Incidental Mutation 'R6939:Cyp2c67'
ID 540472
Institutional Source Beutler Lab
Gene Symbol Cyp2c67
Ensembl Gene ENSMUSG00000062624
Gene Name cytochrome P450, family 2, subfamily c, polypeptide 67
Synonyms C730004C24Rik
MMRRC Submission 045053-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.102) question?
Stock # R6939 (G1)
Quality Score 225.009
Status Validated
Chromosome 19
Chromosomal Location 39608842-39649051 bp(-) (GRCm38)
Type of Mutation missense
DNA Base Change (assembly) T to C at 39643334 bp (GRCm38)
Zygosity Heterozygous
Amino Acid Change Threonine to Alanine at position 140 (T140A)
Ref Sequence ENSEMBL: ENSMUSP00000065796 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000067328]
AlphaFold Q569X9
Predicted Effect possibly damaging
Transcript: ENSMUST00000067328
AA Change: T140A

PolyPhen 2 Score 0.681 (Sensitivity: 0.86; Specificity: 0.92)
SMART Domains Protein: ENSMUSP00000065796
Gene: ENSMUSG00000062624
AA Change: T140A

DomainStartEndE-ValueType
signal peptide 1 25 N/A INTRINSIC
Pfam:p450 30 487 8.5e-150 PFAM
Coding Region Coverage
  • 1x: 100.0%
  • 3x: 99.9%
  • 10x: 99.3%
  • 20x: 97.9%
Validation Efficiency 99% (66/67)
Allele List at MGI
Other mutations in this stock
Total: 66 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
1700014D04Rik T A 13: 59,742,058 (GRCm38) K231N possibly damaging Het
2810403A07Rik T A 3: 88,686,517 (GRCm38) M71K probably damaging Het
A1bg G A 15: 60,920,395 (GRCm38) P128L probably damaging Het
Acsm3 T C 7: 119,778,455 (GRCm38) V401A probably damaging Het
Arhgef11 C A 3: 87,686,920 (GRCm38) N93K probably damaging Het
C1ra G A 6: 124,512,801 (GRCm38) probably null Het
Camk2a A G 18: 60,958,154 (GRCm38) E236G probably damaging Het
Casc1 A G 6: 145,175,219 (GRCm38) F625L possibly damaging Het
Cav2 C A 6: 17,281,411 (GRCm38) D17E possibly damaging Het
Ccdc149 T C 5: 52,376,265 (GRCm38) S520G probably benign Het
Chd4 C A 6: 125,106,538 (GRCm38) H674Q probably damaging Het
Clrn2 A T 5: 45,453,754 (GRCm38) probably benign Het
Cntnap1 A C 11: 101,186,511 (GRCm38) I1000L probably damaging Het
D7Ertd443e T C 7: 134,364,479 (GRCm38) probably null Het
Dcdc2c G T 12: 28,541,497 (GRCm38) Q131K probably benign Het
Dmpk T A 7: 19,088,224 (GRCm38) V369E probably damaging Het
Dnah11 A T 12: 118,106,562 (GRCm38) W1503R probably damaging Het
Dok2 T C 14: 70,775,605 (GRCm38) V71A probably benign Het
Dqx1 A T 6: 83,059,465 (GRCm38) Q150L probably damaging Het
Extl3 A G 14: 65,066,740 (GRCm38) I740T possibly damaging Het
Fan1 T A 7: 64,372,486 (GRCm38) N340Y probably damaging Het
Fat2 C T 11: 55,252,474 (GRCm38) W4183* probably null Het
Fkrp C T 7: 16,811,826 (GRCm38) R37Q probably benign Het
Frem3 A G 8: 80,615,145 (GRCm38) K1356E probably benign Het
Fus A T 7: 127,972,569 (GRCm38) probably benign Het
Gabarapl2 C A 8: 111,942,569 (GRCm38) S53* probably null Het
Gjc1 A C 11: 102,800,907 (GRCm38) M90R probably damaging Het
Gm30083 C T 14: 34,003,600 (GRCm38) probably null Het
Gm7356 T A 17: 14,001,125 (GRCm38) Y214F probably benign Het
Hexdc A T 11: 121,222,338 (GRCm38) D533V probably benign Het
Ift172 G A 5: 31,257,586 (GRCm38) A1364V probably damaging Het
Ighmbp2 A T 19: 3,276,907 (GRCm38) F186Y probably damaging Het
Inpp5e C A 2: 26,407,762 (GRCm38) probably null Het
Iqcb1 A G 16: 36,839,912 (GRCm38) T146A possibly damaging Het
Kcnmb2 A G 3: 32,198,316 (GRCm38) Y222C probably damaging Het
Kdm6b A G 11: 69,406,762 (GRCm38) W284R probably damaging Het
Ksr2 T A 5: 117,765,561 (GRCm38) *952R probably null Het
Ldlrap1 C A 4: 134,767,974 (GRCm38) probably benign Het
Mpdu1 G A 11: 69,658,055 (GRCm38) probably benign Het
Mrgprh A T 17: 12,876,935 (GRCm38) T21S probably benign Het
Muc16 T A 9: 18,638,537 (GRCm38) T5487S probably benign Het
Mydgf A G 17: 56,183,737 (GRCm38) probably null Het
Napa T C 7: 16,115,257 (GRCm38) C241R possibly damaging Het
Olfr181 A T 16: 58,926,285 (GRCm38) Y95* probably null Het
Olfr479 C A 7: 108,055,105 (GRCm38) A41E possibly damaging Het
Olfr964-ps1 T C 9: 39,686,891 (GRCm38) T18A possibly damaging Het
Pla2g4f A T 2: 120,307,301 (GRCm38) L326Q probably damaging Het
Pramef25 T C 4: 143,948,796 (GRCm38) T487A probably benign Het
Psme4 T A 11: 30,837,291 (GRCm38) Y1029N probably damaging Het
Ptprj T C 2: 90,459,514 (GRCm38) T707A possibly damaging Het
Raet1e T A 10: 22,174,357 (GRCm38) M13K possibly damaging Het
Rftn2 T C 1: 55,194,349 (GRCm38) probably null Het
Rmi1 A G 13: 58,409,355 (GRCm38) I473V probably benign Het
Rps6ka4 A G 19: 6,838,069 (GRCm38) F186L probably damaging Het
Ryr1 T A 7: 29,052,326 (GRCm38) M3672L possibly damaging Het
Smarca5 A T 8: 80,705,320 (GRCm38) C890S possibly damaging Het
Tdrd12 C T 7: 35,485,599 (GRCm38) probably null Het
Tecta T C 9: 42,347,997 (GRCm38) N1530S probably damaging Het
Tenm4 G A 7: 96,553,496 (GRCm38) R106H probably benign Het
Tmem94 A G 11: 115,785,830 (GRCm38) S54G possibly damaging Het
Tnk2 T C 16: 32,663,878 (GRCm38) V41A probably damaging Het
Trpm1 A G 7: 64,268,297 (GRCm38) T462A probably benign Het
Tsg101 T C 7: 46,907,099 (GRCm38) T61A probably benign Het
Usp42 T C 5: 143,727,969 (GRCm38) N17D probably damaging Het
Zfp607a T A 7: 27,879,048 (GRCm38) C514* probably null Het
Zfp866 G T 8: 69,766,221 (GRCm38) Q250K probably damaging Het
Other mutations in Cyp2c67
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00955:Cyp2c67 APN 19 39,643,385 (GRCm38) missense possibly damaging 0.95
IGL01025:Cyp2c67 APN 19 39,639,932 (GRCm38) nonsense probably null
IGL01363:Cyp2c67 APN 19 39,639,967 (GRCm38) missense probably damaging 0.99
IGL01819:Cyp2c67 APN 19 39,615,721 (GRCm38) missense probably damaging 0.98
IGL01902:Cyp2c67 APN 19 39,649,026 (GRCm38) missense probably damaging 1.00
IGL02172:Cyp2c67 APN 19 39,649,002 (GRCm38) missense possibly damaging 0.76
IGL02351:Cyp2c67 APN 19 39,617,417 (GRCm38) missense probably damaging 1.00
IGL02355:Cyp2c67 APN 19 39,617,382 (GRCm38) nonsense probably null
IGL02355:Cyp2c67 APN 19 39,643,405 (GRCm38) missense probably benign 0.34
IGL02358:Cyp2c67 APN 19 39,617,417 (GRCm38) missense probably damaging 1.00
IGL02362:Cyp2c67 APN 19 39,617,382 (GRCm38) nonsense probably null
IGL02362:Cyp2c67 APN 19 39,643,405 (GRCm38) missense probably benign 0.34
IGL02388:Cyp2c67 APN 19 39,643,355 (GRCm38) missense probably benign 0.20
IGL03106:Cyp2c67 APN 19 39,643,675 (GRCm38) missense probably benign 0.27
IGL03219:Cyp2c67 APN 19 39,643,294 (GRCm38) missense possibly damaging 0.54
IGL03326:Cyp2c67 APN 19 39,643,269 (GRCm38) critical splice donor site probably null
IGL03349:Cyp2c67 APN 19 39,643,684 (GRCm38) missense probably damaging 1.00
IGL03356:Cyp2c67 APN 19 39,639,961 (GRCm38) missense probably damaging 1.00
IGL03052:Cyp2c67 UTSW 19 39,648,885 (GRCm38) missense possibly damaging 0.88
R0585:Cyp2c67 UTSW 19 39,638,694 (GRCm38) missense possibly damaging 0.59
R0975:Cyp2c67 UTSW 19 39,609,178 (GRCm38) missense possibly damaging 0.49
R0976:Cyp2c67 UTSW 19 39,643,374 (GRCm38) missense probably damaging 1.00
R1252:Cyp2c67 UTSW 19 39,626,141 (GRCm38) missense possibly damaging 0.93
R1398:Cyp2c67 UTSW 19 39,638,625 (GRCm38) missense probably damaging 0.96
R1411:Cyp2c67 UTSW 19 39,638,591 (GRCm38) missense probably damaging 1.00
R1505:Cyp2c67 UTSW 19 39,648,964 (GRCm38) missense probably benign 0.00
R1543:Cyp2c67 UTSW 19 39,643,264 (GRCm38) splice site probably benign
R1613:Cyp2c67 UTSW 19 39,626,199 (GRCm38) missense probably benign 0.00
R1618:Cyp2c67 UTSW 19 39,643,264 (GRCm38) splice site probably benign
R1667:Cyp2c67 UTSW 19 39,643,590 (GRCm38) critical splice donor site probably null
R1852:Cyp2c67 UTSW 19 39,617,367 (GRCm38) missense probably benign 0.01
R2005:Cyp2c67 UTSW 19 39,643,345 (GRCm38) missense probably damaging 1.00
R2105:Cyp2c67 UTSW 19 39,626,237 (GRCm38) missense probably benign 0.24
R2181:Cyp2c67 UTSW 19 39,609,097 (GRCm38) missense possibly damaging 0.94
R3817:Cyp2c67 UTSW 19 39,638,683 (GRCm38) missense probably benign 0.00
R4669:Cyp2c67 UTSW 19 39,643,654 (GRCm38) missense probably benign 0.00
R4689:Cyp2c67 UTSW 19 39,638,588 (GRCm38) missense probably benign 0.00
R4756:Cyp2c67 UTSW 19 39,643,744 (GRCm38) missense probably benign 0.03
R4823:Cyp2c67 UTSW 19 39,615,724 (GRCm38) missense probably benign 0.13
R5152:Cyp2c67 UTSW 19 39,638,688 (GRCm38) missense probably benign 0.00
R5345:Cyp2c67 UTSW 19 39,626,232 (GRCm38) missense probably benign 0.01
R5580:Cyp2c67 UTSW 19 39,615,650 (GRCm38) missense probably damaging 0.99
R5644:Cyp2c67 UTSW 19 39,615,694 (GRCm38) missense possibly damaging 0.84
R6116:Cyp2c67 UTSW 19 39,617,435 (GRCm38) missense probably damaging 1.00
R6516:Cyp2c67 UTSW 19 39,617,429 (GRCm38) missense probably damaging 1.00
R6550:Cyp2c67 UTSW 19 39,617,410 (GRCm38) nonsense probably null
R6995:Cyp2c67 UTSW 19 39,615,679 (GRCm38) missense probably damaging 0.96
R7028:Cyp2c67 UTSW 19 39,639,897 (GRCm38) missense possibly damaging 0.68
R7144:Cyp2c67 UTSW 19 39,615,694 (GRCm38) missense probably benign 0.00
R7242:Cyp2c67 UTSW 19 39,617,339 (GRCm38) missense probably benign 0.30
R7335:Cyp2c67 UTSW 19 39,640,007 (GRCm38) nonsense probably null
R7337:Cyp2c67 UTSW 19 39,609,264 (GRCm38) splice site probably null
R7474:Cyp2c67 UTSW 19 39,617,432 (GRCm38) missense probably null 0.05
R7642:Cyp2c67 UTSW 19 39,615,640 (GRCm38) missense probably damaging 0.97
R7870:Cyp2c67 UTSW 19 39,609,225 (GRCm38) missense probably damaging 1.00
R8152:Cyp2c67 UTSW 19 39,640,008 (GRCm38) missense probably benign 0.21
R8367:Cyp2c67 UTSW 19 39,638,674 (GRCm38) missense probably benign 0.01
R8717:Cyp2c67 UTSW 19 39,638,711 (GRCm38) missense probably benign 0.05
R8728:Cyp2c67 UTSW 19 39,626,161 (GRCm38) missense probably damaging 1.00
R9275:Cyp2c67 UTSW 19 39,609,255 (GRCm38) missense probably damaging 1.00
R9278:Cyp2c67 UTSW 19 39,609,255 (GRCm38) missense probably damaging 1.00
R9376:Cyp2c67 UTSW 19 39,638,734 (GRCm38) missense probably damaging 1.00
Z1177:Cyp2c67 UTSW 19 39,643,679 (GRCm38) missense possibly damaging 0.89
Predicted Primers PCR Primer
(F):5'- ATGGTACCTATACTCATGACATCTC -3'
(R):5'- GCAGTTTCCAGAGCAAGCTG -3'

Sequencing Primer
(F):5'- GAGAATCTGACCTGCACT -3'
(R):5'- AGAGTAGAGGTCATGCTTGC -3'
Posted On 2018-11-06