Incidental Mutation 'R6955:Ly75'
ID 541404
Institutional Source Beutler Lab
Gene Symbol Ly75
Ensembl Gene ENSMUSG00000026980
Gene Name lymphocyte antigen 75
Synonyms DEC-205, CD205
Accession Numbers

Genbank: NM_013825

Essential gene? Non essential (E-score: 0.000) question?
Stock # R6955 (G1)
Quality Score 225.009
Status Not validated
Chromosome 2
Chromosomal Location 60292103-60383303 bp(-) (GRCm38)
Type of Mutation missense
DNA Base Change (assembly) T to C at 60327873 bp (GRCm38)
Zygosity Heterozygous
Amino Acid Change Isoleucine to Valine at position 1023 (I1023V)
Ref Sequence ENSEMBL: ENSMUSP00000108152 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000028362] [ENSMUST00000112533]
AlphaFold Q60767
Predicted Effect probably benign
Transcript: ENSMUST00000028362
AA Change: I1023V

PolyPhen 2 Score 0.430 (Sensitivity: 0.89; Specificity: 0.90)
SMART Domains Protein: ENSMUSP00000028362
Gene: ENSMUSG00000026980
AA Change: I1023V

DomainStartEndE-ValueType
signal peptide 1 27 N/A INTRINSIC
RICIN 33 146 2.63e-17 SMART
FN2 162 209 1.22e-23 SMART
CLECT 216 341 7.36e-32 SMART
CLECT 361 486 9.28e-29 SMART
CLECT 501 624 1.11e-17 SMART
CLECT 643 791 1.93e-26 SMART
CLECT 811 932 7.94e-2 SMART
CLECT 952 1091 5.81e-21 SMART
CLECT 1104 1222 1.04e-22 SMART
CLECT 1240 1382 3.48e-10 SMART
CLECT 1395 1513 9.59e-22 SMART
CLECT 1530 1661 7.79e-22 SMART
transmembrane domain 1670 1692 N/A INTRINSIC
Predicted Effect possibly damaging
Transcript: ENSMUST00000112533
AA Change: I1023V

PolyPhen 2 Score 0.485 (Sensitivity: 0.88; Specificity: 0.90)
SMART Domains Protein: ENSMUSP00000108152
Gene: ENSMUSG00000026980
AA Change: I1023V

DomainStartEndE-ValueType
signal peptide 1 27 N/A INTRINSIC
RICIN 33 146 2.63e-17 SMART
FN2 162 209 1.22e-23 SMART
CLECT 216 341 7.36e-32 SMART
CLECT 361 486 9.28e-29 SMART
CLECT 501 624 1.11e-17 SMART
CLECT 643 791 1.93e-26 SMART
CLECT 811 932 7.94e-2 SMART
CLECT 952 1091 5.81e-21 SMART
CLECT 1104 1222 1.04e-22 SMART
CLECT 1240 1382 3.48e-10 SMART
CLECT 1395 1513 9.59e-22 SMART
CLECT 1530 1661 7.79e-22 SMART
transmembrane domain 1670 1692 N/A INTRINSIC
Meta Mutation Damage Score 0.7518 question?
Coding Region Coverage
  • 1x: 100.0%
  • 3x: 99.9%
  • 10x: 99.4%
  • 20x: 97.8%
Validation Efficiency
MGI Phenotype PHENOTYPE: Mice homozygous for a knock-out allele display abnormalities in CD8-positive T cell morphology and cytotoxic T cell physiology. [provided by MGI curators]
Allele List at MGI

All alleles(7) : Targeted, knock-out(1) Targeted, other(1) Gene trapped(5)

Other mutations in this stock
Total: 40 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Abca13 T A 11: 9,294,307 (GRCm38) F2057I probably benign Het
Abl2 A G 1: 156,622,649 (GRCm38) T108A probably damaging Het
Amfr A T 8: 94,000,376 (GRCm38) W70R probably damaging Het
Cacna1h T C 17: 25,388,056 (GRCm38) T963A probably damaging Het
Cdca2 A G 14: 67,715,004 (GRCm38) M1T probably null Het
Chd2 A G 7: 73,475,423 (GRCm38) V62A probably damaging Het
Cpeb4 T A 11: 31,908,864 (GRCm38) L87Q possibly damaging Het
Ddx17 T C 15: 79,530,467 (GRCm38) M500V probably benign Het
Emilin1 T C 5: 30,917,909 (GRCm38) L498P probably damaging Het
Fhod1 C T 8: 105,333,007 (GRCm38) C682Y probably benign Het
Fshr A T 17: 88,985,466 (GRCm38) S595T probably benign Het
Gpt2 G A 8: 85,518,052 (GRCm38) E325K probably benign Het
Inf2 T C 12: 112,610,731 (GRCm38) V1003A unknown Het
Itpr3 A G 17: 27,121,467 (GRCm38) E2651G probably damaging Het
Kalrn A G 16: 34,220,136 (GRCm38) W735R probably damaging Het
Kdelc1 A T 1: 44,117,097 (GRCm38) L110Q probably damaging Het
Kif5b T C 18: 6,211,070 (GRCm38) N798S probably benign Het
Klb T A 5: 65,379,088 (GRCm38) L587* probably null Het
Krt82 T A 15: 101,542,849 (GRCm38) D375V probably damaging Het
Lig4 A T 8: 9,973,384 (GRCm38) V132D probably damaging Het
Lrpprc T C 17: 84,776,989 (GRCm38) I99V probably damaging Het
Mcam T A 9: 44,139,269 (GRCm38) I286N probably damaging Het
Myh15 G T 16: 49,081,235 (GRCm38) probably null Het
Nup210 T C 6: 91,087,927 (GRCm38) E197G probably damaging Het
Nup93 T A 8: 94,309,673 (GRCm38) Y702N probably damaging Het
Olfr1192-ps1 T A 2: 88,653,004 (GRCm38) I284N probably damaging Het
Osbpl8 T C 10: 111,269,444 (GRCm38) probably null Het
Pdzd2 A G 15: 12,401,464 (GRCm38) S767P probably damaging Het
Plcd1 A T 9: 119,071,856 (GRCm38) N765K probably benign Het
Rnf208 T C 2: 25,243,402 (GRCm38) V36A probably benign Het
Rpl5 G A 5: 107,902,046 (GRCm38) R33Q probably benign Het
Selp A T 1: 164,144,909 (GRCm38) I706F possibly damaging Het
Sfmbt1 A G 14: 30,766,034 (GRCm38) probably benign Het
Slc25a39 T C 11: 102,403,518 (GRCm38) I328V probably benign Het
Smc4 G A 3: 69,024,309 (GRCm38) E604K possibly damaging Het
Sorcs3 A G 19: 48,749,343 (GRCm38) Y733C possibly damaging Het
Ttll5 T C 12: 85,864,579 (GRCm38) V237A possibly damaging Het
Uimc1 T A 13: 55,040,546 (GRCm38) R567W possibly damaging Het
Wbp4 A T 14: 79,472,360 (GRCm38) I145N probably benign Het
Xbp1 A G 11: 5,522,018 (GRCm38) E32G probably null Het
Other mutations in Ly75
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00561:Ly75 APN 2 60,376,077 (GRCm38) missense probably damaging 1.00
IGL01072:Ly75 APN 2 60,354,496 (GRCm38) missense probably damaging 1.00
IGL01409:Ly75 APN 2 60,321,692 (GRCm38) splice site probably null
IGL01432:Ly75 APN 2 60,376,007 (GRCm38) missense probably damaging 1.00
IGL01626:Ly75 APN 2 60,301,015 (GRCm38) missense probably benign 0.13
IGL01690:Ly75 APN 2 60,338,311 (GRCm38) missense probably damaging 1.00
IGL01862:Ly75 APN 2 60,299,172 (GRCm38) missense probably damaging 1.00
IGL01982:Ly75 APN 2 60,311,764 (GRCm38) missense probably damaging 1.00
IGL02075:Ly75 APN 2 60,352,356 (GRCm38) missense probably damaging 0.99
IGL02338:Ly75 APN 2 60,354,452 (GRCm38) missense probably benign 0.04
IGL02364:Ly75 APN 2 60,358,507 (GRCm38) missense probably damaging 1.00
IGL02456:Ly75 APN 2 60,293,781 (GRCm38) missense probably benign 0.09
IGL02474:Ly75 APN 2 60,383,182 (GRCm38) missense probably null 1.00
IGL02608:Ly75 APN 2 60,321,900 (GRCm38) missense probably benign 0.41
IGL02986:Ly75 APN 2 60,308,191 (GRCm38) missense probably damaging 1.00
IGL03015:Ly75 APN 2 60,376,160 (GRCm38) missense probably damaging 1.00
IGL03049:Ly75 APN 2 60,352,070 (GRCm38) missense probably damaging 0.99
euphues UTSW 2 60,299,045 (GRCm38) critical splice donor site probably null
four_score UTSW 2 60,311,771 (GRCm38) missense possibly damaging 0.75
lyly UTSW 2 60,327,873 (GRCm38) missense possibly damaging 0.49
Witty UTSW 2 60,354,500 (GRCm38) missense probably damaging 1.00
D605:Ly75 UTSW 2 60,352,352 (GRCm38) critical splice donor site probably null
R0046:Ly75 UTSW 2 60,339,457 (GRCm38) intron probably benign
R0055:Ly75 UTSW 2 60,321,918 (GRCm38) missense probably benign 0.01
R0055:Ly75 UTSW 2 60,321,918 (GRCm38) missense probably benign 0.01
R0071:Ly75 UTSW 2 60,321,819 (GRCm38) missense probably benign 0.01
R0071:Ly75 UTSW 2 60,321,819 (GRCm38) missense probably benign 0.01
R0285:Ly75 UTSW 2 60,318,319 (GRCm38) missense probably damaging 1.00
R0387:Ly75 UTSW 2 60,306,404 (GRCm38) missense probably benign 0.20
R0492:Ly75 UTSW 2 60,308,276 (GRCm38) missense probably damaging 1.00
R0688:Ly75 UTSW 2 60,316,221 (GRCm38) missense probably benign 0.41
R1367:Ly75 UTSW 2 60,293,758 (GRCm38) splice site probably null
R1463:Ly75 UTSW 2 60,368,757 (GRCm38) critical splice donor site probably null
R1581:Ly75 UTSW 2 60,327,893 (GRCm38) missense probably damaging 1.00
R1663:Ly75 UTSW 2 60,314,234 (GRCm38) missense probably damaging 1.00
R1818:Ly75 UTSW 2 60,311,777 (GRCm38) missense probably damaging 1.00
R1881:Ly75 UTSW 2 60,349,940 (GRCm38) missense probably benign 0.00
R2244:Ly75 UTSW 2 60,349,913 (GRCm38) missense probably benign 0.01
R2905:Ly75 UTSW 2 60,334,554 (GRCm38) missense probably benign 0.00
R3967:Ly75 UTSW 2 60,327,873 (GRCm38) missense possibly damaging 0.49
R3968:Ly75 UTSW 2 60,327,873 (GRCm38) missense possibly damaging 0.49
R4039:Ly75 UTSW 2 60,352,995 (GRCm38) missense probably damaging 1.00
R4406:Ly75 UTSW 2 60,354,550 (GRCm38) missense probably damaging 1.00
R4526:Ly75 UTSW 2 60,330,773 (GRCm38) missense probably benign 0.09
R4647:Ly75 UTSW 2 60,308,278 (GRCm38) missense probably damaging 1.00
R4795:Ly75 UTSW 2 60,349,940 (GRCm38) missense probably benign 0.00
R4796:Ly75 UTSW 2 60,349,940 (GRCm38) missense probably benign 0.00
R4962:Ly75 UTSW 2 60,352,125 (GRCm38) missense probably damaging 1.00
R4979:Ly75 UTSW 2 60,375,894 (GRCm38) missense probably damaging 1.00
R5072:Ly75 UTSW 2 60,375,963 (GRCm38) missense probably damaging 1.00
R5288:Ly75 UTSW 2 60,303,641 (GRCm38) missense probably damaging 1.00
R5373:Ly75 UTSW 2 60,311,771 (GRCm38) missense possibly damaging 0.75
R5374:Ly75 UTSW 2 60,311,771 (GRCm38) missense possibly damaging 0.75
R5384:Ly75 UTSW 2 60,334,487 (GRCm38) nonsense probably null
R5385:Ly75 UTSW 2 60,303,641 (GRCm38) missense probably damaging 1.00
R5395:Ly75 UTSW 2 60,365,111 (GRCm38) missense probably benign 0.41
R5531:Ly75 UTSW 2 60,365,145 (GRCm38) missense probably damaging 0.98
R5662:Ly75 UTSW 2 60,352,381 (GRCm38) missense probably damaging 1.00
R5667:Ly75 UTSW 2 60,308,311 (GRCm38) missense probably damaging 1.00
R5668:Ly75 UTSW 2 60,354,500 (GRCm38) missense probably damaging 1.00
R5671:Ly75 UTSW 2 60,308,311 (GRCm38) missense probably damaging 1.00
R5677:Ly75 UTSW 2 60,299,082 (GRCm38) missense probably benign 0.00
R5764:Ly75 UTSW 2 60,318,439 (GRCm38) missense probably benign
R5896:Ly75 UTSW 2 60,383,146 (GRCm38) missense probably benign
R6025:Ly75 UTSW 2 60,375,962 (GRCm38) missense probably damaging 1.00
R6113:Ly75 UTSW 2 60,368,873 (GRCm38) missense probably benign 0.04
R6448:Ly75 UTSW 2 60,299,045 (GRCm38) critical splice donor site probably null
R6601:Ly75 UTSW 2 60,318,376 (GRCm38) missense probably benign 0.11
R6745:Ly75 UTSW 2 60,308,179 (GRCm38) missense probably damaging 1.00
R6960:Ly75 UTSW 2 60,306,405 (GRCm38) missense probably benign
R7100:Ly75 UTSW 2 60,306,434 (GRCm38) missense probably benign
R7110:Ly75 UTSW 2 60,376,184 (GRCm38) missense probably benign 0.31
R7203:Ly75 UTSW 2 60,323,852 (GRCm38) nonsense probably null
R7291:Ly75 UTSW 2 60,329,993 (GRCm38) missense probably damaging 0.98
R7308:Ly75 UTSW 2 60,334,515 (GRCm38) missense probably benign 0.04
R7447:Ly75 UTSW 2 60,334,474 (GRCm38) nonsense probably null
R7512:Ly75 UTSW 2 60,334,563 (GRCm38) missense probably damaging 1.00
R7595:Ly75 UTSW 2 60,293,827 (GRCm38) missense probably benign 0.01
R7976:Ly75 UTSW 2 60,365,088 (GRCm38) missense probably damaging 1.00
R8005:Ly75 UTSW 2 60,332,934 (GRCm38) missense probably damaging 1.00
R8171:Ly75 UTSW 2 60,314,228 (GRCm38) missense possibly damaging 0.51
R8392:Ly75 UTSW 2 60,349,940 (GRCm38) missense probably benign 0.00
R8705:Ly75 UTSW 2 60,318,385 (GRCm38) missense probably damaging 0.98
R8714:Ly75 UTSW 2 60,334,485 (GRCm38) missense probably damaging 1.00
R8798:Ly75 UTSW 2 60,323,926 (GRCm38) missense probably benign 0.32
R8799:Ly75 UTSW 2 60,348,441 (GRCm38) missense probably damaging 1.00
R8834:Ly75 UTSW 2 60,331,089 (GRCm38) missense probably benign
R8990:Ly75 UTSW 2 60,358,559 (GRCm38) missense probably benign 0.10
R9015:Ly75 UTSW 2 60,316,098 (GRCm38) missense probably benign
R9547:Ly75 UTSW 2 60,330,725 (GRCm38) critical splice donor site probably null
R9628:Ly75 UTSW 2 60,327,941 (GRCm38) missense probably damaging 1.00
R9659:Ly75 UTSW 2 60,338,321 (GRCm38) missense probably damaging 1.00
R9660:Ly75 UTSW 2 60,323,840 (GRCm38) missense probably damaging 1.00
R9747:Ly75 UTSW 2 60,306,328 (GRCm38) critical splice donor site probably null
X0025:Ly75 UTSW 2 60,354,475 (GRCm38) missense probably damaging 1.00
Z1177:Ly75 UTSW 2 60,352,133 (GRCm38) missense possibly damaging 0.65
Z1177:Ly75 UTSW 2 60,350,004 (GRCm38) nonsense probably null
Predicted Primers PCR Primer
(F):5'- GCATTGGGCCACTCCTTTATTG -3'
(R):5'- TTTCCGTTAGAGAAGGCAAAAGGC -3'

Sequencing Primer
(F):5'- GAGACAGGGTTTCCTATATCCCAG -3'
(R):5'- ACACTCATATGTGACGATCAGAG -3'
Posted On 2018-11-28