Mutagenetix > Incidental Mutation

Incidental Mutation 'R6938:Nlrp1b'

540395

Institutional Source

Beutler Lab

Gene Symbol

Nlrp1b

Ensembl Gene

ENSMUSG00000070390

Gene Name

NLR family, pyrin domain containing 1B

Synonyms

Nalp1b

MMRRC Submission

045052-MU

Accession Numbers

Essential gene?

Probably non essential (E-score: 0.063) question?

Stock #

R6938 (G1)

Quality Score

225.009

Status

Not validated

Chromosome

Chromosomal Location

71043928-71121559 bp(-) (GRCm39)

Type of Mutation

missense

DNA Base Change (assembly)

G to A at 71109042 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Alanine to Valine at position 153 (A153V)

Ref Sequence

ENSEMBL: ENSMUSP00000121155 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000094046] [ENSMUST00000108516] [ENSMUST00000136493]

AlphaFold

A1Z198

Predicted Effect

probably damaging
Transcript: ENSMUST00000094046
AA Change: A153V

PolyPhen 2 Score 0.999 (Sensitivity: 0.14; Specificity: 0.99)

SMART Domains

Protein: ENSMUSP00000091588
Gene: ENSMUSG00000070390
AA Change: A153V

Domain	Start	End	E-Value	Type
Pfam:NACHT	131	300	6.7e-43	PFAM
LRR	627	654	2.24e0	SMART
LRR	656	683	8.82e0	SMART
LRR	684	711	3.49e-5	SMART
Pfam:FIIND	812	1064	8.2e-104	PFAM
Pfam:CARD	1083	1166	3.1e-22	PFAM

Predicted Effect

probably damaging
Transcript: ENSMUST00000108516
AA Change: A153V

PolyPhen 2 Score 0.999 (Sensitivity: 0.14; Specificity: 0.99)

SMART Domains

Protein: ENSMUSP00000104156
Gene: ENSMUSG00000070390
AA Change: A153V

Domain	Start	End	E-Value	Type
Pfam:NACHT	131	300	2.2e-42	PFAM
LRR	627	654	2.24e0	SMART
LRR	656	683	8.82e0	SMART
LRR	684	711	3.49e-5	SMART
Pfam:FIIND	811	1065	3.9e-136	PFAM
Pfam:CARD	1083	1166	1.1e-21	PFAM

Predicted Effect

probably damaging
Transcript: ENSMUST00000136493
AA Change: A153V

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)

SMART Domains

Protein: ENSMUSP00000121155
Gene: ENSMUSG00000070390
AA Change: A153V

Domain	Start	End	E-Value	Type
Pfam:NACHT	131	300	8.9e-43	PFAM
PDB:4IM6\|A	610	662	6e-10	PDB
Blast:LRR	627	654	3e-11	BLAST

Coding Region Coverage

1x: 100.0%
3x: 99.9%
10x: 99.2%
20x: 97.3%

Validation Efficiency

MGI Phenotype

FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes a member of the Ced-4 family of apoptosis proteins. Ced-family members contain a caspase recruitment domain (CARD) and are known to be key mediators of programmed cell death. The encoded protein contains a distinct N-terminal pyrin-like motif, which is possibly involved in protein-protein interactions. This protein interacts strongly with caspase 2 and weakly with caspase 9. Overexpression of this gene was demonstrated to induce apoptosis in cells. Multiple alternatively spliced transcript variants encoding distinct isoforms have been found for this gene, but the biological validity of some variants has not been determined. [provided by RefSeq, Jul 2008]
PHENOTYPE: Mice homozygous for a knock-out allele exhibit protection from anthrax lethal toxin-induced lung injury and pyroptosis of macrophages. [provided by MGI curators]

Allele List at MGI

Other mutations in this stock

Total: 41 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Acot7	T	C	4: 152,302,351 (GRCm39)		probably null	Het
Acp6	T	C	3: 97,082,949 (GRCm39)	M320T	probably benign	Het
Adam22	A	T	5: 8,196,499 (GRCm39)	Y259N	probably benign	Het
Akap9	C	A	5: 4,096,628 (GRCm39)	A2501D	possibly damaging	Het
Angpt2	G	T	8: 18,748,105 (GRCm39)	S385*	probably null	Het
Asxl2	G	C	12: 3,526,149 (GRCm39)	R255T	probably damaging	Het
Btg3	T	C	16: 78,157,216 (GRCm39)	I244V	probably benign	Het
Casr	T	C	16: 36,316,283 (GRCm39)	T596A	probably damaging	Het
Ccl1	A	T	11: 82,067,684 (GRCm39)	V82D	probably damaging	Het
Col18a1	T	A	10: 76,948,333 (GRCm39)		probably benign	Het
Crybg1	T	C	10: 43,873,379 (GRCm39)	D1243G	probably benign	Het
Dnaaf9	A	C	2: 130,617,673 (GRCm39)	H297Q	probably benign	Het
Drc3	A	T	11: 60,284,949 (GRCm39)		probably null	Het
Enpep	T	C	3: 129,092,599 (GRCm39)	D528G	probably damaging	Het
Fan1	T	A	7: 64,022,234 (GRCm39)	N340Y	probably damaging	Het
Gbp4	T	C	5: 105,282,943 (GRCm39)	D109G	probably damaging	Het
Gstz1	A	G	12: 87,193,943 (GRCm39)		probably null	Het
Kctd10	C	A	5: 114,508,191 (GRCm39)	E106*	probably null	Het
Kctd20	G	A	17: 29,180,555 (GRCm39)	G110S	probably benign	Het
Klk1b26	A	T	7: 43,665,718 (GRCm39)	T177S	probably benign	Het
Kyat3	T	A	3: 142,431,183 (GRCm39)	V118E	probably damaging	Het
Maml3	T	C	3: 52,011,159 (GRCm39)	K136E	probably damaging	Het
Mex3d	T	C	10: 80,218,074 (GRCm39)	N381S	possibly damaging	Het
Mmrn2	A	T	14: 34,120,671 (GRCm39)	T514S	probably benign	Het
Or13e8	C	T	4: 43,696,286 (GRCm39)	V296M	probably damaging	Het
Pcolce	T	C	5: 137,603,878 (GRCm39)	T365A	probably benign	Het
Plbd1	T	C	6: 136,593,985 (GRCm39)	I377V	probably benign	Het
Plk2	T	A	13: 110,533,214 (GRCm39)	Y192*	probably null	Het
Rev3l	T	A	10: 39,738,706 (GRCm39)	V2820D	probably damaging	Het
Secisbp2l	G	T	2: 125,592,272 (GRCm39)	P650T	probably damaging	Het
Slc9a5	T	C	8: 106,080,064 (GRCm39)	L69P	probably damaging	Het
Sp9	T	C	2: 73,103,616 (GRCm39)	C57R	probably damaging	Het
Tbl3	A	T	17: 24,924,187 (GRCm39)	V190D	possibly damaging	Het
Timm8b	A	G	9: 50,516,294 (GRCm39)	D49G	possibly damaging	Het
Tmem231	T	C	8: 112,660,144 (GRCm39)	S53G	probably damaging	Het
Topbp1	T	A	9: 103,205,753 (GRCm39)	V797D	probably damaging	Het
Trip11	A	T	12: 101,803,886 (GRCm39)	D1665E	probably damaging	Het
Txk	C	A	5: 72,856,492 (GRCm39)	R433L	probably damaging	Het
Vmn1r19	T	C	6: 57,381,992 (GRCm39)	S182P	possibly damaging	Het
Vps13b	T	G	15: 35,423,344 (GRCm39)	I221M	probably damaging	Het
Xpo7	T	C	14: 70,903,464 (GRCm39)	N1082D	probably benign	Het

Other mutations in Nlrp1b

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL00161:Nlrp1b	APN	11	71,072,007 (GRCm39)	intron	probably benign
IGL00571:Nlrp1b	APN	11	71,054,799 (GRCm39)	missense	probably null	0.48
IGL01358:Nlrp1b	APN	11	71,072,682 (GRCm39)	missense	possibly damaging	0.91
IGL01937:Nlrp1b	APN	11	71,072,233 (GRCm39)	missense	probably damaging	0.98
IGL01945:Nlrp1b	APN	11	71,072,233 (GRCm39)	missense	probably damaging	0.98
IGL02375:Nlrp1b	APN	11	71,052,506 (GRCm39)	missense	probably damaging	1.00
IGL02552:Nlrp1b	APN	11	71,063,057 (GRCm39)	missense	possibly damaging	0.96
IGL02552:Nlrp1b	APN	11	71,072,878 (GRCm39)	missense	possibly damaging	0.57
IGL02588:Nlrp1b	APN	11	71,073,105 (GRCm39)	nonsense	probably null
IGL02833:Nlrp1b	APN	11	71,051,998 (GRCm39)	missense	probably benign
IGL02955:Nlrp1b	APN	11	71,060,637 (GRCm39)	missense	possibly damaging	0.73
IGL03002:Nlrp1b	APN	11	71,059,685 (GRCm39)	missense	probably benign	0.00
IGL03033:Nlrp1b	APN	11	71,052,665 (GRCm39)	missense	probably benign	0.22
IGL03122:Nlrp1b	APN	11	71,072,659 (GRCm39)	missense	probably benign	0.00
IGL03131:Nlrp1b	APN	11	71,052,741 (GRCm39)	missense	possibly damaging	0.82
androcles	UTSW	11	71,062,901 (GRCm39)	nonsense	probably null
Fangled	UTSW	11	71,062,997 (GRCm39)	missense	possibly damaging	0.94
glitz	UTSW	11	71,072,376 (GRCm39)	missense	possibly damaging	0.89
honeydew	UTSW	11	71,108,710 (GRCm39)	missense	possibly damaging	0.93
Mush	UTSW	11	71,046,905 (GRCm39)	missense	probably damaging	1.00
Thorn	UTSW	11	71,047,126 (GRCm39)	splice site	probably benign
R0001:Nlrp1b	UTSW	11	71,052,585 (GRCm39)	missense	probably damaging	1.00
R0022:Nlrp1b	UTSW	11	71,052,755 (GRCm39)	missense	possibly damaging	0.61
R0022:Nlrp1b	UTSW	11	71,052,755 (GRCm39)	missense	possibly damaging	0.61
R0038:Nlrp1b	UTSW	11	71,062,997 (GRCm39)	missense	possibly damaging	0.94
R0038:Nlrp1b	UTSW	11	71,062,997 (GRCm39)	missense	possibly damaging	0.94
R0164:Nlrp1b	UTSW	11	71,054,925 (GRCm39)	missense	probably damaging	1.00
R0164:Nlrp1b	UTSW	11	71,054,925 (GRCm39)	missense	probably damaging	1.00
R0271:Nlrp1b	UTSW	11	71,052,591 (GRCm39)	missense	possibly damaging	0.51
R0464:Nlrp1b	UTSW	11	71,109,070 (GRCm39)	missense	probably damaging	1.00
R0504:Nlrp1b	UTSW	11	71,073,241 (GRCm39)	missense	probably damaging	0.99
R0605:Nlrp1b	UTSW	11	71,047,005 (GRCm39)	missense	possibly damaging	0.88
R0863:Nlrp1b	UTSW	11	71,072,173 (GRCm39)	missense	probably benign	0.00
R1075:Nlrp1b	UTSW	11	71,072,512 (GRCm39)	missense	probably benign	0.35
R1221:Nlrp1b	UTSW	11	71,072,290 (GRCm39)	missense	probably benign	0.07
R1501:Nlrp1b	UTSW	11	71,046,885 (GRCm39)	missense	probably damaging	1.00
R1654:Nlrp1b	UTSW	11	71,072,124 (GRCm39)	missense	probably damaging	0.99
R1671:Nlrp1b	UTSW	11	71,092,085 (GRCm39)	missense	probably benign	0.45
R1676:Nlrp1b	UTSW	11	71,073,637 (GRCm39)	missense	probably benign	0.13
R1694:Nlrp1b	UTSW	11	71,107,681 (GRCm39)	critical splice donor site	probably null
R1709:Nlrp1b	UTSW	11	71,092,099 (GRCm39)	missense	probably benign	0.11
R1770:Nlrp1b	UTSW	11	71,050,979 (GRCm39)	missense	probably benign	0.22
R1775:Nlrp1b	UTSW	11	71,052,647 (GRCm39)	missense	probably damaging	1.00
R1851:Nlrp1b	UTSW	11	71,073,442 (GRCm39)	missense	possibly damaging	0.96
R1932:Nlrp1b	UTSW	11	71,072,964 (GRCm39)	missense	probably damaging	0.96
R2063:Nlrp1b	UTSW	11	71,051,912 (GRCm39)	missense	probably benign	0.09
R2189:Nlrp1b	UTSW	11	71,060,621 (GRCm39)	missense	probably damaging	1.00
R2223:Nlrp1b	UTSW	11	71,046,815 (GRCm39)	splice site	probably benign
R2284:Nlrp1b	UTSW	11	71,047,110 (GRCm39)	missense	probably benign	0.00
R2434:Nlrp1b	UTSW	11	71,047,552 (GRCm39)	splice site	probably null
R3079:Nlrp1b	UTSW	11	71,108,794 (GRCm39)	missense	probably benign	0.27
R3775:Nlrp1b	UTSW	11	71,047,126 (GRCm39)	splice site	probably benign
R3980:Nlrp1b	UTSW	11	71,072,437 (GRCm39)	missense	possibly damaging	0.56
R4016:Nlrp1b	UTSW	11	71,063,911 (GRCm39)	missense	probably damaging	1.00
R4085:Nlrp1b	UTSW	11	71,052,588 (GRCm39)	missense	probably damaging	0.98
R4542:Nlrp1b	UTSW	11	71,119,151 (GRCm39)	missense	probably damaging	1.00
R4623:Nlrp1b	UTSW	11	71,052,669 (GRCm39)	missense	probably benign	0.00
R4726:Nlrp1b	UTSW	11	71,072,232 (GRCm39)	missense	probably benign	0.10
R4764:Nlrp1b	UTSW	11	71,073,489 (GRCm39)	missense	probably damaging	1.00
R4885:Nlrp1b	UTSW	11	71,108,710 (GRCm39)	missense	possibly damaging	0.93
R4910:Nlrp1b	UTSW	11	71,108,103 (GRCm39)	missense	probably benign	0.09
R4997:Nlrp1b	UTSW	11	71,109,160 (GRCm39)	missense	probably damaging	1.00
R5046:Nlrp1b	UTSW	11	71,050,898 (GRCm39)	missense	possibly damaging	0.95
R5126:Nlrp1b	UTSW	11	71,072,359 (GRCm39)	missense	possibly damaging	0.67
R5369:Nlrp1b	UTSW	11	71,072,625 (GRCm39)	missense	probably benign
R5388:Nlrp1b	UTSW	11	71,062,967 (GRCm39)	missense	probably damaging	1.00
R5445:Nlrp1b	UTSW	11	71,108,701 (GRCm39)	missense	probably benign	0.21
R5546:Nlrp1b	UTSW	11	71,108,102 (GRCm39)	missense	probably benign	0.04
R5567:Nlrp1b	UTSW	11	71,072,229 (GRCm39)	missense	probably benign
R5826:Nlrp1b	UTSW	11	71,072,022 (GRCm39)	missense	probably benign	0.17
R5955:Nlrp1b	UTSW	11	71,108,691 (GRCm39)	missense	probably damaging	1.00
R5995:Nlrp1b	UTSW	11	71,072,572 (GRCm39)	missense	probably damaging	1.00
R6059:Nlrp1b	UTSW	11	71,107,836 (GRCm39)	missense	possibly damaging	0.53
R6170:Nlrp1b	UTSW	11	71,046,905 (GRCm39)	missense	probably damaging	1.00
R6191:Nlrp1b	UTSW	11	71,109,283 (GRCm39)	nonsense	probably null
R6250:Nlrp1b	UTSW	11	71,072,625 (GRCm39)	missense	probably benign	0.11
R6312:Nlrp1b	UTSW	11	71,119,223 (GRCm39)	missense	probably benign	0.38
R6352:Nlrp1b	UTSW	11	71,072,527 (GRCm39)	missense	probably damaging	0.99
R6807:Nlrp1b	UTSW	11	71,108,530 (GRCm39)	missense	probably damaging	1.00
R6854:Nlrp1b	UTSW	11	71,119,259 (GRCm39)	missense	possibly damaging	0.93
R6908:Nlrp1b	UTSW	11	71,108,122 (GRCm39)	missense	probably benign
R7098:Nlrp1b	UTSW	11	71,109,100 (GRCm39)	missense	possibly damaging	0.89
R7142:Nlrp1b	UTSW	11	71,062,901 (GRCm39)	nonsense	probably null
R7149:Nlrp1b	UTSW	11	71,072,482 (GRCm39)	nonsense	probably null
R7349:Nlrp1b	UTSW	11	71,072,943 (GRCm39)	missense	probably benign	0.36
R7354:Nlrp1b	UTSW	11	71,072,376 (GRCm39)	missense	possibly damaging	0.89
R7750:Nlrp1b	UTSW	11	71,059,665 (GRCm39)	missense	probably benign	0.11
R7913:Nlrp1b	UTSW	11	71,108,537 (GRCm39)	missense	possibly damaging	0.93
R8031:Nlrp1b	UTSW	11	71,107,747 (GRCm39)	missense	probably benign	0.15
R8087:Nlrp1b	UTSW	11	71,062,897 (GRCm39)	missense	probably benign	0.04
R8164:Nlrp1b	UTSW	11	71,119,243 (GRCm39)	missense	possibly damaging	0.78
R8378:Nlrp1b	UTSW	11	71,052,545 (GRCm39)	missense	possibly damaging	0.95
R8405:Nlrp1b	UTSW	11	71,073,356 (GRCm39)	missense	possibly damaging	0.66
R8441:Nlrp1b	UTSW	11	71,073,204 (GRCm39)	missense	probably damaging	1.00
R8792:Nlrp1b	UTSW	11	71,050,919 (GRCm39)	missense	probably benign	0.02
R8898:Nlrp1b	UTSW	11	71,073,288 (GRCm39)	missense	probably damaging	1.00
R8953:Nlrp1b	UTSW	11	71,052,632 (GRCm39)	missense	probably damaging	0.96
R8963:Nlrp1b	UTSW	11	71,108,658 (GRCm39)	missense	probably damaging	1.00
R9145:Nlrp1b	UTSW	11	71,109,193 (GRCm39)	missense	probably benign
R9184:Nlrp1b	UTSW	11	71,072,067 (GRCm39)	missense	probably damaging	1.00
R9286:Nlrp1b	UTSW	11	71,060,573 (GRCm39)	missense	probably benign
R9322:Nlrp1b	UTSW	11	71,108,118 (GRCm39)	missense	probably benign	0.12
R9453:Nlrp1b	UTSW	11	71,072,913 (GRCm39)	missense	probably damaging	0.98
R9533:Nlrp1b	UTSW	11	71,109,095 (GRCm39)	missense	probably benign	0.12
R9659:Nlrp1b	UTSW	11	71,073,132 (GRCm39)	missense	possibly damaging	0.77
Z1176:Nlrp1b	UTSW	11	71,073,096 (GRCm39)	missense	probably damaging	1.00
Z1177:Nlrp1b	UTSW	11	71,108,050 (GRCm39)	missense	probably benign	0.03
Z1177:Nlrp1b	UTSW	11	71,072,125 (GRCm39)	nonsense	probably null
Z1186:Nlrp1b	UTSW	11	71,073,370 (GRCm39)	missense	probably benign	0.00
Z1186:Nlrp1b	UTSW	11	71,073,280 (GRCm39)	missense	probably benign	0.00
Z1186:Nlrp1b	UTSW	11	71,073,266 (GRCm39)	missense	probably benign
Z1186:Nlrp1b	UTSW	11	71,073,148 (GRCm39)	missense	probably benign
Z1186:Nlrp1b	UTSW	11	71,073,135 (GRCm39)	missense	probably benign
Z1186:Nlrp1b	UTSW	11	71,072,625 (GRCm39)	missense	probably benign
Z1186:Nlrp1b	UTSW	11	71,072,539 (GRCm39)	missense	probably benign
Z1186:Nlrp1b	UTSW	11	71,072,534 (GRCm39)	missense	probably benign	0.02
Z1186:Nlrp1b	UTSW	11	71,073,503 (GRCm39)	missense	probably benign
Z1186:Nlrp1b	UTSW	11	71,073,396 (GRCm39)	missense	probably benign	0.02
Z1186:Nlrp1b	UTSW	11	71,073,378 (GRCm39)	missense	probably benign
Z1187:Nlrp1b	UTSW	11	71,073,370 (GRCm39)	missense	probably benign	0.00
Z1187:Nlrp1b	UTSW	11	71,073,280 (GRCm39)	missense	probably benign	0.00
Z1187:Nlrp1b	UTSW	11	71,073,266 (GRCm39)	missense	probably benign
Z1187:Nlrp1b	UTSW	11	71,073,148 (GRCm39)	missense	probably benign
Z1187:Nlrp1b	UTSW	11	71,072,625 (GRCm39)	missense	probably benign
Z1187:Nlrp1b	UTSW	11	71,072,539 (GRCm39)	missense	probably benign
Z1187:Nlrp1b	UTSW	11	71,072,534 (GRCm39)	missense	probably benign	0.02
Z1187:Nlrp1b	UTSW	11	71,073,503 (GRCm39)	missense	probably benign
Z1187:Nlrp1b	UTSW	11	71,073,396 (GRCm39)	missense	probably benign	0.02
Z1187:Nlrp1b	UTSW	11	71,073,378 (GRCm39)	missense	probably benign
Z1188:Nlrp1b	UTSW	11	71,073,378 (GRCm39)	missense	probably benign
Z1188:Nlrp1b	UTSW	11	71,073,396 (GRCm39)	missense	probably benign	0.02
Z1188:Nlrp1b	UTSW	11	71,073,503 (GRCm39)	missense	probably benign
Z1188:Nlrp1b	UTSW	11	71,072,534 (GRCm39)	missense	probably benign	0.02
Z1188:Nlrp1b	UTSW	11	71,072,539 (GRCm39)	missense	probably benign
Z1188:Nlrp1b	UTSW	11	71,072,625 (GRCm39)	missense	probably benign
Z1188:Nlrp1b	UTSW	11	71,073,135 (GRCm39)	missense	probably benign
Z1188:Nlrp1b	UTSW	11	71,073,148 (GRCm39)	missense	probably benign
Z1188:Nlrp1b	UTSW	11	71,073,266 (GRCm39)	missense	probably benign
Z1188:Nlrp1b	UTSW	11	71,073,280 (GRCm39)	missense	probably benign	0.00
Z1188:Nlrp1b	UTSW	11	71,073,370 (GRCm39)	missense	probably benign	0.00
Z1189:Nlrp1b	UTSW	11	71,073,370 (GRCm39)	missense	probably benign	0.00
Z1189:Nlrp1b	UTSW	11	71,073,280 (GRCm39)	missense	probably benign	0.00
Z1189:Nlrp1b	UTSW	11	71,073,266 (GRCm39)	missense	probably benign
Z1189:Nlrp1b	UTSW	11	71,073,148 (GRCm39)	missense	probably benign
Z1189:Nlrp1b	UTSW	11	71,073,135 (GRCm39)	missense	probably benign
Z1189:Nlrp1b	UTSW	11	71,072,625 (GRCm39)	missense	probably benign
Z1189:Nlrp1b	UTSW	11	71,072,539 (GRCm39)	missense	probably benign
Z1189:Nlrp1b	UTSW	11	71,072,534 (GRCm39)	missense	probably benign	0.02
Z1189:Nlrp1b	UTSW	11	71,073,503 (GRCm39)	missense	probably benign
Z1189:Nlrp1b	UTSW	11	71,073,396 (GRCm39)	missense	probably benign	0.02
Z1189:Nlrp1b	UTSW	11	71,073,378 (GRCm39)	missense	probably benign
Z1190:Nlrp1b	UTSW	11	71,073,370 (GRCm39)	missense	probably benign	0.00
Z1190:Nlrp1b	UTSW	11	71,073,378 (GRCm39)	missense	probably benign
Z1190:Nlrp1b	UTSW	11	71,073,396 (GRCm39)	missense	probably benign	0.02
Z1190:Nlrp1b	UTSW	11	71,073,503 (GRCm39)	missense	probably benign
Z1190:Nlrp1b	UTSW	11	71,072,534 (GRCm39)	missense	probably benign	0.02
Z1190:Nlrp1b	UTSW	11	71,072,539 (GRCm39)	missense	probably benign
Z1190:Nlrp1b	UTSW	11	71,072,625 (GRCm39)	missense	probably benign
Z1190:Nlrp1b	UTSW	11	71,073,135 (GRCm39)	missense	probably benign
Z1190:Nlrp1b	UTSW	11	71,073,148 (GRCm39)	missense	probably benign
Z1190:Nlrp1b	UTSW	11	71,073,266 (GRCm39)	missense	probably benign
Z1190:Nlrp1b	UTSW	11	71,073,280 (GRCm39)	missense	probably benign	0.00
Z1191:Nlrp1b	UTSW	11	71,073,280 (GRCm39)	missense	probably benign	0.00
Z1191:Nlrp1b	UTSW	11	71,073,266 (GRCm39)	missense	probably benign
Z1191:Nlrp1b	UTSW	11	71,073,148 (GRCm39)	missense	probably benign
Z1191:Nlrp1b	UTSW	11	71,073,135 (GRCm39)	missense	probably benign
Z1191:Nlrp1b	UTSW	11	71,072,625 (GRCm39)	missense	probably benign
Z1191:Nlrp1b	UTSW	11	71,072,539 (GRCm39)	missense	probably benign
Z1191:Nlrp1b	UTSW	11	71,072,534 (GRCm39)	missense	probably benign	0.02
Z1191:Nlrp1b	UTSW	11	71,073,503 (GRCm39)	missense	probably benign
Z1191:Nlrp1b	UTSW	11	71,073,396 (GRCm39)	missense	probably benign	0.02
Z1191:Nlrp1b	UTSW	11	71,073,378 (GRCm39)	missense	probably benign
Z1191:Nlrp1b	UTSW	11	71,073,370 (GRCm39)	missense	probably benign	0.00
Z1192:Nlrp1b	UTSW	11	71,073,396 (GRCm39)	missense	probably benign	0.02
Z1192:Nlrp1b	UTSW	11	71,073,378 (GRCm39)	missense	probably benign
Z1192:Nlrp1b	UTSW	11	71,073,370 (GRCm39)	missense	probably benign	0.00
Z1192:Nlrp1b	UTSW	11	71,073,280 (GRCm39)	missense	probably benign	0.00
Z1192:Nlrp1b	UTSW	11	71,073,266 (GRCm39)	missense	probably benign
Z1192:Nlrp1b	UTSW	11	71,073,148 (GRCm39)	missense	probably benign
Z1192:Nlrp1b	UTSW	11	71,072,625 (GRCm39)	missense	probably benign
Z1192:Nlrp1b	UTSW	11	71,072,534 (GRCm39)	missense	probably benign	0.02
Z1192:Nlrp1b	UTSW	11	71,073,503 (GRCm39)	missense	probably benign

Predicted Primers

PCR Primer
(F):5'- CCCATGCTGGCTCATCTATG -3'
(R):5'- AAATTGTGCTCAAGAGGCTCAG -3'

Sequencing Primer
(F):5'- TCATCTATGCCATCCAGGATGAAGAG -3'
(R):5'- GCTCAAGAGGCTCAGAAAACTTGATC -3'

Posted On

2018-11-06