Incidental Mutation 'R6947:Or5m10b'
ID 540914
Institutional Source Beutler Lab
Gene Symbol Or5m10b
Ensembl Gene ENSMUSG00000057761
Gene Name olfactory receptor family 5 subfamily M member 10B
Synonyms GA_x6K02T2Q125-47347069-47348016, Olfr1022, MOR196-1
MMRRC Submission 045060-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.057) question?
Stock # R6947 (G1)
Quality Score 225.009
Status Validated
Chromosome 2
Chromosomal Location 85698938-85699885 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to C at 85699271 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Phenylalanine to Leucine at position 112 (F112L)
Ref Sequence ENSEMBL: ENSMUSP00000059312 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000054736] [ENSMUST00000121914]
AlphaFold L7MTT3
Predicted Effect probably benign
Transcript: ENSMUST00000054736
AA Change: F112L

PolyPhen 2 Score 0.012 (Sensitivity: 0.96; Specificity: 0.78)
SMART Domains Protein: ENSMUSP00000059312
Gene: ENSMUSG00000057761
AA Change: F112L

DomainStartEndE-ValueType
Pfam:7tm_4 31 312 4.8e-51 PFAM
Pfam:7TM_GPCR_Srsx 35 304 8e-6 PFAM
Pfam:7tm_1 41 290 9.8e-22 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000121914
Coding Region Coverage
  • 1x: 100.0%
  • 3x: 99.8%
  • 10x: 99.0%
  • 20x: 96.0%
Validation Efficiency 100% (46/46)
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 45 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Adamts7 C A 9: 90,073,857 (GRCm39) probably null Het
Adcy4 T C 14: 56,015,848 (GRCm39) T414A possibly damaging Het
Bop1 A G 15: 76,338,188 (GRCm39) F561L probably damaging Het
Ccdc18 T C 5: 108,309,401 (GRCm39) V332A probably benign Het
Cep290 A G 10: 100,365,918 (GRCm39) T1042A probably damaging Het
Cnot8 G T 11: 58,008,331 (GRCm39) V266L probably benign Het
Cxxc4 C T 3: 133,946,277 (GRCm39) S286F possibly damaging Het
Cyp2d12 A T 15: 82,443,248 (GRCm39) I386L probably benign Het
Dgka A T 10: 128,568,884 (GRCm39) I227N probably damaging Het
Eif2d T C 1: 131,092,404 (GRCm39) V354A probably benign Het
Fgr T A 4: 132,722,380 (GRCm39) probably null Het
Idnk A G 13: 58,308,055 (GRCm39) probably null Het
Kmt2e T C 5: 23,702,543 (GRCm39) S952P probably damaging Het
Kng1 A G 16: 22,896,124 (GRCm39) H343R probably benign Het
Lgals8 G A 13: 12,469,682 (GRCm39) probably benign Het
Lrit3 T A 3: 129,582,883 (GRCm39) Q368L probably benign Het
Lypd8 A T 11: 58,273,592 (GRCm39) T24S probably benign Het
Map3k4 G A 17: 12,479,456 (GRCm39) Q704* probably null Het
Mcm3ap A G 10: 76,351,500 (GRCm39) I1948V probably benign Het
Mettl25 A G 10: 105,662,053 (GRCm39) F306L probably benign Het
Mos A C 4: 3,871,585 (GRCm39) V77G probably damaging Het
Muc4 C T 16: 32,596,177 (GRCm39) R3130C possibly damaging Het
Naxd T C 8: 11,552,757 (GRCm39) V59A probably damaging Het
Nup107 A G 10: 117,593,179 (GRCm39) V833A probably benign Het
Or1p4-ps1 C T 11: 74,208,370 (GRCm39) S173L unknown Het
Pcnx2 C T 8: 126,577,021 (GRCm39) probably null Het
Pde10a T A 17: 9,188,424 (GRCm39) I908N probably damaging Het
Plcb1 A G 2: 135,228,075 (GRCm39) K1058R probably benign Het
Rad17 A T 13: 100,759,383 (GRCm39) F548Y probably damaging Het
Rad54b T G 4: 11,569,859 (GRCm39) S58R possibly damaging Het
Rbm20 G A 19: 53,839,696 (GRCm39) G895D probably damaging Het
Rgs22 T C 15: 36,104,036 (GRCm39) probably null Het
Rhobtb3 A G 13: 76,058,785 (GRCm39) S338P probably benign Het
Ruvbl2 A G 7: 45,074,373 (GRCm39) probably null Het
Slc16a12 A G 19: 34,650,007 (GRCm39) F343L probably benign Het
Slc22a28 A G 19: 8,041,875 (GRCm39) L444P possibly damaging Het
Slc44a4 A T 17: 35,147,044 (GRCm39) Q358L probably null Het
Sowaha A G 11: 53,369,225 (GRCm39) F504L probably benign Het
Syne1 A G 10: 5,125,789 (GRCm39) L6035P probably damaging Het
Thbs2 A T 17: 14,910,029 (GRCm39) M190K possibly damaging Het
Tmem171 A G 13: 98,824,950 (GRCm39) F227L possibly damaging Het
Trp53 A G 11: 69,479,307 (GRCm39) K162E possibly damaging Het
Ttn T A 2: 76,724,732 (GRCm39) K2098* probably null Het
Usp30 T C 5: 114,241,821 (GRCm39) S88P probably benign Het
Zfp276 C A 8: 123,981,643 (GRCm39) D63E probably benign Het
Other mutations in Or5m10b
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL02701:Or5m10b APN 2 85,699,802 (GRCm39) missense probably benign 0.22
IGL03265:Or5m10b APN 2 85,699,494 (GRCm39) missense possibly damaging 0.80
PIT4366001:Or5m10b UTSW 2 85,699,226 (GRCm39) missense probably damaging 1.00
R0057:Or5m10b UTSW 2 85,699,597 (GRCm39) nonsense probably null
R0057:Or5m10b UTSW 2 85,699,597 (GRCm39) nonsense probably null
R0554:Or5m10b UTSW 2 85,699,863 (GRCm39) missense probably benign 0.00
R3873:Or5m10b UTSW 2 85,699,306 (GRCm39) nonsense probably null
R3913:Or5m10b UTSW 2 85,699,115 (GRCm39) missense probably damaging 1.00
R4698:Or5m10b UTSW 2 85,699,596 (GRCm39) missense possibly damaging 0.90
R5628:Or5m10b UTSW 2 85,699,149 (GRCm39) missense probably damaging 0.99
R6467:Or5m10b UTSW 2 85,699,714 (GRCm39) nonsense probably null
R7092:Or5m10b UTSW 2 85,698,951 (GRCm39) missense probably damaging 1.00
R7351:Or5m10b UTSW 2 85,694,415 (GRCm39) unclassified probably benign
R7574:Or5m10b UTSW 2 85,699,350 (GRCm39) missense probably benign 0.03
R8430:Or5m10b UTSW 2 85,699,526 (GRCm39) missense probably benign 0.00
R8771:Or5m10b UTSW 2 85,699,712 (GRCm39) missense probably damaging 0.99
R8969:Or5m10b UTSW 2 85,699,832 (GRCm39) missense probably benign 0.19
R9101:Or5m10b UTSW 2 85,694,523 (GRCm39) unclassified probably benign
R9630:Or5m10b UTSW 2 85,699,493 (GRCm39) missense probably benign 0.00
R9649:Or5m10b UTSW 2 85,699,819 (GRCm39) missense probably damaging 1.00
R9649:Or5m10b UTSW 2 85,699,278 (GRCm39) missense possibly damaging 0.96
Predicted Primers PCR Primer
(F):5'- AACCTGTGTATGATTGTGCTGATC -3'
(R):5'- TGATTTCATGGGAGCCACAG -3'

Sequencing Primer
(F):5'- GTGCTGATCAGGACCAATTCC -3'
(R):5'- TTTCATGGGAGCCACAGAAAGAC -3'
Posted On 2018-11-28