Mutagenetix > Incidental Mutation

Incidental Mutation 'R6913:Olfr1465'

539211

Institutional Source

Beutler Lab

Gene Symbol

Olfr1465

Ensembl Gene

ENSMUSG00000062199

Gene Name

olfactory receptor 1465

Synonyms

MOR202-28, GA_x6K02T2RE5P-3645346-3644423

MMRRC Submission

Accession Numbers

Essential gene?

Probably non essential (E-score: 0.077) question?

Stock #

R6913 (G1)

Quality Score

225.009

Status

Validated

Chromosome

Chromosomal Location

13312768-13315541 bp(-) (GRCm38)

Type of Mutation

missense

DNA Base Change (assembly)

A to G at 13313634 bp (GRCm38)

Zygosity

Heterozygous

Amino Acid Change

Isoleucine to Threonine at position 217 (I217T)

Ref Sequence

ENSEMBL: ENSMUSP00000146645 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000080142] [ENSMUST00000207340]

AlphaFold

Q7TQR2

Predicted Effect

probably benign
Transcript: ENSMUST00000080142
AA Change: I217T

PolyPhen 2 Score 0.007 (Sensitivity: 0.96; Specificity: 0.75)

SMART Domains

Protein: ENSMUSP00000079039
Gene: ENSMUSG00000062199
AA Change: I217T

Domain	Start	End	E-Value	Type
Pfam:7tm_4	29	306	7.4e-47	PFAM
Pfam:7tm_1	39	288	3.7e-20	PFAM

Predicted Effect

probably benign
Transcript: ENSMUST00000207340
AA Change: I217T

PolyPhen 2 Score 0.007 (Sensitivity: 0.96; Specificity: 0.75)

Coding Region Coverage

1x: 100.0%
3x: 99.9%
10x: 99.1%
20x: 96.9%

Validation Efficiency

97% (74/76)

MGI Phenotype

FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]

Allele List at MGI

Other mutations in this stock

Total: 76 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Abcc5	A	T	16: 20,378,744	I619N	possibly damaging	Het
Accsl	T	C	2: 93,866,143	K41E	possibly damaging	Het
Actr6	T	C	10: 89,726,696	E107G	probably damaging	Het
Adam7	T	A	14: 68,533,651	M9L	probably benign	Het
Adamts12	T	A	15: 11,215,692	H266Q	probably damaging	Het
Adamts16	A	G	13: 70,728,898	F1208S	possibly damaging	Het
Ankrd11	T	C	8: 122,894,911	D734G	probably benign	Het
Ap1b1	T	C	11: 5,012,972	V43A	possibly damaging	Het
Asnsd1	A	G	1: 53,348,231	V79A	probably damaging	Het
Aste1	T	A	9: 105,397,408	S221R	probably benign	Het
Ccndbp1	G	A	2: 121,009,866	E94K	probably benign	Het
Cdc34	G	A	10: 79,685,103		probably null	Het
Cdh16	T	C	8: 104,622,264	D67G	probably benign	Het
Chd8	T	C	14: 52,214,494	E1348G	probably damaging	Het
Chl1	C	T	6: 103,665,948	Q216*	probably null	Het
Cse1l	G	A	2: 166,929,877	V353I	possibly damaging	Het
Ctbp2	G	A	7: 133,014,726	S160F	possibly damaging	Het
Cyp1a1	C	A	9: 57,700,293	T68K	probably damaging	Het
Dlgap2	T	A	8: 14,778,374	M594K	probably benign	Het
Dnah6	C	T	6: 73,212,522	E48K	probably benign	Het
Dock2	A	G	11: 34,756,222	V35A	probably damaging	Het
E330009J07Rik	T	C	6: 40,406,917	N397S	possibly damaging	Het
Edem2	A	T	2: 155,726,674	S73R	probably damaging	Het
Eps15	T	C	4: 109,361,230	V430A	probably benign	Het
Frem2	T	C	3: 53,516,821	N3065S	probably damaging	Het
Gal3st4	A	T	5: 138,270,828	S123R	possibly damaging	Het
Garnl3	T	A	2: 32,986,829	I937F	possibly damaging	Het
Gfod2	C	T	8: 105,717,363	V183M	possibly damaging	Het
Glipr1l1	T	C	10: 112,062,434		probably null	Het
Gm4070	G	A	7: 105,901,980	Q622*	probably null	Het
Gm7145	T	G	1: 117,985,981	C198G	probably damaging	Het
Gm906	G	T	13: 50,245,257	P1011H	probably damaging	Het
H2-Eb2	G	A	17: 34,333,549	A123T	possibly damaging	Het
Ighv1-55	T	C	12: 115,208,509	I7V	probably benign	Het
Itpripl2	G	T	7: 118,491,109	P76T	possibly damaging	Het
Kat6a	C	A	8: 22,903,199	A231E	possibly damaging	Het
Lipo1	C	T	19: 33,780,305	V255I	probably benign	Het
Mamstr	A	T	7: 45,643,238	M141L	probably benign	Het
Med13	A	G	11: 86,319,876	V480A	probably benign	Het
Mei1	A	G	15: 82,089,609	N523S	probably benign	Het
Mill2	A	G	7: 18,856,426	T144A	probably null	Het
Muc16	C	A	9: 18,642,663	L4111F	unknown	Het
Mylk2	G	A	2: 152,913,690	G258E	possibly damaging	Het
Myom2	T	G	8: 15,065,710	S42A	probably benign	Het
Nab1	C	A	1: 52,464,836	G401C	possibly damaging	Het
Nifk	T	C	1: 118,332,862	V244A	possibly damaging	Het
Nipsnap2	C	A	5: 129,753,293	Q224K	probably benign	Het
Nop16	T	G	13: 54,589,740	K47Q	probably damaging	Het
Nup153	A	T	13: 46,699,716	S548R	probably damaging	Het
Olfr1284	A	G	2: 111,379,002	M1V	probably null	Het
Olfr521	A	C	7: 99,767,717	D185A	probably damaging	Het
Pard6g	G	A	18: 80,117,319	V216I	possibly damaging	Het
Pcdh20	C	T	14: 88,468,602	V421I	probably benign	Het
Pcif1	G	A	2: 164,884,304		probably null	Het
Pde11a	C	A	2: 76,337,740	V290F	probably damaging	Het
Pisd	T	C	5: 32,737,429	Y511C	probably damaging	Het
Polg	A	T	7: 79,460,657	D276E	probably damaging	Het
Polr3b	T	C	10: 84,713,632	V906A	probably damaging	Het
Prkcg	C	T	7: 3,313,819	P270S	probably benign	Het
Rapgef2	T	A	3: 79,085,974	I884F	probably damaging	Het
Rpl13	C	A	8: 123,103,275	N113K	possibly damaging	Het
Rxra	T	A	2: 27,741,174	I139N	probably damaging	Het
Sf3b5	T	A	10: 13,008,743	C41S	probably benign	Het
Stk24	C	T	14: 121,302,809	R126Q	probably damaging	Het
Taar8b	T	C	10: 24,092,065	D77G	possibly damaging	Het
Tbc1d1	T	A	5: 64,311,109	C566S	probably benign	Het
Tenm3	A	T	8: 48,298,937	M948K	probably damaging	Het
Thbs4	T	A	13: 92,757,936	Q693L	possibly damaging	Het
Tnfrsf26	A	T	7: 143,618,389	C61*	probably null	Het
Trp63	A	G	16: 25,889,168	E636G	probably damaging	Het
Try5	T	C	6: 41,311,332	Y121C	probably damaging	Het
Ttn	G	T	2: 76,830,411		probably benign	Het
Vamp1	T	A	6: 125,218,945	V55D	probably damaging	Het
Vmn2r117	T	C	17: 23,479,563	N12S	probably damaging	Het
Vmn2r90	G	A	17: 17,704,061	G41S	probably damaging	Het
Zfp462	T	A	4: 55,007,775	D71E	probably benign	Het

Other mutations in Olfr1465

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL01296:Olfr1465	APN	19	13314126	missense	probably damaging	1.00
IGL01548:Olfr1465	APN	19	13313986	missense	possibly damaging	0.95
IGL02548:Olfr1465	APN	19	13313938	missense	probably damaging	0.98
IGL02663:Olfr1465	APN	19	13313379	missense	probably benign	0.01
BB010:Olfr1465	UTSW	19	13314205	missense	probably benign
BB020:Olfr1465	UTSW	19	13314205	missense	probably benign
PIT4651001:Olfr1465	UTSW	19	13314192	missense	probably benign	0.12
R0563:Olfr1465	UTSW	19	13313748	missense	probably benign	0.28
R1803:Olfr1465	UTSW	19	13314171	missense	possibly damaging	0.90
R2146:Olfr1465	UTSW	19	13314121	missense	probably benign	0.23
R4674:Olfr1465	UTSW	19	13313814	missense	probably benign	0.17
R4697:Olfr1465	UTSW	19	13313717	missense	probably benign	0.39
R4825:Olfr1465	UTSW	19	13314320	splice site	probably null
R4884:Olfr1465	UTSW	19	13313670	missense	probably benign	0.28
R5647:Olfr1465	UTSW	19	13314189	missense	probably damaging	1.00
R6401:Olfr1465	UTSW	19	13313514	missense	probably damaging	1.00
R6996:Olfr1465	UTSW	19	13313672	missense	probably benign	0.15
R7933:Olfr1465	UTSW	19	13314205	missense	probably benign
R8946:Olfr1465	UTSW	19	13314138	missense	probably damaging	0.97
R8966:Olfr1465	UTSW	19	13313832	missense	probably damaging	1.00
R9641:Olfr1465	UTSW	19	13313736	missense	probably damaging	0.98

Predicted Primers

PCR Primer
(F):5'- TGCTGTAGACCAGAGGATTCAG -3'
(R):5'- CACATTGGGGACACCTTCAATC -3'

Sequencing Primer
(F):5'- TTCAGCATAGGGATGATCATGG -3'
(R):5'- GGGGACACCTTCAATCTTTCTTTCTG -3'

Posted On

2018-11-06