Mutagenetix > Incidental Mutation

Incidental Mutation 'R6909:Vmn2r117'

538953

Institutional Source

Beutler Lab

Gene Symbol

Vmn2r117

Ensembl Gene

ENSMUSG00000091407

Gene Name

vomeronasal 2, receptor 117

Synonyms

EG619788

MMRRC Submission

Accession Numbers

Essential gene?

Probably non essential (E-score: 0.087) question?

Stock #

R6909 (G1)

Quality Score

98.0078

Status

Not validated

Chromosome

Chromosomal Location

23459675-23479597 bp(-) (GRCm38)

Type of Mutation

missense

DNA Base Change (assembly)

C to G at 23479505 bp (GRCm38)

Zygosity

Heterozygous

Amino Acid Change

Glutamine to Histidine at position 31 (Q31H)

Ref Sequence

ENSEMBL: ENSMUSP00000126885 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000171996]

AlphaFold

K7N6V1

Predicted Effect

possibly damaging
Transcript: ENSMUST00000171996
AA Change: Q31H

PolyPhen 2 Score 0.669 (Sensitivity: 0.86; Specificity: 0.91)

SMART Domains

Protein: ENSMUSP00000126885
Gene: ENSMUSG00000091407
AA Change: Q31H

Domain	Start	End	E-Value	Type
signal peptide	1	18	N/A	INTRINSIC
Pfam:ANF_receptor	73	471	2.6e-28	PFAM
Pfam:NCD3G	512	565	5e-20	PFAM
Pfam:7tm_3	595	833	8.2e-54	PFAM

Coding Region Coverage

1x: 100.0%
3x: 99.9%
10x: 99.1%
20x: 97.1%

Validation Efficiency

Allele List at MGI

Other mutations in this stock

Total: 59 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Abca9	G	T	11: 110,115,497	Q1261K	probably benign	Het
Acpp	T	C	9: 104,300,965	Y329C	probably damaging	Het
Agrn	G	T	4: 156,177,007	H585N	possibly damaging	Het
Ano1	G	A	7: 144,655,731	T211M	probably damaging	Het
Atic	T	G	1: 71,576,846		probably null	Het
Catsperd	T	A	17: 56,650,781	S229R	probably damaging	Het
Ccdc173	A	T	2: 69,781,848		probably null	Het
Cmya5	T	C	13: 93,091,252	T2443A	probably benign	Het
Dysf	A	T	6: 84,192,938	E1772V	probably damaging	Het
Eps8l1	T	A	7: 4,469,900	L107*	probably null	Het
Fam92a	T	C	4: 12,168,309	T97A	probably benign	Het
Fpr3	T	A	17: 17,971,167	F233L	probably benign	Het
Gjc2	A	T	11: 59,177,092	V188E	unknown	Het
Gm45861	T	A	8: 27,527,081	Y690N	unknown	Het
Gm8251	C	T	1: 44,059,775	R721Q	possibly damaging	Het
Gsdma2	T	A	11: 98,652,557	C224*	probably null	Het
Gucy2d	T	A	7: 98,467,625	Y881N	probably damaging	Het
Hcn3	A	G	3: 89,152,629		probably null	Het
Hectd1	G	T	12: 51,764,162		probably null	Het
Ifitm5	A	G	7: 140,949,259	F146L	probably benign	Het
Impg2	T	C	16: 56,204,584	F18S	probably damaging	Het
Ino80c	T	A	18: 24,108,755		probably benign	Het
Itga10	A	G	3: 96,662,599	H1109R	probably benign	Het
Kdm3b	T	A	18: 34,827,328		probably null	Het
Klra8	T	G	6: 130,125,160	N104T	probably benign	Het
Llgl2	G	A	11: 115,850,799	C585Y	probably damaging	Het
Lmod2	T	A	6: 24,604,158	D377E	probably benign	Het
Lrat	G	A	3: 82,903,654	S20F	probably damaging	Het
Lrrc43	T	A	5: 123,500,419	H363Q	probably benign	Het
Lyst	T	G	13: 13,743,375	I3340S	probably damaging	Het
Magi1	C	A	6: 93,697,320	G948W	probably damaging	Het
Map3k4	A	C	17: 12,270,985	F520V	probably damaging	Het
Mcm4	A	T	16: 15,628,697	N607K	probably damaging	Het
Mta3	T	C	17: 83,766,551	V216A	possibly damaging	Het
Ncor1	C	A	11: 62,329,486	G2131V	probably damaging	Het
Olfr1123	A	G	2: 87,418,615	H189R	probably damaging	Het
Olfr1155	A	G	2: 87,942,690	S313P	probably benign	Het
Olfr373	T	A	8: 72,100,528	V256E	possibly damaging	Het
Olfr827	T	A	10: 130,210,753	I126L	probably benign	Het
Pramef8	T	C	4: 143,417,909	L275P	probably damaging	Het
Ptpn2	A	T	18: 67,675,971		probably null	Het
Scn10a	A	G	9: 119,609,790	I1671T	probably damaging	Het
Scyl2	A	T	10: 89,645,742	S622T	probably benign	Het
Sim1	C	T	10: 50,909,410	R192C	possibly damaging	Het
Skor2	A	G	18: 76,860,557	H658R	possibly damaging	Het
Slc10a5	A	G	3: 10,335,595	S2P	possibly damaging	Het
Slc37a4	A	T	9: 44,400,034	K207N	possibly damaging	Het
Syne2	G	T	12: 76,064,195	V5768L	probably benign	Het
Tdpoz3	T	A	3: 93,826,465	V149E	probably damaging	Het
Tekt5	T	C	16: 10,358,301	N460S	probably damaging	Het
Tk2	G	T	8: 104,236,810	Y142*	probably null	Het
Tkfc	T	A	19: 10,596,266	Q236L	probably benign	Het
Tln2	G	A	9: 67,392,532	T148I	probably damaging	Het
Trim62	A	G	4: 128,884,228	D20G	probably damaging	Het
Tspan14	A	C	14: 40,913,441	V166G	probably benign	Het
Ttn	A	T	2: 76,881,721		probably benign	Het
Vmn1r217	T	A	13: 23,113,938	M265L	probably benign	Het
Wdr66	A	G	5: 123,287,752	Y418C	probably damaging	Het
Zfp72	T	C	13: 74,371,742	T406A	possibly damaging	Het

Other mutations in Vmn2r117

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL00990:Vmn2r117	APN	17	23477840	missense	probably damaging	1.00
IGL00990:Vmn2r117	APN	17	23475429	missense	probably damaging	1.00
IGL00990:Vmn2r117	APN	17	23479546	missense	probably benign
IGL01078:Vmn2r117	APN	17	23477804	missense	probably damaging	1.00
IGL01139:Vmn2r117	APN	17	23477804	missense	probably damaging	1.00
IGL01374:Vmn2r117	APN	17	23478382	missense	possibly damaging	0.46
IGL01779:Vmn2r117	APN	17	23477241	missense	probably benign	0.00
IGL02283:Vmn2r117	APN	17	23475382	missense	probably damaging	0.99
IGL02527:Vmn2r117	APN	17	23477225	missense	possibly damaging	0.65
IGL02612:Vmn2r117	APN	17	23459784	missense	possibly damaging	0.91
IGL02887:Vmn2r117	APN	17	23475578	splice site	probably benign
IGL03167:Vmn2r117	APN	17	23477707	missense	probably damaging	1.00
R0315:Vmn2r117	UTSW	17	23460165	missense	probably benign	0.11
R0610:Vmn2r117	UTSW	17	23475514	missense	probably benign	0.00
R0747:Vmn2r117	UTSW	17	23475503	nonsense	probably null
R1411:Vmn2r117	UTSW	17	23460553	missense	probably damaging	1.00
R1471:Vmn2r117	UTSW	17	23478473	missense	probably benign	0.00
R1853:Vmn2r117	UTSW	17	23477455	missense	probably damaging	0.99
R1925:Vmn2r117	UTSW	17	23478389	missense	probably benign	0.00
R1940:Vmn2r117	UTSW	17	23477480	missense	probably damaging	1.00
R2005:Vmn2r117	UTSW	17	23477644	missense	probably damaging	1.00
R2082:Vmn2r117	UTSW	17	23460256	missense	possibly damaging	0.55
R2698:Vmn2r117	UTSW	17	23459911	missense	probably damaging	0.98
R2972:Vmn2r117	UTSW	17	23459856	missense	probably damaging	1.00
R2973:Vmn2r117	UTSW	17	23459856	missense	probably damaging	1.00
R2974:Vmn2r117	UTSW	17	23459856	missense	probably damaging	1.00
R3160:Vmn2r117	UTSW	17	23460378	missense	probably damaging	1.00
R3161:Vmn2r117	UTSW	17	23460378	missense	probably damaging	1.00
R3162:Vmn2r117	UTSW	17	23460378	missense	probably damaging	1.00
R3847:Vmn2r117	UTSW	17	23460415	missense	probably damaging	0.97
R3848:Vmn2r117	UTSW	17	23460415	missense	probably damaging	0.97
R4082:Vmn2r117	UTSW	17	23460106	missense	probably benign	0.00
R4320:Vmn2r117	UTSW	17	23479513	frame shift	probably null
R4560:Vmn2r117	UTSW	17	23459877	missense	probably damaging	1.00
R4658:Vmn2r117	UTSW	17	23478416	missense	probably benign	0.01
R4881:Vmn2r117	UTSW	17	23477885	missense	probably damaging	1.00
R4908:Vmn2r117	UTSW	17	23459838	missense	probably damaging	1.00
R4910:Vmn2r117	UTSW	17	23479513	frame shift	probably null
R5078:Vmn2r117	UTSW	17	23460148	missense	probably damaging	1.00
R5327:Vmn2r117	UTSW	17	23477874	nonsense	probably null
R5774:Vmn2r117	UTSW	17	23477202	missense	probably damaging	0.98
R6014:Vmn2r117	UTSW	17	23479561	missense	probably damaging	0.97
R6390:Vmn2r117	UTSW	17	23460114	missense	possibly damaging	0.95
R6520:Vmn2r117	UTSW	17	23460219	missense	probably damaging	0.99
R6674:Vmn2r117	UTSW	17	23460049	nonsense	probably null
R6736:Vmn2r117	UTSW	17	23478308	missense	probably damaging	0.99
R6913:Vmn2r117	UTSW	17	23479563	missense	probably damaging	0.99
R7220:Vmn2r117	UTSW	17	23477203	missense	probably damaging	1.00
R7260:Vmn2r117	UTSW	17	23475385	missense	probably benign	0.06
R7440:Vmn2r117	UTSW	17	23475565	missense	probably benign	0.26
R7443:Vmn2r117	UTSW	17	23460133	missense	probably benign	0.25
R7443:Vmn2r117	UTSW	17	23460345	missense	probably damaging	1.00
R7449:Vmn2r117	UTSW	17	23459895	missense	probably damaging	1.00
R7644:Vmn2r117	UTSW	17	23477291	missense	probably damaging	0.98
R7914:Vmn2r117	UTSW	17	23460126	missense	possibly damaging	0.95
R8001:Vmn2r117	UTSW	17	23479407	missense	possibly damaging	0.89
R8029:Vmn2r117	UTSW	17	23477770	missense	probably benign	0.00
R8340:Vmn2r117	UTSW	17	23460537	missense	probably benign	0.01
R8519:Vmn2r117	UTSW	17	23479468	missense	probably benign
R8723:Vmn2r117	UTSW	17	23477369	missense	probably damaging	1.00
R8914:Vmn2r117	UTSW	17	23460169	missense	probably benign	0.02
R9010:Vmn2r117	UTSW	17	23460471	missense	probably benign	0.10
R9129:Vmn2r117	UTSW	17	23459944	nonsense	probably null
R9244:Vmn2r117	UTSW	17	23477615	missense	probably damaging	0.98
R9464:Vmn2r117	UTSW	17	23477604	missense	probably benign	0.23
R9620:Vmn2r117	UTSW	17	23478476	missense	probably damaging	0.97
V5622:Vmn2r117	UTSW	17	23477840	missense	probably damaging	1.00
V5622:Vmn2r117	UTSW	17	23479505	missense	possibly damaging	0.67
Z1176:Vmn2r117	UTSW	17	23459766	missense	probably benign	0.00

Predicted Primers

PCR Primer
(F):5'- CCTCATCCTCAGTAGTCTTGGG -3'
(R):5'- ATGATTCCTCCAGGGGTGAG -3'

Sequencing Primer
(F):5'- CCTCAGTAGTCTTGGGAAACATTC -3'
(R):5'- CTCCCTGGGACACAGTGTTAATAG -3'

Posted On

2018-11-06