Incidental Mutation 'R6925:Olfr642'
ID 541089
Institutional Source Beutler Lab
Gene Symbol Olfr642
Ensembl Gene ENSMUSG00000049797
Gene Name olfactory receptor 642
Synonyms MOR13-6, GA_x6K02T2PBJ9-6784380-6783436
MMRRC Submission
Accession Numbers

Genbank: NM_146329.1

Is this an essential gene? Probably non essential (E-score: 0.066) question?
Stock # R6925 (G1)
Quality Score 225.009
Status Validated
Chromosome 7
Chromosomal Location 104046529-104052666 bp(-) (GRCm38)
Type of Mutation missense
DNA Base Change (assembly) C to T at 104049740 bp (GRCm38)
Zygosity Heterozygous
Amino Acid Change Valine to Isoleucine at position 205 (V205I)
Ref Sequence ENSEMBL: ENSMUSP00000148961 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000052660] [ENSMUST00000074064] [ENSMUST00000138055] [ENSMUST00000214299]
AlphaFold Q924X8
Predicted Effect probably benign
Transcript: ENSMUST00000052660
AA Change: V205I

PolyPhen 2 Score 0.164 (Sensitivity: 0.92; Specificity: 0.87)
SMART Domains Protein: ENSMUSP00000061462
Gene: ENSMUSG00000049797
AA Change: V205I

DomainStartEndE-ValueType
Pfam:7tm_4 33 312 8.5e-119 PFAM
Pfam:7TM_GPCR_Srsx 37 309 1.7e-7 PFAM
Pfam:7tm_1 43 294 4.1e-23 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000074064
SMART Domains Protein: ENSMUSP00000073707
Gene: ENSMUSG00000090219

DomainStartEndE-ValueType
Pfam:7tm_4 33 312 2.6e-124 PFAM
Pfam:7TM_GPCR_Srsx 37 255 3.1e-7 PFAM
Pfam:7tm_1 43 294 3.2e-21 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000138055
SMART Domains Protein: ENSMUSP00000139240
Gene: ENSMUSG00000109824

DomainStartEndE-ValueType
transmembrane domain 29 51 N/A INTRINSIC
Predicted Effect probably benign
Transcript: ENSMUST00000214299
AA Change: V205I

PolyPhen 2 Score 0.164 (Sensitivity: 0.92; Specificity: 0.87)
Meta Mutation Damage Score 0.0898 question?
Coding Region Coverage
  • 1x: 100.0%
  • 3x: 99.9%
  • 10x: 99.4%
  • 20x: 98.0%
Validation Efficiency 100% (91/91)
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 90 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
5430419D17Rik A G 7: 131,222,707 Q177R possibly damaging Het
Acat1 A T 9: 53,592,029 V170E probably benign Het
Atp2b2 T A 6: 113,760,720 I902F probably damaging Het
Cacna1d A G 14: 30,051,637 V1697A probably benign Het
Ccdc14 T A 16: 34,690,749 F31Y probably benign Het
Ccdc17 T A 4: 116,598,210 V250E probably damaging Het
Cct7 A G 6: 85,459,182 N25S probably damaging Het
Cep19 G C 16: 32,103,942 G9R probably damaging Het
Ces5a A T 8: 93,523,057 probably null Het
Chd1l T G 3: 97,582,826 E471A probably damaging Het
Chd6 A G 2: 161,013,127 I787T probably damaging Het
Cntnap5c A C 17: 58,395,266 T1194P probably benign Het
Col6a3 T A 1: 90,816,002 M208L probably benign Het
Coro7 A T 16: 4,628,674 probably null Het
Csrnp2 T C 15: 100,481,958 K484R probably benign Het
Cyp2c39 T A 19: 39,513,195 V64E probably damaging Het
Ddr2 T C 1: 169,998,132 K300E probably benign Het
Ddx56 T C 11: 6,263,980 E393G probably damaging Het
Diaph1 A C 18: 37,853,679 Y1084* probably null Het
Disp1 A T 1: 183,086,478 F1459L probably benign Het
Dnajc8 G A 4: 132,544,113 A80T probably damaging Het
Elfn1 T A 5: 139,971,685 M148K probably benign Het
Emcn T A 3: 137,419,002 I154N probably damaging Het
Enah C G 1: 181,905,898 probably null Het
Enah T A 1: 181,905,899 probably null Het
Ep300 C A 15: 81,649,981 Q2080K probably benign Het
Epha2 T A 4: 141,308,757 M168K probably benign Het
Ercc6 T A 14: 32,562,608 I776N probably damaging Het
Fan1 T A 7: 64,372,486 N340Y probably damaging Het
Fat4 G T 3: 38,996,204 probably null Het
G3bp1 A G 11: 55,497,960 R333G possibly damaging Het
Gm3604 A G 13: 62,369,390 F385L probably benign Het
Gm5800 T C 14: 51,713,700 I147M possibly damaging Het
Hipk1 A G 3: 103,778,245 F18S unknown Het
Ighv3-8 A T 12: 114,322,330 C131S probably benign Het
Il23r T G 6: 67,423,493 T618P probably damaging Het
Il31ra G A 13: 112,527,529 T538I possibly damaging Het
Kcns2 A G 15: 34,839,913 D474G unknown Het
Klc4 T C 17: 46,636,229 T407A possibly damaging Het
Klra5 C T 6: 129,911,457 S2N probably benign Het
Krt10 T C 11: 99,388,851 Y161C probably damaging Het
Kxd1 A T 8: 70,523,278 M1K probably null Het
Lgals1 A C 15: 78,928,040 D27A possibly damaging Het
Lgr5 T C 10: 115,466,346 S308G probably benign Het
Lrp1 G A 10: 127,556,988 S2736L probably benign Het
Lrpap1 G T 5: 35,102,536 H73N probably benign Het
Mcpt1 C A 14: 56,019,065 T86K probably damaging Het
Megf6 A T 4: 154,254,587 D527V probably damaging Het
Mical3 A T 6: 120,959,390 S1392T probably benign Het
Mmp2 A T 8: 92,839,382 D437V probably damaging Het
Mob4 T A 1: 55,152,722 Y166* probably null Het
Mrap2 G A 9: 87,182,474 M89I possibly damaging Het
Mug1 G A 6: 121,881,787 A1155T probably damaging Het
Myh2 G T 11: 67,193,218 A1556S probably benign Het
Nfatc3 A G 8: 106,119,322 D1028G probably benign Het
Ngef T G 1: 87,503,263 probably null Het
Nlrp1a A T 11: 71,092,513 L1209Q probably null Het
Npr2 C T 4: 43,647,553 R819C probably damaging Het
Nsd2 A T 5: 33,879,110 D646V probably damaging Het
Nsun7 A G 5: 66,277,072 H252R probably damaging Het
Olfr267 A T 4: 58,785,647 I25N possibly damaging Het
Olfr447 T A 6: 42,911,857 C111* probably null Het
Olfr951 A T 9: 39,393,860 Q20L probably benign Het
Olfr951 G T 9: 39,393,861 Q20H probably benign Het
Pcdhga2 A T 18: 37,670,585 D494V probably damaging Het
Pcsk2 A G 2: 143,813,747 E617G probably damaging Het
Pdc T C 1: 150,333,180 I138T probably damaging Het
Phc2 T A 4: 128,748,134 S750T probably damaging Het
Pkd2l1 T A 19: 44,191,508 N88Y possibly damaging Het
Plcl1 C T 1: 55,406,598 R71* probably null Het
Prag1 C A 8: 36,103,894 L544M probably damaging Het
Prkg2 A G 5: 98,966,510 probably null Het
Psd2 G A 18: 35,979,711 S153N probably damaging Het
Rab11fip1 A T 8: 27,152,972 S600T probably damaging Het
Rbms1 T G 2: 60,762,304 T222P probably benign Het
Slfn8 A T 11: 83,013,417 Y382* probably null Het
Socs4 T A 14: 47,289,738 C43* probably null Het
Sorl1 T A 9: 42,033,626 T868S probably damaging Het
St6gal1 A G 16: 23,356,213 Y267C probably damaging Het
Syne1 A G 10: 5,126,682 V6879A probably benign Het
Syne2 C A 12: 75,854,132 H22N possibly damaging Het
Tmeff2 T A 1: 50,928,021 L25Q probably damaging Het
Tmprss11g G T 5: 86,487,426 D396E probably benign Het
Tmprss11g T A 5: 86,487,436 H393L probably benign Het
Vmn2r23 A G 6: 123,704,553 E140G probably damaging Het
Wapl T C 14: 34,677,363 S130P probably benign Het
Zeb2 T A 2: 44,994,529 K982M probably damaging Het
Zfhx3 C G 8: 108,956,821 H3631D unknown Het
Zfp719 T C 7: 43,590,706 S573P probably damaging Het
Zfp979 A T 4: 147,613,542 C237S possibly damaging Het
Other mutations in Olfr642
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01457:Olfr642 APN 7 104050169 missense probably damaging 1.00
IGL01933:Olfr642 APN 7 104049814 missense probably damaging 1.00
IGL01980:Olfr642 APN 7 104050093 missense probably benign 0.21
IGL02161:Olfr642 APN 7 104049590 missense possibly damaging 0.66
IGL02639:Olfr642 APN 7 104049781 missense probably damaging 0.99
I2289:Olfr642 UTSW 7 104049754 missense probably damaging 1.00
R0418:Olfr642 UTSW 7 104049772 missense probably benign 0.00
R1647:Olfr642 UTSW 7 104050169 missense probably damaging 1.00
R1648:Olfr642 UTSW 7 104050169 missense probably damaging 1.00
R1701:Olfr642 UTSW 7 104050195 missense possibly damaging 0.95
R2142:Olfr642 UTSW 7 104050300 missense probably damaging 1.00
R2165:Olfr642 UTSW 7 104049638 missense probably benign 0.22
R2655:Olfr642 UTSW 7 104049431 missense probably benign 0.03
R6216:Olfr642 UTSW 7 104049695 missense probably damaging 1.00
R6759:Olfr642 UTSW 7 104050127 missense probably damaging 1.00
R7243:Olfr642 UTSW 7 104049755 missense probably damaging 1.00
R7684:Olfr642 UTSW 7 104049460 missense probably damaging 0.99
R7699:Olfr642 UTSW 7 104050593 start gained probably benign
R8316:Olfr642 UTSW 7 104049622 missense probably damaging 1.00
R8458:Olfr642 UTSW 7 104049668 missense possibly damaging 0.93
R8836:Olfr642 UTSW 7 104049848 missense probably benign 0.07
R9161:Olfr642 UTSW 7 104050518 start gained probably benign
R9519:Olfr642 UTSW 7 104049429 missense probably benign 0.00
Z1176:Olfr642 UTSW 7 104050273 missense probably benign
Predicted Primers PCR Primer
(F):5'- GGGATGTGAACTTGTGCACATAC -3'
(R):5'- GGGTATGTCCATCATCATCCG -3'

Sequencing Primer
(F):5'- GAACTTGTGCACATACTCTGGCG -3'
(R):5'- GTATGTCCATCATCATCCGCAGTTTC -3'
Posted On 2018-11-28