Incidental Mutation 'R6909:Mta3'
ID 538955
Institutional Source Beutler Lab
Gene Symbol Mta3
Ensembl Gene ENSMUSG00000055817
Gene Name metastasis associated 3
Synonyms 1110002J22Rik
MMRRC Submission 045001-MU
Accession Numbers
Essential gene? Possibly essential (E-score: 0.506) question?
Stock # R6909 (G1)
Quality Score 225.009
Status Not validated
Chromosome 17
Chromosomal Location 84013592-84128945 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to C at 84073980 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Valine to Alanine at position 216 (V216A)
Ref Sequence ENSEMBL: ENSMUSP00000107971 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000067826] [ENSMUST00000112349] [ENSMUST00000112350] [ENSMUST00000112352] [ENSMUST00000176816] [ENSMUST00000177069]
AlphaFold Q924K8
Predicted Effect possibly damaging
Transcript: ENSMUST00000067826
AA Change: V215A

PolyPhen 2 Score 0.844 (Sensitivity: 0.83; Specificity: 0.93)
SMART Domains Protein: ENSMUSP00000068931
Gene: ENSMUSG00000055817
AA Change: V215A

DomainStartEndE-ValueType
BAH 4 147 2.62e-30 SMART
ELM2 150 203 3.49e-16 SMART
SANT 266 315 7.94e-8 SMART
ZnF_GATA 371 425 8.33e-15 SMART
Predicted Effect possibly damaging
Transcript: ENSMUST00000112349
AA Change: V216A

PolyPhen 2 Score 0.795 (Sensitivity: 0.85; Specificity: 0.93)
SMART Domains Protein: ENSMUSP00000107968
Gene: ENSMUSG00000055817
AA Change: V216A

DomainStartEndE-ValueType
BAH 4 147 2.62e-30 SMART
ELM2 150 204 2.5e-17 SMART
SANT 267 316 7.94e-8 SMART
ZnF_GATA 373 427 8.33e-15 SMART
Predicted Effect possibly damaging
Transcript: ENSMUST00000112350
AA Change: V216A

PolyPhen 2 Score 0.654 (Sensitivity: 0.87; Specificity: 0.91)
SMART Domains Protein: ENSMUSP00000107969
Gene: ENSMUSG00000055817
AA Change: V216A

DomainStartEndE-ValueType
BAH 4 147 2.62e-30 SMART
ELM2 150 204 2.5e-17 SMART
SANT 267 316 7.94e-8 SMART
ZnF_GATA 372 426 8.33e-15 SMART
Predicted Effect possibly damaging
Transcript: ENSMUST00000112352
AA Change: V216A

PolyPhen 2 Score 0.920 (Sensitivity: 0.81; Specificity: 0.94)
SMART Domains Protein: ENSMUSP00000107971
Gene: ENSMUSG00000055817
AA Change: V216A

DomainStartEndE-ValueType
BAH 4 147 2.62e-30 SMART
ELM2 150 204 2.5e-17 SMART
SANT 267 316 7.94e-8 SMART
ZnF_GATA 372 426 8.33e-15 SMART
Predicted Effect possibly damaging
Transcript: ENSMUST00000176816
AA Change: V64A

PolyPhen 2 Score 0.795 (Sensitivity: 0.85; Specificity: 0.93)
SMART Domains Protein: ENSMUSP00000135752
Gene: ENSMUSG00000055817
AA Change: V64A

DomainStartEndE-ValueType
ELM2 1 52 3.23e-11 SMART
SANT 115 164 7.94e-8 SMART
Predicted Effect probably benign
Transcript: ENSMUST00000177069
Meta Mutation Damage Score 0.0913 question?
Coding Region Coverage
  • 1x: 100.0%
  • 3x: 99.9%
  • 10x: 99.1%
  • 20x: 97.1%
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 59 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Abca9 G T 11: 110,006,323 (GRCm39) Q1261K probably benign Het
Acp3 T C 9: 104,178,164 (GRCm39) Y329C probably damaging Het
Agrn G T 4: 156,261,464 (GRCm39) H585N possibly damaging Het
Ano1 G A 7: 144,209,468 (GRCm39) T211M probably damaging Het
Atic T G 1: 71,616,005 (GRCm39) probably null Het
Catsperd T A 17: 56,957,781 (GRCm39) S229R probably damaging Het
Ccdc168 C T 1: 44,098,935 (GRCm39) R721Q possibly damaging Het
Cfap210 A T 2: 69,612,192 (GRCm39) probably null Het
Cfap251 A G 5: 123,425,815 (GRCm39) Y418C probably damaging Het
Cibar1 T C 4: 12,168,309 (GRCm39) T97A probably benign Het
Cmya5 T C 13: 93,227,760 (GRCm39) T2443A probably benign Het
Dysf A T 6: 84,169,920 (GRCm39) E1772V probably damaging Het
Eps8l1 T A 7: 4,472,899 (GRCm39) L107* probably null Het
Fpr3 T A 17: 18,191,429 (GRCm39) F233L probably benign Het
Gjc2 A T 11: 59,067,918 (GRCm39) V188E unknown Het
Gm45861 T A 8: 28,017,109 (GRCm39) Y690N unknown Het
Gsdma2 T A 11: 98,543,383 (GRCm39) C224* probably null Het
Gucy2d T A 7: 98,116,832 (GRCm39) Y881N probably damaging Het
Hcn3 A G 3: 89,059,936 (GRCm39) probably null Het
Hectd1 G T 12: 51,810,945 (GRCm39) probably null Het
Ifitm5 A G 7: 140,529,172 (GRCm39) F146L probably benign Het
Impg2 T C 16: 56,024,947 (GRCm39) F18S probably damaging Het
Ino80c T A 18: 24,241,812 (GRCm39) probably benign Het
Itga10 A G 3: 96,569,915 (GRCm39) H1109R probably benign Het
Kdm3b T A 18: 34,960,381 (GRCm39) probably null Het
Klra8 T G 6: 130,102,123 (GRCm39) N104T probably benign Het
Llgl2 G A 11: 115,741,625 (GRCm39) C585Y probably damaging Het
Lmod2 T A 6: 24,604,157 (GRCm39) D377E probably benign Het
Lrat G A 3: 82,810,961 (GRCm39) S20F probably damaging Het
Lrrc43 T A 5: 123,638,482 (GRCm39) H363Q probably benign Het
Lyst T G 13: 13,917,960 (GRCm39) I3340S probably damaging Het
Magi1 C A 6: 93,674,301 (GRCm39) G948W probably damaging Het
Map3k4 A C 17: 12,489,872 (GRCm39) F520V probably damaging Het
Mcm4 A T 16: 15,446,561 (GRCm39) N607K probably damaging Het
Ncor1 C A 11: 62,220,312 (GRCm39) G2131V probably damaging Het
Or10ag2 A G 2: 87,248,959 (GRCm39) H189R probably damaging Het
Or2z9 T A 8: 72,854,372 (GRCm39) V256E possibly damaging Het
Or5d16 A G 2: 87,773,034 (GRCm39) S313P probably benign Het
Or9k7 T A 10: 130,046,622 (GRCm39) I126L probably benign Het
Pramel12 T C 4: 143,144,479 (GRCm39) L275P probably damaging Het
Ptpn2 A T 18: 67,809,041 (GRCm39) probably null Het
Scn10a A G 9: 119,438,856 (GRCm39) I1671T probably damaging Het
Scyl2 A T 10: 89,481,604 (GRCm39) S622T probably benign Het
Sim1 C T 10: 50,785,506 (GRCm39) R192C possibly damaging Het
Skor2 A G 18: 76,948,252 (GRCm39) H658R possibly damaging Het
Slc10a5 A G 3: 10,400,655 (GRCm39) S2P possibly damaging Het
Slc37a4 A T 9: 44,311,331 (GRCm39) K207N possibly damaging Het
Syne2 G T 12: 76,110,969 (GRCm39) V5768L probably benign Het
Tdpoz3 T A 3: 93,733,772 (GRCm39) V149E probably damaging Het
Tekt5 T C 16: 10,176,165 (GRCm39) N460S probably damaging Het
Tk2 G T 8: 104,963,442 (GRCm39) Y142* probably null Het
Tkfc T A 19: 10,573,630 (GRCm39) Q236L probably benign Het
Tln2 G A 9: 67,299,814 (GRCm39) T148I probably damaging Het
Trim62 A G 4: 128,778,021 (GRCm39) D20G probably damaging Het
Tspan14 A C 14: 40,635,398 (GRCm39) V166G probably benign Het
Ttn A T 2: 76,712,065 (GRCm39) probably benign Het
Vmn1r217 T A 13: 23,298,108 (GRCm39) M265L probably benign Het
Vmn2r117 C G 17: 23,698,479 (GRCm39) Q31H possibly damaging Het
Zfp87 T C 13: 74,519,861 (GRCm39) T406A possibly damaging Het
Other mutations in Mta3
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00433:Mta3 APN 17 84,015,861 (GRCm39) missense probably damaging 1.00
IGL00467:Mta3 APN 17 84,063,113 (GRCm39) splice site probably benign
IGL00475:Mta3 APN 17 84,015,861 (GRCm39) missense probably damaging 1.00
IGL00539:Mta3 APN 17 84,070,412 (GRCm39) missense probably benign 0.25
IGL01722:Mta3 APN 17 84,063,072 (GRCm39) missense possibly damaging 0.95
IGL03355:Mta3 APN 17 84,107,474 (GRCm39) splice site probably benign
container UTSW 17 84,015,875 (GRCm39) missense probably damaging 1.00
R0440:Mta3 UTSW 17 84,074,016 (GRCm39) missense probably damaging 1.00
R0630:Mta3 UTSW 17 84,022,056 (GRCm39) missense probably damaging 0.98
R1848:Mta3 UTSW 17 84,062,980 (GRCm39) splice site probably benign
R1870:Mta3 UTSW 17 84,089,397 (GRCm39) missense probably damaging 0.98
R2358:Mta3 UTSW 17 84,070,417 (GRCm39) missense probably damaging 0.96
R2373:Mta3 UTSW 17 84,091,730 (GRCm39) nonsense probably null
R2447:Mta3 UTSW 17 84,111,973 (GRCm39) missense probably benign 0.03
R3711:Mta3 UTSW 17 84,070,417 (GRCm39) missense probably damaging 0.96
R3712:Mta3 UTSW 17 84,070,417 (GRCm39) missense probably damaging 0.96
R4107:Mta3 UTSW 17 84,070,343 (GRCm39) missense probably benign 0.00
R4771:Mta3 UTSW 17 84,063,103 (GRCm39) missense probably damaging 0.98
R5259:Mta3 UTSW 17 84,112,003 (GRCm39) missense probably damaging 1.00
R5980:Mta3 UTSW 17 84,015,834 (GRCm39) missense probably damaging 1.00
R6175:Mta3 UTSW 17 84,099,222 (GRCm39) missense probably benign
R6555:Mta3 UTSW 17 84,015,875 (GRCm39) missense probably damaging 1.00
R7170:Mta3 UTSW 17 84,022,091 (GRCm39) missense probably damaging 1.00
R7350:Mta3 UTSW 17 84,015,870 (GRCm39) missense probably damaging 1.00
R7597:Mta3 UTSW 17 84,083,011 (GRCm39) missense probably benign 0.05
R7638:Mta3 UTSW 17 84,107,572 (GRCm39) missense probably benign
R7747:Mta3 UTSW 17 84,099,165 (GRCm39) nonsense probably null
R7894:Mta3 UTSW 17 84,070,363 (GRCm39) missense probably benign 0.01
R8170:Mta3 UTSW 17 84,099,090 (GRCm39) missense probably damaging 1.00
R8799:Mta3 UTSW 17 84,096,369 (GRCm39) missense possibly damaging 0.93
R8944:Mta3 UTSW 17 84,083,146 (GRCm39) missense probably damaging 1.00
R9210:Mta3 UTSW 17 84,015,846 (GRCm39) missense probably damaging 0.99
R9212:Mta3 UTSW 17 84,015,846 (GRCm39) missense probably damaging 0.99
Z1088:Mta3 UTSW 17 84,070,343 (GRCm39) missense probably benign 0.00
Z1177:Mta3 UTSW 17 84,089,397 (GRCm39) missense probably damaging 0.98
Predicted Primers PCR Primer
(F):5'- ACTTGGAACTTCCCTCGCTAAG -3'
(R):5'- CAAACAAGAGGTCACTCCGG -3'

Sequencing Primer
(F):5'- CTCGCTAAGTTGCTTTTGTTCATAG -3'
(R):5'- GCTAACCTGAGTCAACTTGGTAGAC -3'
Posted On 2018-11-06