Incidental Mutation 'R6945:Slc22a15'
ID 540830
Institutional Source Beutler Lab
Gene Symbol Slc22a15
Ensembl Gene ENSMUSG00000033147
Gene Name solute carrier family 22 (organic anion/cation transporter), member 15
Synonyms 2610034P21Rik, A530052I06Rik
MMRRC Submission 045059-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.058) question?
Stock # R6945 (G1)
Quality Score 225.009
Status Not validated
Chromosome 3
Chromosomal Location 101763092-101831769 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to C at 101831430 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Glutamic Acid to Glycine at position 2 (E2G)
Ref Sequence ENSEMBL: ENSMUSP00000139518 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000106928] [ENSMUST00000183255] [ENSMUST00000190824]
AlphaFold Q504N2
Predicted Effect probably benign
Transcript: ENSMUST00000106928
AA Change: E2G

PolyPhen 2 Score 0.049 (Sensitivity: 0.94; Specificity: 0.83)
SMART Domains Protein: ENSMUSP00000102541
Gene: ENSMUSG00000033147
AA Change: E2G

DomainStartEndE-ValueType
transmembrane domain 20 42 N/A INTRINSIC
Pfam:Sugar_tr 58 495 6.9e-29 PFAM
Pfam:MFS_1 69 450 3.4e-24 PFAM
low complexity region 524 532 N/A INTRINSIC
Predicted Effect possibly damaging
Transcript: ENSMUST00000183255
AA Change: E2G

PolyPhen 2 Score 0.892 (Sensitivity: 0.82; Specificity: 0.94)
SMART Domains Protein: ENSMUSP00000138357
Gene: ENSMUSG00000033147
AA Change: E2G

DomainStartEndE-ValueType
transmembrane domain 20 42 N/A INTRINSIC
Pfam:Sugar_tr 56 244 5.2e-13 PFAM
Pfam:MFS_1 69 244 7.6e-13 PFAM
Predicted Effect probably damaging
Transcript: ENSMUST00000190824
AA Change: E2G

PolyPhen 2 Score 0.992 (Sensitivity: 0.70; Specificity: 0.97)
SMART Domains Protein: ENSMUSP00000139518
Gene: ENSMUSG00000033147
AA Change: E2G

DomainStartEndE-ValueType
signal peptide 1 36 N/A INTRINSIC
Pfam:Sugar_tr 88 341 3.3e-5 PFAM
low complexity region 369 377 N/A INTRINSIC
Coding Region Coverage
  • 1x: 100.0%
  • 3x: 99.9%
  • 10x: 99.3%
  • 20x: 97.5%
Validation Efficiency 96% (51/53)
MGI Phenotype FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] Organic ion transporters, such as SLC22A15, transport various medically and physiologically important compounds, including pharmaceuticals, toxins, hormones, neurotransmitters, and cellular metabolites. These transporters are also referred to as amphiphilic solute facilitators (ASFs).[supplied by OMIM, Apr 2004]
Allele List at MGI
Other mutations in this stock
Total: 54 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Abcc5 T A 16: 20,218,759 (GRCm39) T208S probably benign Het
Acaa2 A G 18: 74,926,380 (GRCm39) E112G probably benign Het
Adgrb1 A G 15: 74,421,873 (GRCm39) N881S probably damaging Het
Adgre1 A G 17: 57,717,844 (GRCm39) E314G probably benign Het
Adgre1 A G 17: 57,727,399 (GRCm39) E443G probably benign Het
Akp3 A G 1: 87,053,353 (GRCm39) Y102C probably damaging Het
Birc6 A G 17: 74,886,526 (GRCm39) N618S probably benign Het
Bpifc A G 10: 85,815,078 (GRCm39) V296A probably benign Het
Cacna2d3 G A 14: 28,691,275 (GRCm39) probably benign Het
Cacnb4 T C 2: 52,364,966 (GRCm39) N99S probably damaging Het
Cd38 A G 5: 44,065,348 (GRCm39) Y283C probably damaging Het
Celf4 T A 18: 25,629,293 (GRCm39) Q411L probably damaging Het
Cemip A T 7: 83,647,755 (GRCm39) H108Q probably damaging Het
Col23a1 A G 11: 51,452,720 (GRCm39) E225G unknown Het
Dnah11 T C 12: 118,024,045 (GRCm39) E1902G probably damaging Het
Dst A G 1: 34,229,571 (GRCm39) D2063G probably damaging Het
Fsip2 A T 2: 82,823,184 (GRCm39) I6306L probably benign Het
Furin A G 7: 80,040,838 (GRCm39) S667P possibly damaging Het
Glmp T A 3: 88,233,139 (GRCm39) S92R probably benign Het
Gm11563 C G 11: 99,549,298 (GRCm39) C152S unknown Het
Gm3486 A G 14: 41,206,518 (GRCm39) V185A probably benign Het
Gvin2 G A 7: 105,551,187 (GRCm39) Q622* probably null Het
Hyal1 C A 9: 107,456,369 (GRCm39) A102E probably damaging Het
Invs T C 4: 48,421,785 (GRCm39) C806R probably benign Het
L1td1 T C 4: 98,621,933 (GRCm39) V165A probably benign Het
Lama1 A G 17: 68,120,861 (GRCm39) T2666A Het
Lrit1 G C 14: 36,782,052 (GRCm39) V242L probably damaging Het
Lrrc8a A G 2: 30,146,239 (GRCm39) Y351C probably damaging Het
Myh7b T C 2: 155,464,152 (GRCm39) F551S possibly damaging Het
Myo19 A G 11: 84,788,386 (GRCm39) T333A probably benign Het
Nrp2 A T 1: 62,799,947 (GRCm39) N387I probably damaging Het
Oas2 T C 5: 120,874,204 (GRCm39) D543G probably benign Het
Or2g25 A G 17: 37,970,405 (GRCm39) I273T possibly damaging Het
Or5al6 A G 2: 85,976,428 (GRCm39) S217P probably damaging Het
Pak5 A G 2: 135,942,859 (GRCm39) V427A probably benign Het
Pfas G A 11: 68,891,356 (GRCm39) A247V probably benign Het
Pramel52-ps C T 5: 94,531,490 (GRCm39) H125Y possibly damaging Het
Psat1 T A 19: 15,894,545 (GRCm39) T115S probably benign Het
Psme4 T A 11: 30,787,437 (GRCm39) D1077E probably benign Het
Rabgap1l A G 1: 160,509,752 (GRCm39) S442P probably benign Het
Ralgapa1 A G 12: 55,822,976 (GRCm39) M280T possibly damaging Het
Rb1cc1 A T 1: 6,331,256 (GRCm39) E394D probably damaging Het
Seh1l T C 18: 67,922,460 (GRCm39) V271A probably benign Het
Sf3b1 A T 1: 55,036,315 (GRCm39) N919K probably benign Het
Sftpd A G 14: 40,896,449 (GRCm39) S245P possibly damaging Het
Spta1 A G 1: 174,036,891 (GRCm39) D1134G possibly damaging Het
Syna A G 5: 134,587,815 (GRCm39) V378A probably damaging Het
Tchp A G 5: 114,847,411 (GRCm39) K77E possibly damaging Het
Tescl T C 7: 24,032,956 (GRCm39) N123S probably benign Het
Trio C T 15: 27,824,176 (GRCm39) R1443Q probably damaging Het
Trrap A T 5: 144,727,665 (GRCm39) Y462F possibly damaging Het
Vmn1r78 A G 7: 11,886,832 (GRCm39) T148A probably benign Het
Vmn2r111 T C 17: 22,778,032 (GRCm39) N549S possibly damaging Het
Zfp1007 A C 5: 109,824,711 (GRCm39) N246K probably benign Het
Other mutations in Slc22a15
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00846:Slc22a15 APN 3 101,768,136 (GRCm39) missense probably benign 0.00
IGL01120:Slc22a15 APN 3 101,804,482 (GRCm39) missense probably damaging 1.00
IGL01345:Slc22a15 APN 3 101,787,492 (GRCm39) missense probably benign 0.00
IGL01871:Slc22a15 APN 3 101,768,110 (GRCm39) splice site probably benign
IGL01880:Slc22a15 APN 3 101,768,164 (GRCm39) missense probably benign 0.32
R0310:Slc22a15 UTSW 3 101,767,827 (GRCm39) missense probably benign 0.12
R1758:Slc22a15 UTSW 3 101,767,769 (GRCm39) nonsense probably null
R1937:Slc22a15 UTSW 3 101,787,505 (GRCm39) critical splice acceptor site probably null
R3804:Slc22a15 UTSW 3 101,804,590 (GRCm39) missense probably damaging 1.00
R4830:Slc22a15 UTSW 3 101,782,919 (GRCm39) intron probably benign
R5564:Slc22a15 UTSW 3 101,771,905 (GRCm39) missense probably benign 0.34
R5684:Slc22a15 UTSW 3 101,770,271 (GRCm39) missense probably damaging 1.00
R6034:Slc22a15 UTSW 3 101,770,235 (GRCm39) missense possibly damaging 0.80
R6034:Slc22a15 UTSW 3 101,770,235 (GRCm39) missense possibly damaging 0.80
R6114:Slc22a15 UTSW 3 101,768,168 (GRCm39) nonsense probably null
R6481:Slc22a15 UTSW 3 101,790,899 (GRCm39) missense possibly damaging 0.88
R6641:Slc22a15 UTSW 3 101,783,022 (GRCm39) missense possibly damaging 0.52
R7354:Slc22a15 UTSW 3 101,771,897 (GRCm39) missense probably benign 0.09
R7373:Slc22a15 UTSW 3 101,785,213 (GRCm39) missense possibly damaging 0.78
R7431:Slc22a15 UTSW 3 101,805,256 (GRCm39) missense probably benign 0.13
R7758:Slc22a15 UTSW 3 101,805,251 (GRCm39) critical splice donor site probably null
R8058:Slc22a15 UTSW 3 101,771,926 (GRCm39) missense probably benign
R8129:Slc22a15 UTSW 3 101,822,658 (GRCm39) missense possibly damaging 0.82
R8838:Slc22a15 UTSW 3 101,790,849 (GRCm39) missense probably damaging 1.00
R9652:Slc22a15 UTSW 3 101,790,848 (GRCm39) missense possibly damaging 0.94
Predicted Primers PCR Primer
(F):5'- CTTTCAACTAGCTCTGGTGGCG -3'
(R):5'- TCACTTCTGACAGGAAGCGG -3'

Sequencing Primer
(F):5'- AAGTGTCAGTGCCAGGCTC -3'
(R):5'- GACCAGCATCGCATCTCCG -3'
Posted On 2018-11-28