Incidental Mutation 'R6921:Or8b1b'
ID 539646
Institutional Source Beutler Lab
Gene Symbol Or8b1b
Ensembl Gene ENSMUSG00000094380
Gene Name olfactory receptor family 8 subfamily B member 1B
Synonyms Olfr904, MOR167-3, GA_x6K02T2PVTD-32156773-32157705
MMRRC Submission 045006-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.080) question?
Stock # R6921 (G1)
Quality Score 225.009
Status Validated
Chromosome 9
Chromosomal Location 38375330-38378952 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to G at 38375543 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Isoleucine to Valine at position 69 (I69V)
Ref Sequence ENSEMBL: ENSMUSP00000150057 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000058153] [ENSMUST00000216724]
AlphaFold Q7TRC9
Predicted Effect probably benign
Transcript: ENSMUST00000058153
AA Change: I69V

PolyPhen 2 Score 0.011 (Sensitivity: 0.96; Specificity: 0.78)
SMART Domains Protein: ENSMUSP00000057148
Gene: ENSMUSG00000094380
AA Change: I69V

DomainStartEndE-ValueType
Pfam:7tm_4 31 308 5.7e-51 PFAM
Pfam:7tm_1 41 291 1.5e-23 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000216724
AA Change: I69V

PolyPhen 2 Score 0.011 (Sensitivity: 0.96; Specificity: 0.78)
Coding Region Coverage
  • 1x: 100.0%
  • 3x: 99.8%
  • 10x: 98.9%
  • 20x: 96.4%
Validation Efficiency 96% (46/48)
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 47 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
1700017B05Rik A T 9: 57,166,019 (GRCm39) H118Q probably damaging Het
Adgrl3 T G 5: 81,796,560 (GRCm39) V623G probably damaging Het
B9d2 A G 7: 25,385,442 (GRCm39) D84G probably damaging Het
Clec1a A T 6: 129,405,827 (GRCm39) L268H probably damaging Het
Copa A T 1: 171,939,491 (GRCm39) N576I possibly damaging Het
Cyp11b1 T C 15: 74,712,798 (GRCm39) T88A probably benign Het
Dis3l2 T C 1: 86,785,063 (GRCm39) I318T probably benign Het
Dmtf1 T C 5: 9,180,654 (GRCm39) probably benign Het
Dnah17 C A 11: 117,932,310 (GRCm39) A3639S probably damaging Het
Dnajc8 T A 4: 132,272,031 (GRCm39) I89N probably damaging Het
Dync2h1 T A 9: 7,102,549 (GRCm39) H377L probably benign Het
Erfe T A 1: 91,298,054 (GRCm39) I212N probably benign Het
Fam117b A G 1: 59,992,094 (GRCm39) T248A probably damaging Het
Fbxo10 A T 4: 45,044,849 (GRCm39) N595K probably damaging Het
Fzd10 T A 5: 128,678,646 (GRCm39) M122K probably damaging Het
Gpr15 C T 16: 58,538,144 (GRCm39) R315H probably benign Het
Gvin2 G A 7: 105,551,187 (GRCm39) Q622* probably null Het
H6pd T C 4: 150,066,508 (GRCm39) D626G probably damaging Het
Hexd A G 11: 121,113,107 (GRCm39) D514G probably damaging Het
Hoxd4 T C 2: 74,558,836 (GRCm39) S220P possibly damaging Het
Invs A G 4: 48,396,260 (GRCm39) H311R possibly damaging Het
Ip6k1 A G 9: 107,901,634 (GRCm39) T70A probably damaging Het
Lipt2 T C 7: 99,809,578 (GRCm39) C222R probably damaging Het
Lrrc3 T A 10: 77,736,866 (GRCm39) D190V probably damaging Het
Marchf10 T C 11: 105,280,603 (GRCm39) T561A probably benign Het
Mcm10 G A 2: 5,005,746 (GRCm39) T463I probably benign Het
Mideas A G 12: 84,203,233 (GRCm39) S890P probably damaging Het
Mmel1 T C 4: 154,966,134 (GRCm39) L52P probably damaging Het
Nipbl T C 15: 8,332,969 (GRCm39) N2218S probably benign Het
Nr4a3 C T 4: 48,051,486 (GRCm39) P80L probably benign Het
Nrip1 C T 16: 76,089,476 (GRCm39) G694R possibly damaging Het
Oit3 A T 10: 59,271,767 (GRCm39) C197S probably damaging Het
Or5al1 C T 2: 85,990,196 (GRCm39) V173M probably benign Het
Otol1 A G 3: 69,935,433 (GRCm39) E475G possibly damaging Het
Pes1 T C 11: 3,923,330 (GRCm39) F168L probably damaging Het
Plch1 C T 3: 63,615,155 (GRCm39) R780H possibly damaging Het
Pxdn C G 12: 30,065,504 (GRCm39) P1275A probably damaging Het
Sgcz T C 8: 37,993,443 (GRCm39) E218G probably damaging Het
Slc27a5 A T 7: 12,725,135 (GRCm39) N437K probably damaging Het
Sult2b1 A G 7: 45,384,612 (GRCm39) S155P probably damaging Het
Tgfbrap1 T C 1: 43,091,056 (GRCm39) M690V probably benign Het
Tmem151a A T 19: 5,133,119 (GRCm39) L29Q probably damaging Het
Tmprss2 A G 16: 97,369,637 (GRCm39) I379T probably damaging Het
Vmn1r168 T A 7: 23,240,323 (GRCm39) V60E probably damaging Het
Vmn2r73 A C 7: 85,507,446 (GRCm39) V622G probably benign Het
Wdr72 A G 9: 74,117,928 (GRCm39) H880R probably benign Het
Zfhx3 A G 8: 109,678,024 (GRCm39) T3025A possibly damaging Het
Other mutations in Or8b1b
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01352:Or8b1b APN 9 38,376,030 (GRCm39) missense probably benign
IGL01966:Or8b1b APN 9 38,376,225 (GRCm39) missense possibly damaging 0.82
IGL02328:Or8b1b APN 9 38,375,972 (GRCm39) missense probably benign
IGL03394:Or8b1b APN 9 38,375,517 (GRCm39) missense probably damaging 1.00
R0085:Or8b1b UTSW 9 38,375,958 (GRCm39) missense probably benign 0.37
R0125:Or8b1b UTSW 9 38,375,757 (GRCm39) nonsense probably null
R1506:Or8b1b UTSW 9 38,375,439 (GRCm39) missense probably benign 0.02
R1545:Or8b1b UTSW 9 38,375,815 (GRCm39) missense probably benign 0.37
R1610:Or8b1b UTSW 9 38,375,927 (GRCm39) missense probably damaging 0.97
R2008:Or8b1b UTSW 9 38,375,537 (GRCm39) missense probably damaging 1.00
R2424:Or8b1b UTSW 9 38,376,128 (GRCm39) missense probably damaging 0.99
R3824:Or8b1b UTSW 9 38,375,822 (GRCm39) missense probably benign 0.13
R3964:Or8b1b UTSW 9 38,375,979 (GRCm39) missense probably benign 0.25
R4093:Or8b1b UTSW 9 38,375,379 (GRCm39) missense probably null 1.00
R4454:Or8b1b UTSW 9 38,375,938 (GRCm39) missense probably benign 0.03
R5650:Or8b1b UTSW 9 38,376,023 (GRCm39) nonsense probably null
R7406:Or8b1b UTSW 9 38,375,439 (GRCm39) missense possibly damaging 0.88
R7597:Or8b1b UTSW 9 38,375,802 (GRCm39) missense probably benign 0.01
R7959:Or8b1b UTSW 9 38,376,211 (GRCm39) missense probably damaging 0.99
Predicted Primers PCR Primer
(F):5'- CTGCAAATGTGTCTTTGGTGAC -3'
(R):5'- ATGGCAACCGTGTACAAGAG -3'

Sequencing Primer
(F):5'- CAAATGTGTCTTTGGTGACTGAATTC -3'
(R):5'- TGGATTACAGATGGCCACATAGC -3'
Posted On 2018-11-06