Mutagenetix > Incidental Mutation

Incidental Mutation 'IGL01018:Gm21738'

53973

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Gm21738

Ensembl Gene

ENSMUSG00000095280

Gene Name

predicted gene, 21738

Synonyms

Accession Numbers

Essential gene?

Probably essential (E-score: 0.874) question?

Stock #

IGL01018

Quality Score

Status

Chromosome

Chromosomal Location

19415857-19418930 bp(-) (GRCm38)

Type of Mutation

missense

DNA Base Change (assembly)

G to A at 19418856 bp (GRCm38)

Zygosity

Heterozygous

Amino Acid Change

Proline to Leucine at position 24 (P24L)

Ref Sequence

ENSEMBL: ENSMUSP00000137127 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000177817]

AlphaFold

no structure available at present

Predicted Effect

probably benign
Transcript: ENSMUST00000177817
AA Change: P24L

PolyPhen 2 Score 0.392 (Sensitivity: 0.90; Specificity: 0.89)

SMART Domains

Protein: ENSMUSP00000137127
Gene: ENSMUSG00000095280
AA Change: P24L

Domain	Start	End	E-Value	Type
internal_repeat_1	1	19	1.11e-9	PROSPERO
transmembrane domain	20	42	N/A	INTRINSIC
transmembrane domain	77	99	N/A	INTRINSIC
internal_repeat_1	117	135	1.11e-9	PROSPERO
transmembrane domain	152	174	N/A	INTRINSIC
low complexity region	179	195	N/A	INTRINSIC
transmembrane domain	198	220	N/A	INTRINSIC

Coding Region Coverage

Validation Efficiency

Allele List at MGI

Other mutations in this stock

Total: 51 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
4931408C20Rik	T	C	1: 26,682,910	E1063G	probably damaging	Het
5530400C23Rik	G	T	6: 133,294,497	R168I	probably benign	Het
5530400C23Rik	A	T	6: 133,294,498	R168S	probably benign	Het
9230019H11Rik	C	T	10: 3,125,193		noncoding transcript	Het
9230019H11Rik	A	G	10: 3,120,231		noncoding transcript	Het
9230019H11Rik	A	G	10: 3,120,209		noncoding transcript	Het
9230019H11Rik	G	A	10: 3,125,031		noncoding transcript	Het
Armt1	C	T	10: 4,454,237		probably benign	Het
Armt1	T	A	10: 4,450,732	S160T	probably benign	Het
Ccdc170	T	C	10: 4,512,788	W35R	probably benign	Het
Ccdc170	G	T	10: 4,514,155	A99S	probably benign	Het
Ccdc170	T	C	10: 4,514,114	V31A	probably benign	Het
Glp2r	C	A	11: 67,709,644	V460F	probably benign	Het
Gm21411	T	C	4: 146,892,577	Q80R	probably benign	Het
Gm21411	C	T	4: 146,892,610	S69N	possibly damaging	Het
Gm21671	G	T	5: 25,950,723	H208N	probably benign	Het
H2-M10.6	C	T	17: 36,812,220	A15V	probably benign	Het
H60c	T	C	10: 3,259,766	M174V	probably benign	Het
H60c	A	C	10: 3,260,343	F69V	probably benign	Het
Ipcef1	C	T	10: 6,919,968	R144Q	probably damaging	Het
Ipcef1	G	A	10: 6,890,551	A382V	probably benign	Het
Mapk8ip3	T	G	17: 24,899,719		probably benign	Het
Mthfd1l	T	C	10: 4,032,345		probably benign	Het
Mthfd1l	T	C	10: 3,978,708	V100A	probably benign	Het
Mthfd1l	T	C	10: 4,007,800	V279A	probably benign	Het
Mtrf1l	A	G	10: 5,814,180		probably benign	Het
Myo18b	T	C	5: 112,809,747	E1450G	probably damaging	Het
Obscn	C	T	11: 59,128,069	V973M	probably damaging	Het
Olfr414	G	A	1: 174,431,342	V305I	probably benign	Het
Oprm1	T	C	10: 7,037,170		probably benign	Het
Pou5f2	A	G	13: 78,025,938		probably benign	Het
Ralgapa2	G	A	2: 146,410,193	H891Y	probably benign	Het
Ralgapa2	T	G	2: 146,410,192	H806P	probably benign	Het
Rmnd1	A	T	10: 4,427,290	S130T	probably benign	Het
Rmnd1	A	G	10: 4,427,392	W96R	probably benign	Het
Trappc12	A	C	12: 28,691,854		probably benign	Het
Vip	A	G	10: 5,642,480	D40G	probably benign	Het
Vmn2r125	T	A	4: 156,351,226	L300M	probably benign	Het
Vmn2r125	T	C	4: 156,350,612		probably benign	Het
Vmn2r125	C	T	4: 156,351,038	T237I	probably benign	Het
Vmn2r125	A	T	4: 156,351,037	T237S	probably benign	Het
Vmn2r125	A	C	4: 156,350,900	Q191P	probably benign	Het
Vmn2r125	C	A	4: 156,350,899	Q191K	probably benign	Het
Vmn2r125	A	G	4: 156,350,845	N173D	probably damaging	Het
Vmn2r40	G	A	7: 8,908,176	S706F	probably damaging	Het
Vmn2r-ps159	A	T	4: 156,338,146		noncoding transcript	Het
Vmn2r-ps159	C	A	4: 156,338,435		noncoding transcript	Het
Vmn2r-ps159	T	C	4: 156,334,263		noncoding transcript	Het
Vmn2r-ps159	T	C	4: 156,335,590		noncoding transcript	Het
Vmn2r-ps159	G	A	4: 156,334,605		noncoding transcript	Het
Zfp14	T	A	7: 30,038,101	R486S	probably damaging	Het

Other mutations in Gm21738

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL00990:Gm21738	APN	14	19418885	missense	probably benign
IGL01010:Gm21738	APN	14	19417361	missense	probably benign	0.03
IGL01865:Gm21738	APN	14	19416979	missense	probably benign	0.01
IGL01869:Gm21738	APN	14	19416979	missense	probably benign	0.01
IGL01873:Gm21738	APN	14	19416979	missense	probably benign	0.01
IGL01877:Gm21738	APN	14	19416979	missense	probably benign	0.01
IGL01878:Gm21738	APN	14	19416979	missense	probably benign	0.01
IGL01879:Gm21738	APN	14	19416979	missense	probably benign	0.01
IGL01880:Gm21738	APN	14	19416979	missense	probably benign	0.01
IGL01882:Gm21738	APN	14	19416979	missense	probably benign	0.01
IGL01883:Gm21738	APN	14	19416979	missense	probably benign	0.01
IGL01884:Gm21738	APN	14	19416979	missense	probably benign	0.01
IGL01885:Gm21738	APN	14	19416979	missense	probably benign	0.01
IGL01886:Gm21738	APN	14	19416979	missense	probably benign	0.01
IGL01888:Gm21738	APN	14	19416979	missense	probably benign	0.01
IGL01891:Gm21738	APN	14	19416979	missense	probably benign	0.01
IGL01892:Gm21738	APN	14	19416979	missense	probably benign	0.01
IGL01893:Gm21738	APN	14	19416979	missense	probably benign	0.01
IGL01894:Gm21738	APN	14	19416979	missense	probably benign	0.01
IGL01895:Gm21738	APN	14	19416979	missense	probably benign	0.01
IGL01896:Gm21738	APN	14	19416979	missense	probably benign	0.01
IGL01898:Gm21738	APN	14	19416979	missense	probably benign	0.01
IGL01899:Gm21738	APN	14	19416979	missense	probably benign	0.01
IGL01900:Gm21738	APN	14	19416979	missense	probably benign	0.01
IGL01901:Gm21738	APN	14	19416979	missense	probably benign	0.01
IGL01902:Gm21738	APN	14	19416979	missense	probably benign	0.01
IGL01903:Gm21738	APN	14	19416979	missense	probably benign	0.01
IGL01904:Gm21738	APN	14	19416979	missense	probably benign	0.01
IGL01905:Gm21738	APN	14	19416979	missense	probably benign	0.01
IGL01906:Gm21738	APN	14	19416979	missense	probably benign	0.01
IGL01908:Gm21738	APN	14	19416979	missense	probably benign	0.01
IGL01909:Gm21738	APN	14	19416979	missense	probably benign	0.01
IGL01910:Gm21738	APN	14	19416979	missense	probably benign	0.01
IGL01911:Gm21738	APN	14	19416979	missense	probably benign	0.01
IGL01912:Gm21738	APN	14	19416979	missense	probably benign	0.01
IGL01913:Gm21738	APN	14	19416979	missense	probably benign	0.01
IGL01914:Gm21738	APN	14	19416979	missense	probably benign	0.01
IGL01915:Gm21738	APN	14	19416979	missense	probably benign	0.01
IGL01916:Gm21738	APN	14	19416979	missense	probably benign	0.01
IGL01917:Gm21738	APN	14	19416979	missense	probably benign	0.01
IGL01918:Gm21738	APN	14	19416979	missense	probably benign	0.01
IGL01919:Gm21738	APN	14	19416979	missense	probably benign	0.01
IGL01922:Gm21738	APN	14	19416979	missense	probably benign	0.01
IGL01923:Gm21738	APN	14	19416979	missense	probably benign	0.01
IGL01924:Gm21738	APN	14	19416979	missense	probably benign	0.01
IGL01925:Gm21738	APN	14	19416979	missense	probably benign	0.01
IGL01926:Gm21738	APN	14	19416979	missense	probably benign	0.01
IGL01932:Gm21738	APN	14	19416979	missense	probably benign	0.01
IGL01940:Gm21738	APN	14	19416979	missense	probably benign	0.01
IGL01949:Gm21738	APN	14	19416979	missense	probably benign	0.01
PIT4131001:Gm21738	UTSW	14	19417330	missense	probably benign	0.00
PIT4142001:Gm21738	UTSW	14	19417330	missense	probably benign	0.00
R0831:Gm21738	UTSW	14	19415957	missense	probably benign	0.01
R0831:Gm21738	UTSW	14	19415963	missense	probably benign
R0976:Gm21738	UTSW	14	19415963	missense	probably benign
R1029:Gm21738	UTSW	14	19415957	missense	probably benign	0.01
R1146:Gm21738	UTSW	14	19415963	missense	probably benign
R1231:Gm21738	UTSW	14	19415957	missense	probably benign	0.01
R1231:Gm21738	UTSW	14	19415963	missense	probably benign
R1402:Gm21738	UTSW	14	19415957	missense	probably benign	0.01
R1402:Gm21738	UTSW	14	19415963	missense	probably benign
R1638:Gm21738	UTSW	14	19418908	missense	probably benign
R1874:Gm21738	UTSW	14	19418824	missense	possibly damaging	0.64
R4392:Gm21738	UTSW	14	19417178	missense	probably benign
R4393:Gm21738	UTSW	14	19417178	missense	probably benign
R5049:Gm21738	UTSW	14	19415957	missense	probably benign	0.01
R5257:Gm21738	UTSW	14	19415942	missense	probably benign
R6756:Gm21738	UTSW	14	19418824	missense	possibly damaging	0.64
R6915:Gm21738	UTSW	14	19415933	missense	probably benign
V5622:Gm21738	UTSW	14	19417180	missense	probably damaging	1.00

Posted On

2013-06-28