Validation Efficiency
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 59 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Abca9 G T 11: 110,006,323 (GRCm39) Q1261K probably benign Het
Acp3 T C 9: 104,178,164 (GRCm39) Y329C probably damaging Het
Agrn G T 4: 156,261,464 (GRCm39) H585N possibly damaging Het
Ano1 G A 7: 144,209,468 (GRCm39) T211M probably damaging Het
Atic T G 1: 71,616,005 (GRCm39) probably null Het
Catsperd T A 17: 56,957,781 (GRCm39) S229R probably damaging Het
Ccdc168 C T 1: 44,098,935 (GRCm39) R721Q possibly damaging Het
Cfap210 A T 2: 69,612,192 (GRCm39) probably null Het
Cfap251 A G 5: 123,425,815 (GRCm39) Y418C probably damaging Het
Cibar1 T C 4: 12,168,309 (GRCm39) T97A probably benign Het
Cmya5 T C 13: 93,227,760 (GRCm39) T2443A probably benign Het
Dysf A T 6: 84,169,920 (GRCm39) E1772V probably damaging Het
Eps8l1 T A 7: 4,472,899 (GRCm39) L107* probably null Het
Fpr3 T A 17: 18,191,429 (GRCm39) F233L probably benign Het
Gjc2 A T 11: 59,067,918 (GRCm39) V188E unknown Het
Gm45861 T A 8: 28,017,109 (GRCm39) Y690N unknown Het
Gsdma2 T A 11: 98,543,383 (GRCm39) C224* probably null Het
Gucy2d T A 7: 98,116,832 (GRCm39) Y881N probably damaging Het
Hcn3 A G 3: 89,059,936 (GRCm39) probably null Het
Hectd1 G T 12: 51,810,945 (GRCm39) probably null Het
Ifitm5 A G 7: 140,529,172 (GRCm39) F146L probably benign Het
Impg2 T C 16: 56,024,947 (GRCm39) F18S probably damaging Het
Ino80c T A 18: 24,241,812 (GRCm39) probably benign Het
Itga10 A G 3: 96,569,915 (GRCm39) H1109R probably benign Het
Kdm3b T A 18: 34,960,381 (GRCm39) probably null Het
Klra8 T G 6: 130,102,123 (GRCm39) N104T probably benign Het
Llgl2 G A 11: 115,741,625 (GRCm39) C585Y probably damaging Het
Lmod2 T A 6: 24,604,157 (GRCm39) D377E probably benign Het
Lrat G A 3: 82,810,961 (GRCm39) S20F probably damaging Het
Lrrc43 T A 5: 123,638,482 (GRCm39) H363Q probably benign Het
Lyst T G 13: 13,917,960 (GRCm39) I3340S probably damaging Het
Magi1 C A 6: 93,674,301 (GRCm39) G948W probably damaging Het
Map3k4 A C 17: 12,489,872 (GRCm39) F520V probably damaging Het
Mcm4 A T 16: 15,446,561 (GRCm39) N607K probably damaging Het
Mta3 T C 17: 84,073,980 (GRCm39) V216A possibly damaging Het
Ncor1 C A 11: 62,220,312 (GRCm39) G2131V probably damaging Het
Or10ag2 A G 2: 87,248,959 (GRCm39) H189R probably damaging Het
Or5d16 A G 2: 87,773,034 (GRCm39) S313P probably benign Het
Or9k7 T A 10: 130,046,622 (GRCm39) I126L probably benign Het
Pramel12 T C 4: 143,144,479 (GRCm39) L275P probably damaging Het
Ptpn2 A T 18: 67,809,041 (GRCm39) probably null Het
Scn10a A G 9: 119,438,856 (GRCm39) I1671T probably damaging Het
Scyl2 A T 10: 89,481,604 (GRCm39) S622T probably benign Het
Sim1 C T 10: 50,785,506 (GRCm39) R192C possibly damaging Het
Skor2 A G 18: 76,948,252 (GRCm39) H658R possibly damaging Het
Slc10a5 A G 3: 10,400,655 (GRCm39) S2P possibly damaging Het
Slc37a4 A T 9: 44,311,331 (GRCm39) K207N possibly damaging Het
Syne2 G T 12: 76,110,969 (GRCm39) V5768L probably benign Het
Tdpoz3 T A 3: 93,733,772 (GRCm39) V149E probably damaging Het
Tekt5 T C 16: 10,176,165 (GRCm39) N460S probably damaging Het
Tk2 G T 8: 104,963,442 (GRCm39) Y142* probably null Het
Tkfc T A 19: 10,573,630 (GRCm39) Q236L probably benign Het
Tln2 G A 9: 67,299,814 (GRCm39) T148I probably damaging Het
Trim62 A G 4: 128,778,021 (GRCm39) D20G probably damaging Het
Tspan14 A C 14: 40,635,398 (GRCm39) V166G probably benign Het
Ttn A T 2: 76,712,065 (GRCm39) probably benign Het
Vmn1r217 T A 13: 23,298,108 (GRCm39) M265L probably benign Het
Vmn2r117 C G 17: 23,698,479 (GRCm39) Q31H possibly damaging Het
Zfp87 T C 13: 74,519,861 (GRCm39) T406A possibly damaging Het
Other mutations in Or2z9
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01592:Or2z9 APN 8 72,854,356 (GRCm39) missense probably damaging 1.00
IGL02440:Or2z9 APN 8 72,854,374 (GRCm39) missense probably damaging 1.00
IGL03403:Or2z9 APN 8 72,854,341 (GRCm39) missense probably benign 0.00
R1099:Or2z9 UTSW 8 72,854,503 (GRCm39) missense probably benign 0.00
R1418:Or2z9 UTSW 8 72,854,231 (GRCm39) missense probably damaging 1.00
R1452:Or2z9 UTSW 8 72,854,020 (GRCm39) nonsense probably null
R1621:Or2z9 UTSW 8 72,853,973 (GRCm39) missense probably damaging 1.00
R2021:Or2z9 UTSW 8 72,853,930 (GRCm39) missense possibly damaging 0.90
R4230:Or2z9 UTSW 8 72,854,188 (GRCm39) missense probably damaging 1.00
R4290:Or2z9 UTSW 8 72,853,612 (GRCm39) missense probably benign
R5035:Or2z9 UTSW 8 72,853,922 (GRCm39) missense probably damaging 1.00
R6884:Or2z9 UTSW 8 72,854,345 (GRCm39) missense probably benign 0.26
R7233:Or2z9 UTSW 8 72,853,900 (GRCm39) missense probably benign
R7304:Or2z9 UTSW 8 72,854,190 (GRCm39) nonsense probably null
R7312:Or2z9 UTSW 8 72,853,793 (GRCm39) missense probably damaging 1.00
R7701:Or2z9 UTSW 8 72,854,030 (GRCm39) missense probably damaging 1.00
R8789:Or2z9 UTSW 8 72,854,135 (GRCm39) missense probably damaging 1.00
Z1088:Or2z9 UTSW 8 72,854,361 (GRCm39) missense probably benign 0.00
Predicted Primers PCR Primer
(F):5'- TCTGTGAGATGCCAGCTCTC -3'
(R):5'- ACCTTGAAGTCAGACCTGCC -3'

Sequencing Primer
(F):5'- TCAAGCTGTCATGTGCAGAC -3'
(R):5'- GTCAGACCTGCCCATGAACTTG -3'
Posted On 2018-11-06