Mutagenetix > Incidental Mutation

Incidental Mutation 'IGL01160:Zfp429'

53925

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Zfp429

Ensembl Gene

ENSMUSG00000078994

Gene Name

zinc finger protein 429

Synonyms

2810487A22Rik

Accession Numbers

Essential gene?

Probably non essential (E-score: 0.069) question?

Stock #

IGL01160

Quality Score

Status

Chromosome

Chromosomal Location

67536024-67547938 bp(-) (GRCm39)

Type of Mutation

missense

DNA Base Change (assembly)

G to A at 67539132 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Serine to Leucine at position 91 (S91L)

Ref Sequence

ENSEMBL: ENSMUSP00000153005 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000109732] [ENSMUST00000181071] [ENSMUST00000224684] [ENSMUST00000224825]

AlphaFold

Q7M6Y0

Predicted Effect

possibly damaging
Transcript: ENSMUST00000109732
AA Change: S104L

PolyPhen 2 Score 0.802 (Sensitivity: 0.84; Specificity: 0.93)

SMART Domains

Protein: ENSMUSP00000105354
Gene: ENSMUSG00000078994
AA Change: S104L

Domain	Start	End	E-Value	Type
KRAB	15	75	7.16e-34	SMART
ZnF_C2H2	119	141	5.12e1	SMART
ZnF_C2H2	147	169	2.27e-4	SMART
ZnF_C2H2	175	197	1.28e-3	SMART
ZnF_C2H2	203	225	1.56e-2	SMART
ZnF_C2H2	259	281	4.62e1	SMART
ZnF_C2H2	287	309	5.14e-3	SMART
ZnF_C2H2	315	337	6.78e-3	SMART
ZnF_C2H2	343	365	3.11e-2	SMART
ZnF_C2H2	371	393	1.25e-1	SMART
ZnF_C2H2	399	421	6.32e-3	SMART
ZnF_C2H2	427	449	1.47e-3	SMART
ZnF_C2H2	455	477	5.42e-2	SMART

Predicted Effect

probably benign
Transcript: ENSMUST00000181071

SMART Domains

Protein: ENSMUSP00000137755
Gene: ENSMUSG00000078994

Domain	Start	End	E-Value	Type
KRAB	15	75	7.16e-34	SMART

Predicted Effect

probably benign
Transcript: ENSMUST00000224684
AA Change: S104L

PolyPhen 2 Score 0.245 (Sensitivity: 0.91; Specificity: 0.88)

Predicted Effect

probably damaging
Transcript: ENSMUST00000224825
AA Change: S91L

PolyPhen 2 Score 0.965 (Sensitivity: 0.78; Specificity: 0.95)

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000225810

Coding Region Coverage

Validation Efficiency

Allele List at MGI

Other mutations in this stock

Total: 46 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Atp11a	A	G	8: 12,894,609 (GRCm39)	T188A	probably damaging	Het
Bfsp2	A	G	9: 103,357,367 (GRCm39)	V20A	probably benign	Het
Btn1a1	G	A	13: 23,645,907 (GRCm39)	T154M	possibly damaging	Het
Ccdc117	T	C	11: 5,481,532 (GRCm39)	S200G	probably benign	Het
Col24a1	G	A	3: 145,213,468 (GRCm39)	G1358S	probably damaging	Het
Crlf2	T	C	5: 109,705,436 (GRCm39)	T40A	possibly damaging	Het
Cstf2	T	A	X: 132,961,478 (GRCm39)		probably benign	Het
Dcdc2a	A	G	13: 25,303,312 (GRCm39)	D281G	probably benign	Het
Dmd	T	C	X: 82,968,567 (GRCm39)	L1855P	probably damaging	Het
Dnajc5g	T	C	5: 31,267,529 (GRCm39)	V112A	probably benign	Het
Dnmt1	G	A	9: 20,828,615 (GRCm39)	P828S	possibly damaging	Het
Dock3	A	T	9: 106,783,887 (GRCm39)	S268R	probably damaging	Het
Dpep2	C	T	8: 106,713,076 (GRCm39)	V440M	possibly damaging	Het
F8	A	T	X: 74,331,667 (GRCm39)	M741K	probably damaging	Het
Fermt3	C	T	19: 6,980,626 (GRCm39)		probably null	Het
Fosb	A	G	7: 19,041,039 (GRCm39)		probably null	Het
Gm3238	C	A	10: 77,606,717 (GRCm39)		probably benign	Het
Hyal5	T	A	6: 24,876,480 (GRCm39)	S118T	possibly damaging	Het
Igf2r	T	C	17: 12,923,662 (GRCm39)	D1140G	possibly damaging	Het
Ighmbp2	G	T	19: 3,326,750 (GRCm39)		probably benign	Het
Irf3	C	A	7: 44,648,220 (GRCm39)	D28E	possibly damaging	Het
Ly6i	A	T	15: 74,851,881 (GRCm39)	I96N	possibly damaging	Het
Macrod2	T	C	2: 140,666,962 (GRCm39)		probably benign	Het
Or2b4	A	G	17: 38,116,941 (GRCm39)	R302G	probably benign	Het
Or4c117	A	T	2: 88,956,072 (GRCm39)	M1K	probably null	Het
Or4f15	A	G	2: 111,814,278 (GRCm39)	L47P	probably damaging	Het
Or52z1	C	T	7: 103,436,843 (GRCm39)	G214R	probably damaging	Het
Otof	A	T	5: 30,538,879 (GRCm39)	M1128K	probably benign	Het
Parp9	A	T	16: 35,768,368 (GRCm39)	I183F	probably damaging	Het
Pbsn	T	C	X: 76,886,177 (GRCm39)	N147S	probably benign	Het
Pcf11	A	G	7: 92,310,894 (GRCm39)	S365P	possibly damaging	Het
Pcnx4	T	G	12: 72,626,151 (GRCm39)	V1119G	probably damaging	Het
Qng1	A	G	13: 58,529,790 (GRCm39)	V274A	probably damaging	Het
Rsf1	C	T	7: 97,334,791 (GRCm39)	T1308M	probably damaging	Het
Sidt2	A	G	9: 45,854,024 (GRCm39)	L647P	probably damaging	Het
Slc28a2b	A	C	2: 122,355,277 (GRCm39)		probably null	Het
Slc7a8	A	G	14: 54,972,581 (GRCm39)	V280A	probably benign	Het
Spart	T	A	3: 55,029,177 (GRCm39)	F323I	probably damaging	Het
Supt16	A	T	14: 52,420,589 (GRCm39)	D70E	probably benign	Het
Tmc4	T	C	7: 3,678,517 (GRCm39)	Y38C	possibly damaging	Het
Tmco5b	G	T	2: 113,118,143 (GRCm39)		probably benign	Het
Trav10	G	A	14: 53,743,239 (GRCm39)		probably benign	Het
Vmn2r28	A	T	7: 5,489,477 (GRCm39)	M454K	probably damaging	Het
Vmn2r85	T	C	10: 130,254,690 (GRCm39)	T665A	probably benign	Het
Yipf7	T	C	5: 69,676,660 (GRCm39)	I160V	probably benign	Het
Zc3h18	T	C	8: 123,134,989 (GRCm39)		probably benign	Het

Other mutations in Zfp429

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL01913:Zfp429	APN	13	67,544,793 (GRCm39)	missense	probably damaging	1.00
IGL02343:Zfp429	APN	13	67,538,844 (GRCm39)	missense	probably damaging	0.98
IGL02679:Zfp429	APN	13	67,547,855 (GRCm39)	intron	probably benign
IGL03396:Zfp429	APN	13	67,544,159 (GRCm39)	splice site	probably benign
FR4342:Zfp429	UTSW	13	67,544,769 (GRCm39)	missense	probably benign	0.02
R0012:Zfp429	UTSW	13	67,538,796 (GRCm39)	missense	probably benign	0.01
R1232:Zfp429	UTSW	13	67,538,751 (GRCm39)	missense	possibly damaging	0.47
R1330:Zfp429	UTSW	13	67,544,262 (GRCm39)	splice site	probably null
R1653:Zfp429	UTSW	13	67,538,043 (GRCm39)	missense	possibly damaging	0.87
R1761:Zfp429	UTSW	13	67,544,195 (GRCm39)	missense	probably benign	0.28
R1813:Zfp429	UTSW	13	67,538,505 (GRCm39)	missense	possibly damaging	0.55
R2356:Zfp429	UTSW	13	67,538,746 (GRCm39)	missense	probably benign
R4280:Zfp429	UTSW	13	67,538,914 (GRCm39)	missense	probably damaging	1.00
R4283:Zfp429	UTSW	13	67,538,914 (GRCm39)	missense	probably damaging	1.00
R4464:Zfp429	UTSW	13	67,538,617 (GRCm39)	missense	probably benign	0.13
R4789:Zfp429	UTSW	13	67,538,523 (GRCm39)	missense	probably benign	0.06
R5187:Zfp429	UTSW	13	67,538,959 (GRCm39)	missense	probably damaging	0.99
R5250:Zfp429	UTSW	13	67,538,638 (GRCm39)	missense	probably benign	0.00
R6688:Zfp429	UTSW	13	67,544,249 (GRCm39)	missense	probably damaging	0.98
R6772:Zfp429	UTSW	13	67,538,317 (GRCm39)	missense	probably damaging	1.00
R6989:Zfp429	UTSW	13	67,538,080 (GRCm39)	missense	probably benign	0.00
R7041:Zfp429	UTSW	13	67,538,830 (GRCm39)	missense	probably damaging	1.00
R7101:Zfp429	UTSW	13	67,538,931 (GRCm39)	missense	possibly damaging	0.88
R7593:Zfp429	UTSW	13	67,538,410 (GRCm39)	missense	probably damaging	1.00
R7792:Zfp429	UTSW	13	67,538,558 (GRCm39)	nonsense	probably null
R8500:Zfp429	UTSW	13	67,538,828 (GRCm39)	nonsense	probably null
R8721:Zfp429	UTSW	13	67,538,331 (GRCm39)	missense	probably damaging	0.98
R8891:Zfp429	UTSW	13	67,538,830 (GRCm39)	missense	probably damaging	1.00
R9364:Zfp429	UTSW	13	67,538,531 (GRCm39)	missense	probably benign	0.12
R9554:Zfp429	UTSW	13	67,538,531 (GRCm39)	missense	probably benign	0.12

Posted On

2013-06-28