Incidental Mutation 'R6944:Vmn2r-ps158'
ID 540772
Institutional Source Beutler Lab
Gene Symbol Vmn2r-ps158
Ensembl Gene ENSMUSG00000091528
Gene Name vomeronasal 2, receptor, pseudogene 158
Synonyms Vmn2r126, Gm9268
MMRRC Submission 045058-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.093) question?
Stock # R6944 (G1)
Quality Score 214.009
Status Validated
Chromosome 7
Chromosomal Location 42668222-42697530 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to C at 42697393 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Phenylalanine to Leucine at position 817 (F817L)
Ref Sequence ENSEMBL: ENSMUSP00000129068 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000166914] [ENSMUST00000173815]
AlphaFold E9Q0M3
Predicted Effect possibly damaging
Transcript: ENSMUST00000166914
AA Change: F817L

PolyPhen 2 Score 0.954 (Sensitivity: 0.79; Specificity: 0.95)
SMART Domains Protein: ENSMUSP00000129068
Gene: ENSMUSG00000091528
AA Change: F817L

DomainStartEndE-ValueType
signal peptide 1 18 N/A INTRINSIC
Pfam:ANF_receptor 77 473 1.1e-41 PFAM
Pfam:NCD3G 516 569 1.7e-23 PFAM
Pfam:7tm_3 602 837 9.6e-51 PFAM
Predicted Effect possibly damaging
Transcript: ENSMUST00000173815
AA Change: F810L

PolyPhen 2 Score 0.695 (Sensitivity: 0.86; Specificity: 0.92)
SMART Domains Protein: ENSMUSP00000134441
Gene: ENSMUSG00000091528
AA Change: F810L

DomainStartEndE-ValueType
signal peptide 1 18 N/A INTRINSIC
Pfam:ANF_receptor 77 467 5.3e-40 PFAM
Pfam:NCD3G 509 562 4.6e-22 PFAM
Pfam:7tm_3 594 831 1.1e-73 PFAM
Coding Region Coverage
  • 1x: 100.0%
  • 3x: 99.9%
  • 10x: 99.5%
  • 20x: 98.2%
Validation Efficiency 97% (75/77)
Allele List at MGI
Other mutations in this stock
Total: 76 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Abcb1b T G 5: 8,863,693 (GRCm39) V216G probably damaging Het
Abcb5 T C 12: 118,875,265 (GRCm39) R636G probably benign Het
Ago1 G T 4: 126,354,215 (GRCm39) F198L possibly damaging Het
Ankrd42 C T 7: 92,268,755 (GRCm39) probably null Het
Anxa11 T A 14: 25,875,176 (GRCm39) F274I probably damaging Het
Ascc1 T C 10: 59,849,475 (GRCm39) L122P probably damaging Het
Bptf T C 11: 106,971,649 (GRCm39) S953G probably damaging Het
Chml T A 1: 175,515,727 (GRCm39) N65Y probably damaging Het
Clcc1 A G 3: 108,578,284 (GRCm39) K262E probably damaging Het
Clhc1 T G 11: 29,519,346 (GRCm39) D384E probably damaging Het
Cnot2 G A 10: 116,373,128 (GRCm39) probably benign Het
Cntnap1 T C 11: 101,073,730 (GRCm39) V627A probably damaging Het
Col6a4 A G 9: 105,949,370 (GRCm39) V755A probably damaging Het
Cyp4f18 T A 8: 72,743,738 (GRCm39) I406F probably benign Het
Dclre1a T C 19: 56,533,451 (GRCm39) E381G possibly damaging Het
Dnah1 A G 14: 30,990,861 (GRCm39) Y3153H probably damaging Het
Dnah8 C A 17: 31,013,633 (GRCm39) D3791E probably benign Het
Dnah9 T C 11: 65,975,975 (GRCm39) E1358G possibly damaging Het
Eef1g G A 19: 8,945,656 (GRCm39) R30H probably benign Het
Egln3 A T 12: 54,230,738 (GRCm39) I181N probably benign Het
Entpd6 A G 2: 150,605,519 (GRCm39) T250A probably damaging Het
Epb41l5 C T 1: 119,536,859 (GRCm39) R344Q probably damaging Het
Fam20b T C 1: 156,515,091 (GRCm39) D258G probably benign Het
Fbxw18 A T 9: 109,531,655 (GRCm39) D21E probably damaging Het
Fbxw21 T C 9: 108,986,603 (GRCm39) E92G probably damaging Het
Fzd6 T A 15: 38,889,212 (GRCm39) M110K possibly damaging Het
Golgb1 C T 16: 36,732,475 (GRCm39) P574L probably benign Het
Gpr153 A G 4: 152,363,820 (GRCm39) E80G probably damaging Het
Gvin2 G A 7: 105,551,187 (GRCm39) Q622* probably null Het
Kcnt1 T C 2: 25,767,840 (GRCm39) probably benign Het
Kcnt2 T G 1: 140,511,803 (GRCm39) V962G probably benign Het
Malt1 T C 18: 65,570,991 (GRCm39) V109A probably benign Het
Marchf7 A G 2: 60,064,587 (GRCm39) I288V probably benign Het
Mief1 C T 15: 80,133,644 (GRCm39) R234C probably damaging Het
Morc3 A G 16: 93,667,460 (GRCm39) S613G probably benign Het
Myt1 A G 2: 181,439,387 (GRCm39) E345G possibly damaging Het
Napb T C 2: 148,548,889 (GRCm39) T133A probably benign Het
Nwd1 T C 8: 73,380,162 (GRCm39) V16A possibly damaging Het
Oas1f G A 5: 120,986,247 (GRCm39) E67K probably benign Het
Obscn T C 11: 58,929,756 (GRCm39) K5153R probably damaging Het
Or2w3b T A 11: 58,623,068 (GRCm39) S308C possibly damaging Het
Or5a3 G T 19: 12,400,628 (GRCm39) M318I probably benign Het
Or5g26 C T 2: 85,494,195 (GRCm39) M194I probably benign Het
Or6d12 T C 6: 116,492,791 (GRCm39) F18L possibly damaging Het
Pdcd2 T C 17: 15,745,632 (GRCm39) N185S possibly damaging Het
Pgap1 A T 1: 54,569,320 (GRCm39) W349R probably damaging Het
Prpf39 T A 12: 65,089,454 (GRCm39) V64E probably benign Het
Ptpn13 T A 5: 103,624,857 (GRCm39) W54R probably null Het
Rbms3 G T 9: 116,939,173 (GRCm39) P29Q probably damaging Het
Rnf123 A G 9: 107,940,822 (GRCm39) L679P probably benign Het
Samd4 T A 14: 47,254,092 (GRCm39) D84E possibly damaging Het
Scarf1 T C 11: 75,413,032 (GRCm39) V426A probably benign Het
Slc12a1 A G 2: 125,002,454 (GRCm39) N145D probably damaging Het
Slc2a6 A T 2: 26,916,076 (GRCm39) M99K probably damaging Het
Slc34a2 A T 5: 53,222,225 (GRCm39) I306L probably benign Het
Slx4ip A G 2: 136,910,195 (GRCm39) K397E probably damaging Het
Smr3a C T 5: 88,155,949 (GRCm39) probably benign Het
Spata31h1 A C 10: 82,132,056 (GRCm39) I318R probably benign Het
Spef2 T C 15: 9,592,835 (GRCm39) E1502G probably damaging Het
Sri A T 5: 8,113,365 (GRCm39) T119S probably benign Het
Synrg T A 11: 83,915,912 (GRCm39) L1085H probably damaging Het
Taf7 A T 18: 37,775,910 (GRCm39) L219H probably damaging Het
Tmco3 T A 8: 13,353,729 (GRCm39) V347E probably damaging Het
Tmem8b A T 4: 43,674,465 (GRCm39) I250F probably damaging Het
Tom1l2 A G 11: 60,139,817 (GRCm39) V239A probably damaging Het
Trpm1 T A 7: 63,893,181 (GRCm39) M1011K probably damaging Het
Tspan9 A T 6: 127,942,769 (GRCm39) Y153N probably benign Het
Ttll11 T C 2: 35,642,306 (GRCm39) H675R probably benign Het
Unc50 C T 1: 37,471,743 (GRCm39) T131M probably damaging Het
Vgf T A 5: 137,061,206 (GRCm39) I456N probably damaging Het
Vmn1r223 A G 13: 23,433,483 (GRCm39) I26V unknown Het
Vmn1r39 T C 6: 66,782,205 (GRCm39) M1V probably null Het
Vmn2r111 T C 17: 22,778,032 (GRCm39) N549S possibly damaging Het
Vmn2r14 T C 5: 109,363,925 (GRCm39) T664A probably benign Het
Vmn2r14 G A 5: 109,364,140 (GRCm39) T592I probably benign Het
Vmn2r96 T A 17: 18,817,891 (GRCm39) F489L probably benign Het
Other mutations in Vmn2r-ps158
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01676:Vmn2r-ps158 APN 7 42,674,133 (GRCm39) missense probably damaging 0.97
IGL01753:Vmn2r-ps158 APN 7 42,674,139 (GRCm39) missense probably damaging 1.00
IGL02338:Vmn2r-ps158 APN 7 42,697,160 (GRCm39) missense probably damaging 1.00
IGL02541:Vmn2r-ps158 APN 7 42,673,092 (GRCm39) splice site probably benign
R0751:Vmn2r-ps158 UTSW 7 42,696,833 (GRCm39) missense probably damaging 0.99
R0849:Vmn2r-ps158 UTSW 7 42,674,142 (GRCm39) missense probably damaging 1.00
R1460:Vmn2r-ps158 UTSW 7 42,672,639 (GRCm39) missense probably benign 0.25
R1617:Vmn2r-ps158 UTSW 7 42,673,503 (GRCm39) missense probably benign 0.18
R1962:Vmn2r-ps158 UTSW 7 42,696,824 (GRCm39) missense probably benign 0.00
R1999:Vmn2r-ps158 UTSW 7 42,696,883 (GRCm39) missense probably damaging 1.00
R2022:Vmn2r-ps158 UTSW 7 42,673,454 (GRCm39) missense probably benign
R2434:Vmn2r-ps158 UTSW 7 42,696,881 (GRCm39) missense probably damaging 0.99
R3760:Vmn2r-ps158 UTSW 7 42,673,502 (GRCm39) missense probably benign 0.00
R4562:Vmn2r-ps158 UTSW 7 42,672,986 (GRCm39) nonsense probably null
R4890:Vmn2r-ps158 UTSW 7 42,697,024 (GRCm39) missense probably damaging 1.00
R5221:Vmn2r-ps158 UTSW 7 42,672,684 (GRCm39) missense probably benign 0.31
R5597:Vmn2r-ps158 UTSW 7 42,674,073 (GRCm39) missense probably benign 0.01
R6589:Vmn2r-ps158 UTSW 7 42,673,022 (GRCm39) missense possibly damaging 0.91
R6831:Vmn2r-ps158 UTSW 7 42,673,004 (GRCm39) missense probably damaging 1.00
R6834:Vmn2r-ps158 UTSW 7 42,673,004 (GRCm39) missense probably damaging 1.00
R6910:Vmn2r-ps158 UTSW 7 42,673,475 (GRCm39) missense probably benign 0.01
R7470:Vmn2r-ps158 UTSW 7 42,697,310 (GRCm39) missense probably damaging 1.00
R7553:Vmn2r-ps158 UTSW 7 42,697,447 (GRCm39) missense probably damaging 1.00
R7661:Vmn2r-ps158 UTSW 7 42,672,582 (GRCm39) missense probably benign 0.00
R7677:Vmn2r-ps158 UTSW 7 42,674,163 (GRCm39) missense probably damaging 1.00
R8087:Vmn2r-ps158 UTSW 7 42,697,094 (GRCm39) missense probably benign 0.04
R8210:Vmn2r-ps158 UTSW 7 42,673,462 (GRCm39) missense probably benign 0.16
R8379:Vmn2r-ps158 UTSW 7 42,697,270 (GRCm39) missense probably damaging 1.00
R8692:Vmn2r-ps158 UTSW 7 42,697,108 (GRCm39) missense probably benign 0.13
R8917:Vmn2r-ps158 UTSW 7 42,697,433 (GRCm39) missense probably damaging 1.00
R9255:Vmn2r-ps158 UTSW 7 42,673,965 (GRCm39) missense possibly damaging 0.75
R9375:Vmn2r-ps158 UTSW 7 42,673,499 (GRCm39) missense possibly damaging 0.87
R9452:Vmn2r-ps158 UTSW 7 42,697,257 (GRCm39) missense possibly damaging 0.88
R9647:Vmn2r-ps158 UTSW 7 42,697,171 (GRCm39) missense probably damaging 1.00
Predicted Primers PCR Primer
(F):5'- CTTTCCACTGTGTACTGGGATAC -3'
(R):5'- GGTGTGGCACTGGTTTCAAC -3'

Sequencing Primer
(F):5'- CTGTCATTCAGCATGCAG -3'
(R):5'- CCTGATGTCAAGACGTGA -3'
Posted On 2018-11-28