Incidental Mutation 'R6953:Or6c204'
ID 541321
Institutional Source Beutler Lab
Gene Symbol Or6c204
Ensembl Gene ENSMUSG00000096000
Gene Name olfactory receptor family 6 subfamily C member 204
Synonyms Olfr773-ps1, GA_x6K02T2PULF-10872859-10871923, MOR114-15, Olfr773
MMRRC Submission 045065-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.055) question?
Stock # R6953 (G1)
Quality Score 225.009
Status Validated
Chromosome 10
Chromosomal Location 129022353-129023288 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to T at 129022474 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Methionine to Lysine at position 272 (M272K)
Ref Sequence ENSEMBL: ENSMUSP00000072743 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000072976]
AlphaFold F6VS78
Predicted Effect probably benign
Transcript: ENSMUST00000072976
AA Change: M272K

PolyPhen 2 Score 0.007 (Sensitivity: 0.96; Specificity: 0.75)
SMART Domains Protein: ENSMUSP00000072743
Gene: ENSMUSG00000096000
AA Change: M272K

DomainStartEndE-ValueType
Pfam:7tm_4 28 305 1.6e-48 PFAM
Pfam:7tm_1 38 287 4.4e-22 PFAM
Coding Region Coverage
  • 1x: 100.0%
  • 3x: 99.9%
  • 10x: 99.2%
  • 20x: 97.3%
Validation Efficiency 98% (54/55)
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 56 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
9130401M01Rik C A 15: 57,892,223 (GRCm39) S128I probably damaging Het
Aadacl2 A C 3: 59,932,181 (GRCm39) H232P possibly damaging Het
Abcc3 A G 11: 94,265,661 (GRCm39) Y125H probably benign Het
Adgrb3 A G 1: 25,865,592 (GRCm39) S84P probably damaging Het
Adgrd1 A T 5: 129,192,142 (GRCm39) K71* probably null Het
Ap2m1 T A 16: 20,361,468 (GRCm39) W381R probably damaging Het
Ascc3 A G 10: 50,521,762 (GRCm39) I426V probably benign Het
BC024063 T A 10: 81,943,733 (GRCm39) D31E possibly damaging Het
C3ar1 G A 6: 122,827,591 (GRCm39) H209Y possibly damaging Het
Ccp110 T C 7: 118,321,644 (GRCm39) V433A possibly damaging Het
Cfap54 A G 10: 92,830,540 (GRCm39) S1199P probably benign Het
Cyp24a1 T G 2: 170,329,866 (GRCm39) D362A probably benign Het
Dapk2 C G 9: 66,161,904 (GRCm39) R271G probably benign Het
Dnmt1 G T 9: 20,829,822 (GRCm39) Q633K probably benign Het
Ercc4 T A 16: 12,948,550 (GRCm39) V499D probably damaging Het
Ier3ip1 C G 18: 77,027,309 (GRCm39) P46R probably damaging Het
Ifi211 T C 1: 173,733,832 (GRCm39) T110A probably damaging Het
Isoc1 A G 18: 58,804,374 (GRCm39) D134G possibly damaging Het
Kif26b A G 1: 178,701,637 (GRCm39) D672G possibly damaging Het
Klhl33 T A 14: 51,128,973 (GRCm39) D752V possibly damaging Het
Lcn4 A G 2: 26,559,367 (GRCm39) Y133H probably benign Het
Mrs2 C A 13: 25,185,771 (GRCm39) V134L probably benign Het
Muc16 T C 9: 18,551,825 (GRCm39) T4823A probably benign Het
Ogfod3 A G 11: 121,093,824 (GRCm39) I62T probably benign Het
Or2m13 C T 16: 19,226,278 (GRCm39) V164I probably benign Het
Or2y10 A G 11: 49,455,117 (GRCm39) Y123C probably damaging Het
Or7e175 A T 9: 20,049,299 (GRCm39) I296L probably benign Het
Papln G A 12: 83,828,659 (GRCm39) W788* probably null Het
Pcdhac2 A G 18: 37,277,479 (GRCm39) Q153R probably benign Het
Pcdhgb2 C T 18: 37,823,807 (GRCm39) T266I possibly damaging Het
Pcdhgc5 C A 18: 37,953,514 (GRCm39) R263S possibly damaging Het
Phactr4 T C 4: 132,104,662 (GRCm39) T185A possibly damaging Het
Plcxd2 T C 16: 45,800,882 (GRCm39) D114G probably damaging Het
Polr2a A T 11: 69,632,537 (GRCm39) I987N probably damaging Het
Prl3d3 A G 13: 27,345,029 (GRCm39) M134V probably benign Het
Pum2 T A 12: 8,778,779 (GRCm39) probably null Het
Racgap1 T C 15: 99,524,210 (GRCm39) E399G probably damaging Het
Sbspon A T 1: 15,930,519 (GRCm39) S156T probably damaging Het
Scn1a T C 2: 66,149,813 (GRCm39) T927A probably damaging Het
Sec23ip C A 7: 128,354,520 (GRCm39) S78* probably null Het
Serpina1d G A 12: 103,733,989 (GRCm39) T105I probably benign Het
Slc25a21 T A 12: 57,205,954 (GRCm39) N26Y probably benign Het
Smim20 T A 5: 53,435,258 (GRCm39) D64E probably damaging Het
Spag17 T G 3: 99,942,291 (GRCm39) I772S possibly damaging Het
Tars2 T C 3: 95,660,426 (GRCm39) T99A possibly damaging Het
Tdrd1 C T 19: 56,819,803 (GRCm39) T101I probably damaging Het
Tldc2 T G 2: 156,931,198 (GRCm39) probably null Het
Ttn A G 2: 76,601,929 (GRCm39) Y10251H probably damaging Het
Ush2a A G 1: 187,995,342 (GRCm39) R38G possibly damaging Het
Usp19 T C 9: 108,376,130 (GRCm39) L991P possibly damaging Het
Vmn2r109 G A 17: 20,760,973 (GRCm39) P795S possibly damaging Het
Vmn2r26 T C 6: 124,016,741 (GRCm39) Y402H probably benign Het
Vmn2r-ps117 T G 17: 19,045,095 (GRCm39) I504R probably benign Het
Zfp551 A T 7: 12,150,715 (GRCm39) C231* probably null Het
Zfp607a T A 7: 27,577,790 (GRCm39) C287S possibly damaging Het
Zim1 T A 7: 6,690,706 (GRCm39) T40S unknown Het
Other mutations in Or6c204
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01539:Or6c204 APN 10 129,022,804 (GRCm39) missense probably benign 0.04
R1924:Or6c204 UTSW 10 129,023,044 (GRCm39) missense possibly damaging 0.78
R4171:Or6c204 UTSW 10 129,022,453 (GRCm39) missense probably benign 0.39
R4688:Or6c204 UTSW 10 129,022,514 (GRCm39) missense probably damaging 0.99
R4952:Or6c204 UTSW 10 129,022,466 (GRCm39) missense probably benign 0.12
R5066:Or6c204 UTSW 10 129,022,433 (GRCm39) missense possibly damaging 0.88
R5610:Or6c204 UTSW 10 129,022,426 (GRCm39) missense probably damaging 0.96
R5633:Or6c204 UTSW 10 129,022,718 (GRCm39) missense probably benign 0.02
R9644:Or6c204 UTSW 10 129,022,738 (GRCm39) missense possibly damaging 0.94
RF007:Or6c204 UTSW 10 129,022,562 (GRCm39) missense probably damaging 1.00
Predicted Primers PCR Primer
(F):5'- GTGTTCAGGGAAAGTCAACTGG -3'
(R):5'- CAGACAGTTCTCATCTGTGCTG -3'

Sequencing Primer
(F):5'- GCTTGCTTGACTTGCCTA -3'
(R):5'- CTGACACTCATTATAACGCTGGTGTG -3'
Posted On 2018-11-28