Mutagenetix > Incidental Mutation

Incidental Mutation 'R6932:Hivep2'

540106

Institutional Source

Beutler Lab

Gene Symbol

Hivep2

Ensembl Gene

ENSMUSG00000015501

Gene Name

human immunodeficiency virus type I enhancer binding protein 2

Synonyms

Gm20114, Shn-2, Schnurri-2, MIBP1

MMRRC Submission

045047-MU

Accession Numbers

Essential gene?

Probably essential (E-score: 0.936) question?

Stock #

R6932 (G1)

Quality Score

225.009

Status

Validated

Chromosome

Chromosomal Location

13841819-14027118 bp(+) (GRCm39)

Type of Mutation

missense

DNA Base Change (assembly)

C to T at 14004245 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Threonine to Methionine at position 281 (T281M)

Ref Sequence

ENSEMBL: ENSMUSP00000140150 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000015645] [ENSMUST00000186989] [ENSMUST00000187083] [ENSMUST00000191138]

AlphaFold

no structure available at present

Predicted Effect

probably damaging
Transcript: ENSMUST00000015645
AA Change: T281M

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)

SMART Domains

Protein: ENSMUSP00000015645
Gene: ENSMUSG00000015501
AA Change: T281M

Domain	Start	End	E-Value	Type
low complexity region	177	188	N/A	INTRINSIC
ZnF_C2H2	189	211	1.82e-3	SMART
ZnF_C2H2	217	239	7.26e-3	SMART
low complexity region	887	909	N/A	INTRINSIC
low complexity region	922	937	N/A	INTRINSIC
low complexity region	939	956	N/A	INTRINSIC
low complexity region	958	974	N/A	INTRINSIC
low complexity region	1499	1521	N/A	INTRINSIC
low complexity region	1548	1569	N/A	INTRINSIC
ZnF_C2H2	1783	1805	2.24e-3	SMART
ZnF_C2H2	1811	1835	1.98e-4	SMART
low complexity region	1853	1862	N/A	INTRINSIC
low complexity region	1883	1910	N/A	INTRINSIC
low complexity region	1943	1956	N/A	INTRINSIC
low complexity region	2013	2038	N/A	INTRINSIC
low complexity region	2090	2103	N/A	INTRINSIC
low complexity region	2233	2241	N/A	INTRINSIC
low complexity region	2271	2289	N/A	INTRINSIC

Predicted Effect

probably damaging
Transcript: ENSMUST00000186989
AA Change: T281M

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)

SMART Domains

Protein: ENSMUSP00000140180
Gene: ENSMUSG00000015501
AA Change: T281M

Domain	Start	End	E-Value	Type
low complexity region	177	188	N/A	INTRINSIC
ZnF_C2H2	189	211	7.9e-6	SMART
ZnF_C2H2	217	239	3.1e-5	SMART

Predicted Effect

probably damaging
Transcript: ENSMUST00000187083
AA Change: T281M

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)

SMART Domains

Protein: ENSMUSP00000140290
Gene: ENSMUSG00000015501
AA Change: T281M

Domain	Start	End	E-Value	Type
low complexity region	177	188	N/A	INTRINSIC
ZnF_C2H2	189	211	1.82e-3	SMART
ZnF_C2H2	217	239	7.26e-3	SMART
low complexity region	887	909	N/A	INTRINSIC
low complexity region	922	937	N/A	INTRINSIC
low complexity region	939	956	N/A	INTRINSIC
low complexity region	958	974	N/A	INTRINSIC
low complexity region	1499	1521	N/A	INTRINSIC
low complexity region	1548	1569	N/A	INTRINSIC
ZnF_C2H2	1783	1805	2.24e-3	SMART
ZnF_C2H2	1811	1835	1.98e-4	SMART
low complexity region	1853	1862	N/A	INTRINSIC
low complexity region	1883	1910	N/A	INTRINSIC
low complexity region	1943	1956	N/A	INTRINSIC
low complexity region	2013	2038	N/A	INTRINSIC
low complexity region	2090	2103	N/A	INTRINSIC
low complexity region	2233	2241	N/A	INTRINSIC
low complexity region	2271	2289	N/A	INTRINSIC

Predicted Effect

probably damaging
Transcript: ENSMUST00000191138
AA Change: T281M

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)

SMART Domains

Protein: ENSMUSP00000140150
Gene: ENSMUSG00000015501
AA Change: T281M

Domain	Start	End	E-Value	Type
low complexity region	177	188	N/A	INTRINSIC
ZnF_C2H2	189	211	1.82e-3	SMART
ZnF_C2H2	217	239	7.26e-3	SMART
low complexity region	887	909	N/A	INTRINSIC
low complexity region	922	937	N/A	INTRINSIC
low complexity region	939	956	N/A	INTRINSIC
low complexity region	958	974	N/A	INTRINSIC
low complexity region	1499	1521	N/A	INTRINSIC
low complexity region	1548	1569	N/A	INTRINSIC
ZnF_C2H2	1783	1805	2.24e-3	SMART
ZnF_C2H2	1811	1835	1.98e-4	SMART
low complexity region	1853	1862	N/A	INTRINSIC
low complexity region	1883	1910	N/A	INTRINSIC
low complexity region	1943	1956	N/A	INTRINSIC
low complexity region	2013	2038	N/A	INTRINSIC
low complexity region	2090	2103	N/A	INTRINSIC
low complexity region	2233	2241	N/A	INTRINSIC
low complexity region	2271	2289	N/A	INTRINSIC

Coding Region Coverage

1x: 100.0%
3x: 99.9%
10x: 99.2%
20x: 97.2%

Validation Efficiency

98% (80/82)

MGI Phenotype

FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes a member of a family of closely related, large, zinc finger-containing transcription factors. The encoded protein regulates transcription by binding to regulatory regions of various cellular and viral genes that maybe involved in growth, development and metastasis. The protein contains the ZAS domain comprised of two widely separated regions of zinc finger motifs, a stretch of highly acidic amino acids and a serine/threonine-rich sequence. [provided by RefSeq, Nov 2012]
PHENOTYPE: Mice homozygous for a knock-out allele display abnormal thymus anatomy, severely defective positive selection of CD4+ and CD8+ cells, and enhanced T-helper 2 cell differentiation. [provided by MGI curators]

Allele List at MGI

Other mutations in this stock

Total: 81 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Acads	A	T	5: 115,250,331 (GRCm39)	F198I	probably damaging	Het
Acy1	A	G	9: 106,314,826 (GRCm39)		probably null	Het
Adk	A	G	14: 21,126,376 (GRCm39)	M1V	probably null	Het
Ahi1	A	G	10: 20,839,590 (GRCm39)	D167G	probably benign	Het
Ankrd16	T	C	2: 11,791,054 (GRCm39)	V290A	possibly damaging	Het
Arhgef5	T	A	6: 43,251,351 (GRCm39)	S701T	possibly damaging	Het
Atp13a5	C	A	16: 29,100,769 (GRCm39)	M673I	probably damaging	Het
BC005624	T	C	2: 30,868,940 (GRCm39)	D78G	possibly damaging	Het
Bcat2	C	T	7: 45,238,745 (GRCm39)	H347Y	probably damaging	Het
Bpifb4	A	G	2: 153,784,547 (GRCm39)	Y85C	possibly damaging	Het
Cdc42	T	A	4: 137,049,932 (GRCm39)		probably null	Het
Cep170	G	A	1: 176,589,003 (GRCm39)	L541F	possibly damaging	Het
Cfap97d2	CA	CAA	8: 13,784,865 (GRCm39)		probably null	Het
Cgrrf1	T	A	14: 47,091,179 (GRCm39)	N234K	probably benign	Het
Ctrc	C	T	4: 141,568,879 (GRCm39)	C108Y	probably damaging	Het
Cyp2u1	C	T	3: 131,091,945 (GRCm39)	V192M	possibly damaging	Het
Dhx38	A	T	8: 110,279,307 (GRCm39)	L1013Q	probably damaging	Het
Dnah1	T	A	14: 31,009,733 (GRCm39)	N1945I	probably damaging	Het
Dnah10	C	G	5: 124,898,514 (GRCm39)	N3765K	possibly damaging	Het
Dnah17	C	A	11: 117,950,905 (GRCm39)	R2906L	possibly damaging	Het
Dnajc10	C	T	2: 80,161,680 (GRCm39)	T306I	probably benign	Het
Efemp2	T	A	19: 5,530,273 (GRCm39)	C287S	probably damaging	Het
Efna1	T	C	3: 89,180,091 (GRCm39)	R143G	probably benign	Het
Emilin1	A	C	5: 31,074,421 (GRCm39)	N221H	probably damaging	Het
Epg5	A	G	18: 77,991,824 (GRCm39)	T174A	probably benign	Het
Fam184b	T	A	5: 45,690,243 (GRCm39)		probably null	Het
Fchsd2	T	A	7: 100,926,621 (GRCm39)	C570*	probably null	Het
Gm4787	A	T	12: 81,425,974 (GRCm39)	D61E	probably benign	Het
Gm7356	C	T	17: 14,221,925 (GRCm39)	G35R	probably damaging	Het
Gm8220	A	G	14: 44,525,645 (GRCm39)	T20A	probably damaging	Het
Ighv2-9-1	A	G	12: 113,733,692 (GRCm39)	V43A	probably damaging	Het
Klhl33	A	T	14: 51,129,373 (GRCm39)	C619S	probably benign	Het
Kmt2a	A	T	9: 44,740,558 (GRCm39)		probably benign	Het
Lax1	A	G	1: 133,607,896 (GRCm39)	C282R	probably benign	Het
Lrrd1	A	G	5: 3,901,395 (GRCm39)	K567E	probably benign	Het
Luzp1	C	T	4: 136,268,124 (GRCm39)	R116*	probably null	Het
Lypd3	G	C	7: 24,337,858 (GRCm39)	G75R	probably damaging	Het
Macrod2	A	T	2: 140,261,833 (GRCm39)	N38I	probably damaging	Het
Map3k14	A	T	11: 103,132,958 (GRCm39)	I80N	probably damaging	Het
Mcm9	A	G	10: 53,496,299 (GRCm39)	S368P	probably benign	Het
Mfge8	T	C	7: 78,793,049 (GRCm39)	D139G	probably benign	Het
Mmp19	A	T	10: 128,627,523 (GRCm39)	I54F	probably benign	Het
Myo15a	G	T	11: 60,390,320 (GRCm39)	W2114L	probably damaging	Het
Myo1a	G	T	10: 127,546,327 (GRCm39)	V277L	probably benign	Het
Myoc	A	G	1: 162,466,915 (GRCm39)	D28G	probably damaging	Het
Myrf	G	T	19: 10,196,924 (GRCm39)	N487K	probably damaging	Het
Omd	T	A	13: 49,743,710 (GRCm39)	F253L	probably damaging	Het
Or2ag19	G	T	7: 106,444,009 (GRCm39)	G64*	probably null	Het
Or5t5	C	G	2: 86,616,499 (GRCm39)	L142V	probably damaging	Het
Or6n1	G	A	1: 173,917,316 (GRCm39)	A237T	probably damaging	Het
Papss1	T	G	3: 131,305,732 (GRCm39)	I238S	probably damaging	Het
Pkhd1	A	T	1: 20,632,675 (GRCm39)	F580Y	probably benign	Het
Polk	T	A	13: 96,653,189 (GRCm39)	K70N	probably damaging	Het
Ppig	T	A	2: 69,562,755 (GRCm39)	D31E	probably benign	Het
Ppp6r1	G	T	7: 4,636,291 (GRCm39)	S766R	possibly damaging	Het
Rab11fip5	T	C	6: 85,318,540 (GRCm39)	D783G	probably benign	Het
Reln	T	C	5: 22,190,855 (GRCm39)	I1511V	probably benign	Het
Rnh1	T	C	7: 140,743,096 (GRCm39)	N268S	probably damaging	Het
Rpia	A	G	6: 70,750,424 (GRCm39)	V236A	probably benign	Het
Rpl10a	G	T	17: 28,548,424 (GRCm39)	V80L	probably benign	Het
Sap130	T	G	18: 31,799,407 (GRCm39)	S295A	possibly damaging	Het
Sgms1	C	T	19: 32,120,193 (GRCm39)	V238I	probably benign	Het
Sh3tc1	A	G	5: 35,864,778 (GRCm39)	S470P	probably benign	Het
Slc25a32	A	G	15: 38,960,984 (GRCm39)	V233A	possibly damaging	Het
Slc2a2	T	C	3: 28,771,668 (GRCm39)	S158P	probably benign	Het
Slc6a2	A	G	8: 93,722,653 (GRCm39)	Y550C	probably benign	Het
Slc7a9	C	A	7: 35,151,936 (GRCm39)	T77K	probably benign	Het
Snd1	A	T	6: 28,626,100 (GRCm39)	D385V	probably benign	Het
Ssh3	A	T	19: 4,314,448 (GRCm39)	F369I	probably damaging	Het
Syk	A	G	13: 52,766,495 (GRCm39)		probably null	Het
Tbc1d16	A	G	11: 119,099,742 (GRCm39)	S211P	probably damaging	Het
Ttc3	A	G	16: 94,244,312 (GRCm39)	T1439A	probably benign	Het
Usp18	A	G	6: 121,229,473 (GRCm39)	M31V	probably benign	Het
Vav1	G	T	17: 57,609,330 (GRCm39)	E415D	possibly damaging	Het
Vps13a	A	T	19: 16,655,439 (GRCm39)	V1863D	probably benign	Het
Xdh	T	A	17: 74,229,557 (GRCm39)	I299F	probably damaging	Het
Zc3h14	A	G	12: 98,737,336 (GRCm39)		probably benign	Het
Zfp345	G	A	2: 150,315,331 (GRCm39)	H69Y	probably damaging	Het
Zfp652	G	T	11: 95,654,667 (GRCm39)	V357L	probably benign	Het
Zfp712	A	T	13: 67,188,891 (GRCm39)	Y545*	probably null	Het
Zgrf1	T	C	3: 127,353,281 (GRCm39)		probably null	Het

Other mutations in Hivep2

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL00495:Hivep2	APN	10	14,017,988 (GRCm39)	missense	probably damaging	1.00
IGL00963:Hivep2	APN	10	14,005,091 (GRCm39)	missense	probably damaging	1.00
IGL01066:Hivep2	APN	10	14,024,768 (GRCm39)	missense	possibly damaging	0.92
IGL01395:Hivep2	APN	10	14,008,544 (GRCm39)	critical splice donor site	probably null
IGL01474:Hivep2	APN	10	14,019,406 (GRCm39)	missense	probably damaging	1.00
IGL01481:Hivep2	APN	10	14,024,981 (GRCm39)	missense	probably benign
IGL01597:Hivep2	APN	10	14,025,118 (GRCm39)	nonsense	probably null
IGL01719:Hivep2	APN	10	14,006,267 (GRCm39)	missense	probably damaging	1.00
IGL01952:Hivep2	APN	10	14,018,075 (GRCm39)	missense	possibly damaging	0.54
IGL02170:Hivep2	APN	10	14,003,548 (GRCm39)	missense	possibly damaging	0.46
IGL02315:Hivep2	APN	10	14,006,983 (GRCm39)	missense	probably benign	0.01
IGL02517:Hivep2	APN	10	14,006,926 (GRCm39)	missense	probably benign	0.01
IGL02535:Hivep2	APN	10	14,015,241 (GRCm39)	missense	probably damaging	1.00
IGL02539:Hivep2	APN	10	14,007,622 (GRCm39)	missense	probably damaging	0.97
IGL02637:Hivep2	APN	10	14,006,452 (GRCm39)	missense	possibly damaging	0.89
IGL02715:Hivep2	APN	10	14,007,131 (GRCm39)	missense	probably benign	0.03
IGL02948:Hivep2	APN	10	14,004,757 (GRCm39)	missense	probably benign	0.44
IGL03113:Hivep2	APN	10	14,006,395 (GRCm39)	missense	probably damaging	1.00
IGL03161:Hivep2	APN	10	14,019,100 (GRCm39)	missense	probably damaging	1.00
IGL03173:Hivep2	APN	10	14,003,726 (GRCm39)	missense	possibly damaging	0.75
IGL03310:Hivep2	APN	10	14,019,411 (GRCm39)	missense	probably damaging	1.00
BB010:Hivep2	UTSW	10	14,003,581 (GRCm39)	missense	probably damaging	1.00
BB020:Hivep2	UTSW	10	14,003,581 (GRCm39)	missense	probably damaging	1.00
R0005:Hivep2	UTSW	10	14,004,493 (GRCm39)	missense	probably damaging	0.99
R0053:Hivep2	UTSW	10	14,007,865 (GRCm39)	missense	probably damaging	1.00
R0053:Hivep2	UTSW	10	14,007,865 (GRCm39)	missense	probably damaging	1.00
R0136:Hivep2	UTSW	10	14,007,622 (GRCm39)	missense	probably benign	0.04
R0143:Hivep2	UTSW	10	14,005,099 (GRCm39)	missense	probably damaging	1.00
R0172:Hivep2	UTSW	10	14,015,218 (GRCm39)	missense	probably damaging	1.00
R0226:Hivep2	UTSW	10	14,005,456 (GRCm39)	missense	probably benign	0.26
R0348:Hivep2	UTSW	10	14,005,702 (GRCm39)	missense	possibly damaging	0.76
R0352:Hivep2	UTSW	10	14,019,039 (GRCm39)	missense	possibly damaging	0.74
R0657:Hivep2	UTSW	10	14,007,622 (GRCm39)	missense	probably benign	0.04
R1710:Hivep2	UTSW	10	14,005,249 (GRCm39)	nonsense	probably null
R1959:Hivep2	UTSW	10	14,008,453 (GRCm39)	missense	probably benign	0.02
R2017:Hivep2	UTSW	10	14,006,501 (GRCm39)	missense	probably damaging	0.96
R2085:Hivep2	UTSW	10	14,004,713 (GRCm39)	missense	probably benign	0.16
R2085:Hivep2	UTSW	10	14,015,273 (GRCm39)	nonsense	probably null
R2163:Hivep2	UTSW	10	14,003,970 (GRCm39)	nonsense	probably null
R2206:Hivep2	UTSW	10	14,004,713 (GRCm39)	missense	probably benign	0.16
R2207:Hivep2	UTSW	10	14,004,713 (GRCm39)	missense	probably benign	0.16
R2228:Hivep2	UTSW	10	14,004,107 (GRCm39)	missense	probably damaging	1.00
R2241:Hivep2	UTSW	10	14,004,713 (GRCm39)	missense	probably benign	0.16
R2242:Hivep2	UTSW	10	14,004,713 (GRCm39)	missense	probably benign	0.16
R2243:Hivep2	UTSW	10	14,004,713 (GRCm39)	missense	probably benign	0.16
R2246:Hivep2	UTSW	10	14,004,713 (GRCm39)	missense	probably benign	0.16
R2247:Hivep2	UTSW	10	14,004,713 (GRCm39)	missense	probably benign	0.16
R2273:Hivep2	UTSW	10	14,008,187 (GRCm39)	missense	probably benign	0.02
R2357:Hivep2	UTSW	10	14,019,043 (GRCm39)	missense	probably benign	0.01
R2517:Hivep2	UTSW	10	14,004,713 (GRCm39)	missense	probably benign	0.16
R2519:Hivep2	UTSW	10	14,004,713 (GRCm39)	missense	probably benign	0.16
R2858:Hivep2	UTSW	10	14,004,713 (GRCm39)	missense	probably benign	0.16
R2859:Hivep2	UTSW	10	14,004,713 (GRCm39)	missense	probably benign	0.16
R2916:Hivep2	UTSW	10	14,004,713 (GRCm39)	missense	probably benign	0.16
R2921:Hivep2	UTSW	10	14,004,713 (GRCm39)	missense	probably benign	0.16
R3051:Hivep2	UTSW	10	14,004,713 (GRCm39)	missense	probably benign	0.16
R3177:Hivep2	UTSW	10	14,004,713 (GRCm39)	missense	probably benign	0.16
R3277:Hivep2	UTSW	10	14,004,713 (GRCm39)	missense	probably benign	0.16
R3620:Hivep2	UTSW	10	14,004,713 (GRCm39)	missense	probably benign	0.16
R3621:Hivep2	UTSW	10	14,004,713 (GRCm39)	missense	probably benign	0.16
R3701:Hivep2	UTSW	10	14,004,713 (GRCm39)	missense	probably benign	0.16
R3802:Hivep2	UTSW	10	14,024,705 (GRCm39)	missense	possibly damaging	0.94
R3810:Hivep2	UTSW	10	14,006,101 (GRCm39)	missense	probably benign
R3811:Hivep2	UTSW	10	14,006,101 (GRCm39)	missense	probably benign
R3817:Hivep2	UTSW	10	14,019,685 (GRCm39)	missense	possibly damaging	0.46
R3818:Hivep2	UTSW	10	14,019,685 (GRCm39)	missense	possibly damaging	0.46
R3819:Hivep2	UTSW	10	14,019,685 (GRCm39)	missense	possibly damaging	0.46
R3836:Hivep2	UTSW	10	14,004,713 (GRCm39)	missense	probably benign	0.16
R3837:Hivep2	UTSW	10	14,004,713 (GRCm39)	missense	probably benign	0.16
R3838:Hivep2	UTSW	10	14,004,713 (GRCm39)	missense	probably benign	0.16
R3839:Hivep2	UTSW	10	14,004,713 (GRCm39)	missense	probably benign	0.16
R3897:Hivep2	UTSW	10	14,004,713 (GRCm39)	missense	probably benign	0.16
R3900:Hivep2	UTSW	10	14,004,713 (GRCm39)	missense	probably benign	0.16
R3932:Hivep2	UTSW	10	14,004,713 (GRCm39)	missense	probably benign	0.16
R3954:Hivep2	UTSW	10	14,004,713 (GRCm39)	missense	probably benign	0.16
R3957:Hivep2	UTSW	10	14,004,713 (GRCm39)	missense	probably benign	0.16
R4001:Hivep2	UTSW	10	14,003,476 (GRCm39)	missense	probably damaging	1.00
R4134:Hivep2	UTSW	10	14,004,713 (GRCm39)	missense	probably benign	0.16
R4180:Hivep2	UTSW	10	14,004,713 (GRCm39)	missense	probably benign	0.16
R4248:Hivep2	UTSW	10	14,007,299 (GRCm39)	missense	probably damaging	1.00
R4416:Hivep2	UTSW	10	14,004,914 (GRCm39)	missense	probably benign
R4436:Hivep2	UTSW	10	14,004,713 (GRCm39)	missense	probably benign	0.16
R4437:Hivep2	UTSW	10	14,004,713 (GRCm39)	missense	probably benign	0.16
R4474:Hivep2	UTSW	10	14,004,713 (GRCm39)	missense	probably benign	0.16
R4475:Hivep2	UTSW	10	14,004,713 (GRCm39)	missense	probably benign	0.16
R4476:Hivep2	UTSW	10	14,004,713 (GRCm39)	missense	probably benign	0.16
R4636:Hivep2	UTSW	10	14,004,713 (GRCm39)	missense	probably benign	0.16
R4637:Hivep2	UTSW	10	14,004,713 (GRCm39)	missense	probably benign	0.16
R4791:Hivep2	UTSW	10	14,004,713 (GRCm39)	missense	probably benign	0.16
R4792:Hivep2	UTSW	10	14,004,713 (GRCm39)	missense	probably benign	0.16
R4825:Hivep2	UTSW	10	14,007,063 (GRCm39)	missense	possibly damaging	0.81
R4955:Hivep2	UTSW	10	14,006,702 (GRCm39)	missense	probably benign	0.44
R5094:Hivep2	UTSW	10	14,007,893 (GRCm39)	missense	probably benign
R5129:Hivep2	UTSW	10	14,006,608 (GRCm39)	missense	probably damaging	1.00
R5163:Hivep2	UTSW	10	14,015,169 (GRCm39)	missense	probably damaging	1.00
R5255:Hivep2	UTSW	10	14,007,011 (GRCm39)	splice site	probably null
R5330:Hivep2	UTSW	10	14,007,164 (GRCm39)	missense	probably damaging	1.00
R5341:Hivep2	UTSW	10	14,008,336 (GRCm39)	missense	possibly damaging	0.94
R5453:Hivep2	UTSW	10	14,003,972 (GRCm39)	missense	possibly damaging	0.78
R5513:Hivep2	UTSW	10	14,008,417 (GRCm39)	nonsense	probably null
R5535:Hivep2	UTSW	10	14,006,766 (GRCm39)	missense	probably benign	0.00
R5613:Hivep2	UTSW	10	14,015,239 (GRCm39)	missense	probably damaging	1.00
R5804:Hivep2	UTSW	10	14,009,519 (GRCm39)	missense	probably benign	0.01
R6074:Hivep2	UTSW	10	14,007,485 (GRCm39)	missense	probably benign	0.18
R6163:Hivep2	UTSW	10	14,005,736 (GRCm39)	missense	probably damaging	0.98
R6250:Hivep2	UTSW	10	14,007,503 (GRCm39)	missense	probably benign	0.01
R6696:Hivep2	UTSW	10	14,009,503 (GRCm39)	missense	probably benign	0.06
R6754:Hivep2	UTSW	10	14,005,382 (GRCm39)	missense	probably benign	0.06
R6756:Hivep2	UTSW	10	14,008,303 (GRCm39)	missense	probably damaging	1.00
R6799:Hivep2	UTSW	10	14,004,757 (GRCm39)	missense	probably benign	0.28
R6862:Hivep2	UTSW	10	14,006,327 (GRCm39)	missense	probably damaging	1.00
R6943:Hivep2	UTSW	10	14,004,058 (GRCm39)	missense	probably damaging	1.00
R7027:Hivep2	UTSW	10	14,025,322 (GRCm39)	missense	probably damaging	1.00
R7027:Hivep2	UTSW	10	14,025,321 (GRCm39)	missense	probably damaging	0.99
R7198:Hivep2	UTSW	10	14,005,710 (GRCm39)	missense	probably benign
R7248:Hivep2	UTSW	10	14,006,909 (GRCm39)	missense	possibly damaging	0.86
R7256:Hivep2	UTSW	10	14,004,845 (GRCm39)	missense	probably benign	0.29
R7426:Hivep2	UTSW	10	14,007,061 (GRCm39)	missense	possibly damaging	0.93
R7427:Hivep2	UTSW	10	14,009,485 (GRCm39)	missense	possibly damaging	0.94
R7638:Hivep2	UTSW	10	14,019,595 (GRCm39)	missense	possibly damaging	0.81
R7731:Hivep2	UTSW	10	14,025,458 (GRCm39)	missense	probably benign
R7740:Hivep2	UTSW	10	14,003,414 (GRCm39)	missense	probably damaging	1.00
R7797:Hivep2	UTSW	10	14,005,847 (GRCm39)	missense	probably benign
R7933:Hivep2	UTSW	10	14,003,581 (GRCm39)	missense	probably damaging	1.00
R8329:Hivep2	UTSW	10	14,004,011 (GRCm39)	missense	probably damaging	1.00
R8399:Hivep2	UTSW	10	14,008,178 (GRCm39)	missense	possibly damaging	0.63
R8767:Hivep2	UTSW	10	14,004,992 (GRCm39)	missense	probably damaging	1.00
R8802:Hivep2	UTSW	10	14,015,166 (GRCm39)	missense	probably damaging	1.00
R9002:Hivep2	UTSW	10	14,008,157 (GRCm39)	missense	probably benign	0.02
R9088:Hivep2	UTSW	10	14,006,995 (GRCm39)	missense	probably damaging	1.00
R9137:Hivep2	UTSW	10	14,004,712 (GRCm39)	missense	probably benign
R9198:Hivep2	UTSW	10	14,005,621 (GRCm39)	missense	probably benign	0.06
R9338:Hivep2	UTSW	10	14,004,693 (GRCm39)	nonsense	probably null
R9408:Hivep2	UTSW	10	14,007,505 (GRCm39)	missense	probably damaging	1.00
R9514:Hivep2	UTSW	10	14,005,523 (GRCm39)	missense	probably benign	0.34
R9516:Hivep2	UTSW	10	14,005,523 (GRCm39)	missense	probably benign	0.34
R9591:Hivep2	UTSW	10	14,019,640 (GRCm39)	missense	probably damaging	0.96
R9623:Hivep2	UTSW	10	14,006,546 (GRCm39)	missense	probably damaging	1.00
R9710:Hivep2	UTSW	10	14,015,203 (GRCm39)	missense	probably damaging	1.00
R9738:Hivep2	UTSW	10	14,019,583 (GRCm39)	missense	probably damaging	1.00
R9781:Hivep2	UTSW	10	14,005,828 (GRCm39)	missense	probably benign
Z1177:Hivep2	UTSW	10	14,019,051 (GRCm39)	missense	probably damaging	0.98
Z1177:Hivep2	UTSW	10	14,007,530 (GRCm39)	missense	probably damaging	1.00

Predicted Primers

PCR Primer
(F):5'- CGTATCCATGTATACCTTGTGGC -3'
(R):5'- TGGGGAGCATTTCAGAGCTC -3'

Sequencing Primer
(F):5'- GTGGCTTCTCTTTCAAGACAAAG -3'
(R):5'- GAGCATTTCAGAGCTCAGATACTG -3'

Posted On

2018-11-06