Incidental Mutation 'R6934:Or8b1c'
ID 540208
Institutional Source Beutler Lab
Gene Symbol Or8b1c
Ensembl Gene ENSMUSG00000096794
Gene Name olfactory receptor family 8 subfamily B member 1C
Synonyms GA_x6K02T2PVTD-32165709-32166641, Olfr905, MOR167-1
MMRRC Submission 045049-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.063) question?
Stock # R6934 (G1)
Quality Score 225.009
Status Not validated
Chromosome 9
Chromosomal Location 38384045-38384977 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to G at 38384472 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Isoleucine to Serine at position 143 (I143S)
Ref Sequence ENSEMBL: ENSMUSP00000150357 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000051111] [ENSMUST00000214377] [ENSMUST00000216724]
AlphaFold L7N1X5
Predicted Effect probably benign
Transcript: ENSMUST00000051111
AA Change: I143S

PolyPhen 2 Score 0.000 (Sensitivity: 1.00; Specificity: 0.00)
SMART Domains Protein: ENSMUSP00000057998
Gene: ENSMUSG00000096794
AA Change: I143S

DomainStartEndE-ValueType
Pfam:7tm_4 31 308 1.9e-50 PFAM
Pfam:7tm_1 41 298 4e-22 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000214377
AA Change: I143S

PolyPhen 2 Score 0.000 (Sensitivity: 1.00; Specificity: 0.00)
Predicted Effect probably benign
Transcript: ENSMUST00000216724
Coding Region Coverage
  • 1x: 100.0%
  • 3x: 99.9%
  • 10x: 99.3%
  • 20x: 97.9%
Validation Efficiency
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 43 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
1700018B08Rik T A 8: 122,266,712 (GRCm39) Y58F probably benign Het
Asap2 T C 12: 21,218,251 (GRCm39) V58A probably damaging Het
Bccip A G 7: 133,322,520 (GRCm39) M289V probably benign Het
Bhmt2 A T 13: 93,798,819 (GRCm39) I334N probably benign Het
Copa T A 1: 171,938,253 (GRCm39) I513N possibly damaging Het
Cspg4b T C 13: 113,505,800 (GRCm39) S2310P probably benign Het
Ctif G A 18: 75,568,431 (GRCm39) T569M probably benign Het
Dennd1a A T 2: 37,691,225 (GRCm39) M231K possibly damaging Het
Dnah3 A G 7: 119,653,824 (GRCm39) probably null Het
Fat3 T C 9: 16,288,252 (GRCm39) I424V probably damaging Het
Foxred2 G T 15: 77,836,530 (GRCm39) C328* probably null Het
Gemin5 A T 11: 58,038,738 (GRCm39) H590Q probably damaging Het
Gm5475 T C 15: 100,325,007 (GRCm39) probably benign Het
Gmip A G 8: 70,273,576 (GRCm39) T956A probably benign Het
Hmbox1 A T 14: 65,134,281 (GRCm39) D106E probably benign Het
Irs2 A T 8: 11,054,697 (GRCm39) I1245N probably damaging Het
Kcnk1 A G 8: 126,752,129 (GRCm39) Y245C probably damaging Het
Krtap4-9 A T 11: 99,676,708 (GRCm39) R210* probably null Het
Lama1 A G 17: 68,081,538 (GRCm39) D1325G probably benign Het
Lyz3 C T 10: 117,074,413 (GRCm39) D25N probably benign Het
Mep1a A T 17: 43,793,121 (GRCm39) V361E probably damaging Het
Mrgprx2 A G 7: 48,131,813 (GRCm39) I92T possibly damaging Het
Nup214 A T 2: 31,872,683 (GRCm39) R242* probably null Het
Nynrin T G 14: 56,101,335 (GRCm39) S335A probably benign Het
Or13a24 T G 7: 140,154,564 (GRCm39) L166R probably damaging Het
Or5p60 A G 7: 107,724,026 (GRCm39) V148A probably benign Het
Orc2 T C 1: 58,539,523 (GRCm39) K39E probably benign Het
Ppl C T 16: 4,912,373 (GRCm39) G736D probably benign Het
Ppp2r1a A G 17: 21,181,895 (GRCm39) E471G possibly damaging Het
Prrc2c G A 1: 162,548,074 (GRCm39) P161S probably benign Het
Rnf213 A G 11: 119,310,893 (GRCm39) I804V probably benign Het
Saal1 A G 7: 46,352,088 (GRCm39) C144R probably benign Het
Slc29a4 G A 5: 142,698,713 (GRCm39) V125I probably benign Het
Smarcc2 A G 10: 128,305,541 (GRCm39) T322A probably benign Het
Srgap2 A T 1: 131,244,969 (GRCm39) M591K possibly damaging Het
Stard9 A G 2: 120,528,176 (GRCm39) I1478V probably benign Het
Tet2 A G 3: 133,188,998 (GRCm39) probably null Het
Tmem150c C T 5: 100,243,465 (GRCm39) probably null Het
Tmem39b T A 4: 129,572,366 (GRCm39) H412L possibly damaging Het
Tox A C 4: 6,697,635 (GRCm39) H389Q probably damaging Het
Trank1 T C 9: 111,202,158 (GRCm39) I1595T probably damaging Het
Vmn2r-ps117 T G 17: 19,044,967 (GRCm39) Y461* probably null Het
Vps13a T C 19: 16,653,558 (GRCm39) H1941R probably damaging Het
Other mutations in Or8b1c
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01143:Or8b1c APN 9 38,384,338 (GRCm39) missense possibly damaging 0.52
IGL03168:Or8b1c APN 9 38,384,315 (GRCm39) missense probably benign
R0003:Or8b1c UTSW 9 38,384,612 (GRCm39) missense probably benign 0.24
R0062:Or8b1c UTSW 9 38,384,554 (GRCm39) missense probably benign 0.03
R0625:Or8b1c UTSW 9 38,384,504 (GRCm39) missense possibly damaging 0.90
R0744:Or8b1c UTSW 9 38,384,081 (GRCm39) missense probably benign 0.04
R0836:Or8b1c UTSW 9 38,384,081 (GRCm39) missense probably benign 0.04
R2085:Or8b1c UTSW 9 38,384,223 (GRCm39) missense probably damaging 1.00
R2898:Or8b1c UTSW 9 38,384,271 (GRCm39) missense probably damaging 0.99
R4462:Or8b1c UTSW 9 38,384,360 (GRCm39) missense probably benign 0.32
R4655:Or8b1c UTSW 9 38,384,120 (GRCm39) missense probably damaging 0.99
R5209:Or8b1c UTSW 9 38,384,817 (GRCm39) missense possibly damaging 0.52
R5759:Or8b1c UTSW 9 38,384,831 (GRCm39) missense possibly damaging 0.73
R6453:Or8b1c UTSW 9 38,384,871 (GRCm39) missense probably benign 0.18
R6501:Or8b1c UTSW 9 38,384,585 (GRCm39) missense possibly damaging 0.88
R6999:Or8b1c UTSW 9 38,384,535 (GRCm39) missense probably damaging 1.00
R7295:Or8b1c UTSW 9 38,384,739 (GRCm39) missense probably benign 0.07
R7677:Or8b1c UTSW 9 38,384,831 (GRCm39) missense possibly damaging 0.73
R7708:Or8b1c UTSW 9 38,384,681 (GRCm39) missense probably damaging 1.00
R7843:Or8b1c UTSW 9 38,384,243 (GRCm39) missense probably damaging 0.99
R8947:Or8b1c UTSW 9 38,384,685 (GRCm39) missense probably damaging 1.00
R8998:Or8b1c UTSW 9 38,384,787 (GRCm39) missense probably benign 0.08
R9215:Or8b1c UTSW 9 38,384,694 (GRCm39) missense probably damaging 1.00
R9607:Or8b1c UTSW 9 38,384,913 (GRCm39) missense probably damaging 1.00
X0053:Or8b1c UTSW 9 38,384,472 (GRCm39) missense probably benign
X0065:Or8b1c UTSW 9 38,384,302 (GRCm39) missense probably benign 0.09
Predicted Primers PCR Primer
(F):5'- TTTTCACACCCAAAATGCTGGAG -3'
(R):5'- ACAATGATGTTGATGCCCACAAC -3'

Sequencing Primer
(F):5'- CCCAAAATGCTGGAGAGCTTTATATC -3'
(R):5'- ACAACAAATACCTCCAGTTCATTG -3'
Posted On 2018-11-06