Mutagenetix > Incidental Mutations

Incidental Mutation 'R6911:Olfr1331'

539014

Institutional Source

Beutler Lab

Gene Symbol

Olfr1331

Ensembl Gene

ENSMUSG00000073769

Gene Name

olfactory receptor 1331

Synonyms

MOR259-3P, GA_x6K02T2QD9B-18670866-18669913

MMRRC Submission

Accession Numbers

Is this an essential gene?

Probably non essential (E-score: 0.054) question?

Stock #

R6911 (G1)

Quality Score

225.009

Status

Validated

Chromosome

Chromosomal Location

118864649-118871707 bp(+) (GRCm38)

Type of Mutation

missense

DNA Base Change (assembly)

T to A at 118869138 bp

Zygosity

Heterozygous

Amino Acid Change

Methionine to Lysine at position 119 (M119K)

Ref Sequence

ENSEMBL: ENSMUSP00000101967 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000094831] [ENSMUST00000106360] [ENSMUST00000216589]

Predicted Effect

probably damaging
Transcript: ENSMUST00000094831
AA Change: M119K

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)

SMART Domains

Protein: ENSMUSP00000092426
Gene: ENSMUSG00000073769
AA Change: M119K

Domain	Start	End	E-Value	Type
Pfam:7tm_4	32	308	2.1e-53	PFAM
Pfam:7tm_1	42	291	3.9e-22	PFAM

Predicted Effect

probably damaging
Transcript: ENSMUST00000106360
AA Change: M119K

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)

SMART Domains

Protein: ENSMUSP00000101967
Gene: ENSMUSG00000073769
AA Change: M119K

Domain	Start	End	E-Value	Type
Pfam:7tm_1	41	290	1.2e-28	PFAM
Pfam:7tm_4	139	283	2.8e-45	PFAM

Predicted Effect

probably damaging
Transcript: ENSMUST00000216589
AA Change: M118K

PolyPhen 2 Score 0.999 (Sensitivity: 0.14; Specificity: 0.99)

Meta Mutation Damage Score

0.1973

Coding Region Coverage

1x: 100.0%
3x: 99.9%
10x: 99.1%
20x: 97.1%

Validation Efficiency

98% (60/61)

MGI Phenotype

FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]

Allele List at MGI

Other mutations in this stock

Total: 60 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
2610507B11Rik	T	A	11: 78,268,353	I459N	probably damaging	Het
4930407I10Rik	T	A	15: 82,063,867	M655K	probably benign	Het
Amt	G	T	9: 108,301,229		probably null	Het
Anapc7	A	T	5: 122,440,280	K443*	probably null	Het
Apcs	A	G	1: 172,894,185	V198A	probably benign	Het
Atp2a1	A	G	7: 126,456,836	V271A	probably damaging	Het
Cdh20	T	C	1: 104,984,686	I555T	possibly damaging	Het
Cgnl1	T	C	9: 71,656,215	E810G	possibly damaging	Het
Cntnap5c	A	G	17: 57,892,014	D101G	probably damaging	Het
Coq7	T	A	7: 118,510,162	H221L	unknown	Het
Depdc5	A	T	5: 32,924,192	Q566L	probably damaging	Het
Dync1i2	G	A	2: 71,247,102	V233I	probably benign	Het
Erp44	G	T	4: 48,204,268	H298N	probably benign	Het
Fam162a	A	G	16: 36,046,377		probably null	Het
Fancd2	A	G	6: 113,548,385	E274G	probably damaging	Het
Fkbp15	G	T	4: 62,340,290	Q147K	probably damaging	Het
Ganab	T	A	19: 8,907,788		probably null	Het
Gfm1	T	C	3: 67,451,303	V409A	possibly damaging	Het
Gm5346	A	T	8: 43,625,109	F693I	probably benign	Het
Gnptab	G	A	10: 88,431,396	G450S	probably damaging	Het
Gpatch2l	G	A	12: 86,244,184	R47H	probably damaging	Het
Grid1	A	T	14: 34,820,228	M1L	probably benign	Het
Helz	C	T	11: 107,619,225	T558I	probably benign	Het
Htra4	A	G	8: 25,025,705	V439A	probably damaging	Het
Kctd17	A	G	15: 78,434,006	E95G	probably damaging	Het
Kif18b	T	C	11: 102,916,380	D43G	probably damaging	Het
Lrpprc	G	A	17: 84,756,283	S550L	possibly damaging	Het
Lrrfip1	T	A	1: 91,114,807	C311*	probably null	Het
Mcoln2	C	T	3: 146,192,256	T44I	probably damaging	Het
Med13l	A	G	5: 118,755,658	T2010A	possibly damaging	Het
Med23	C	T	10: 24,902,181	T803M	probably damaging	Het
Mfsd13a	T	C	19: 46,369,277	F290S	probably damaging	Het
Myh13	C	T	11: 67,354,927	Q1095*	probably null	Het
Nktr	C	A	9: 121,754,326	Y93*	probably null	Het
Nox3	A	G	17: 3,685,923	S143P	probably damaging	Het
Ntrk2	A	T	13: 58,859,215	E210D	probably damaging	Het
Nup210	G	T	6: 91,030,130	A568E	probably damaging	Het
Olfr1111	T	A	2: 87,149,767	K298I	probably damaging	Het
Olfr1279	A	G	2: 111,306,273	T23A	probably benign	Het
Olfr1393	A	G	11: 49,280,807	I220V	probably benign	Het
Pdlim5	T	C	3: 142,304,315	I289V	probably damaging	Het
Peg10	GC	GCTCC	6: 4,756,452		probably benign	Het
Per1	C	T	11: 69,103,257	T443M	probably damaging	Het
Plxna1	A	G	6: 89,320,974	V1774A	probably damaging	Het
Poteg	A	G	8: 27,450,298	Y165C	probably damaging	Het
Prlr	A	G	15: 10,329,184	T582A	probably benign	Het
Psma5	A	G	3: 108,265,148	E60G	probably damaging	Het
Rsrc1	C	T	3: 66,994,649	P44L	unknown	Het
Ryr2	T	C	13: 11,827,559	N484S	possibly damaging	Het
Sec31a	A	G	5: 100,393,264	I328T	possibly damaging	Het
Slc12a2	G	T	18: 57,919,469	V787L	probably benign	Het
St14	C	T	9: 31,106,785	R177Q	probably benign	Het
Tcof1	G	C	18: 60,829,051	A702G	possibly damaging	Het
Tom1l1	G	T	11: 90,644,161		probably null	Het
Ttf1	A	G	2: 29,064,851	R76G	probably benign	Het
Ube4a	C	T	9: 44,942,758	E581K	probably damaging	Het
Vmn2r114	A	G	17: 23,291,130	V792A	probably damaging	Het
Wdr11	T	C	7: 129,607,095	I430T	probably benign	Het
Xkr4	T	C	1: 3,671,321	K10E	possibly damaging	Het
Zfp451	T	C	1: 33,803,456		probably benign	Het

Other mutations in Olfr1331

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL00090:Olfr1331	APN	4	118869287	missense	probably damaging	1.00
IGL01314:Olfr1331	APN	4	118869131	missense	probably benign	0.26
IGL02025:Olfr1331	APN	4	118869165	missense	probably damaging	1.00
IGL02458:Olfr1331	APN	4	118869300	missense	possibly damaging	0.83
IGL02793:Olfr1331	APN	4	118869597	missense	probably damaging	1.00
IGL02827:Olfr1331	APN	4	118868960	missense	probably damaging	0.99
IGL02863:Olfr1331	APN	4	118868886	missense	possibly damaging	0.52
IGL03125:Olfr1331	APN	4	118868921	missense	possibly damaging	0.95
R0078:Olfr1331	UTSW	4	118869227	missense	probably benign
R0152:Olfr1331	UTSW	4	118868886	missense	possibly damaging	0.89
R0299:Olfr1331	UTSW	4	118869416	missense	probably benign	0.00
R3881:Olfr1331	UTSW	4	118869353	missense	probably benign	0.00
R3928:Olfr1331	UTSW	4	118868982	missense	probably damaging	1.00
R3929:Olfr1331	UTSW	4	118868982	missense	probably damaging	1.00
R5288:Olfr1331	UTSW	4	118869575	missense	probably damaging	1.00
R5552:Olfr1331	UTSW	4	118869468	missense	probably damaging	1.00
R5672:Olfr1331	UTSW	4	118869182	missense	possibly damaging	0.83
R5773:Olfr1331	UTSW	4	118869521	missense	probably damaging	0.97
R6117:Olfr1331	UTSW	4	118869144	missense	probably benign	0.39
R6910:Olfr1331	UTSW	4	118869138	missense	probably damaging	1.00
R6912:Olfr1331	UTSW	4	118869138	missense	probably damaging	1.00
R7164:Olfr1331	UTSW	4	118869725	missense	probably benign	0.30
R7446:Olfr1331	UTSW	4	118868822	missense	possibly damaging	0.83
T0975:Olfr1331	UTSW	4	118869303	missense	probably benign	0.02

Predicted Primers

PCR Primer
(F):5'- ATCATCATGCTGGTCTGCCTG -3'
(R):5'- ACAAGTAGTGGTTGACCCTGTTG -3'

Sequencing Primer
(F):5'- TGGTCTGCCTGGACACACAG -3'
(R):5'- CCTGTTGGGCCCACAATATG -3'

Posted On

2018-11-06