Incidental Mutation 'R6918:Ly6h'
ID 539460
Institutional Source Beutler Lab
Gene Symbol Ly6h
Ensembl Gene ENSMUSG00000022577
Gene Name lymphocyte antigen 6 family member H
Synonyms
MMRRC Submission 045005-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.074) question?
Stock # R6918 (G1)
Quality Score 225.009
Status Validated
Chromosome 15
Chromosomal Location 75436594-75439114 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to C at 75437507 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Serine to Glycine at position 37 (S37G)
Ref Sequence ENSEMBL: ENSMUSP00000130781 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000023241] [ENSMUST00000065417] [ENSMUST00000126129] [ENSMUST00000127095] [ENSMUST00000156032] [ENSMUST00000163116]
AlphaFold Q9WUC3
Predicted Effect probably damaging
Transcript: ENSMUST00000023241
AA Change: S37G

PolyPhen 2 Score 0.989 (Sensitivity: 0.72; Specificity: 0.97)
SMART Domains Protein: ENSMUSP00000023241
Gene: ENSMUSG00000022577
AA Change: S37G

DomainStartEndE-ValueType
signal peptide 1 25 N/A INTRINSIC
LU 26 123 2.68e-6 SMART
Predicted Effect probably damaging
Transcript: ENSMUST00000065417
AA Change: S37G

PolyPhen 2 Score 0.989 (Sensitivity: 0.72; Specificity: 0.97)
SMART Domains Protein: ENSMUSP00000070646
Gene: ENSMUSG00000022577
AA Change: S37G

DomainStartEndE-ValueType
signal peptide 1 25 N/A INTRINSIC
LU 26 123 2.68e-6 SMART
Predicted Effect probably damaging
Transcript: ENSMUST00000126129
AA Change: S37G

PolyPhen 2 Score 0.989 (Sensitivity: 0.72; Specificity: 0.97)
SMART Domains Protein: ENSMUSP00000121951
Gene: ENSMUSG00000022577
AA Change: S37G

DomainStartEndE-ValueType
signal peptide 1 25 N/A INTRINSIC
LU 26 123 2.68e-6 SMART
Predicted Effect probably damaging
Transcript: ENSMUST00000127095
AA Change: S58G

PolyPhen 2 Score 0.989 (Sensitivity: 0.72; Specificity: 0.97)
SMART Domains Protein: ENSMUSP00000122061
Gene: ENSMUSG00000022577
AA Change: S58G

DomainStartEndE-ValueType
signal peptide 1 46 N/A INTRINSIC
LU 47 144 2.68e-6 SMART
Predicted Effect probably damaging
Transcript: ENSMUST00000156032
AA Change: S58G

PolyPhen 2 Score 0.989 (Sensitivity: 0.72; Specificity: 0.97)
SMART Domains Protein: ENSMUSP00000122878
Gene: ENSMUSG00000022577
AA Change: S58G

DomainStartEndE-ValueType
signal peptide 1 46 N/A INTRINSIC
LU 47 144 2.68e-6 SMART
Predicted Effect probably damaging
Transcript: ENSMUST00000163116
AA Change: S37G

PolyPhen 2 Score 0.989 (Sensitivity: 0.72; Specificity: 0.97)
SMART Domains Protein: ENSMUSP00000130781
Gene: ENSMUSG00000022577
AA Change: S37G

DomainStartEndE-ValueType
signal peptide 1 25 N/A INTRINSIC
LU 26 123 2.68e-6 SMART
Meta Mutation Damage Score 0.1188 question?
Coding Region Coverage
  • 1x: 100.0%
  • 3x: 99.9%
  • 10x: 99.4%
  • 20x: 98.2%
Validation Efficiency 100% (48/48)
Allele List at MGI
Other mutations in this stock
Total: 47 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Abca3 A C 17: 24,627,632 (GRCm39) K1359Q probably damaging Het
Ace T C 11: 105,863,769 (GRCm39) Y406H probably damaging Het
Acsl6 A G 11: 54,232,582 (GRCm39) probably null Het
Alms1 T A 6: 85,599,643 (GRCm39) Y1959N possibly damaging Het
Chrna7 T A 7: 62,809,299 (GRCm39) I76F probably benign Het
Cuedc1 C T 11: 88,077,899 (GRCm39) T296I probably benign Het
Ddc A G 11: 11,769,307 (GRCm39) V409A probably damaging Het
Dhx8 T A 11: 101,629,247 (GRCm39) Y212* probably null Het
Dnah6 T A 6: 73,158,738 (GRCm39) K622* probably null Het
Dscaml1 A G 9: 45,341,805 (GRCm39) H72R probably benign Het
Dyrk1b A G 7: 27,885,350 (GRCm39) D396G probably damaging Het
Gstm2 A G 3: 107,892,557 (GRCm39) probably null Het
Hsd3b1 A G 3: 98,760,425 (GRCm39) Y189H probably damaging Het
Kif1c G A 11: 70,597,813 (GRCm39) E356K probably damaging Het
Kirrel2 A C 7: 30,150,239 (GRCm39) C17G probably damaging Het
Klhl12 A G 1: 134,403,584 (GRCm39) H259R possibly damaging Het
Krt1 A G 15: 101,758,612 (GRCm39) V184A probably damaging Het
Lmod2 A T 6: 24,603,594 (GRCm39) N190Y probably benign Het
Lrp2 A C 2: 69,319,649 (GRCm39) V1958G probably damaging Het
Man2a2 A T 7: 80,002,940 (GRCm39) H1056Q possibly damaging Het
Misp3 T G 8: 84,738,313 (GRCm39) M1L probably benign Het
Mixl1 T A 1: 180,522,243 (GRCm39) I213F probably benign Het
Morc3 T C 16: 93,650,023 (GRCm39) I268T probably benign Het
Mtx2 C T 2: 74,706,697 (GRCm39) T224I probably damaging Het
Or8c15 G A 9: 38,120,948 (GRCm39) V198M possibly damaging Het
Oscp1 A C 4: 125,970,571 (GRCm39) D120A possibly damaging Het
Parp1 G A 1: 180,416,235 (GRCm39) V545I possibly damaging Het
Pipox A G 11: 77,772,380 (GRCm39) I330T probably damaging Het
Pkp2 A G 16: 16,090,082 (GRCm39) Y790C probably damaging Het
Pomt1 T A 2: 32,142,873 (GRCm39) probably null Het
Pp2d1 G A 17: 53,822,487 (GRCm39) T193M probably damaging Het
Prkra G T 2: 76,460,797 (GRCm39) H300Q probably damaging Het
Ror2 T G 13: 53,265,487 (GRCm39) N523T probably damaging Het
Rp1 A T 1: 4,069,831 (GRCm39) D1355E unknown Het
Rsph4a T C 10: 33,781,272 (GRCm39) Y41H probably benign Het
Scn1a T A 2: 66,162,557 (GRCm39) I230F probably damaging Het
Taar7e T A 10: 23,913,513 (GRCm39) M1K probably null Het
Tex15 T G 8: 34,063,212 (GRCm39) L1155V probably benign Het
Tmprss3 T C 17: 31,407,331 (GRCm39) K321E probably benign Het
Trappc14 A G 5: 138,258,926 (GRCm39) V211A probably benign Het
Tsc2 A T 17: 24,832,203 (GRCm39) C728S probably damaging Het
Ube2e3 A T 2: 78,750,383 (GRCm39) K203M probably damaging Het
Unc50 A T 1: 37,477,783 (GRCm39) T222S probably damaging Het
Vmn1r236 A T 17: 21,507,878 (GRCm39) H332L probably benign Het
Vmn2r7 G A 3: 64,598,760 (GRCm39) T599I probably benign Het
Zfp334 A T 2: 165,223,799 (GRCm39) D81E possibly damaging Het
Zfp710 A G 7: 79,731,788 (GRCm39) I322V possibly damaging Het
Other mutations in Ly6h
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01327:Ly6h APN 15 75,436,948 (GRCm39) utr 3 prime probably benign
R1148:Ly6h UTSW 15 75,437,021 (GRCm39) missense unknown
R1148:Ly6h UTSW 15 75,437,021 (GRCm39) missense unknown
R1265:Ly6h UTSW 15 75,438,032 (GRCm39) missense probably benign 0.05
R1468:Ly6h UTSW 15 75,437,986 (GRCm39) missense probably benign 0.09
R1468:Ly6h UTSW 15 75,437,986 (GRCm39) missense probably benign 0.09
R2235:Ly6h UTSW 15 75,437,038 (GRCm39) missense probably benign
R8058:Ly6h UTSW 15 75,437,061 (GRCm39) missense probably benign 0.01
R8807:Ly6h UTSW 15 75,438,056 (GRCm39) missense probably benign 0.05
R9131:Ly6h UTSW 15 75,437,522 (GRCm39) missense probably damaging 0.99
Predicted Primers PCR Primer
(F):5'- ACCCTCCAGATCAGTTTAAGACG -3'
(R):5'- GGAGTGAACTCTTCTGTGAGC -3'

Sequencing Primer
(F):5'- CAAAGTCATGATCTTGTCCCAGGG -3'
(R):5'- AACTCTTCTGTGAGCATGGTTC -3'
Posted On 2018-11-06