Incidental Mutation 'R6953:Vmn2r26'
| ID |
541307 |
| Institutional Source |
Beutler Lab
|
| Gene Symbol |
Vmn2r26
|
| Ensembl Gene |
ENSMUSG00000096630 |
| Gene Name |
vomeronasal 2, receptor 26 |
| Synonyms |
V2r1b |
| MMRRC Submission |
045065-MU
|
| Accession Numbers |
|
| Essential gene? |
Probably non essential
(E-score: 0.088)
|
| Stock # |
R6953 (G1)
|
| Quality Score |
225.009 |
|
Status
|
Validated
|
| Chromosome |
6 |
| Chromosomal Location |
124024758-124062035 bp(+) (GRCm38) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
T to C
at 124039782 bp (GRCm38)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Tyrosine to Histidine
at position 402
(Y402H)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000032238
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000032238]
|
| AlphaFold |
Q6TAC4 |
| Predicted Effect |
probably benign
Transcript: ENSMUST00000032238
AA Change: Y402H
PolyPhen 2
Score 0.001 (Sensitivity: 0.99; Specificity: 0.15)
|
| SMART Domains |
Protein: ENSMUSP00000032238
Gene: ENSMUSG00000096630
AA Change: Y402H
| Domain | Start | End | E-Value | Type |
|---|
|
signal peptide
|
1 |
22 |
N/A |
INTRINSIC |
|
Pfam:ANF_receptor
|
82 |
471 |
1.5e-31 |
PFAM |
|
Pfam:NCD3G
|
519 |
572 |
4.6e-25 |
PFAM |
|
Pfam:7tm_3
|
603 |
840 |
1.5e-55 |
PFAM |
|
| Coding Region Coverage |
- 1x: 100.0%
- 3x: 99.9%
- 10x: 99.2%
- 20x: 97.3%
|
| Validation Efficiency |
98% (54/55) |
| MGI Phenotype |
PHENOTYPE: Mice homozygous for a knock-out allele exhibit abnormal vomeronasal sensory neuron physiology and avnosmia. [provided by MGI curators]
|
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 56 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| 9130401M01Rik |
C |
A |
15: 58,028,827 (GRCm38) |
S128I |
probably damaging |
Het |
| Aadacl2 |
A |
C |
3: 60,024,760 (GRCm38) |
H232P |
possibly damaging |
Het |
| Abcc3 |
A |
G |
11: 94,374,835 (GRCm38) |
Y125H |
probably benign |
Het |
| Adgrb3 |
A |
G |
1: 25,826,511 (GRCm38) |
S84P |
probably damaging |
Het |
| Adgrd1 |
A |
T |
5: 129,115,078 (GRCm38) |
K71* |
probably null |
Het |
| Ap2m1 |
T |
A |
16: 20,542,718 (GRCm38) |
W381R |
probably damaging |
Het |
| Ascc3 |
A |
G |
10: 50,645,666 (GRCm38) |
I426V |
probably benign |
Het |
| BC024063 |
T |
A |
10: 82,107,899 (GRCm38) |
D31E |
possibly damaging |
Het |
| C3ar1 |
G |
A |
6: 122,850,632 (GRCm38) |
H209Y |
possibly damaging |
Het |
| Ccp110 |
T |
C |
7: 118,722,421 (GRCm38) |
V433A |
possibly damaging |
Het |
| Cfap54 |
A |
G |
10: 92,994,678 (GRCm38) |
S1199P |
probably benign |
Het |
| Cyp24a1 |
T |
G |
2: 170,487,946 (GRCm38) |
D362A |
probably benign |
Het |
| Dapk2 |
C |
G |
9: 66,254,622 (GRCm38) |
R271G |
probably benign |
Het |
| Dnmt1 |
G |
T |
9: 20,918,526 (GRCm38) |
Q633K |
probably benign |
Het |
| Ercc4 |
T |
A |
16: 13,130,686 (GRCm38) |
V499D |
probably damaging |
Het |
| Ier3ip1 |
C |
G |
18: 76,939,613 (GRCm38) |
P46R |
probably damaging |
Het |
| Ifi211 |
T |
C |
1: 173,906,266 (GRCm38) |
T110A |
probably damaging |
Het |
| Isoc1 |
A |
G |
18: 58,671,302 (GRCm38) |
D134G |
possibly damaging |
Het |
| Kif26b |
A |
G |
1: 178,874,072 (GRCm38) |
D672G |
possibly damaging |
Het |
| Klhl33 |
T |
A |
14: 50,891,516 (GRCm38) |
D752V |
possibly damaging |
Het |
| Lcn4 |
A |
G |
2: 26,669,355 (GRCm38) |
Y133H |
probably benign |
Het |
| Mrs2 |
C |
A |
13: 25,001,788 (GRCm38) |
V134L |
probably benign |
Het |
| Muc16 |
T |
C |
9: 18,640,529 (GRCm38) |
T4823A |
probably benign |
Het |
| Ogfod3 |
A |
G |
11: 121,202,998 (GRCm38) |
I62T |
probably benign |
Het |
| Olfr1380 |
A |
G |
11: 49,564,290 (GRCm38) |
Y123C |
probably damaging |
Het |
| Olfr165 |
C |
T |
16: 19,407,528 (GRCm38) |
V164I |
probably benign |
Het |
| Olfr773 |
A |
T |
10: 129,186,605 (GRCm38) |
M272K |
probably benign |
Het |
| Olfr869 |
A |
T |
9: 20,138,003 (GRCm38) |
I296L |
probably benign |
Het |
| Papln |
G |
A |
12: 83,781,885 (GRCm38) |
W788* |
probably null |
Het |
| Pcdhac2 |
A |
G |
18: 37,144,426 (GRCm38) |
Q153R |
probably benign |
Het |
| Pcdhgb2 |
C |
T |
18: 37,690,754 (GRCm38) |
T266I |
possibly damaging |
Het |
| Pcdhgc5 |
C |
A |
18: 37,820,461 (GRCm38) |
R263S |
possibly damaging |
Het |
| Phactr4 |
T |
C |
4: 132,377,351 (GRCm38) |
T185A |
possibly damaging |
Het |
| Plcxd2 |
T |
C |
16: 45,980,519 (GRCm38) |
D114G |
probably damaging |
Het |
| Polr2a |
A |
T |
11: 69,741,711 (GRCm38) |
I987N |
probably damaging |
Het |
| Prl3d3 |
A |
G |
13: 27,161,046 (GRCm38) |
M134V |
probably benign |
Het |
| Pum2 |
T |
A |
12: 8,728,779 (GRCm38) |
|
probably null |
Het |
| Racgap1 |
T |
C |
15: 99,626,329 (GRCm38) |
E399G |
probably damaging |
Het |
| Sbspon |
A |
T |
1: 15,860,295 (GRCm38) |
S156T |
probably damaging |
Het |
| Scn1a |
T |
C |
2: 66,319,469 (GRCm38) |
T927A |
probably damaging |
Het |
| Sec23ip |
C |
A |
7: 128,752,796 (GRCm38) |
S78* |
probably null |
Het |
| Serpina1d |
G |
A |
12: 103,767,730 (GRCm38) |
T105I |
probably benign |
Het |
| Slc25a21 |
T |
A |
12: 57,159,169 (GRCm38) |
N26Y |
probably benign |
Het |
| Smim20 |
T |
A |
5: 53,277,916 (GRCm38) |
D64E |
probably damaging |
Het |
| Spag17 |
T |
G |
3: 100,034,975 (GRCm38) |
I772S |
possibly damaging |
Het |
| Tars2 |
T |
C |
3: 95,753,114 (GRCm38) |
T99A |
possibly damaging |
Het |
| Tdrd1 |
C |
T |
19: 56,831,371 (GRCm38) |
T101I |
probably damaging |
Het |
| Tldc2 |
T |
G |
2: 157,089,278 (GRCm38) |
|
probably null |
Het |
| Ttn |
A |
G |
2: 76,771,585 (GRCm38) |
Y10251H |
probably damaging |
Het |
| Ush2a |
A |
G |
1: 188,263,145 (GRCm38) |
R38G |
possibly damaging |
Het |
| Usp19 |
T |
C |
9: 108,498,931 (GRCm38) |
L991P |
possibly damaging |
Het |
| Vmn2r109 |
G |
A |
17: 20,540,711 (GRCm38) |
P795S |
possibly damaging |
Het |
| Vmn2r-ps117 |
T |
G |
17: 18,824,833 (GRCm38) |
I504R |
probably benign |
Het |
| Zfp551 |
A |
T |
7: 12,416,788 (GRCm38) |
C231* |
probably null |
Het |
| Zfp607a |
T |
A |
7: 27,878,365 (GRCm38) |
C287S |
possibly damaging |
Het |
| Zim1 |
T |
A |
7: 6,687,707 (GRCm38) |
T40S |
unknown |
Het |
|
| Other mutations in Vmn2r26 |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL01070:Vmn2r26
|
APN |
6 |
124,061,607 (GRCm38) |
missense |
probably benign |
0.00 |
|
IGL01370:Vmn2r26
|
APN |
6 |
124,061,756 (GRCm38) |
missense |
probably benign |
0.08 |
|
IGL01603:Vmn2r26
|
APN |
6 |
124,053,874 (GRCm38) |
missense |
probably damaging |
1.00 |
|
IGL01651:Vmn2r26
|
APN |
6 |
124,050,673 (GRCm38) |
missense |
probably benign |
0.01 |
|
IGL02282:Vmn2r26
|
APN |
6 |
124,061,625 (GRCm38) |
missense |
probably damaging |
1.00 |
|
IGL02425:Vmn2r26
|
APN |
6 |
124,061,818 (GRCm38) |
missense |
probably damaging |
1.00 |
|
IGL02551:Vmn2r26
|
APN |
6 |
124,026,141 (GRCm38) |
missense |
probably benign |
0.11 |
|
IGL02690:Vmn2r26
|
APN |
6 |
124,026,132 (GRCm38) |
missense |
probably benign |
0.14 |
|
IGL03002:Vmn2r26
|
APN |
6 |
124,039,795 (GRCm38) |
missense |
possibly damaging |
0.78 |
|
IGL03270:Vmn2r26
|
APN |
6 |
124,050,819 (GRCm38) |
missense |
probably benign |
0.16 |
|
R0032:Vmn2r26
|
UTSW |
6 |
124,039,899 (GRCm38) |
missense |
possibly damaging |
0.72 |
|
R0052:Vmn2r26
|
UTSW |
6 |
124,062,033 (GRCm38) |
makesense |
probably null |
|
|
R0083:Vmn2r26
|
UTSW |
6 |
124,053,981 (GRCm38) |
splice site |
probably null |
|
|
R0682:Vmn2r26
|
UTSW |
6 |
124,061,170 (GRCm38) |
missense |
probably damaging |
0.97 |
|
R1061:Vmn2r26
|
UTSW |
6 |
124,061,644 (GRCm38) |
missense |
probably benign |
0.12 |
|
R1077:Vmn2r26
|
UTSW |
6 |
124,053,913 (GRCm38) |
missense |
probably benign |
0.00 |
|
R1263:Vmn2r26
|
UTSW |
6 |
124,050,708 (GRCm38) |
missense |
probably benign |
|
|
R1579:Vmn2r26
|
UTSW |
6 |
124,039,747 (GRCm38) |
missense |
probably benign |
0.00 |
|
R1741:Vmn2r26
|
UTSW |
6 |
124,061,472 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R1834:Vmn2r26
|
UTSW |
6 |
124,061,410 (GRCm38) |
missense |
possibly damaging |
0.54 |
|
R1838:Vmn2r26
|
UTSW |
6 |
124,024,771 (GRCm38) |
missense |
probably benign |
|
|
R1956:Vmn2r26
|
UTSW |
6 |
124,053,887 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R1996:Vmn2r26
|
UTSW |
6 |
124,061,185 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R2140:Vmn2r26
|
UTSW |
6 |
124,061,237 (GRCm38) |
missense |
probably benign |
0.01 |
|
R2327:Vmn2r26
|
UTSW |
6 |
124,039,749 (GRCm38) |
missense |
probably benign |
0.07 |
|
R2417:Vmn2r26
|
UTSW |
6 |
124,061,350 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R3930:Vmn2r26
|
UTSW |
6 |
124,025,979 (GRCm38) |
missense |
probably benign |
|
|
R4490:Vmn2r26
|
UTSW |
6 |
124,050,738 (GRCm38) |
missense |
possibly damaging |
0.47 |
|
R4629:Vmn2r26
|
UTSW |
6 |
124,061,191 (GRCm38) |
missense |
possibly damaging |
0.50 |
|
R4655:Vmn2r26
|
UTSW |
6 |
124,061,416 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R4709:Vmn2r26
|
UTSW |
6 |
124,053,965 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R4992:Vmn2r26
|
UTSW |
6 |
124,026,111 (GRCm38) |
missense |
probably benign |
0.00 |
|
R5297:Vmn2r26
|
UTSW |
6 |
124,061,873 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R5482:Vmn2r26
|
UTSW |
6 |
124,061,326 (GRCm38) |
missense |
possibly damaging |
0.88 |
|
R5517:Vmn2r26
|
UTSW |
6 |
124,050,717 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R5737:Vmn2r26
|
UTSW |
6 |
124,039,449 (GRCm38) |
missense |
probably benign |
0.00 |
|
R5739:Vmn2r26
|
UTSW |
6 |
124,025,966 (GRCm38) |
missense |
probably benign |
0.00 |
|
R5873:Vmn2r26
|
UTSW |
6 |
124,061,674 (GRCm38) |
missense |
probably benign |
0.01 |
|
R5907:Vmn2r26
|
UTSW |
6 |
124,039,871 (GRCm38) |
missense |
probably benign |
0.00 |
|
R6086:Vmn2r26
|
UTSW |
6 |
124,039,560 (GRCm38) |
missense |
possibly damaging |
0.48 |
|
R6134:Vmn2r26
|
UTSW |
6 |
124,061,485 (GRCm38) |
missense |
probably damaging |
0.97 |
|
R6391:Vmn2r26
|
UTSW |
6 |
124,061,389 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R6428:Vmn2r26
|
UTSW |
6 |
124,026,080 (GRCm38) |
missense |
probably benign |
0.17 |
|
R6637:Vmn2r26
|
UTSW |
6 |
124,061,691 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R6927:Vmn2r26
|
UTSW |
6 |
124,039,098 (GRCm38) |
missense |
possibly damaging |
0.93 |
|
R7173:Vmn2r26
|
UTSW |
6 |
124,061,296 (GRCm38) |
missense |
probably benign |
0.16 |
|
R7206:Vmn2r26
|
UTSW |
6 |
124,039,768 (GRCm38) |
missense |
probably benign |
0.17 |
|
R7208:Vmn2r26
|
UTSW |
6 |
124,061,989 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R7283:Vmn2r26
|
UTSW |
6 |
124,025,955 (GRCm38) |
missense |
probably damaging |
0.97 |
|
R7506:Vmn2r26
|
UTSW |
6 |
124,039,741 (GRCm38) |
missense |
probably benign |
0.00 |
|
R7672:Vmn2r26
|
UTSW |
6 |
124,039,647 (GRCm38) |
missense |
probably benign |
0.25 |
|
R7674:Vmn2r26
|
UTSW |
6 |
124,039,362 (GRCm38) |
missense |
probably benign |
|
|
R7696:Vmn2r26
|
UTSW |
6 |
124,061,535 (GRCm38) |
missense |
possibly damaging |
0.94 |
|
R7716:Vmn2r26
|
UTSW |
6 |
124,061,745 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R7831:Vmn2r26
|
UTSW |
6 |
124,039,799 (GRCm38) |
nonsense |
probably null |
|
|
R8063:Vmn2r26
|
UTSW |
6 |
124,024,955 (GRCm38) |
missense |
probably benign |
0.00 |
|
R8331:Vmn2r26
|
UTSW |
6 |
124,061,928 (GRCm38) |
missense |
probably benign |
0.22 |
|
R8352:Vmn2r26
|
UTSW |
6 |
124,039,618 (GRCm38) |
missense |
probably benign |
0.09 |
|
R8445:Vmn2r26
|
UTSW |
6 |
124,026,036 (GRCm38) |
missense |
probably damaging |
0.97 |
|
R8452:Vmn2r26
|
UTSW |
6 |
124,039,618 (GRCm38) |
missense |
probably benign |
0.09 |
|
R8681:Vmn2r26
|
UTSW |
6 |
124,024,918 (GRCm38) |
missense |
probably benign |
0.00 |
|
R8914:Vmn2r26
|
UTSW |
6 |
124,062,024 (GRCm38) |
missense |
probably benign |
|
|
R9333:Vmn2r26
|
UTSW |
6 |
124,026,050 (GRCm38) |
missense |
probably benign |
0.13 |
|
R9351:Vmn2r26
|
UTSW |
6 |
124,039,374 (GRCm38) |
missense |
probably benign |
|
|
R9436:Vmn2r26
|
UTSW |
6 |
124,025,867 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R9515:Vmn2r26
|
UTSW |
6 |
124,061,178 (GRCm38) |
missense |
probably damaging |
1.00 |
|
RF010:Vmn2r26
|
UTSW |
6 |
124,039,489 (GRCm38) |
missense |
possibly damaging |
0.90 |
|
| Predicted Primers |
PCR Primer
(F):5'- TACACACTTTGGTGGAGGATTATC -3'
(R):5'- AAGCCAGAGTCAAACAGCTTAG -3'
Sequencing Primer
(F):5'- CTGGGATTCAAGGATTTTCTCAGAAG -3'
(R):5'- CCAGAGTCAAACAGCTTAGAAAAAG -3'
|
| Posted On |
2018-11-28 |
Incidental Mutation