Incidental Mutation 'R6945:Vmn1r78'
ID 540840
Institutional Source Beutler Lab
Gene Symbol Vmn1r78
Ensembl Gene ENSMUSG00000061602
Gene Name vomeronasal 1 receptor 78
Synonyms V1rg7
MMRRC Submission 045059-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.070) question?
Stock # R6945 (G1)
Quality Score 225.009
Status Validated
Chromosome 7
Chromosomal Location 11886391-11887332 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to G at 11886832 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Threonine to Alanine at position 148 (T148A)
Ref Sequence ENSEMBL: ENSMUSP00000154797 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000078039] [ENSMUST00000228244] [ENSMUST00000228664]
AlphaFold K7N608
Predicted Effect probably benign
Transcript: ENSMUST00000078039
AA Change: T148A

PolyPhen 2 Score 0.011 (Sensitivity: 0.96; Specificity: 0.78)
SMART Domains Protein: ENSMUSP00000077186
Gene: ENSMUSG00000061602
AA Change: T148A

DomainStartEndE-ValueType
Pfam:TAS2R 3 304 5.7e-8 PFAM
Pfam:V1R 12 301 1.5e-29 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000228244
AA Change: T148A

PolyPhen 2 Score 0.011 (Sensitivity: 0.96; Specificity: 0.78)
Predicted Effect probably benign
Transcript: ENSMUST00000228664
AA Change: T148A

PolyPhen 2 Score 0.011 (Sensitivity: 0.96; Specificity: 0.78)
Coding Region Coverage
  • 1x: 100.0%
  • 3x: 99.9%
  • 10x: 99.3%
  • 20x: 97.5%
Validation Efficiency 96% (51/53)
Allele List at MGI
Other mutations in this stock
Total: 54 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Abcc5 T A 16: 20,218,759 (GRCm39) T208S probably benign Het
Acaa2 A G 18: 74,926,380 (GRCm39) E112G probably benign Het
Adgrb1 A G 15: 74,421,873 (GRCm39) N881S probably damaging Het
Adgre1 A G 17: 57,717,844 (GRCm39) E314G probably benign Het
Adgre1 A G 17: 57,727,399 (GRCm39) E443G probably benign Het
Akp3 A G 1: 87,053,353 (GRCm39) Y102C probably damaging Het
Birc6 A G 17: 74,886,526 (GRCm39) N618S probably benign Het
Bpifc A G 10: 85,815,078 (GRCm39) V296A probably benign Het
Cacna2d3 G A 14: 28,691,275 (GRCm39) probably benign Het
Cacnb4 T C 2: 52,364,966 (GRCm39) N99S probably damaging Het
Cd38 A G 5: 44,065,348 (GRCm39) Y283C probably damaging Het
Celf4 T A 18: 25,629,293 (GRCm39) Q411L probably damaging Het
Cemip A T 7: 83,647,755 (GRCm39) H108Q probably damaging Het
Col23a1 A G 11: 51,452,720 (GRCm39) E225G unknown Het
Dnah11 T C 12: 118,024,045 (GRCm39) E1902G probably damaging Het
Dst A G 1: 34,229,571 (GRCm39) D2063G probably damaging Het
Fsip2 A T 2: 82,823,184 (GRCm39) I6306L probably benign Het
Furin A G 7: 80,040,838 (GRCm39) S667P possibly damaging Het
Glmp T A 3: 88,233,139 (GRCm39) S92R probably benign Het
Gm11563 C G 11: 99,549,298 (GRCm39) C152S unknown Het
Gm3486 A G 14: 41,206,518 (GRCm39) V185A probably benign Het
Gvin2 G A 7: 105,551,187 (GRCm39) Q622* probably null Het
Hyal1 C A 9: 107,456,369 (GRCm39) A102E probably damaging Het
Invs T C 4: 48,421,785 (GRCm39) C806R probably benign Het
L1td1 T C 4: 98,621,933 (GRCm39) V165A probably benign Het
Lama1 A G 17: 68,120,861 (GRCm39) T2666A Het
Lrit1 G C 14: 36,782,052 (GRCm39) V242L probably damaging Het
Lrrc8a A G 2: 30,146,239 (GRCm39) Y351C probably damaging Het
Myh7b T C 2: 155,464,152 (GRCm39) F551S possibly damaging Het
Myo19 A G 11: 84,788,386 (GRCm39) T333A probably benign Het
Nrp2 A T 1: 62,799,947 (GRCm39) N387I probably damaging Het
Oas2 T C 5: 120,874,204 (GRCm39) D543G probably benign Het
Or2g25 A G 17: 37,970,405 (GRCm39) I273T possibly damaging Het
Or5al6 A G 2: 85,976,428 (GRCm39) S217P probably damaging Het
Pak5 A G 2: 135,942,859 (GRCm39) V427A probably benign Het
Pfas G A 11: 68,891,356 (GRCm39) A247V probably benign Het
Pramel52-ps C T 5: 94,531,490 (GRCm39) H125Y possibly damaging Het
Psat1 T A 19: 15,894,545 (GRCm39) T115S probably benign Het
Psme4 T A 11: 30,787,437 (GRCm39) D1077E probably benign Het
Rabgap1l A G 1: 160,509,752 (GRCm39) S442P probably benign Het
Ralgapa1 A G 12: 55,822,976 (GRCm39) M280T possibly damaging Het
Rb1cc1 A T 1: 6,331,256 (GRCm39) E394D probably damaging Het
Seh1l T C 18: 67,922,460 (GRCm39) V271A probably benign Het
Sf3b1 A T 1: 55,036,315 (GRCm39) N919K probably benign Het
Sftpd A G 14: 40,896,449 (GRCm39) S245P possibly damaging Het
Slc22a15 T C 3: 101,831,430 (GRCm39) E2G probably damaging Het
Spta1 A G 1: 174,036,891 (GRCm39) D1134G possibly damaging Het
Syna A G 5: 134,587,815 (GRCm39) V378A probably damaging Het
Tchp A G 5: 114,847,411 (GRCm39) K77E possibly damaging Het
Tescl T C 7: 24,032,956 (GRCm39) N123S probably benign Het
Trio C T 15: 27,824,176 (GRCm39) R1443Q probably damaging Het
Trrap A T 5: 144,727,665 (GRCm39) Y462F possibly damaging Het
Vmn2r111 T C 17: 22,778,032 (GRCm39) N549S possibly damaging Het
Zfp1007 A C 5: 109,824,711 (GRCm39) N246K probably benign Het
Other mutations in Vmn1r78
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01129:Vmn1r78 APN 7 11,887,165 (GRCm39) missense probably benign 0.10
IGL02019:Vmn1r78 APN 7 11,886,634 (GRCm39) missense probably damaging 0.99
IGL02143:Vmn1r78 APN 7 11,886,407 (GRCm39) missense probably benign
IGL02154:Vmn1r78 APN 7 11,886,472 (GRCm39) missense probably benign 0.22
IGL02290:Vmn1r78 APN 7 11,887,082 (GRCm39) missense probably damaging 1.00
IGL03012:Vmn1r78 APN 7 11,887,291 (GRCm39) missense probably benign 0.32
IGL03256:Vmn1r78 APN 7 11,886,725 (GRCm39) missense probably damaging 1.00
IGL03373:Vmn1r78 APN 7 11,887,270 (GRCm39) missense possibly damaging 0.86
IGL03384:Vmn1r78 APN 7 11,887,136 (GRCm39) missense possibly damaging 0.94
R0016:Vmn1r78 UTSW 7 11,887,279 (GRCm39) missense probably benign 0.02
R1445:Vmn1r78 UTSW 7 11,886,508 (GRCm39) missense possibly damaging 0.64
R1748:Vmn1r78 UTSW 7 11,887,250 (GRCm39) missense probably damaging 1.00
R2017:Vmn1r78 UTSW 7 11,887,270 (GRCm39) missense possibly damaging 0.86
R2032:Vmn1r78 UTSW 7 11,887,210 (GRCm39) missense probably benign 0.00
R2198:Vmn1r78 UTSW 7 11,886,487 (GRCm39) missense probably benign 0.06
R4330:Vmn1r78 UTSW 7 11,886,386 (GRCm39) splice site probably null
R4564:Vmn1r78 UTSW 7 11,886,485 (GRCm39) missense probably damaging 1.00
R4769:Vmn1r78 UTSW 7 11,886,725 (GRCm39) missense probably damaging 1.00
R4801:Vmn1r78 UTSW 7 11,886,891 (GRCm39) nonsense probably null
R4802:Vmn1r78 UTSW 7 11,886,891 (GRCm39) nonsense probably null
R4860:Vmn1r78 UTSW 7 11,886,683 (GRCm39) missense probably damaging 1.00
R4860:Vmn1r78 UTSW 7 11,886,683 (GRCm39) missense probably damaging 1.00
R5648:Vmn1r78 UTSW 7 11,886,693 (GRCm39) missense possibly damaging 0.92
R6561:Vmn1r78 UTSW 7 11,886,826 (GRCm39) missense probably damaging 1.00
R6869:Vmn1r78 UTSW 7 11,886,676 (GRCm39) missense probably benign 0.01
R7793:Vmn1r78 UTSW 7 11,887,241 (GRCm39) missense probably benign 0.01
R7954:Vmn1r78 UTSW 7 11,887,227 (GRCm39) nonsense probably null
R8698:Vmn1r78 UTSW 7 11,886,539 (GRCm39) missense probably benign 0.06
R8830:Vmn1r78 UTSW 7 11,887,118 (GRCm39) missense probably damaging 0.98
R9624:Vmn1r78 UTSW 7 11,886,410 (GRCm39) missense probably benign
Z1088:Vmn1r78 UTSW 7 11,886,641 (GRCm39) missense probably damaging 1.00
Predicted Primers PCR Primer
(F):5'- TCCAGAGACACTGTCAGATTTGG -3'
(R):5'- ATACTTGAGCAGGCCATGAG -3'

Sequencing Primer
(F):5'- CCTGGATGATATTGGTTGTAAATTGG -3'
(R):5'- AGCAGGCCATGAGACCCAG -3'
Posted On 2018-11-28