Incidental Mutation 'R6918:Morc3'
ID 539463
Institutional Source Beutler Lab
Gene Symbol Morc3
Ensembl Gene ENSMUSG00000039456
Gene Name microrchidia 3
Synonyms Zcwcc3, D16Jhu32e, 1110051N18Rik, 1110051N18Rik
MMRRC Submission 045005-MU
Accession Numbers
Essential gene? Essential (E-score: 1.000) question?
Stock # R6918 (G1)
Quality Score 225.009
Status Validated
Chromosome 16
Chromosomal Location 93629009-93672961 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to C at 93650023 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Isoleucine to Threonine at position 268 (I268T)
Ref Sequence ENSEMBL: ENSMUSP00000144369 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000044068] [ENSMUST00000201097] [ENSMUST00000201754] [ENSMUST00000202261]
AlphaFold F7BJB9
Predicted Effect probably benign
Transcript: ENSMUST00000044068
AA Change: I268T

PolyPhen 2 Score 0.364 (Sensitivity: 0.90; Specificity: 0.89)
SMART Domains Protein: ENSMUSP00000040152
Gene: ENSMUSG00000039456
AA Change: I268T

DomainStartEndE-ValueType
Pfam:HATPase_c 25 130 8e-8 PFAM
Pfam:HATPase_c_3 26 164 1.1e-18 PFAM
Pfam:zf-CW 409 452 2.7e-19 PFAM
low complexity region 461 472 N/A INTRINSIC
low complexity region 630 639 N/A INTRINSIC
coiled coil region 765 871 N/A INTRINSIC
Predicted Effect probably benign
Transcript: ENSMUST00000201097
AA Change: I197T

PolyPhen 2 Score 0.364 (Sensitivity: 0.90; Specificity: 0.89)
SMART Domains Protein: ENSMUSP00000144058
Gene: ENSMUSG00000039456
AA Change: I197T

DomainStartEndE-ValueType
Blast:HATPase_c 1 70 4e-39 BLAST
Pfam:zf-CW 340 383 1.2e-16 PFAM
low complexity region 392 403 N/A INTRINSIC
low complexity region 557 566 N/A INTRINSIC
coiled coil region 692 798 N/A INTRINSIC
Predicted Effect probably benign
Transcript: ENSMUST00000201754
SMART Domains Protein: ENSMUSP00000144357
Gene: ENSMUSG00000039456

DomainStartEndE-ValueType
Pfam:HATPase_c 25 91 1.3e-6 PFAM
Pfam:HATPase_c_3 26 92 1.2e-8 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000202261
AA Change: I268T

PolyPhen 2 Score 0.364 (Sensitivity: 0.90; Specificity: 0.89)
SMART Domains Protein: ENSMUSP00000144369
Gene: ENSMUSG00000039456
AA Change: I268T

DomainStartEndE-ValueType
Pfam:HATPase_c 25 130 8e-8 PFAM
Pfam:HATPase_c_3 26 164 1.1e-18 PFAM
Pfam:zf-CW 409 452 2.7e-19 PFAM
low complexity region 461 472 N/A INTRINSIC
low complexity region 630 639 N/A INTRINSIC
coiled coil region 765 871 N/A INTRINSIC
Coding Region Coverage
  • 1x: 100.0%
  • 3x: 99.9%
  • 10x: 99.4%
  • 20x: 98.2%
Validation Efficiency 100% (48/48)
MGI Phenotype FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes a protein that localizes to the nuclear matrix and forms nuclear bodies via an ATP-dependent mechanism. The protein is predicted to have coiled-coil and zinc finger domains and has RNA binding activity. Alternative splicing produces multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Feb 2016]
PHENOTYPE: Mice homozygous for a null allele die at or within a day of birth. [provided by MGI curators]
Allele List at MGI
Other mutations in this stock
Total: 47 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Abca3 A C 17: 24,627,632 (GRCm39) K1359Q probably damaging Het
Ace T C 11: 105,863,769 (GRCm39) Y406H probably damaging Het
Acsl6 A G 11: 54,232,582 (GRCm39) probably null Het
Alms1 T A 6: 85,599,643 (GRCm39) Y1959N possibly damaging Het
Chrna7 T A 7: 62,809,299 (GRCm39) I76F probably benign Het
Cuedc1 C T 11: 88,077,899 (GRCm39) T296I probably benign Het
Ddc A G 11: 11,769,307 (GRCm39) V409A probably damaging Het
Dhx8 T A 11: 101,629,247 (GRCm39) Y212* probably null Het
Dnah6 T A 6: 73,158,738 (GRCm39) K622* probably null Het
Dscaml1 A G 9: 45,341,805 (GRCm39) H72R probably benign Het
Dyrk1b A G 7: 27,885,350 (GRCm39) D396G probably damaging Het
Gstm2 A G 3: 107,892,557 (GRCm39) probably null Het
Hsd3b1 A G 3: 98,760,425 (GRCm39) Y189H probably damaging Het
Kif1c G A 11: 70,597,813 (GRCm39) E356K probably damaging Het
Kirrel2 A C 7: 30,150,239 (GRCm39) C17G probably damaging Het
Klhl12 A G 1: 134,403,584 (GRCm39) H259R possibly damaging Het
Krt1 A G 15: 101,758,612 (GRCm39) V184A probably damaging Het
Lmod2 A T 6: 24,603,594 (GRCm39) N190Y probably benign Het
Lrp2 A C 2: 69,319,649 (GRCm39) V1958G probably damaging Het
Ly6h T C 15: 75,437,507 (GRCm39) S37G probably damaging Het
Man2a2 A T 7: 80,002,940 (GRCm39) H1056Q possibly damaging Het
Misp3 T G 8: 84,738,313 (GRCm39) M1L probably benign Het
Mixl1 T A 1: 180,522,243 (GRCm39) I213F probably benign Het
Mtx2 C T 2: 74,706,697 (GRCm39) T224I probably damaging Het
Or8c15 G A 9: 38,120,948 (GRCm39) V198M possibly damaging Het
Oscp1 A C 4: 125,970,571 (GRCm39) D120A possibly damaging Het
Parp1 G A 1: 180,416,235 (GRCm39) V545I possibly damaging Het
Pipox A G 11: 77,772,380 (GRCm39) I330T probably damaging Het
Pkp2 A G 16: 16,090,082 (GRCm39) Y790C probably damaging Het
Pomt1 T A 2: 32,142,873 (GRCm39) probably null Het
Pp2d1 G A 17: 53,822,487 (GRCm39) T193M probably damaging Het
Prkra G T 2: 76,460,797 (GRCm39) H300Q probably damaging Het
Ror2 T G 13: 53,265,487 (GRCm39) N523T probably damaging Het
Rp1 A T 1: 4,069,831 (GRCm39) D1355E unknown Het
Rsph4a T C 10: 33,781,272 (GRCm39) Y41H probably benign Het
Scn1a T A 2: 66,162,557 (GRCm39) I230F probably damaging Het
Taar7e T A 10: 23,913,513 (GRCm39) M1K probably null Het
Tex15 T G 8: 34,063,212 (GRCm39) L1155V probably benign Het
Tmprss3 T C 17: 31,407,331 (GRCm39) K321E probably benign Het
Trappc14 A G 5: 138,258,926 (GRCm39) V211A probably benign Het
Tsc2 A T 17: 24,832,203 (GRCm39) C728S probably damaging Het
Ube2e3 A T 2: 78,750,383 (GRCm39) K203M probably damaging Het
Unc50 A T 1: 37,477,783 (GRCm39) T222S probably damaging Het
Vmn1r236 A T 17: 21,507,878 (GRCm39) H332L probably benign Het
Vmn2r7 G A 3: 64,598,760 (GRCm39) T599I probably benign Het
Zfp334 A T 2: 165,223,799 (GRCm39) D81E possibly damaging Het
Zfp710 A G 7: 79,731,788 (GRCm39) I322V possibly damaging Het
Other mutations in Morc3
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00561:Morc3 APN 16 93,670,283 (GRCm39) critical splice donor site probably null
IGL01015:Morc3 APN 16 93,659,534 (GRCm39) missense probably damaging 1.00
IGL01374:Morc3 APN 16 93,641,101 (GRCm39) missense probably damaging 1.00
IGL01634:Morc3 APN 16 93,670,125 (GRCm39) missense probably benign 0.02
IGL01845:Morc3 APN 16 93,657,455 (GRCm39) missense probably damaging 0.96
IGL02202:Morc3 APN 16 93,667,749 (GRCm39) missense probably benign 0.01
IGL02478:Morc3 APN 16 93,661,844 (GRCm39) splice site probably benign
IGL03026:Morc3 APN 16 93,659,612 (GRCm39) splice site probably benign
IGL03115:Morc3 APN 16 93,667,971 (GRCm39) missense probably damaging 0.99
Ballista UTSW 16 93,638,271 (GRCm39) missense probably damaging 1.00
mindy UTSW 16 93,663,421 (GRCm39) missense probably benign 0.03
Pfaff UTSW 16 93,659,572 (GRCm39) missense probably damaging 0.96
shield UTSW 16 93,671,700 (GRCm39) missense probably damaging 0.98
sparkle UTSW 16 93,667,362 (GRCm39) missense probably damaging 1.00
Stooges UTSW 16 93,638,275 (GRCm39) missense probably damaging 1.00
Sword UTSW 16 93,671,645 (GRCm39) critical splice acceptor site probably null
R0173:Morc3 UTSW 16 93,629,094 (GRCm39) splice site probably null
R0413:Morc3 UTSW 16 93,667,362 (GRCm39) missense probably damaging 1.00
R0639:Morc3 UTSW 16 93,650,738 (GRCm39) missense probably damaging 1.00
R0842:Morc3 UTSW 16 93,670,284 (GRCm39) critical splice donor site probably null
R1134:Morc3 UTSW 16 93,667,557 (GRCm39) missense probably benign
R1162:Morc3 UTSW 16 93,649,996 (GRCm39) missense probably damaging 1.00
R1498:Morc3 UTSW 16 93,650,743 (GRCm39) missense probably damaging 1.00
R1520:Morc3 UTSW 16 93,641,129 (GRCm39) missense probably damaging 0.96
R1603:Morc3 UTSW 16 93,663,391 (GRCm39) missense probably benign
R1622:Morc3 UTSW 16 93,671,694 (GRCm39) missense probably benign 0.28
R1630:Morc3 UTSW 16 93,663,421 (GRCm39) missense probably benign 0.03
R1818:Morc3 UTSW 16 93,652,398 (GRCm39) missense probably damaging 1.00
R1902:Morc3 UTSW 16 93,667,385 (GRCm39) missense probably damaging 1.00
R2090:Morc3 UTSW 16 93,663,341 (GRCm39) missense probably benign 0.23
R2261:Morc3 UTSW 16 93,650,109 (GRCm39) splice site probably benign
R2360:Morc3 UTSW 16 93,638,275 (GRCm39) missense probably damaging 1.00
R2407:Morc3 UTSW 16 93,641,215 (GRCm39) critical splice donor site probably null
R2519:Morc3 UTSW 16 93,659,427 (GRCm39) splice site probably null
R3736:Morc3 UTSW 16 93,671,700 (GRCm39) missense probably damaging 0.98
R3873:Morc3 UTSW 16 93,659,324 (GRCm39) missense probably damaging 0.99
R4114:Morc3 UTSW 16 93,670,227 (GRCm39) missense probably benign 0.01
R4115:Morc3 UTSW 16 93,670,227 (GRCm39) missense probably benign 0.01
R4116:Morc3 UTSW 16 93,670,227 (GRCm39) missense probably benign 0.01
R4472:Morc3 UTSW 16 93,671,645 (GRCm39) critical splice acceptor site probably null
R4609:Morc3 UTSW 16 93,661,856 (GRCm39) missense probably benign 0.01
R4708:Morc3 UTSW 16 93,670,126 (GRCm39) missense probably benign 0.19
R4883:Morc3 UTSW 16 93,667,250 (GRCm39) critical splice acceptor site probably null
R4945:Morc3 UTSW 16 93,668,082 (GRCm39) missense probably damaging 1.00
R4965:Morc3 UTSW 16 93,657,475 (GRCm39) nonsense probably null
R5399:Morc3 UTSW 16 93,659,427 (GRCm39) splice site probably null
R5481:Morc3 UTSW 16 93,659,543 (GRCm39) missense probably damaging 0.99
R5540:Morc3 UTSW 16 93,644,268 (GRCm39) missense probably benign
R5970:Morc3 UTSW 16 93,663,341 (GRCm39) missense possibly damaging 0.65
R6006:Morc3 UTSW 16 93,663,381 (GRCm39) missense possibly damaging 0.67
R6044:Morc3 UTSW 16 93,663,330 (GRCm39) missense probably benign 0.02
R6045:Morc3 UTSW 16 93,671,733 (GRCm39) missense probably damaging 1.00
R6155:Morc3 UTSW 16 93,659,313 (GRCm39) missense possibly damaging 0.94
R6165:Morc3 UTSW 16 93,638,271 (GRCm39) missense probably damaging 1.00
R6225:Morc3 UTSW 16 93,642,082 (GRCm39) nonsense probably null
R6240:Morc3 UTSW 16 93,659,572 (GRCm39) missense probably damaging 0.96
R6835:Morc3 UTSW 16 93,644,309 (GRCm39) missense probably damaging 1.00
R6944:Morc3 UTSW 16 93,667,460 (GRCm39) missense probably benign
R7311:Morc3 UTSW 16 93,646,061 (GRCm39) missense probably damaging 1.00
R7398:Morc3 UTSW 16 93,671,748 (GRCm39) missense probably damaging 1.00
R7553:Morc3 UTSW 16 93,667,824 (GRCm39) missense probably damaging 0.98
R8056:Morc3 UTSW 16 93,642,064 (GRCm39) missense probably benign 0.07
R8299:Morc3 UTSW 16 93,650,088 (GRCm39) missense probably damaging 1.00
R8317:Morc3 UTSW 16 93,659,417 (GRCm39) missense probably benign 0.25
R8542:Morc3 UTSW 16 93,644,319 (GRCm39) critical splice donor site probably null
R8697:Morc3 UTSW 16 93,667,908 (GRCm39) missense probably benign 0.00
R8739:Morc3 UTSW 16 93,657,398 (GRCm39) missense probably damaging 1.00
R9072:Morc3 UTSW 16 93,667,482 (GRCm39) missense probably benign 0.00
R9235:Morc3 UTSW 16 93,659,321 (GRCm39) missense probably damaging 1.00
R9305:Morc3 UTSW 16 93,667,302 (GRCm39) missense probably benign 0.00
R9405:Morc3 UTSW 16 93,642,036 (GRCm39) missense probably damaging 1.00
R9431:Morc3 UTSW 16 93,667,771 (GRCm39) nonsense probably null
R9440:Morc3 UTSW 16 93,649,975 (GRCm39) critical splice acceptor site probably null
R9524:Morc3 UTSW 16 93,667,401 (GRCm39) missense probably benign 0.09
R9571:Morc3 UTSW 16 93,641,107 (GRCm39) missense possibly damaging 0.89
X0023:Morc3 UTSW 16 93,644,287 (GRCm39) missense probably damaging 1.00
Predicted Primers PCR Primer
(F):5'- ACCATGTTTACCTCTGAACTATGC -3'
(R):5'- TGGAGCGTGGAACTCTATGAG -3'

Sequencing Primer
(F):5'- GTCCTGGAACTCACTGTGTAGAC -3'
(R):5'- AAGGACTCCTGCAAGTTGTC -3'
Posted On 2018-11-06