Mutagenetix > Incidental Mutation

Incidental Mutation 'R6946:Clec4b2'

540883

Institutional Source

Beutler Lab

Gene Symbol

Clec4b2

Ensembl Gene

ENSMUSG00000067767

Gene Name

C-type lectin domain family 4, member b2

Synonyms

mDCAR1, F830043G12Rik

Accession Numbers

Essential gene?

Probably non essential (E-score: 0.050) question?

Stock #

R6946 (G1)

Quality Score

225.009

Status

Not validated

Chromosome

Chromosomal Location

123149852-123181630 bp(+) (GRCm39)

Type of Mutation

nonsense

DNA Base Change (assembly)

C to T at 123177987 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Glutamine to Stop codon at position 101 (Q101*)

Ref Sequence

ENSEMBL: ENSMUSP00000085802 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000088455]

AlphaFold

Q67DU8

Predicted Effect

probably null
Transcript: ENSMUST00000088455
AA Change: Q101*

SMART Domains

Protein: ENSMUSP00000085802
Gene: ENSMUSG00000067767
AA Change: Q101*

Domain	Start	End	E-Value	Type
transmembrane domain	21	43	N/A	INTRINSIC
CLECT	79	202	1.87e-33	SMART

Coding Region Coverage

1x: 100.0%
3x: 99.8%
10x: 98.9%
20x: 95.7%

Validation Efficiency

100% (42/42)

Allele List at MGI

Other mutations in this stock

Total: 41 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Abcc9	T	A	6: 142,624,953 (GRCm39)	S481C	probably damaging	Het
Atp8a1	T	C	5: 67,779,968 (GRCm39)	T1142A	possibly damaging	Het
Atxn1l	G	T	8: 110,458,648 (GRCm39)	P538H	probably damaging	Het
Carmil1	T	C	13: 24,299,528 (GRCm39)	N332S	possibly damaging	Het
Clstn2	A	T	9: 97,351,875 (GRCm39)	F517I	probably damaging	Het
Dap3	T	A	3: 88,845,523 (GRCm39)		probably benign	Het
Dgki	C	A	6: 37,276,571 (GRCm39)	G105*	probably null	Het
Dnm3	T	C	1: 162,141,224 (GRCm39)	E345G	possibly damaging	Het
Fam120a	A	T	13: 49,034,496 (GRCm39)	S1039T	possibly damaging	Het
Gpr132	T	A	12: 112,815,830 (GRCm39)	Y332F	probably benign	Het
Ifi44	A	T	3: 151,451,536 (GRCm39)	I190N	possibly damaging	Het
Ighv1-42	T	A	12: 114,901,155 (GRCm39)	N4Y	possibly damaging	Het
Igll1	A	G	16: 16,678,920 (GRCm39)	V130A	probably damaging	Het
Ikzf2	T	A	1: 69,616,955 (GRCm39)	K137*	probably null	Het
Klra9	T	A	6: 130,156,003 (GRCm39)	I251F	probably benign	Het
Lrp1b	T	C	2: 40,587,451 (GRCm39)	I166V	probably benign	Het
Map3k1	C	T	13: 111,905,035 (GRCm39)	W213*	probably null	Het
Map3k12	A	G	15: 102,413,569 (GRCm39)	M134T	possibly damaging	Het
Mfsd3	T	A	15: 76,587,349 (GRCm39)	M344K	probably damaging	Het
Mier2	C	A	10: 79,376,673 (GRCm39)		probably benign	Het
Nop53	C	T	7: 15,672,283 (GRCm39)	R462Q	probably damaging	Het
Oog2	A	T	4: 143,923,034 (GRCm39)	D433V	possibly damaging	Het
Or5p76	T	A	7: 108,122,528 (GRCm39)	I210F	probably benign	Het
Or7d11	A	T	9: 19,966,670 (GRCm39)	L30M	possibly damaging	Het
Or8g30	C	A	9: 39,230,315 (GRCm39)	L198F	probably damaging	Het
Or8k38	T	A	2: 86,487,932 (GRCm39)	Y290F	probably damaging	Het
Pan2	A	G	10: 128,151,506 (GRCm39)	T867A	probably benign	Het
Pcdhb3	T	A	18: 37,435,672 (GRCm39)	L546Q	probably damaging	Het
Plcg2	A	T	8: 118,230,929 (GRCm39)	M4L	probably benign	Het
Prss21	T	C	17: 24,087,138 (GRCm39)	S24P	possibly damaging	Het
Ryr3	T	C	2: 112,661,545 (GRCm39)	D1815G	probably damaging	Het
Scd4	A	G	19: 44,321,953 (GRCm39)	E8G	probably null	Het
Sec31b	T	C	19: 44,522,755 (GRCm39)	D79G	probably damaging	Het
Siah1a	G	T	8: 87,451,770 (GRCm39)	A238E	probably damaging	Het
Spag17	G	A	3: 99,911,999 (GRCm39)	E290K	possibly damaging	Het
Srl	T	C	16: 4,300,423 (GRCm39)	I883V	probably benign	Het
Tas2r117	T	C	6: 132,780,288 (GRCm39)	L142S	probably damaging	Het
Trgv1	T	C	13: 19,524,190 (GRCm39)	L2P	probably benign	Het
Ttn	A	T	2: 76,580,199 (GRCm39)	W23565R	probably damaging	Het
Vipr2	A	T	12: 116,102,819 (GRCm39)	T310S	possibly damaging	Het
Zfp112	A	T	7: 23,824,766 (GRCm39)	N245Y	probably damaging	Het

Other mutations in Clec4b2

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL00956:Clec4b2	APN	6	123,179,110 (GRCm39)	nonsense	probably null
IGL01753:Clec4b2	APN	6	123,179,169 (GRCm39)	missense	possibly damaging	0.90
IGL02168:Clec4b2	APN	6	123,181,156 (GRCm39)	missense	probably damaging	0.98
IGL02388:Clec4b2	APN	6	123,179,187 (GRCm39)	splice site	probably null
IGL03194:Clec4b2	APN	6	123,177,946 (GRCm39)	missense	probably benign	0.07
P0041:Clec4b2	UTSW	6	123,158,253 (GRCm39)	missense	possibly damaging	0.72
R0013:Clec4b2	UTSW	6	123,179,108 (GRCm39)	missense	probably damaging	1.00
R0121:Clec4b2	UTSW	6	123,181,131 (GRCm39)	missense	probably benign	0.02
R0401:Clec4b2	UTSW	6	123,158,259 (GRCm39)	nonsense	probably null
R1072:Clec4b2	UTSW	6	123,181,233 (GRCm39)	missense	probably damaging	0.99
R2520:Clec4b2	UTSW	6	123,177,942 (GRCm39)	missense	probably damaging	1.00
R4575:Clec4b2	UTSW	6	123,150,639 (GRCm39)	missense	probably damaging	0.99
R4897:Clec4b2	UTSW	6	123,177,999 (GRCm39)	nonsense	probably null
R4898:Clec4b2	UTSW	6	123,181,163 (GRCm39)	missense	probably benign	0.36
R5022:Clec4b2	UTSW	6	123,177,915 (GRCm39)	missense	probably null	1.00
R5023:Clec4b2	UTSW	6	123,177,915 (GRCm39)	missense	probably null	1.00
R5057:Clec4b2	UTSW	6	123,177,915 (GRCm39)	missense	probably null	1.00
R5404:Clec4b2	UTSW	6	123,158,308 (GRCm39)	missense	probably benign	0.06
R5508:Clec4b2	UTSW	6	123,150,001 (GRCm39)	start gained	probably benign
R6082:Clec4b2	UTSW	6	123,181,100 (GRCm39)	critical splice acceptor site	probably null
R6333:Clec4b2	UTSW	6	123,177,637 (GRCm39)	splice site	probably null
R6902:Clec4b2	UTSW	6	123,177,987 (GRCm39)	nonsense	probably null
R7144:Clec4b2	UTSW	6	123,158,343 (GRCm39)	missense	probably benign	0.02
R7709:Clec4b2	UTSW	6	123,149,974 (GRCm39)	start gained	probably benign
R7973:Clec4b2	UTSW	6	123,181,148 (GRCm39)	missense	probably benign	0.05
R8810:Clec4b2	UTSW	6	123,158,269 (GRCm39)	missense	probably benign	0.23
R9278:Clec4b2	UTSW	6	123,181,224 (GRCm39)	missense	probably damaging	0.99

Predicted Primers

Posted On

2018-11-28