Incidental Mutation 'R6934:Trank1'
ID 540209
Institutional Source Beutler Lab
Gene Symbol Trank1
Ensembl Gene ENSMUSG00000062296
Gene Name tetratricopeptide repeat and ankyrin repeat containing 1
Synonyms A230061D21Rik, LOC235639, C030048J01Rik, Lba1
MMRRC Submission 045049-MU
Accession Numbers
Essential gene? Non essential (E-score: 0.000) question?
Stock # R6934 (G1)
Quality Score 225.009
Status Not validated
Chromosome 9
Chromosomal Location 111311739-111395775 bp(+) (GRCm38)
Type of Mutation missense
DNA Base Change (assembly) T to C at 111373090 bp (GRCm38)
Zygosity Heterozygous
Amino Acid Change Isoleucine to Threonine at position 1595 (I1595T)
Ref Sequence ENSEMBL: ENSMUSP00000077697 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000078626]
AlphaFold no structure available at present
Predicted Effect probably damaging
Transcript: ENSMUST00000078626
AA Change: I1595T

PolyPhen 2 Score 0.989 (Sensitivity: 0.72; Specificity: 0.97)
SMART Domains Protein: ENSMUSP00000077697
Gene: ENSMUSG00000062296
AA Change: I1595T

DomainStartEndE-ValueType
low complexity region 4 30 N/A INTRINSIC
low complexity region 34 52 N/A INTRINSIC
low complexity region 113 129 N/A INTRINSIC
Blast:TPR 144 177 1e-15 BLAST
Blast:TPR 178 209 8e-13 BLAST
Blast:ANK 332 361 1e-6 BLAST
ANK 369 405 5.29e0 SMART
ANK 538 567 2.11e2 SMART
ANK 572 609 7.29e2 SMART
ANK 621 652 1.21e2 SMART
low complexity region 887 895 N/A INTRINSIC
low complexity region 1152 1172 N/A INTRINSIC
Blast:AAA 1351 1569 1e-6 BLAST
low complexity region 2166 2177 N/A INTRINSIC
low complexity region 2395 2411 N/A INTRINSIC
low complexity region 2636 2649 N/A INTRINSIC
low complexity region 2966 2983 N/A INTRINSIC
Coding Region Coverage
  • 1x: 100.0%
  • 3x: 99.9%
  • 10x: 99.3%
  • 20x: 97.9%
Validation Efficiency
Allele List at MGI

All alleles(2) : Targeted, other(2)

Other mutations in this stock
Total: 43 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
1700018B08Rik T A 8: 121,539,973 (GRCm38) Y58F probably benign Het
9530003J23Rik C T 10: 117,238,508 (GRCm38) D25N probably benign Het
Asap2 T C 12: 21,168,250 (GRCm38) V58A probably damaging Het
BC067074 T C 13: 113,369,266 (GRCm38) S2310P probably benign Het
Bccip A G 7: 133,720,791 (GRCm38) M289V probably benign Het
Bhmt2 A T 13: 93,662,311 (GRCm38) I334N probably benign Het
Copa T A 1: 172,110,686 (GRCm38) I513N possibly damaging Het
Ctif G A 18: 75,435,360 (GRCm38) T569M probably benign Het
Dennd1a A T 2: 37,801,213 (GRCm38) M231K possibly damaging Het
Dnah3 A G 7: 120,054,601 (GRCm38) probably null Het
Fat3 T C 9: 16,376,956 (GRCm38) I424V probably damaging Het
Foxred2 G T 15: 77,952,330 (GRCm38) C328* probably null Het
Gemin5 A T 11: 58,147,912 (GRCm38) H590Q probably damaging Het
Gm5475 T C 15: 100,427,126 (GRCm38) probably benign Het
Gmip A G 8: 69,820,926 (GRCm38) T956A probably benign Het
Hmbox1 A T 14: 64,896,832 (GRCm38) D106E probably benign Het
Irs2 A T 8: 11,004,697 (GRCm38) I1245N probably damaging Het
Kcnk1 A G 8: 126,025,390 (GRCm38) Y245C probably damaging Het
Krtap4-9 A T 11: 99,785,882 (GRCm38) R210* probably null Het
Lama1 A G 17: 67,774,543 (GRCm38) D1325G probably benign Het
Mep1a A T 17: 43,482,230 (GRCm38) V361E probably damaging Het
Mrgprx2 A G 7: 48,482,065 (GRCm38) I92T possibly damaging Het
Nup214 A T 2: 31,982,671 (GRCm38) R242* probably null Het
Nynrin T G 14: 55,863,878 (GRCm38) S335A probably benign Het
Olfr484 A G 7: 108,124,819 (GRCm38) V148A probably benign Het
Olfr538 T G 7: 140,574,651 (GRCm38) L166R probably damaging Het
Olfr905 T G 9: 38,473,176 (GRCm38) I143S probably benign Het
Orc2 T C 1: 58,500,364 (GRCm38) K39E probably benign Het
Ppl C T 16: 5,094,509 (GRCm38) G736D probably benign Het
Ppp2r1a A G 17: 20,961,633 (GRCm38) E471G possibly damaging Het
Prrc2c G A 1: 162,720,505 (GRCm38) P161S probably benign Het
Rnf213 A G 11: 119,420,067 (GRCm38) I804V probably benign Het
Saal1 A G 7: 46,702,664 (GRCm38) C144R probably benign Het
Slc29a4 G A 5: 142,712,958 (GRCm38) V125I probably benign Het
Smarcc2 A G 10: 128,469,672 (GRCm38) T322A probably benign Het
Srgap2 A T 1: 131,317,231 (GRCm38) M591K possibly damaging Het
Stard9 A G 2: 120,697,695 (GRCm38) I1478V probably benign Het
Tet2 A G 3: 133,483,237 (GRCm38) probably null Het
Tmem150c C T 5: 100,095,606 (GRCm38) probably null Het
Tmem39b T A 4: 129,678,573 (GRCm38) H412L possibly damaging Het
Tox A C 4: 6,697,635 (GRCm38) H389Q probably damaging Het
Vmn2r-ps117 T G 17: 18,824,705 (GRCm38) Y461* probably null Het
Vps13a T C 19: 16,676,194 (GRCm38) H1941R probably damaging Het
Other mutations in Trank1
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00234:Trank1 APN 9 111,392,609 (GRCm38) missense probably damaging 1.00
IGL00467:Trank1 APN 9 111,364,666 (GRCm38) splice site probably benign
IGL00569:Trank1 APN 9 111,345,511 (GRCm38) missense possibly damaging 0.69
IGL00585:Trank1 APN 9 111,349,290 (GRCm38) missense possibly damaging 0.82
IGL01070:Trank1 APN 9 111,366,793 (GRCm38) missense probably damaging 1.00
IGL01134:Trank1 APN 9 111,391,781 (GRCm38) missense probably benign
IGL01154:Trank1 APN 9 111,386,400 (GRCm38) missense probably benign 0.00
IGL01355:Trank1 APN 9 111,365,520 (GRCm38) missense possibly damaging 0.94
IGL01407:Trank1 APN 9 111,364,722 (GRCm38) missense probably damaging 0.99
IGL01410:Trank1 APN 9 111,365,049 (GRCm38) missense probably benign 0.00
IGL01410:Trank1 APN 9 111,365,259 (GRCm38) missense probably benign 0.00
IGL01504:Trank1 APN 9 111,373,544 (GRCm38) missense probably damaging 1.00
IGL01744:Trank1 APN 9 111,349,363 (GRCm38) missense probably damaging 1.00
IGL02043:Trank1 APN 9 111,363,960 (GRCm38) missense probably damaging 0.98
IGL02104:Trank1 APN 9 111,390,712 (GRCm38) missense possibly damaging 0.85
IGL02193:Trank1 APN 9 111,367,276 (GRCm38) missense probably benign 0.43
IGL02581:Trank1 APN 9 111,383,125 (GRCm38) missense probably benign 0.00
IGL02630:Trank1 APN 9 111,373,075 (GRCm38) missense possibly damaging 0.70
IGL02839:Trank1 APN 9 111,364,756 (GRCm38) missense probably damaging 1.00
IGL02897:Trank1 APN 9 111,367,517 (GRCm38) missense probably damaging 0.99
IGL03065:Trank1 APN 9 111,390,293 (GRCm38) missense possibly damaging 0.64
IGL03123:Trank1 APN 9 111,367,407 (GRCm38) missense probably damaging 1.00
IGL03143:Trank1 APN 9 111,366,087 (GRCm38) missense probably damaging 1.00
IGL03323:Trank1 APN 9 111,352,116 (GRCm38) missense probably damaging 1.00
1mM(1):Trank1 UTSW 9 111,392,981 (GRCm38) missense probably damaging 1.00
PIT4486001:Trank1 UTSW 9 111,390,107 (GRCm38) missense probably damaging 1.00
PIT4812001:Trank1 UTSW 9 111,347,912 (GRCm38) missense probably damaging 1.00
R0035:Trank1 UTSW 9 111,366,776 (GRCm38) missense probably benign 0.00
R0064:Trank1 UTSW 9 111,343,195 (GRCm38) missense probably damaging 1.00
R0064:Trank1 UTSW 9 111,343,195 (GRCm38) missense probably damaging 1.00
R0089:Trank1 UTSW 9 111,392,910 (GRCm38) missense probably benign 0.00
R0207:Trank1 UTSW 9 111,366,253 (GRCm38) missense probably damaging 1.00
R0255:Trank1 UTSW 9 111,366,024 (GRCm38) missense possibly damaging 0.92
R0334:Trank1 UTSW 9 111,392,940 (GRCm38) missense probably damaging 1.00
R0334:Trank1 UTSW 9 111,365,353 (GRCm38) missense probably benign 0.00
R0383:Trank1 UTSW 9 111,391,477 (GRCm38) missense probably benign 0.08
R0421:Trank1 UTSW 9 111,391,839 (GRCm38) missense probably damaging 1.00
R0494:Trank1 UTSW 9 111,391,293 (GRCm38) missense probably benign 0.19
R0518:Trank1 UTSW 9 111,333,808 (GRCm38) missense probably damaging 1.00
R0560:Trank1 UTSW 9 111,391,086 (GRCm38) missense possibly damaging 0.88
R0637:Trank1 UTSW 9 111,390,441 (GRCm38) missense probably damaging 1.00
R0731:Trank1 UTSW 9 111,365,488 (GRCm38) missense probably damaging 1.00
R0761:Trank1 UTSW 9 111,366,613 (GRCm38) missense probably damaging 1.00
R0766:Trank1 UTSW 9 111,347,469 (GRCm38) missense probably benign 0.45
R0827:Trank1 UTSW 9 111,349,417 (GRCm38) unclassified probably benign
R1005:Trank1 UTSW 9 111,333,721 (GRCm38) missense probably benign 0.13
R1108:Trank1 UTSW 9 111,365,307 (GRCm38) missense probably benign 0.00
R1155:Trank1 UTSW 9 111,366,970 (GRCm38) missense possibly damaging 0.95
R1470:Trank1 UTSW 9 111,343,232 (GRCm38) missense possibly damaging 0.91
R1470:Trank1 UTSW 9 111,343,232 (GRCm38) missense possibly damaging 0.91
R1596:Trank1 UTSW 9 111,366,290 (GRCm38) missense possibly damaging 0.93
R1601:Trank1 UTSW 9 111,373,477 (GRCm38) missense probably damaging 1.00
R1751:Trank1 UTSW 9 111,391,479 (GRCm38) missense probably benign
R1754:Trank1 UTSW 9 111,392,871 (GRCm38) missense probably benign 0.00
R1767:Trank1 UTSW 9 111,391,479 (GRCm38) missense probably benign
R1768:Trank1 UTSW 9 111,392,927 (GRCm38) missense probably damaging 0.96
R1809:Trank1 UTSW 9 111,392,825 (GRCm38) missense probably benign 0.34
R1912:Trank1 UTSW 9 111,390,709 (GRCm38) missense probably benign 0.00
R1920:Trank1 UTSW 9 111,347,928 (GRCm38) critical splice donor site probably null
R1960:Trank1 UTSW 9 111,391,628 (GRCm38) missense probably damaging 1.00
R1993:Trank1 UTSW 9 111,378,832 (GRCm38) missense probably benign 0.20
R2012:Trank1 UTSW 9 111,365,028 (GRCm38) missense probably benign
R2025:Trank1 UTSW 9 111,392,039 (GRCm38) missense probably benign 0.01
R2050:Trank1 UTSW 9 111,364,788 (GRCm38) missense probably damaging 1.00
R2857:Trank1 UTSW 9 111,366,933 (GRCm38) missense probably benign 0.00
R2912:Trank1 UTSW 9 111,392,483 (GRCm38) missense probably damaging 0.98
R2962:Trank1 UTSW 9 111,352,080 (GRCm38) missense probably damaging 1.00
R3030:Trank1 UTSW 9 111,391,530 (GRCm38) missense possibly damaging 0.63
R3821:Trank1 UTSW 9 111,378,819 (GRCm38) missense probably damaging 1.00
R3822:Trank1 UTSW 9 111,378,819 (GRCm38) missense probably damaging 1.00
R3892:Trank1 UTSW 9 111,364,759 (GRCm38) missense probably benign 0.03
R4105:Trank1 UTSW 9 111,352,197 (GRCm38) missense probably damaging 1.00
R4166:Trank1 UTSW 9 111,373,524 (GRCm38) nonsense probably null
R4237:Trank1 UTSW 9 111,367,035 (GRCm38) missense probably benign 0.04
R4239:Trank1 UTSW 9 111,367,035 (GRCm38) missense probably benign 0.04
R4394:Trank1 UTSW 9 111,365,197 (GRCm38) missense possibly damaging 0.86
R4417:Trank1 UTSW 9 111,365,968 (GRCm38) missense probably benign 0.17
R4611:Trank1 UTSW 9 111,362,261 (GRCm38) missense probably damaging 1.00
R4694:Trank1 UTSW 9 111,392,061 (GRCm38) missense probably benign 0.40
R4731:Trank1 UTSW 9 111,390,410 (GRCm38) missense probably damaging 1.00
R4843:Trank1 UTSW 9 111,366,078 (GRCm38) missense probably benign 0.00
R4852:Trank1 UTSW 9 111,391,895 (GRCm38) missense possibly damaging 0.68
R4859:Trank1 UTSW 9 111,365,010 (GRCm38) missense probably benign 0.17
R4868:Trank1 UTSW 9 111,365,641 (GRCm38) missense probably damaging 1.00
R5080:Trank1 UTSW 9 111,389,221 (GRCm38) missense probably damaging 0.99
R5156:Trank1 UTSW 9 111,390,694 (GRCm38) missense probably damaging 1.00
R5174:Trank1 UTSW 9 111,365,559 (GRCm38) missense probably benign 0.00
R5234:Trank1 UTSW 9 111,386,467 (GRCm38) missense probably damaging 1.00
R5386:Trank1 UTSW 9 111,362,402 (GRCm38) missense probably benign 0.12
R5419:Trank1 UTSW 9 111,391,301 (GRCm38) missense probably damaging 1.00
R5435:Trank1 UTSW 9 111,391,890 (GRCm38) missense probably benign 0.00
R5444:Trank1 UTSW 9 111,392,958 (GRCm38) missense probably benign 0.04
R5543:Trank1 UTSW 9 111,366,112 (GRCm38) missense probably damaging 0.97
R5560:Trank1 UTSW 9 111,390,567 (GRCm38) missense probably damaging 1.00
R5772:Trank1 UTSW 9 111,366,676 (GRCm38) missense possibly damaging 0.86
R5774:Trank1 UTSW 9 111,391,226 (GRCm38) missense probably damaging 1.00
R5843:Trank1 UTSW 9 111,365,860 (GRCm38) missense possibly damaging 0.59
R5858:Trank1 UTSW 9 111,392,536 (GRCm38) missense probably benign
R5878:Trank1 UTSW 9 111,366,685 (GRCm38) missense possibly damaging 0.93
R5900:Trank1 UTSW 9 111,391,716 (GRCm38) missense probably damaging 1.00
R5917:Trank1 UTSW 9 111,362,417 (GRCm38) missense probably benign 0.38
R5954:Trank1 UTSW 9 111,365,133 (GRCm38) missense probably benign 0.13
R6041:Trank1 UTSW 9 111,377,796 (GRCm38) missense possibly damaging 0.94
R6112:Trank1 UTSW 9 111,391,737 (GRCm38) missense probably damaging 1.00
R6165:Trank1 UTSW 9 111,391,872 (GRCm38) missense probably benign 0.00
R6255:Trank1 UTSW 9 111,352,246 (GRCm38) critical splice donor site probably null
R6395:Trank1 UTSW 9 111,367,200 (GRCm38) missense probably damaging 1.00
R6567:Trank1 UTSW 9 111,347,521 (GRCm38) missense probably benign 0.02
R6644:Trank1 UTSW 9 111,364,834 (GRCm38) missense possibly damaging 0.85
R6724:Trank1 UTSW 9 111,365,916 (GRCm38) missense probably damaging 1.00
R6788:Trank1 UTSW 9 111,390,679 (GRCm38) missense probably damaging 1.00
R6831:Trank1 UTSW 9 111,377,899 (GRCm38) missense probably benign 0.00
R7127:Trank1 UTSW 9 111,365,796 (GRCm38) missense possibly damaging 0.85
R7206:Trank1 UTSW 9 111,345,515 (GRCm38) critical splice donor site probably null
R7236:Trank1 UTSW 9 111,373,074 (GRCm38) missense possibly damaging 0.93
R7247:Trank1 UTSW 9 111,367,512 (GRCm38) missense probably damaging 1.00
R7292:Trank1 UTSW 9 111,377,870 (GRCm38) missense probably benign 0.02
R7310:Trank1 UTSW 9 111,367,126 (GRCm38) missense probably damaging 1.00
R7431:Trank1 UTSW 9 111,362,402 (GRCm38) missense probably benign 0.12
R7448:Trank1 UTSW 9 111,366,349 (GRCm38) missense probably benign 0.01
R7477:Trank1 UTSW 9 111,364,957 (GRCm38) missense probably benign 0.00
R7514:Trank1 UTSW 9 111,364,756 (GRCm38) missense probably damaging 1.00
R7595:Trank1 UTSW 9 111,365,991 (GRCm38) missense probably damaging 1.00
R7637:Trank1 UTSW 9 111,365,296 (GRCm38) missense possibly damaging 0.71
R7648:Trank1 UTSW 9 111,391,685 (GRCm38) missense probably benign
R7737:Trank1 UTSW 9 111,366,012 (GRCm38) nonsense probably null
R7784:Trank1 UTSW 9 111,364,103 (GRCm38) missense probably damaging 1.00
R7884:Trank1 UTSW 9 111,392,516 (GRCm38) missense probably benign
R7912:Trank1 UTSW 9 111,391,528 (GRCm38) missense probably benign 0.04
R7938:Trank1 UTSW 9 111,365,028 (GRCm38) missense probably benign
R7979:Trank1 UTSW 9 111,377,899 (GRCm38) missense probably benign 0.00
R8064:Trank1 UTSW 9 111,352,076 (GRCm38) nonsense probably null
R8100:Trank1 UTSW 9 111,392,793 (GRCm38) missense probably damaging 1.00
R8124:Trank1 UTSW 9 111,378,927 (GRCm38) missense probably benign 0.31
R8198:Trank1 UTSW 9 111,390,812 (GRCm38) missense probably benign 0.09
R8219:Trank1 UTSW 9 111,364,909 (GRCm38) missense probably damaging 1.00
R8223:Trank1 UTSW 9 111,365,889 (GRCm38) missense probably damaging 1.00
R8316:Trank1 UTSW 9 111,349,302 (GRCm38) missense probably benign 0.38
R8347:Trank1 UTSW 9 111,367,249 (GRCm38) missense probably damaging 1.00
R8436:Trank1 UTSW 9 111,391,382 (GRCm38) missense possibly damaging 0.86
R8489:Trank1 UTSW 9 111,390,275 (GRCm38) missense probably benign 0.01
R8682:Trank1 UTSW 9 111,365,344 (GRCm38) missense probably benign 0.01
R8768:Trank1 UTSW 9 111,389,276 (GRCm38) missense probably benign 0.00
R8770:Trank1 UTSW 9 111,390,824 (GRCm38) missense probably benign 0.00
R8829:Trank1 UTSW 9 111,347,523 (GRCm38) missense probably benign
R8838:Trank1 UTSW 9 111,364,905 (GRCm38) missense probably benign 0.03
R8855:Trank1 UTSW 9 111,312,221 (GRCm38) missense unknown
R8929:Trank1 UTSW 9 111,378,935 (GRCm38) missense possibly damaging 0.93
R9047:Trank1 UTSW 9 111,362,432 (GRCm38) missense probably damaging 0.99
R9090:Trank1 UTSW 9 111,345,479 (GRCm38) missense probably damaging 1.00
R9114:Trank1 UTSW 9 111,333,775 (GRCm38) missense probably damaging 1.00
R9133:Trank1 UTSW 9 111,391,702 (GRCm38) missense possibly damaging 0.93
R9177:Trank1 UTSW 9 111,392,511 (GRCm38) missense probably benign 0.00
R9178:Trank1 UTSW 9 111,367,200 (GRCm38) missense probably damaging 1.00
R9271:Trank1 UTSW 9 111,345,479 (GRCm38) missense probably damaging 1.00
R9314:Trank1 UTSW 9 111,365,981 (GRCm38) missense probably damaging 1.00
R9373:Trank1 UTSW 9 111,365,191 (GRCm38) missense probably benign 0.25
R9380:Trank1 UTSW 9 111,392,670 (GRCm38) missense probably benign 0.07
R9435:Trank1 UTSW 9 111,364,822 (GRCm38) missense probably benign 0.04
R9501:Trank1 UTSW 9 111,347,875 (GRCm38) missense probably benign 0.00
R9593:Trank1 UTSW 9 111,362,297 (GRCm38) missense probably benign 0.30
R9601:Trank1 UTSW 9 111,373,125 (GRCm38) missense probably benign 0.18
R9729:Trank1 UTSW 9 111,391,469 (GRCm38) missense probably damaging 1.00
X0064:Trank1 UTSW 9 111,343,236 (GRCm38) missense possibly damaging 0.57
Z1088:Trank1 UTSW 9 111,364,710 (GRCm38) missense probably damaging 0.99
Z1177:Trank1 UTSW 9 111,392,870 (GRCm38) missense possibly damaging 0.47
Z1177:Trank1 UTSW 9 111,367,377 (GRCm38) missense possibly damaging 0.83
Z1177:Trank1 UTSW 9 111,311,902 (GRCm38) missense unknown
Predicted Primers PCR Primer
(F):5'- TGCTGTGCAGTATCTGACAGG -3'
(R):5'- CCAGGATTGACTTGGTCATCTCG -3'

Sequencing Primer
(F):5'- GCAGTATCTGACAGGTGCTTTC -3'
(R):5'- GAGATAGTCAATGGCCTCTCTCAAG -3'
Posted On 2018-11-06