Incidental Mutation 'R6939:Zfp866'
ID 540440
Institutional Source Beutler Lab
Gene Symbol Zfp866
Ensembl Gene ENSMUSG00000043090
Gene Name zinc finger protein 866
Synonyms 9830167H18Rik, D330038O06Rik
MMRRC Submission 045053-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.070) question?
Stock # R6939 (G1)
Quality Score 225.009
Status Validated
Chromosome 8
Chromosomal Location 70213974-70227561 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) G to T at 70218871 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Glutamine to Lysine at position 250 (Q250K)
Ref Sequence ENSEMBL: ENSMUSP00000119781 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000131784] [ENSMUST00000137573] [ENSMUST00000149782]
AlphaFold Q6PGD2
Predicted Effect probably benign
Transcript: ENSMUST00000126915
SMART Domains Protein: ENSMUSP00000122850
Gene: ENSMUSG00000092544

DomainStartEndE-ValueType
KRAB 16 73 1.96e-17 SMART
PDB:2I13|B 104 210 3e-6 PDB
SCOP:d1fgja_ 114 216 2e-6 SMART
Blast:KRAB 189 209 3e-6 BLAST
Predicted Effect probably benign
Transcript: ENSMUST00000131784
SMART Domains Protein: ENSMUSP00000116972
Gene: ENSMUSG00000043090

DomainStartEndE-ValueType
Blast:KRAB 1 35 2e-19 BLAST
Predicted Effect probably damaging
Transcript: ENSMUST00000137573
AA Change: Q250K

PolyPhen 2 Score 0.988 (Sensitivity: 0.73; Specificity: 0.96)
SMART Domains Protein: ENSMUSP00000119781
Gene: ENSMUSG00000043090
AA Change: Q250K

DomainStartEndE-ValueType
KRAB 4 67 4.26e-18 SMART
ZnF_C2H2 162 184 6.42e-4 SMART
ZnF_C2H2 190 212 3.69e-4 SMART
ZnF_C2H2 218 240 3.89e-3 SMART
ZnF_C2H2 246 268 3.34e-2 SMART
ZnF_C2H2 274 296 1.76e-1 SMART
ZnF_C2H2 302 324 5.42e-2 SMART
ZnF_C2H2 330 352 1.38e-3 SMART
ZnF_C2H2 358 380 6.78e-3 SMART
ZnF_C2H2 386 408 2.09e-3 SMART
ZnF_C2H2 414 436 9.44e-2 SMART
ZnF_C2H2 442 464 2.95e-3 SMART
ZnF_C2H2 470 492 9.73e-4 SMART
Predicted Effect probably benign
Transcript: ENSMUST00000149782
SMART Domains Protein: ENSMUSP00000123252
Gene: ENSMUSG00000092544

DomainStartEndE-ValueType
KRAB 80 139 1.2e-17 SMART
ZnF_C2H2 155 177 1.69e-3 SMART
ZnF_C2H2 182 204 8.47e-4 SMART
ZnF_C2H2 210 232 7.15e-2 SMART
Coding Region Coverage
  • 1x: 100.0%
  • 3x: 99.9%
  • 10x: 99.3%
  • 20x: 97.9%
Validation Efficiency 99% (66/67)
Allele List at MGI
Other mutations in this stock
Total: 66 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
A1bg G A 15: 60,792,244 (GRCm39) P128L probably damaging Het
Acsm3 T C 7: 119,377,678 (GRCm39) V401A probably damaging Het
Arhgef11 C A 3: 87,594,227 (GRCm39) N93K probably damaging Het
C1ra G A 6: 124,489,760 (GRCm39) probably null Het
Camk2a A G 18: 61,091,226 (GRCm39) E236G probably damaging Het
Cav2 C A 6: 17,281,410 (GRCm39) D17E possibly damaging Het
Ccdc149 T C 5: 52,533,607 (GRCm39) S520G probably benign Het
Chd4 C A 6: 125,083,501 (GRCm39) H674Q probably damaging Het
Clrn2 A T 5: 45,611,096 (GRCm39) probably benign Het
Cntnap1 A C 11: 101,077,337 (GRCm39) I1000L probably damaging Het
Cyp2c67 T C 19: 39,631,778 (GRCm39) T140A possibly damaging Het
D7Ertd443e T C 7: 133,966,208 (GRCm39) probably null Het
Dcdc2c G T 12: 28,591,496 (GRCm39) Q131K probably benign Het
Dmpk T A 7: 18,822,149 (GRCm39) V369E probably damaging Het
Dnah11 A T 12: 118,070,297 (GRCm39) W1503R probably damaging Het
Dnai7 A G 6: 145,120,945 (GRCm39) F625L possibly damaging Het
Dok2 T C 14: 71,013,045 (GRCm39) V71A probably benign Het
Dqx1 A T 6: 83,036,446 (GRCm39) Q150L probably damaging Het
Extl3 A G 14: 65,304,189 (GRCm39) I740T possibly damaging Het
Fan1 T A 7: 64,022,234 (GRCm39) N340Y probably damaging Het
Fat2 C T 11: 55,143,300 (GRCm39) W4183* probably null Het
Fkrp C T 7: 16,545,751 (GRCm39) R37Q probably benign Het
Frem3 A G 8: 81,341,774 (GRCm39) K1356E probably benign Het
Fus A T 7: 127,571,741 (GRCm39) probably benign Het
Gabarapl2 C A 8: 112,669,201 (GRCm39) S53* probably null Het
Gjd3 A C 11: 102,691,733 (GRCm39) M90R probably damaging Het
Gm30083 C T 14: 33,725,557 (GRCm39) probably null Het
Gm7356 T A 17: 14,221,387 (GRCm39) Y214F probably benign Het
Hexd A T 11: 121,113,164 (GRCm39) D533V probably benign Het
Ift172 G A 5: 31,414,930 (GRCm39) A1364V probably damaging Het
Ighmbp2 A T 19: 3,326,907 (GRCm39) F186Y probably damaging Het
Inpp5e C A 2: 26,297,774 (GRCm39) probably null Het
Iqcb1 A G 16: 36,660,274 (GRCm39) T146A possibly damaging Het
Kcnmb2 A G 3: 32,252,465 (GRCm39) Y222C probably damaging Het
Kdm6b A G 11: 69,297,588 (GRCm39) W284R probably damaging Het
Khdc4 T A 3: 88,593,824 (GRCm39) M71K probably damaging Het
Ksr2 T A 5: 117,903,626 (GRCm39) *952R probably null Het
Ldlrap1 C A 4: 134,495,285 (GRCm39) probably benign Het
Mpdu1 G A 11: 69,548,881 (GRCm39) probably benign Het
Mrgprh A T 17: 13,095,822 (GRCm39) T21S probably benign Het
Muc16 T A 9: 18,549,833 (GRCm39) T5487S probably benign Het
Mydgf A G 17: 56,490,737 (GRCm39) probably null Het
Napa T C 7: 15,849,182 (GRCm39) C241R possibly damaging Het
Or10ab4 C A 7: 107,654,312 (GRCm39) A41E possibly damaging Het
Or10n7-ps1 T C 9: 39,598,187 (GRCm39) T18A possibly damaging Het
Or5k17 A T 16: 58,746,648 (GRCm39) Y95* probably null Het
Pla2g4f A T 2: 120,137,782 (GRCm39) L326Q probably damaging Het
Pramel16 T C 4: 143,675,366 (GRCm39) T487A probably benign Het
Psme4 T A 11: 30,787,291 (GRCm39) Y1029N probably damaging Het
Ptprj T C 2: 90,289,858 (GRCm39) T707A possibly damaging Het
Raet1e T A 10: 22,050,256 (GRCm39) M13K possibly damaging Het
Rftn2 T C 1: 55,233,508 (GRCm39) probably null Het
Rmi1 A G 13: 58,557,169 (GRCm39) I473V probably benign Het
Rps6ka4 A G 19: 6,815,437 (GRCm39) F186L probably damaging Het
Ryr1 T A 7: 28,751,751 (GRCm39) M3672L possibly damaging Het
Smarca5 A T 8: 81,431,949 (GRCm39) C890S possibly damaging Het
Spata31d1e T A 13: 59,889,872 (GRCm39) K231N possibly damaging Het
Tdrd12 C T 7: 35,185,024 (GRCm39) probably null Het
Tecta T C 9: 42,259,293 (GRCm39) N1530S probably damaging Het
Tenm4 G A 7: 96,202,703 (GRCm39) R106H probably benign Het
Tmem94 A G 11: 115,676,656 (GRCm39) S54G possibly damaging Het
Tnk2 T C 16: 32,482,696 (GRCm39) V41A probably damaging Het
Trpm1 A G 7: 63,918,045 (GRCm39) T462A probably benign Het
Tsg101 T C 7: 46,556,847 (GRCm39) T61A probably benign Het
Usp42 T C 5: 143,713,724 (GRCm39) N17D probably damaging Het
Zfp607a T A 7: 27,578,473 (GRCm39) C514* probably null Het
Other mutations in Zfp866
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL02755:Zfp866 APN 8 70,219,290 (GRCm39) critical splice donor site probably null
R0238:Zfp866 UTSW 8 70,219,365 (GRCm39) missense probably damaging 1.00
R1073:Zfp866 UTSW 8 70,220,272 (GRCm39) splice site probably benign
R1226:Zfp866 UTSW 8 70,218,940 (GRCm39) missense probably damaging 1.00
R1388:Zfp866 UTSW 8 70,218,834 (GRCm39) missense probably benign 0.16
R5129:Zfp866 UTSW 8 70,220,359 (GRCm39) splice site probably null
R5204:Zfp866 UTSW 8 70,218,690 (GRCm39) missense probably damaging 0.96
R5225:Zfp866 UTSW 8 70,218,091 (GRCm39) missense possibly damaging 0.93
R5504:Zfp866 UTSW 8 70,218,341 (GRCm39) missense probably benign 0.07
R5912:Zfp866 UTSW 8 70,218,934 (GRCm39) missense probably benign 0.03
R6046:Zfp866 UTSW 8 70,218,373 (GRCm39) missense probably damaging 1.00
R7033:Zfp866 UTSW 8 70,218,491 (GRCm39) missense probably damaging 1.00
R7111:Zfp866 UTSW 8 70,219,221 (GRCm39) missense probably benign 0.05
R7351:Zfp866 UTSW 8 70,218,547 (GRCm39) missense probably damaging 1.00
R7458:Zfp866 UTSW 8 70,218,202 (GRCm39) nonsense probably null
R8098:Zfp866 UTSW 8 70,218,628 (GRCm39) missense probably benign 0.02
R8755:Zfp866 UTSW 8 70,219,381 (GRCm39) missense possibly damaging 0.78
R9575:Zfp866 UTSW 8 70,219,288 (GRCm39) missense probably damaging 0.98
Predicted Primers PCR Primer
(F):5'- GTCTAAAGGCTGTACCACATTGC -3'
(R):5'- AAGCTCTGAGTTCTTCCAGTTCC -3'

Sequencing Primer
(F):5'- ACCACATTGCTTACATTCATAGGGC -3'
(R):5'- CCCTATAAATGTCAGCAGTGTGG -3'
Posted On 2018-11-06