Mutagenetix > Incidental Mutation

Incidental Mutation 'IGL01010:Gm3573'

53954

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Gm3573

Ensembl Gene

ENSMUSG00000091792

Gene Name

predicted gene 3573

Synonyms

Accession Numbers

Essential gene?

Not available question?

Stock #

IGL01010

Quality Score

Status

Chromosome

Chromosomal Location

42007348-42012748 bp(-) (GRCm39)

Type of Mutation

missense

DNA Base Change (assembly)

T to A at 42009523 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Isoleucine to Leucine at position 141 (I141L)

Ref Sequence

ENSEMBL: ENSMUSP00000127488 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000168673]

AlphaFold

L7N292

Predicted Effect

probably benign
Transcript: ENSMUST00000168673
AA Change: I141L

PolyPhen 2 Score 0.083 (Sensitivity: 0.93; Specificity: 0.85)

SMART Domains

Protein: ENSMUSP00000127488
Gene: ENSMUSG00000091792
AA Change: I141L

Domain	Start	End	E-Value	Type
Pfam:Takusan	10	88	1.4e-20	PFAM

Coding Region Coverage

Validation Efficiency

Allele List at MGI

Other mutations in this stock

Total: 26 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
1700030K09Rik	C	A	8: 73,199,059 (GRCm39)	S155R	probably damaging	Het
Acss3	G	T	10: 106,859,710 (GRCm39)		probably benign	Het
Ano4	G	A	10: 88,796,462 (GRCm39)	T680I	probably benign	Het
Drosha	C	T	15: 12,827,375 (GRCm39)		probably benign	Het
Ehd3	A	G	17: 74,134,484 (GRCm39)	D281G	probably damaging	Het
Exoc5	A	G	14: 49,275,212 (GRCm39)	L196P	probably damaging	Het
Gal3st1	T	C	11: 3,946,914 (GRCm39)		probably benign	Het
Gart	G	A	16: 91,439,980 (GRCm39)	R4*	probably null	Het
Gm21738	T	A	14: 19,417,361 (GRCm38)	T56S	probably benign	Het
Gpr6	A	G	10: 40,947,147 (GRCm39)	M145T	probably benign	Het
Kcns3	T	C	12: 11,142,427 (GRCm39)	M91V	probably benign	Het
Mtarc2	T	G	1: 184,551,513 (GRCm39)	I308L	probably benign	Het
Mto1	A	G	9: 78,368,925 (GRCm39)	K529R	probably benign	Het
Naip2	A	T	13: 100,291,446 (GRCm39)	V1164D	probably damaging	Het
Or2ag13	T	C	7: 106,473,460 (GRCm39)		probably benign	Het
Or8k21	A	T	2: 86,145,288 (GRCm39)	I114N	probably damaging	Het
Plekha1	T	C	7: 130,503,984 (GRCm39)		probably benign	Het
Psg26	T	C	7: 18,212,255 (GRCm39)	S367G	possibly damaging	Het
Rps6kb1	T	C	11: 86,393,592 (GRCm39)	M513V	probably benign	Het
Slitrk3	C	T	3: 72,956,606 (GRCm39)	G722D	probably benign	Het
Stag1	A	G	9: 100,827,986 (GRCm39)	E1005G	probably benign	Het
Tgfbr2	A	T	9: 115,959,048 (GRCm39)	L122Q	possibly damaging	Het
Traf2	G	A	2: 25,410,450 (GRCm39)	R400*	probably null	Het
Trim33	C	T	3: 103,254,031 (GRCm39)	Q153*	probably null	Het
Zmynd15	T	C	11: 70,356,742 (GRCm39)	Y551H	probably damaging	Het
Znrd2	A	G	19: 5,781,293 (GRCm39)	S78P	probably damaging	Het

Other mutations in Gm3573

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL02548:Gm3573	APN	14	42,009,452 (GRCm39)	critical splice donor site	probably null
R6774:Gm3573	UTSW	14	42,009,472 (GRCm39)	missense	possibly damaging	0.86
R6827:Gm3573	UTSW	14	42,010,429 (GRCm39)	missense	probably benign	0.00
R7607:Gm3573	UTSW	14	42,011,707 (GRCm39)	missense	probably benign	0.18
R9625:Gm3573	UTSW	14	42,011,605 (GRCm39)	missense	possibly damaging	0.71

Posted On

2013-06-28