|Institutional Source||Beutler Lab|
|Gene Name||microsomal glutathione S-transferase 1|
|Is this an essential gene?||Probably non essential (E-score: 0.192)|
|Stock #||R6468 (G1)|
|Chromosomal Location||138140316-138156755 bp(+) (GRCm38)|
|Type of Mutation||unclassified|
|DNA Base Change (assembly)||A to G at 138141587 bp|
|Amino Acid Change|
|Ref Sequence||ENSEMBL: ENSMUSP00000112923 (fasta)|
|Gene Model||predicted gene model for transcript(s): [ENSMUST00000118091]|
|Predicted Effect||probably null
|Meta Mutation Damage Score||0.9755|
|Coding Region Coverage||
|Validation Efficiency||97% (57/59)|
|MGI Phenotype||FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] The MAPEG (Membrane Associated Proteins in Eicosanoid and Glutathione metabolism) family consists of six human proteins, two of which are involved in the production of leukotrienes and prostaglandin E, important mediators of inflammation. Other family members, demonstrating glutathione S-transferase and peroxidase activities, are involved in cellular defense against toxic, carcinogenic, and pharmacologically active electrophilic compounds. This gene encodes a protein that catalyzes the conjugation of glutathione to electrophiles and the reduction of lipid hydroperoxides. This protein is localized to the endoplasmic reticulum and outer mitochondrial membrane where it is thought to protect these membranes from oxidative stress. Several transcript variants, some non-protein coding and some protein coding, have been found for this gene. [provided by RefSeq, May 2012]|
|Allele List at MGI|
|Other mutations in this stock||
|Other mutations in Mgst1||
(F):5'- TGAAAATTGAAGAGTCATGGCCTTG -3'
(R):5'- TGGGATGAAAGACTCCGACAC -3'
(F):5'- GCAGATAGGGCAAACAGTT -3'
(R):5'- TCTACTTTGAAGGAAAGAAGCTTGAG -3'