Incidental Mutation 'R6928:Or5b102'
ID 539880
Institutional Source Beutler Lab
Gene Symbol Or5b102
Ensembl Gene ENSMUSG00000094986
Gene Name olfactory receptor family 5 subfamily B member 102
Synonyms MOR202-14, GA_x6K02T2RE5P-3390804-3391727, Olfr1454
MMRRC Submission 045045-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.079) question?
Stock # R6928 (G1)
Quality Score 225.009
Status Validated
Chromosome 19
Chromosomal Location 13040777-13041700 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to T at 13041348 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Histidine to Leucine at position 191 (H191L)
Ref Sequence ENSEMBL: ENSMUSP00000148859 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000073732] [ENSMUST00000213806] [ENSMUST00000214695] [ENSMUST00000217568]
AlphaFold Q8VFW2
Predicted Effect probably benign
Transcript: ENSMUST00000073732
AA Change: H191L

PolyPhen 2 Score 0.049 (Sensitivity: 0.94; Specificity: 0.83)
SMART Domains Protein: ENSMUSP00000073409
Gene: ENSMUSG00000094986
AA Change: H191L

DomainStartEndE-ValueType
Pfam:7tm_4 29 306 1.1e-50 PFAM
Pfam:7tm_1 39 288 2.7e-18 PFAM
Predicted Effect noncoding transcript
Transcript: ENSMUST00000208608
Predicted Effect probably benign
Transcript: ENSMUST00000213806
AA Change: H191L

PolyPhen 2 Score 0.049 (Sensitivity: 0.94; Specificity: 0.83)
Predicted Effect probably benign
Transcript: ENSMUST00000214695
AA Change: H191L

PolyPhen 2 Score 0.049 (Sensitivity: 0.94; Specificity: 0.83)
Predicted Effect probably benign
Transcript: ENSMUST00000217568
AA Change: H191L

PolyPhen 2 Score 0.049 (Sensitivity: 0.94; Specificity: 0.83)
Coding Region Coverage
  • 1x: 100.0%
  • 3x: 99.9%
  • 10x: 99.1%
  • 20x: 97.5%
Validation Efficiency 98% (62/63)
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 60 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Adcyap1r1 A G 6: 55,456,257 (GRCm39) D215G possibly damaging Het
Asb3 A T 11: 30,948,326 (GRCm39) M40L probably damaging Het
Aspg G A 12: 112,093,123 (GRCm39) V547M possibly damaging Het
Aspm T A 1: 139,407,944 (GRCm39) L2277* probably null Het
Atp7b A G 8: 22,484,828 (GRCm39) S1295P probably benign Het
Cdca2 A G 14: 67,943,193 (GRCm39) S199P probably damaging Het
Cdh1 A G 8: 107,387,642 (GRCm39) E514G possibly damaging Het
Cenpk G T 13: 104,365,500 (GRCm39) probably benign Het
Col6a5 C A 9: 105,817,118 (GRCm39) V398L unknown Het
Colec10 A T 15: 54,326,002 (GRCm39) K277N probably damaging Het
Cryzl2 T G 1: 157,298,357 (GRCm39) S249A probably benign Het
Cspg4 T A 9: 56,805,164 (GRCm39) Y1992N possibly damaging Het
Drd3 G T 16: 43,641,683 (GRCm39) R333L probably benign Het
Espl1 C T 15: 102,207,342 (GRCm39) R269C probably benign Het
Esr2 C T 12: 76,212,252 (GRCm39) C188Y probably damaging Het
Focad A G 4: 88,267,112 (GRCm39) D1041G unknown Het
Frem3 T C 8: 81,337,911 (GRCm39) F68S possibly damaging Het
Gapdh A G 6: 125,139,634 (GRCm39) V212A probably damaging Het
Gzmb T C 14: 56,497,734 (GRCm39) K169E probably benign Het
Hexd T A 11: 121,102,880 (GRCm39) F33I possibly damaging Het
Hsd3b6 T C 3: 98,718,269 (GRCm39) I32V probably benign Het
Jcad T C 18: 4,673,372 (GRCm39) V378A probably benign Het
Kcnmb2 T C 3: 32,253,190 (GRCm39) S177P probably benign Het
Lrriq1 A T 10: 103,050,800 (GRCm39) S651T possibly damaging Het
Map3k2 T C 18: 32,340,593 (GRCm39) probably null Het
Mib1 T G 18: 10,802,282 (GRCm39) S870A probably benign Het
Moap1 T A 12: 102,708,871 (GRCm39) N226I probably damaging Het
Moxd1 T A 10: 24,176,186 (GRCm39) N547K probably damaging Het
Mtmr9 A G 14: 63,781,042 (GRCm39) V16A probably benign Het
Nme1 T C 11: 93,850,229 (GRCm39) Y151C probably damaging Het
Nwd1 T C 8: 73,408,653 (GRCm39) F879L probably benign Het
Nynrin T G 14: 56,101,335 (GRCm39) S335A probably benign Het
Or52ac1 A T 7: 104,245,796 (GRCm39) Y197* probably null Het
Or5ac25 C A 16: 59,181,826 (GRCm39) G252C probably damaging Het
Or5b99 A G 19: 12,977,202 (GRCm39) N284S probably damaging Het
Or8d23 T C 9: 38,841,862 (GRCm39) Y132H probably damaging Het
Or8g21 T C 9: 38,905,928 (GRCm39) M268V probably benign Het
Pcdhb21 A G 18: 37,647,474 (GRCm39) E201G probably damaging Het
Plscr1 T C 9: 92,152,004 (GRCm39) V301A possibly damaging Het
Psg28 A T 7: 18,157,003 (GRCm39) S411T possibly damaging Het
Rif1 T C 2: 51,985,973 (GRCm39) W653R probably damaging Het
Rnd3 T A 2: 51,022,518 (GRCm39) I175L probably benign Het
Rtn4 A G 11: 29,656,791 (GRCm39) E199G possibly damaging Het
Sgpp1 T C 12: 75,763,344 (GRCm39) Y279C probably damaging Het
Slc2a13 A G 15: 91,160,382 (GRCm39) I524T probably damaging Het
Speer4a2 A G 5: 26,290,586 (GRCm39) probably null Het
Spg11 C T 2: 121,900,385 (GRCm39) V1556I probably benign Het
Spopfm1 T A 3: 94,173,855 (GRCm39) C288S probably benign Het
Srebf2 C T 15: 82,087,924 (GRCm39) R215* probably null Het
Tdpoz8 G A 3: 92,981,267 (GRCm39) C95Y probably damaging Het
Tmem19 T C 10: 115,183,179 (GRCm39) N147S possibly damaging Het
Tpr T C 1: 150,284,536 (GRCm39) S408P possibly damaging Het
Trav13d-4 C T 14: 53,310,618 (GRCm39) T53I probably damaging Het
Trf T A 9: 103,099,307 (GRCm39) R168W possibly damaging Het
Trim11 A G 11: 58,879,669 (GRCm39) K273R probably damaging Het
Tsacc T A 3: 88,190,247 (GRCm39) M68L probably benign Het
Ttn T A 2: 76,584,869 (GRCm39) M22110L probably benign Het
Zfp160 G T 17: 21,261,724 (GRCm39) G104V probably benign Het
Zfp582 T C 7: 6,357,266 (GRCm39) Y360H probably damaging Het
Zranb1 G A 7: 132,568,323 (GRCm39) R301H possibly damaging Het
Other mutations in Or5b102
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01598:Or5b102 APN 19 13,041,513 (GRCm39) missense probably damaging 1.00
IGL02942:Or5b102 APN 19 13,041,552 (GRCm39) missense probably benign 0.45
IGL03331:Or5b102 APN 19 13,041,231 (GRCm39) missense probably damaging 1.00
R0551:Or5b102 UTSW 19 13,041,658 (GRCm39) missense probably benign 0.01
R0738:Or5b102 UTSW 19 13,041,102 (GRCm39) missense probably damaging 1.00
R1532:Or5b102 UTSW 19 13,041,639 (GRCm39) missense probably damaging 1.00
R2072:Or5b102 UTSW 19 13,041,044 (GRCm39) missense probably benign 0.00
R2092:Or5b102 UTSW 19 13,041,166 (GRCm39) nonsense probably null
R2656:Or5b102 UTSW 19 13,041,348 (GRCm39) missense probably benign 0.05
R2850:Or5b102 UTSW 19 13,040,934 (GRCm39) missense probably damaging 1.00
R4212:Or5b102 UTSW 19 13,041,123 (GRCm39) missense probably damaging 0.98
R5303:Or5b102 UTSW 19 13,041,139 (GRCm39) nonsense probably null
R6362:Or5b102 UTSW 19 13,040,709 (GRCm39) start gained probably benign
R7183:Or5b102 UTSW 19 13,041,680 (GRCm39) missense probably benign 0.00
R7701:Or5b102 UTSW 19 13,041,445 (GRCm39) missense probably damaging 1.00
R7741:Or5b102 UTSW 19 13,041,423 (GRCm39) missense probably damaging 0.98
R8057:Or5b102 UTSW 19 13,040,638 (GRCm39) start gained probably benign
R8272:Or5b102 UTSW 19 13,040,795 (GRCm39) missense possibly damaging 0.47
R8534:Or5b102 UTSW 19 13,041,432 (GRCm39) missense probably damaging 1.00
R8769:Or5b102 UTSW 19 13,041,307 (GRCm39) nonsense probably null
R9400:Or5b102 UTSW 19 13,041,139 (GRCm39) nonsense probably null
R9511:Or5b102 UTSW 19 13,041,119 (GRCm39) missense probably damaging 0.99
R9651:Or5b102 UTSW 19 13,041,256 (GRCm39) missense probably benign 0.01
Z1176:Or5b102 UTSW 19 13,041,010 (GRCm39) missense probably benign 0.15
Predicted Primers PCR Primer
(F):5'- ATGTAAGCCCCTACATTATGCTAC -3'
(R):5'- AGCTGGGCTGCAAGTACATG -3'

Sequencing Primer
(F):5'- CCCTACATTATGCTACCACCATG -3'
(R):5'- CTGGGCTGCAAGTACATGAATATG -3'
Posted On 2018-11-06