Incidental Mutation 'R6918:Or8c15'
ID 539448
Institutional Source Beutler Lab
Gene Symbol Or8c15
Ensembl Gene ENSMUSG00000093901
Gene Name olfactory receptor family 8 subfamily C member 15
Synonyms GA_x6K02T2PVTD-31889215-31890153, Olfr893, MOR170-11
MMRRC Submission 045005-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.135) question?
Stock # R6918 (G1)
Quality Score 225.009
Status Validated
Chromosome 9
Chromosomal Location 38120348-38121289 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) G to A at 38120948 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Valine to Methionine at position 198 (V198M)
Ref Sequence ENSEMBL: ENSMUSP00000148719 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000093867] [ENSMUST00000211975]
AlphaFold K7N678
Predicted Effect possibly damaging
Transcript: ENSMUST00000093867
AA Change: V200M

PolyPhen 2 Score 0.949 (Sensitivity: 0.79; Specificity: 0.95)
SMART Domains Protein: ENSMUSP00000091390
Gene: ENSMUSG00000093901
AA Change: V200M

DomainStartEndE-ValueType
Pfam:7tm_4 33 309 1.2e-45 PFAM
Pfam:7tm_1 43 292 8e-20 PFAM
Predicted Effect possibly damaging
Transcript: ENSMUST00000211975
AA Change: V198M

PolyPhen 2 Score 0.949 (Sensitivity: 0.79; Specificity: 0.95)
Predicted Effect probably benign
Transcript: ENSMUST00000212815
Coding Region Coverage
  • 1x: 100.0%
  • 3x: 99.9%
  • 10x: 99.4%
  • 20x: 98.2%
Validation Efficiency 100% (48/48)
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 47 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Abca3 A C 17: 24,627,632 (GRCm39) K1359Q probably damaging Het
Ace T C 11: 105,863,769 (GRCm39) Y406H probably damaging Het
Acsl6 A G 11: 54,232,582 (GRCm39) probably null Het
Alms1 T A 6: 85,599,643 (GRCm39) Y1959N possibly damaging Het
Chrna7 T A 7: 62,809,299 (GRCm39) I76F probably benign Het
Cuedc1 C T 11: 88,077,899 (GRCm39) T296I probably benign Het
Ddc A G 11: 11,769,307 (GRCm39) V409A probably damaging Het
Dhx8 T A 11: 101,629,247 (GRCm39) Y212* probably null Het
Dnah6 T A 6: 73,158,738 (GRCm39) K622* probably null Het
Dscaml1 A G 9: 45,341,805 (GRCm39) H72R probably benign Het
Dyrk1b A G 7: 27,885,350 (GRCm39) D396G probably damaging Het
Gstm2 A G 3: 107,892,557 (GRCm39) probably null Het
Hsd3b1 A G 3: 98,760,425 (GRCm39) Y189H probably damaging Het
Kif1c G A 11: 70,597,813 (GRCm39) E356K probably damaging Het
Kirrel2 A C 7: 30,150,239 (GRCm39) C17G probably damaging Het
Klhl12 A G 1: 134,403,584 (GRCm39) H259R possibly damaging Het
Krt1 A G 15: 101,758,612 (GRCm39) V184A probably damaging Het
Lmod2 A T 6: 24,603,594 (GRCm39) N190Y probably benign Het
Lrp2 A C 2: 69,319,649 (GRCm39) V1958G probably damaging Het
Ly6h T C 15: 75,437,507 (GRCm39) S37G probably damaging Het
Man2a2 A T 7: 80,002,940 (GRCm39) H1056Q possibly damaging Het
Misp3 T G 8: 84,738,313 (GRCm39) M1L probably benign Het
Mixl1 T A 1: 180,522,243 (GRCm39) I213F probably benign Het
Morc3 T C 16: 93,650,023 (GRCm39) I268T probably benign Het
Mtx2 C T 2: 74,706,697 (GRCm39) T224I probably damaging Het
Oscp1 A C 4: 125,970,571 (GRCm39) D120A possibly damaging Het
Parp1 G A 1: 180,416,235 (GRCm39) V545I possibly damaging Het
Pipox A G 11: 77,772,380 (GRCm39) I330T probably damaging Het
Pkp2 A G 16: 16,090,082 (GRCm39) Y790C probably damaging Het
Pomt1 T A 2: 32,142,873 (GRCm39) probably null Het
Pp2d1 G A 17: 53,822,487 (GRCm39) T193M probably damaging Het
Prkra G T 2: 76,460,797 (GRCm39) H300Q probably damaging Het
Ror2 T G 13: 53,265,487 (GRCm39) N523T probably damaging Het
Rp1 A T 1: 4,069,831 (GRCm39) D1355E unknown Het
Rsph4a T C 10: 33,781,272 (GRCm39) Y41H probably benign Het
Scn1a T A 2: 66,162,557 (GRCm39) I230F probably damaging Het
Taar7e T A 10: 23,913,513 (GRCm39) M1K probably null Het
Tex15 T G 8: 34,063,212 (GRCm39) L1155V probably benign Het
Tmprss3 T C 17: 31,407,331 (GRCm39) K321E probably benign Het
Trappc14 A G 5: 138,258,926 (GRCm39) V211A probably benign Het
Tsc2 A T 17: 24,832,203 (GRCm39) C728S probably damaging Het
Ube2e3 A T 2: 78,750,383 (GRCm39) K203M probably damaging Het
Unc50 A T 1: 37,477,783 (GRCm39) T222S probably damaging Het
Vmn1r236 A T 17: 21,507,878 (GRCm39) H332L probably benign Het
Vmn2r7 G A 3: 64,598,760 (GRCm39) T599I probably benign Het
Zfp334 A T 2: 165,223,799 (GRCm39) D81E possibly damaging Het
Zfp710 A G 7: 79,731,788 (GRCm39) I322V possibly damaging Het
Other mutations in Or8c15
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00331:Or8c15 APN 9 38,120,534 (GRCm39) missense probably damaging 1.00
IGL00914:Or8c15 APN 9 38,121,095 (GRCm39) splice site probably null
IGL01563:Or8c15 APN 9 38,120,997 (GRCm39) missense probably damaging 1.00
IGL01696:Or8c15 APN 9 38,120,345 (GRCm39) unclassified probably benign
IGL02064:Or8c15 APN 9 38,120,874 (GRCm39) missense probably damaging 1.00
IGL02605:Or8c15 APN 9 38,120,532 (GRCm39) missense probably damaging 0.99
R0415:Or8c15 UTSW 9 38,121,269 (GRCm39) missense probably benign
R0463:Or8c15 UTSW 9 38,120,360 (GRCm39) missense probably benign 0.00
R0843:Or8c15 UTSW 9 38,120,579 (GRCm39) missense possibly damaging 0.81
R1441:Or8c15 UTSW 9 38,120,777 (GRCm39) missense probably damaging 1.00
R1939:Or8c15 UTSW 9 38,120,725 (GRCm39) nonsense probably null
R2512:Or8c15 UTSW 9 38,120,670 (GRCm39) missense probably damaging 1.00
R4890:Or8c15 UTSW 9 38,120,586 (GRCm39) missense probably benign 0.00
R5439:Or8c15 UTSW 9 38,121,050 (GRCm39) missense probably benign 0.00
R7621:Or8c15 UTSW 9 38,120,447 (GRCm39) missense probably benign 0.09
R7715:Or8c15 UTSW 9 38,120,775 (GRCm39) missense probably benign 0.30
R7940:Or8c15 UTSW 9 38,120,496 (GRCm39) missense probably benign 0.00
R8710:Or8c15 UTSW 9 38,121,066 (GRCm39) missense possibly damaging 0.60
R8712:Or8c15 UTSW 9 38,121,099 (GRCm39) missense probably benign 0.39
R8882:Or8c15 UTSW 9 38,120,461 (GRCm39) nonsense probably null
Predicted Primers PCR Primer
(F):5'- ATGTCTCCTCGGATGTGTTC -3'
(R):5'- TGATCTACAGATTCAGCGGATGC -3'

Sequencing Primer
(F):5'- CCCTGCTAATGATTGGGTCC -3'
(R):5'- GCTGGTTTGACATAAGTAAGCAGTCC -3'
Posted On 2018-11-06