Incidental Mutation 'R6935:Dhx58'
ID 540264
Institutional Source Beutler Lab
Gene Symbol Dhx58
Ensembl Gene ENSMUSG00000017830
Gene Name DExH-box helicase 58
Synonyms D11Lgp2e, B430001I08Rik, LPG2
MMRRC Submission 045008-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.201) question?
Stock # R6935 (G1)
Quality Score 225.009
Status Validated
Chromosome 11
Chromosomal Location 100585710-100595097 bp(-) (GRCm39)
Type of Mutation splice site (3 bp from exon)
DNA Base Change (assembly) T to A at 100589232 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change
Ref Sequence ENSEMBL: ENSMUSP00000017974 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000017974]
AlphaFold Q99J87
Predicted Effect probably null
Transcript: ENSMUST00000017974
SMART Domains Protein: ENSMUSP00000017974
Gene: ENSMUSG00000017830

DomainStartEndE-ValueType
DEXDc 2 207 2.86e-22 SMART
HELICc 387 475 3.85e-14 SMART
Blast:HELICc 497 543 4e-12 BLAST
Pfam:RIG-I_C-RD 552 667 1.5e-37 PFAM
Meta Mutation Damage Score 0.9755 question?
Coding Region Coverage
  • 1x: 100.0%
  • 3x: 99.9%
  • 10x: 99.1%
  • 20x: 97.2%
Validation Efficiency 98% (41/42)
MGI Phenotype PHENOTYPE: Mice homozygous for a knock-out allele exhibit increased susceptibility to EMCV infection and decreased susceptibility to VSV infection. Mice homozygous for a different knock-out allele exhibit increased susceptibility to WNV infection. [provided by MGI curators]
Allele List at MGI
Other mutations in this stock
Total: 44 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
4930596D02Rik T A 14: 35,533,864 (GRCm39) H14L probably benign Het
Adar A G 3: 89,654,525 (GRCm39) N368D probably benign Het
Adcy10 T C 1: 165,334,204 (GRCm39) V71A probably benign Het
Ank1 C T 8: 23,598,247 (GRCm39) T755I probably damaging Het
Aoc1 A T 6: 48,885,161 (GRCm39) Y632F probably damaging Het
Bbc3 A G 7: 16,046,124 (GRCm39) D20G possibly damaging Het
Bche T G 3: 73,609,133 (GRCm39) I98L probably benign Het
Cfap97d2 CA CAA 8: 13,784,865 (GRCm39) probably null Het
Col12a1 A G 9: 79,607,782 (GRCm39) Y349H possibly damaging Het
Crip2 T C 12: 113,104,213 (GRCm39) C8R probably damaging Het
Dnah2 G A 11: 69,312,567 (GRCm39) R4333C probably damaging Het
Dnajb12 T C 10: 59,732,325 (GRCm39) probably null Het
Dzank1 T C 2: 144,318,014 (GRCm39) E718G possibly damaging Het
Erfl C A 7: 24,627,986 (GRCm39) G181V possibly damaging Het
Fbxo28 C T 1: 182,169,025 (GRCm39) G38R unknown Het
Foxb2 A G 19: 16,849,983 (GRCm39) F341S probably benign Het
Gabrb3 T A 7: 57,241,561 (GRCm39) I29N probably damaging Het
Gm7298 G A 6: 121,744,653 (GRCm39) R557H probably benign Het
Itih3 T A 14: 30,634,659 (GRCm39) Q116L possibly damaging Het
Lingo1 T C 9: 56,527,149 (GRCm39) Y480C probably damaging Het
Lypd3 G C 7: 24,337,858 (GRCm39) G75R probably damaging Het
Mbd5 A G 2: 49,169,824 (GRCm39) Y113C probably damaging Het
Mcm3ap C T 10: 76,340,087 (GRCm39) P1453S possibly damaging Het
Mdn1 T G 4: 32,774,041 (GRCm39) F5551V possibly damaging Het
Myo16 T A 8: 10,619,820 (GRCm39) M1457K probably benign Het
Nbeal2 T A 9: 110,468,459 (GRCm39) E372V probably damaging Het
Ncam2 T A 16: 81,323,879 (GRCm39) S508T probably benign Het
Nebl A T 2: 17,353,637 (GRCm39) D971E probably damaging Het
Nlrp10 A T 7: 108,526,107 (GRCm39) M77K probably damaging Het
Nynrin T G 14: 56,101,335 (GRCm39) S335A probably benign Het
Or2y1d A G 11: 49,321,825 (GRCm39) N174S probably damaging Het
Or52ad1 A T 7: 102,996,002 (GRCm39) N44K probably damaging Het
Or8c18 G T 9: 38,203,413 (GRCm39) M57I probably benign Het
Pidd1 A T 7: 141,020,215 (GRCm39) D570E probably damaging Het
Ppfia3 T C 7: 45,001,631 (GRCm39) D427G possibly damaging Het
Prex1 T C 2: 166,441,575 (GRCm39) Y364C probably damaging Het
Prlr A G 15: 10,319,388 (GRCm39) S142G probably damaging Het
Rack1 T C 11: 48,694,322 (GRCm39) V174A probably damaging Het
Rhbdl3 C T 11: 80,228,322 (GRCm39) A264V probably damaging Het
Sh3bp5 T A 14: 31,101,473 (GRCm39) M170L probably damaging Het
Skint5 A T 4: 113,799,793 (GRCm39) F125L possibly damaging Het
Slc6a4 T C 11: 76,917,994 (GRCm39) Y579H probably benign Het
Tmem106b A T 6: 13,081,554 (GRCm39) T154S possibly damaging Het
Xrcc5 A G 1: 72,382,189 (GRCm39) D455G possibly damaging Het
Other mutations in Dhx58
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01395:Dhx58 APN 11 100,594,752 (GRCm39) missense probably damaging 0.97
IGL02476:Dhx58 APN 11 100,593,090 (GRCm39) missense probably benign 0.00
R0103:Dhx58 UTSW 11 100,586,096 (GRCm39) missense probably damaging 1.00
R0103:Dhx58 UTSW 11 100,586,096 (GRCm39) missense probably damaging 1.00
R0137:Dhx58 UTSW 11 100,587,823 (GRCm39) missense probably damaging 0.99
R0164:Dhx58 UTSW 11 100,586,150 (GRCm39) missense probably benign 0.42
R0164:Dhx58 UTSW 11 100,586,150 (GRCm39) missense probably benign 0.42
R0369:Dhx58 UTSW 11 100,592,374 (GRCm39) critical splice donor site probably null
R0390:Dhx58 UTSW 11 100,590,090 (GRCm39) missense probably damaging 1.00
R0606:Dhx58 UTSW 11 100,593,077 (GRCm39) missense probably benign 0.00
R1710:Dhx58 UTSW 11 100,594,400 (GRCm39) missense probably benign 0.20
R1816:Dhx58 UTSW 11 100,593,978 (GRCm39) missense probably damaging 0.98
R1993:Dhx58 UTSW 11 100,594,316 (GRCm39) splice site probably null
R2281:Dhx58 UTSW 11 100,588,980 (GRCm39) critical splice donor site probably null
R3176:Dhx58 UTSW 11 100,587,805 (GRCm39) missense probably damaging 1.00
R3276:Dhx58 UTSW 11 100,587,805 (GRCm39) missense probably damaging 1.00
R4651:Dhx58 UTSW 11 100,592,185 (GRCm39) missense probably damaging 1.00
R4652:Dhx58 UTSW 11 100,592,185 (GRCm39) missense probably damaging 1.00
R4716:Dhx58 UTSW 11 100,587,797 (GRCm39) splice site probably null
R5030:Dhx58 UTSW 11 100,586,963 (GRCm39) missense probably damaging 1.00
R5082:Dhx58 UTSW 11 100,587,802 (GRCm39) missense probably benign 0.29
R5098:Dhx58 UTSW 11 100,585,999 (GRCm39) missense probably benign
R5394:Dhx58 UTSW 11 100,589,034 (GRCm39) missense probably benign 0.00
R5397:Dhx58 UTSW 11 100,594,746 (GRCm39) missense probably damaging 1.00
R5787:Dhx58 UTSW 11 100,592,145 (GRCm39) missense possibly damaging 0.91
R5975:Dhx58 UTSW 11 100,593,035 (GRCm39) missense probably damaging 0.98
R6310:Dhx58 UTSW 11 100,590,193 (GRCm39) missense probably benign 0.01
R7311:Dhx58 UTSW 11 100,588,997 (GRCm39) missense probably benign
R7908:Dhx58 UTSW 11 100,586,130 (GRCm39) missense probably damaging 0.99
R8317:Dhx58 UTSW 11 100,594,388 (GRCm39) missense probably damaging 1.00
R8821:Dhx58 UTSW 11 100,594,806 (GRCm39) missense probably damaging 1.00
R8831:Dhx58 UTSW 11 100,594,806 (GRCm39) missense probably damaging 1.00
R9717:Dhx58 UTSW 11 100,592,133 (GRCm39) missense probably benign 0.02
Predicted Primers PCR Primer
(F):5'- TTCTCCATCAGCACCTCCAGAG -3'
(R):5'- ACTCTGGGTTCCCGTAAACC -3'

Sequencing Primer
(F):5'- CCAGAGCCTCATTGGTTAGC -3'
(R):5'- TGGGTTCCCGTAAACCTTTTC -3'
Posted On 2018-11-06