Incidental Mutation 'R6947:Mos'
ID 540918
Institutional Source Beutler Lab
Gene Symbol Mos
Ensembl Gene ENSMUSG00000078365
Gene Name Moloney sarcoma oncogene
Synonyms c-mos
MMRRC Submission 045060-MU
Accession Numbers
Essential gene? Non essential (E-score: 0.000) question?
Stock # R6947 (G1)
Quality Score 225.009
Status Validated
Chromosome 4
Chromosomal Location 3870658-3872105 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to C at 3871585 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Valine to Glycine at position 77 (V77G)
Ref Sequence ENSEMBL: ENSMUSP00000100789 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000105158]
AlphaFold P00536
Predicted Effect probably damaging
Transcript: ENSMUST00000105158
AA Change: V77G

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
SMART Domains Protein: ENSMUSP00000100789
Gene: ENSMUSG00000078365
AA Change: V77G

DomainStartEndE-ValueType
low complexity region 39 54 N/A INTRINSIC
Pfam:Pkinase_Tyr 63 335 9e-41 PFAM
Pfam:Pkinase 64 334 6.3e-43 PFAM
Coding Region Coverage
  • 1x: 100.0%
  • 3x: 99.8%
  • 10x: 99.0%
  • 20x: 96.0%
Validation Efficiency 100% (46/46)
MGI Phenotype FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] MOS is a serine/threonine kinase that activates the MAP kinase cascade through direct phosphorylation of the MAP kinase activator MEK (MAP2K1; MIM 176872) (Prasad et al., 2008 [PubMed 18246541]).[supplied by OMIM, Jul 2009]
PHENOTYPE: Mutations that inactivate the gene result in female infertility and an increased susceptibility to tumors. Oocytes progress through meiosis II without arrest and undergo spontaneous parthenogenetic activation. Male mice are fertile and show no spermatogenic defects. [provided by MGI curators]
Allele List at MGI
Other mutations in this stock
Total: 45 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Adamts7 C A 9: 90,073,857 (GRCm39) probably null Het
Adcy4 T C 14: 56,015,848 (GRCm39) T414A possibly damaging Het
Bop1 A G 15: 76,338,188 (GRCm39) F561L probably damaging Het
Ccdc18 T C 5: 108,309,401 (GRCm39) V332A probably benign Het
Cep290 A G 10: 100,365,918 (GRCm39) T1042A probably damaging Het
Cnot8 G T 11: 58,008,331 (GRCm39) V266L probably benign Het
Cxxc4 C T 3: 133,946,277 (GRCm39) S286F possibly damaging Het
Cyp2d12 A T 15: 82,443,248 (GRCm39) I386L probably benign Het
Dgka A T 10: 128,568,884 (GRCm39) I227N probably damaging Het
Eif2d T C 1: 131,092,404 (GRCm39) V354A probably benign Het
Fgr T A 4: 132,722,380 (GRCm39) probably null Het
Idnk A G 13: 58,308,055 (GRCm39) probably null Het
Kmt2e T C 5: 23,702,543 (GRCm39) S952P probably damaging Het
Kng1 A G 16: 22,896,124 (GRCm39) H343R probably benign Het
Lgals8 G A 13: 12,469,682 (GRCm39) probably benign Het
Lrit3 T A 3: 129,582,883 (GRCm39) Q368L probably benign Het
Lypd8 A T 11: 58,273,592 (GRCm39) T24S probably benign Het
Map3k4 G A 17: 12,479,456 (GRCm39) Q704* probably null Het
Mcm3ap A G 10: 76,351,500 (GRCm39) I1948V probably benign Het
Mettl25 A G 10: 105,662,053 (GRCm39) F306L probably benign Het
Muc4 C T 16: 32,596,177 (GRCm39) R3130C possibly damaging Het
Naxd T C 8: 11,552,757 (GRCm39) V59A probably damaging Het
Nup107 A G 10: 117,593,179 (GRCm39) V833A probably benign Het
Or1p4-ps1 C T 11: 74,208,370 (GRCm39) S173L unknown Het
Or5m10b T C 2: 85,699,271 (GRCm39) F112L probably benign Het
Pcnx2 C T 8: 126,577,021 (GRCm39) probably null Het
Pde10a T A 17: 9,188,424 (GRCm39) I908N probably damaging Het
Plcb1 A G 2: 135,228,075 (GRCm39) K1058R probably benign Het
Rad17 A T 13: 100,759,383 (GRCm39) F548Y probably damaging Het
Rad54b T G 4: 11,569,859 (GRCm39) S58R possibly damaging Het
Rbm20 G A 19: 53,839,696 (GRCm39) G895D probably damaging Het
Rgs22 T C 15: 36,104,036 (GRCm39) probably null Het
Rhobtb3 A G 13: 76,058,785 (GRCm39) S338P probably benign Het
Ruvbl2 A G 7: 45,074,373 (GRCm39) probably null Het
Slc16a12 A G 19: 34,650,007 (GRCm39) F343L probably benign Het
Slc22a28 A G 19: 8,041,875 (GRCm39) L444P possibly damaging Het
Slc44a4 A T 17: 35,147,044 (GRCm39) Q358L probably null Het
Sowaha A G 11: 53,369,225 (GRCm39) F504L probably benign Het
Syne1 A G 10: 5,125,789 (GRCm39) L6035P probably damaging Het
Thbs2 A T 17: 14,910,029 (GRCm39) M190K possibly damaging Het
Tmem171 A G 13: 98,824,950 (GRCm39) F227L possibly damaging Het
Trp53 A G 11: 69,479,307 (GRCm39) K162E possibly damaging Het
Ttn T A 2: 76,724,732 (GRCm39) K2098* probably null Het
Usp30 T C 5: 114,241,821 (GRCm39) S88P probably benign Het
Zfp276 C A 8: 123,981,643 (GRCm39) D63E probably benign Het
Other mutations in Mos
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00848:Mos APN 4 3,871,459 (GRCm39) missense probably damaging 1.00
IGL01302:Mos APN 4 3,871,815 (GRCm39) utr 5 prime probably benign
IGL01739:Mos APN 4 3,871,816 (GRCm39) utr 5 prime probably benign
IGL01867:Mos APN 4 3,870,845 (GRCm39) missense probably benign 0.33
IGL02647:Mos APN 4 3,870,961 (GRCm39) missense probably damaging 1.00
PIT4418001:Mos UTSW 4 3,870,814 (GRCm39) missense possibly damaging 0.86
R0967:Mos UTSW 4 3,870,932 (GRCm39) missense probably benign
R4927:Mos UTSW 4 3,871,093 (GRCm39) missense probably damaging 1.00
R5729:Mos UTSW 4 3,870,971 (GRCm39) missense probably benign 0.01
R8359:Mos UTSW 4 3,871,097 (GRCm39) missense probably damaging 1.00
R8526:Mos UTSW 4 3,871,709 (GRCm39) missense probably damaging 0.99
R9106:Mos UTSW 4 3,871,457 (GRCm39) missense probably benign 0.44
R9336:Mos UTSW 4 3,870,886 (GRCm39) missense probably damaging 1.00
R9347:Mos UTSW 4 3,871,763 (GRCm39) missense probably benign 0.02
R9683:Mos UTSW 4 3,871,186 (GRCm39) missense probably benign 0.02
Predicted Primers PCR Primer
(F):5'- ACCTAGGCTGTTGGAGTCTTC -3'
(R):5'- TCTAAGCCTGTGTCGCTACC -3'

Sequencing Primer
(F):5'- GGAGTCTTCGGGCGTGC -3'
(R):5'- TCGTGAGCTGTCGCCATC -3'
Posted On 2018-11-28