Incidental Mutation 'R6932:Gm4787'
ID 540116
Institutional Source Beutler Lab
Gene Symbol Gm4787
Ensembl Gene ENSMUSG00000072974
Gene Name predicted gene 4787
Synonyms
MMRRC Submission 045047-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.065) question?
Stock # R6932 (G1)
Quality Score 225.009
Status Validated
Chromosome 12
Chromosomal Location 81376991-81379464 bp(-) (GRCm38)
Type of Mutation missense
DNA Base Change (assembly) A to T at 81379200 bp (GRCm38)
Zygosity Heterozygous
Amino Acid Change Aspartic acid to Glutamic Acid at position 61 (D61E)
Ref Sequence ENSEMBL: ENSMUSP00000077390 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000062182] [ENSMUST00000110340] [ENSMUST00000164386] [ENSMUST00000166723]
AlphaFold B2RUD9
Predicted Effect probably benign
Transcript: ENSMUST00000062182
AA Change: D61E

PolyPhen 2 Score 0.039 (Sensitivity: 0.94; Specificity: 0.83)
SMART Domains Protein: ENSMUSP00000077390
Gene: ENSMUSG00000072974
AA Change: D61E

DomainStartEndE-ValueType
signal peptide 1 33 N/A INTRINSIC
Pfam:Pep_M12B_propep 46 163 1.5e-19 PFAM
Pfam:Reprolysin 213 406 4.6e-18 PFAM
DISIN 425 500 2e-33 SMART
ACR 501 644 2.83e-53 SMART
transmembrane domain 714 736 N/A INTRINSIC
Predicted Effect probably benign
Transcript: ENSMUST00000110340
SMART Domains Protein: ENSMUSP00000105969
Gene: ENSMUSG00000091803

DomainStartEndE-ValueType
Pfam:COX16 16 74 6.6e-17 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000164386
SMART Domains Protein: ENSMUSP00000132941
Gene: ENSMUSG00000021139

DomainStartEndE-ValueType
PDZ 21 100 6.16e-24 SMART
Predicted Effect probably benign
Transcript: ENSMUST00000166723
SMART Domains Protein: ENSMUSP00000130935
Gene: ENSMUSG00000091803

DomainStartEndE-ValueType
Pfam:COX16 16 73 6.9e-16 PFAM
Coding Region Coverage
  • 1x: 100.0%
  • 3x: 99.9%
  • 10x: 99.2%
  • 20x: 97.2%
Validation Efficiency 98% (80/82)
Allele List at MGI
Other mutations in this stock
Total: 81 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
4932443I19Rik CA CAA 8: 13,734,865 (GRCm38) probably null Het
Acads A T 5: 115,112,272 (GRCm38) F198I probably damaging Het
Acy1 A G 9: 106,437,627 (GRCm38) probably null Het
Adk A G 14: 21,076,308 (GRCm38) M1V probably null Het
Ahi1 A G 10: 20,963,691 (GRCm38) D167G probably benign Het
Ankrd16 T C 2: 11,786,243 (GRCm38) V290A possibly damaging Het
Arhgef5 T A 6: 43,274,417 (GRCm38) S701T possibly damaging Het
Atp13a5 C A 16: 29,281,951 (GRCm38) M673I probably damaging Het
BC005624 T C 2: 30,978,928 (GRCm38) D78G possibly damaging Het
Bcat2 C T 7: 45,589,321 (GRCm38) H347Y probably damaging Het
Bpifb4 A G 2: 153,942,627 (GRCm38) Y85C possibly damaging Het
Cdc42 T A 4: 137,322,621 (GRCm38) probably null Het
Cep170 G A 1: 176,761,437 (GRCm38) L541F possibly damaging Het
Cgrrf1 T A 14: 46,853,722 (GRCm38) N234K probably benign Het
Ctrc C T 4: 141,841,568 (GRCm38) C108Y probably damaging Het
Cyp2u1 C T 3: 131,298,296 (GRCm38) V192M possibly damaging Het
Dhx38 A T 8: 109,552,675 (GRCm38) L1013Q probably damaging Het
Dnah1 T A 14: 31,287,776 (GRCm38) N1945I probably damaging Het
Dnah10 C G 5: 124,821,450 (GRCm38) N3765K possibly damaging Het
Dnah17 C A 11: 118,060,079 (GRCm38) R2906L possibly damaging Het
Dnajc10 C T 2: 80,331,336 (GRCm38) T306I probably benign Het
Efemp2 T A 19: 5,480,245 (GRCm38) C287S probably damaging Het
Efna1 T C 3: 89,272,784 (GRCm38) R143G probably benign Het
Emilin1 A C 5: 30,917,077 (GRCm38) N221H probably damaging Het
Epg5 A G 18: 77,948,609 (GRCm38) T174A probably benign Het
Fam184b T A 5: 45,532,901 (GRCm38) probably null Het
Fchsd2 T A 7: 101,277,414 (GRCm38) C570* probably null Het
Gm7356 C T 17: 14,001,663 (GRCm38) G35R probably damaging Het
Gm8220 A G 14: 44,288,188 (GRCm38) T20A probably damaging Het
Hivep2 C T 10: 14,128,501 (GRCm38) T281M probably damaging Het
Ighv2-9-1 A G 12: 113,770,072 (GRCm38) V43A probably damaging Het
Klhl33 A T 14: 50,891,916 (GRCm38) C619S probably benign Het
Kmt2a A T 9: 44,829,261 (GRCm38) probably benign Het
Lax1 A G 1: 133,680,158 (GRCm38) C282R probably benign Het
Lrrd1 A G 5: 3,851,395 (GRCm38) K567E probably benign Het
Luzp1 C T 4: 136,540,813 (GRCm38) R116* probably null Het
Lypd3 G C 7: 24,638,433 (GRCm38) G75R probably damaging Het
Macrod2 A T 2: 140,419,913 (GRCm38) N38I probably damaging Het
Map3k14 A T 11: 103,242,132 (GRCm38) I80N probably damaging Het
Mcm9 A G 10: 53,620,203 (GRCm38) S368P probably benign Het
Mfge8 T C 7: 79,143,301 (GRCm38) D139G probably benign Het
Mmp19 A T 10: 128,791,654 (GRCm38) I54F probably benign Het
Myo15 G T 11: 60,499,494 (GRCm38) W2114L probably damaging Het
Myo1a G T 10: 127,710,458 (GRCm38) V277L probably benign Het
Myoc A G 1: 162,639,346 (GRCm38) D28G probably damaging Het
Myrf G T 19: 10,219,560 (GRCm38) N487K probably damaging Het
Olfr1093 C G 2: 86,786,155 (GRCm38) L142V probably damaging Het
Olfr429 G A 1: 174,089,750 (GRCm38) A237T probably damaging Het
Olfr703 G T 7: 106,844,802 (GRCm38) G64* probably null Het
Omd T A 13: 49,590,234 (GRCm38) F253L probably damaging Het
Papss1 T G 3: 131,599,971 (GRCm38) I238S probably damaging Het
Pkhd1 A T 1: 20,562,451 (GRCm38) F580Y probably benign Het
Polk T A 13: 96,516,681 (GRCm38) K70N probably damaging Het
Ppig T A 2: 69,732,411 (GRCm38) D31E probably benign Het
Ppp6r1 G T 7: 4,633,292 (GRCm38) S766R possibly damaging Het
Rab11fip5 T C 6: 85,341,558 (GRCm38) D783G probably benign Het
Reln T C 5: 21,985,857 (GRCm38) I1511V probably benign Het
Rnh1 T C 7: 141,163,183 (GRCm38) N268S probably damaging Het
Rpia A G 6: 70,773,440 (GRCm38) V236A probably benign Het
Rpl10a G T 17: 28,329,450 (GRCm38) V80L probably benign Het
Sap130 T G 18: 31,666,354 (GRCm38) S295A possibly damaging Het
Sgms1 C T 19: 32,142,793 (GRCm38) V238I probably benign Het
Sh3tc1 A G 5: 35,707,434 (GRCm38) S470P probably benign Het
Slc25a32 A G 15: 39,097,589 (GRCm38) V233A possibly damaging Het
Slc2a2 T C 3: 28,717,519 (GRCm38) S158P probably benign Het
Slc6a2 A G 8: 92,996,025 (GRCm38) Y550C probably benign Het
Slc7a9 C A 7: 35,452,511 (GRCm38) T77K probably benign Het
Snd1 A T 6: 28,626,101 (GRCm38) D385V probably benign Het
Ssh3 A T 19: 4,264,420 (GRCm38) F369I probably damaging Het
Syk A G 13: 52,612,459 (GRCm38) probably null Het
Tbc1d16 A G 11: 119,208,916 (GRCm38) S211P probably damaging Het
Ttc3 A G 16: 94,443,453 (GRCm38) T1439A probably benign Het
Usp18 A G 6: 121,252,514 (GRCm38) M31V probably benign Het
Vav1 G T 17: 57,302,330 (GRCm38) E415D possibly damaging Het
Vps13a A T 19: 16,678,075 (GRCm38) V1863D probably benign Het
Xdh T A 17: 73,922,562 (GRCm38) I299F probably damaging Het
Zc3h14 A G 12: 98,771,077 (GRCm38) probably benign Het
Zfp345 G A 2: 150,473,411 (GRCm38) H69Y probably damaging Het
Zfp652 G T 11: 95,763,841 (GRCm38) V357L probably benign Het
Zfp712 A T 13: 67,040,827 (GRCm38) Y545* probably null Het
Zgrf1 T C 3: 127,559,632 (GRCm38) probably null Het
Other mutations in Gm4787
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01719:Gm4787 APN 12 81,377,174 (GRCm38) missense possibly damaging 0.50
IGL01916:Gm4787 APN 12 81,377,444 (GRCm38) missense probably benign 0.36
IGL02193:Gm4787 APN 12 81,378,528 (GRCm38) missense probably benign 0.02
IGL02623:Gm4787 APN 12 81,378,728 (GRCm38) missense probably damaging 1.00
IGL02681:Gm4787 APN 12 81,378,769 (GRCm38) missense possibly damaging 0.88
IGL03257:Gm4787 APN 12 81,378,052 (GRCm38) missense probably damaging 1.00
IGL03410:Gm4787 APN 12 81,379,174 (GRCm38) missense probably damaging 1.00
F5770:Gm4787 UTSW 12 81,377,567 (GRCm38) nonsense probably null
PIT4362001:Gm4787 UTSW 12 81,377,175 (GRCm38) missense probably benign
R0070:Gm4787 UTSW 12 81,379,066 (GRCm38) missense probably damaging 1.00
R0128:Gm4787 UTSW 12 81,377,747 (GRCm38) nonsense probably null
R0220:Gm4787 UTSW 12 81,378,648 (GRCm38) missense probably damaging 0.98
R0304:Gm4787 UTSW 12 81,378,934 (GRCm38) missense probably damaging 1.00
R0513:Gm4787 UTSW 12 81,378,312 (GRCm38) missense probably benign 0.03
R1761:Gm4787 UTSW 12 81,377,176 (GRCm38) missense probably benign 0.02
R1809:Gm4787 UTSW 12 81,378,529 (GRCm38) missense possibly damaging 0.91
R1853:Gm4787 UTSW 12 81,378,334 (GRCm38) missense probably damaging 1.00
R1854:Gm4787 UTSW 12 81,378,334 (GRCm38) missense probably damaging 1.00
R2030:Gm4787 UTSW 12 81,378,770 (GRCm38) missense probably damaging 1.00
R2063:Gm4787 UTSW 12 81,378,920 (GRCm38) missense probably benign 0.39
R2112:Gm4787 UTSW 12 81,377,833 (GRCm38) missense probably damaging 1.00
R2140:Gm4787 UTSW 12 81,378,562 (GRCm38) missense probably benign 0.03
R2151:Gm4787 UTSW 12 81,377,219 (GRCm38) missense probably benign 0.00
R2152:Gm4787 UTSW 12 81,377,219 (GRCm38) missense probably benign 0.00
R2342:Gm4787 UTSW 12 81,378,758 (GRCm38) missense possibly damaging 0.91
R2504:Gm4787 UTSW 12 81,379,137 (GRCm38) missense possibly damaging 0.93
R4038:Gm4787 UTSW 12 81,378,358 (GRCm38) missense probably damaging 1.00
R4604:Gm4787 UTSW 12 81,379,213 (GRCm38) missense probably benign 0.17
R4748:Gm4787 UTSW 12 81,378,056 (GRCm38) missense probably damaging 1.00
R4750:Gm4787 UTSW 12 81,378,367 (GRCm38) missense possibly damaging 0.95
R4928:Gm4787 UTSW 12 81,378,838 (GRCm38) missense probably benign 0.03
R4960:Gm4787 UTSW 12 81,379,316 (GRCm38) missense probably damaging 0.99
R4974:Gm4787 UTSW 12 81,377,629 (GRCm38) missense probably damaging 0.99
R5028:Gm4787 UTSW 12 81,377,830 (GRCm38) missense probably benign 0.01
R5029:Gm4787 UTSW 12 81,377,830 (GRCm38) missense probably benign 0.01
R5031:Gm4787 UTSW 12 81,377,830 (GRCm38) missense probably benign 0.01
R5098:Gm4787 UTSW 12 81,377,830 (GRCm38) missense probably benign 0.01
R5099:Gm4787 UTSW 12 81,377,830 (GRCm38) missense probably benign 0.01
R5100:Gm4787 UTSW 12 81,377,830 (GRCm38) missense probably benign 0.01
R5101:Gm4787 UTSW 12 81,377,830 (GRCm38) missense probably benign 0.01
R5135:Gm4787 UTSW 12 81,377,830 (GRCm38) missense probably benign 0.01
R5152:Gm4787 UTSW 12 81,378,677 (GRCm38) missense probably benign 0.02
R5180:Gm4787 UTSW 12 81,377,830 (GRCm38) missense probably benign 0.01
R5220:Gm4787 UTSW 12 81,377,830 (GRCm38) missense probably benign 0.01
R5257:Gm4787 UTSW 12 81,377,830 (GRCm38) missense probably benign 0.01
R5258:Gm4787 UTSW 12 81,377,830 (GRCm38) missense probably benign 0.01
R5297:Gm4787 UTSW 12 81,377,830 (GRCm38) missense probably benign 0.01
R5324:Gm4787 UTSW 12 81,377,830 (GRCm38) missense probably benign 0.01
R5325:Gm4787 UTSW 12 81,377,830 (GRCm38) missense probably benign 0.01
R5355:Gm4787 UTSW 12 81,377,465 (GRCm38) nonsense probably null
R5364:Gm4787 UTSW 12 81,377,830 (GRCm38) missense probably benign 0.01
R5396:Gm4787 UTSW 12 81,377,830 (GRCm38) missense probably benign 0.01
R5397:Gm4787 UTSW 12 81,377,830 (GRCm38) missense probably benign 0.01
R5398:Gm4787 UTSW 12 81,377,830 (GRCm38) missense probably benign 0.01
R5514:Gm4787 UTSW 12 81,378,328 (GRCm38) missense possibly damaging 0.90
R5634:Gm4787 UTSW 12 81,377,830 (GRCm38) missense probably benign 0.01
R5666:Gm4787 UTSW 12 81,378,031 (GRCm38) missense probably benign 0.23
R5670:Gm4787 UTSW 12 81,378,031 (GRCm38) missense probably benign 0.23
R5787:Gm4787 UTSW 12 81,377,830 (GRCm38) missense probably benign 0.01
R5788:Gm4787 UTSW 12 81,377,830 (GRCm38) missense probably benign 0.01
R6354:Gm4787 UTSW 12 81,377,981 (GRCm38) missense probably damaging 1.00
R7120:Gm4787 UTSW 12 81,378,486 (GRCm38) missense probably benign 0.00
R7237:Gm4787 UTSW 12 81,377,668 (GRCm38) missense probably damaging 0.99
R7937:Gm4787 UTSW 12 81,377,905 (GRCm38) missense probably benign 0.01
R8022:Gm4787 UTSW 12 81,377,720 (GRCm38) missense possibly damaging 0.94
R8140:Gm4787 UTSW 12 81,378,151 (GRCm38) missense probably benign 0.00
R8314:Gm4787 UTSW 12 81,379,135 (GRCm38) missense probably damaging 1.00
R8480:Gm4787 UTSW 12 81,377,506 (GRCm38) missense probably damaging 1.00
R8498:Gm4787 UTSW 12 81,379,066 (GRCm38) missense probably damaging 1.00
R8515:Gm4787 UTSW 12 81,377,269 (GRCm38) missense probably benign 0.00
R9103:Gm4787 UTSW 12 81,378,715 (GRCm38) missense probably benign 0.06
R9457:Gm4787 UTSW 12 81,379,246 (GRCm38) missense probably damaging 1.00
R9557:Gm4787 UTSW 12 81,379,300 (GRCm38) nonsense probably null
R9608:Gm4787 UTSW 12 81,378,312 (GRCm38) missense probably benign 0.03
V7580:Gm4787 UTSW 12 81,377,567 (GRCm38) nonsense probably null
V7581:Gm4787 UTSW 12 81,377,567 (GRCm38) nonsense probably null
V7582:Gm4787 UTSW 12 81,377,567 (GRCm38) nonsense probably null
Predicted Primers PCR Primer
(F):5'- ATCATGCCTTTCAGACCTCCAG -3'
(R):5'- GACCACCTACCTGGACTTTG -3'

Sequencing Primer
(F):5'- ACTCCTTCCAGGTAGCTGTAGAAG -3'
(R):5'- ACTTTGGCCCTCCTGAGAG -3'
Posted On 2018-11-06