|Institutional Source||Beutler Lab|
|Gene Name||F-box protein 44|
|Synonyms||FBG3, Fbx6a, FBX30, Fbxo6a|
|Is this an essential gene?||Non essential (E-score: 0.000)|
|Stock #||R6498 (G1)|
|Chromosomal Location||148152800-148160482 bp(-) (GRCm38)|
|Type of Mutation|
|DNA Base Change (assembly)||C to T at 148154425 bp|
|Amino Acid Change|
|Coding Region Coverage||
|Validation Efficiency||100% (37/37)|
|MGI Phenotype||FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes a member of the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of the ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into 3 classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene belongs to the Fbxs class. It is also a member of the NFB42 (neural F Box 42 kDa) family, similar to F-box only protein 2 and F-box only protein 6. Several alternatively spliced transcript variants encoding two distinct isoforms have been found for this gene. [provided by RefSeq, Feb 2015]|
|Allele List at MGI|
|Other mutations in this stock||
|Other mutations in Fbxo44||
(F):5'- TTTTCGAGAAGAACAGAGGGACA -3'
(R):5'- CAGGACTGAGTTGCCAGTTG -3'
(F):5'- AAGTTCAAGGTCATCCCTGG -3'
(R):5'- AGTTGCCAGTTGATCAGTGAC -3'