Incidental Mutation 'R6948:Or10g1b'
ID 540983
Institutional Source Beutler Lab
Gene Symbol Or10g1b
Ensembl Gene ENSMUSG00000063867
Gene Name olfactory receptor family 10 subfamily G member 1B
Synonyms Olfr1511, GA_x6K02T2RJGY-608749-609705, MOR223-9
Accession Numbers
Essential gene? Probably non essential (E-score: 0.074) question?
Stock # R6948 (G1)
Quality Score 225.009
Status Not validated
Chromosome 14
Chromosomal Location 52627272-52628228 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to T at 52627614 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Phenylalanine to Leucine at position 205 (F205L)
Ref Sequence ENSEMBL: ENSMUSP00000149479 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000078171] [ENSMUST00000214168]
AlphaFold E9PWU0
Predicted Effect probably benign
Transcript: ENSMUST00000078171
AA Change: F205L

PolyPhen 2 Score 0.220 (Sensitivity: 0.91; Specificity: 0.88)
SMART Domains Protein: ENSMUSP00000077302
Gene: ENSMUSG00000063867
AA Change: F205L

DomainStartEndE-ValueType
Pfam:7tm_4 35 310 1.3e-50 PFAM
Pfam:7tm_1 45 293 2.5e-20 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000214168
AA Change: F205L

PolyPhen 2 Score 0.220 (Sensitivity: 0.91; Specificity: 0.88)
Coding Region Coverage
  • 1x: 100.0%
  • 3x: 99.9%
  • 10x: 99.4%
  • 20x: 98.0%
Validation Efficiency 97% (36/37)
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 38 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Arfgap2 A G 2: 91,097,524 (GRCm39) T107A probably benign Het
Calhm3 T A 19: 47,140,344 (GRCm39) M250L probably damaging Het
Catsperb A T 12: 101,447,327 (GRCm39) I276L probably benign Het
Cd70 T C 17: 57,456,594 (GRCm39) E3G probably damaging Het
Cenpj A T 14: 56,790,683 (GRCm39) S455R probably damaging Het
Cgn C G 3: 94,680,531 (GRCm39) E590D probably benign Het
Cpvl T A 6: 53,873,468 (GRCm39) I423F possibly damaging Het
Cyp2c54 T A 19: 40,034,636 (GRCm39) M345L possibly damaging Het
Dner T C 1: 84,383,738 (GRCm39) N549D probably damaging Het
Fat4 T A 3: 39,063,595 (GRCm39) L4517Q probably damaging Het
Fbxw11 A G 11: 32,692,597 (GRCm39) T523A probably damaging Het
Flg A G 3: 93,195,475 (GRCm39) probably benign Het
Gcfc2 A G 6: 81,910,734 (GRCm39) E237G probably benign Het
Ipo5 G T 14: 121,160,527 (GRCm39) M181I probably benign Het
Itprid1 C T 6: 55,955,470 (GRCm39) T1026I probably benign Het
Klhl32 A G 4: 24,629,250 (GRCm39) Y506H probably benign Het
Mast3 G A 8: 71,238,126 (GRCm39) T505I probably damaging Het
Mrgprx2 A T 7: 48,132,464 (GRCm39) V118D possibly damaging Het
Mtor T G 4: 148,621,209 (GRCm39) V1869G probably benign Het
Mycbp2 A T 14: 103,522,703 (GRCm39) M720K possibly damaging Het
Npy4r A G 14: 33,868,731 (GRCm39) Y186H probably benign Het
Obscn A G 11: 58,997,142 (GRCm39) S1520P probably damaging Het
Pex1 A G 5: 3,655,994 (GRCm39) N274D probably benign Het
Plxnb1 T C 9: 108,945,702 (GRCm39) Y2078H probably damaging Het
Rasgrp1 T C 2: 117,129,085 (GRCm39) D178G probably damaging Het
Reln A G 5: 22,177,033 (GRCm39) S1878P probably damaging Het
Rims2 T C 15: 39,374,737 (GRCm39) V1033A probably benign Het
Scaf1 G T 7: 44,662,971 (GRCm39) S14* probably null Het
Serpinb9d A G 13: 33,384,706 (GRCm39) S228G possibly damaging Het
Slc22a14 C A 9: 119,060,482 (GRCm39) A93S probably damaging Het
Sox30 G A 11: 45,908,166 (GRCm39) V778M probably damaging Het
Tecrl T C 5: 83,457,097 (GRCm39) I128V probably benign Het
Trip10 T A 17: 57,569,448 (GRCm39) C491S probably damaging Het
Vmn1r26 A T 6: 57,985,718 (GRCm39) M157K probably damaging Het
Zbtb1 A T 12: 76,432,601 (GRCm39) S196C probably damaging Het
Zfp236 T C 18: 82,662,187 (GRCm39) D582G possibly damaging Het
Zfp384 A G 6: 125,001,873 (GRCm39) T125A probably benign Het
Zpr1 T G 9: 46,184,939 (GRCm39) probably null Het
Other mutations in Or10g1b
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL02614:Or10g1b APN 14 52,627,627 (GRCm39) missense probably damaging 0.99
IGL02645:Or10g1b APN 14 52,627,958 (GRCm39) missense possibly damaging 0.50
R0277:Or10g1b UTSW 14 52,627,846 (GRCm39) missense probably damaging 1.00
R0601:Or10g1b UTSW 14 52,627,283 (GRCm39) nonsense probably null
R1956:Or10g1b UTSW 14 52,628,037 (GRCm39) missense probably benign 0.06
R2342:Or10g1b UTSW 14 52,627,322 (GRCm39) missense possibly damaging 0.89
R5193:Or10g1b UTSW 14 52,628,069 (GRCm39) missense probably benign 0.00
R5439:Or10g1b UTSW 14 52,627,582 (GRCm39) missense probably damaging 1.00
R5506:Or10g1b UTSW 14 52,628,084 (GRCm39) missense probably damaging 1.00
R8191:Or10g1b UTSW 14 52,627,987 (GRCm39) missense probably benign 0.00
R8267:Or10g1b UTSW 14 52,627,903 (GRCm39) missense probably damaging 1.00
R8503:Or10g1b UTSW 14 52,627,354 (GRCm39) missense probably damaging 0.97
X0035:Or10g1b UTSW 14 52,627,823 (GRCm39) missense probably benign 0.18
Predicted Primers PCR Primer
(F):5'- AACTGCTCCATCAAAGGGAC -3'
(R):5'- AGTTGTGCACAATTCTAGTGGC -3'

Sequencing Primer
(F):5'- TGCTCCATCAAAGGGACTCTTGG -3'
(R):5'- CACAATTCTAGTGGCTGGAGC -3'
Posted On 2018-11-28