Incidental Mutation 'R6960:Ptger4'
ID 541725
Institutional Source Beutler Lab
Gene Symbol Ptger4
Ensembl Gene ENSMUSG00000039942
Gene Name prostaglandin E receptor 4 (subtype EP4)
Synonyms Ptgerep4, EP4
MMRRC Submission 045070-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.169) question?
Stock # R6960 (G1)
Quality Score 225.009
Status Validated
Chromosome 15
Chromosomal Location 5262880-5273668 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to C at 5264196 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Arginine to Glycine at position 462 (R462G)
Ref Sequence ENSEMBL: ENSMUSP00000112858 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000047379] [ENSMUST00000120563]
AlphaFold P32240
Predicted Effect probably benign
Transcript: ENSMUST00000047379
AA Change: R487G

PolyPhen 2 Score 0.000 (Sensitivity: 1.00; Specificity: 0.00)
SMART Domains Protein: ENSMUSP00000048736
Gene: ENSMUSG00000039942
AA Change: R487G

DomainStartEndE-ValueType
Pfam:7TM_GPCR_Srx 50 258 1.3e-7 PFAM
Pfam:7tm_1 59 357 1.3e-35 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000120563
AA Change: R462G

PolyPhen 2 Score 0.000 (Sensitivity: 1.00; Specificity: 0.00)
SMART Domains Protein: ENSMUSP00000112858
Gene: ENSMUSG00000039942
AA Change: R462G

DomainStartEndE-ValueType
Pfam:7TM_GPCR_Srx 25 233 1.9e-7 PFAM
Pfam:7tm_1 34 332 8.5e-45 PFAM
Meta Mutation Damage Score 0.0712 question?
Coding Region Coverage
  • 1x: 100.0%
  • 3x: 99.9%
  • 10x: 99.3%
  • 20x: 97.6%
Validation Efficiency 98% (50/51)
MGI Phenotype FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] The protein encoded by this gene is a member of the G-protein coupled receptor family. This protein is one of four receptors identified for prostaglandin E2 (PGE2). This receptor can activate T-cell factor signaling. It has been shown to mediate PGE2 induced expression of early growth response 1 (EGR1), regulate the level and stability of cyclooxygenase-2 mRNA, and lead to the phosphorylation of glycogen synthase kinase-3. Knockout studies in mice suggest that this receptor may be involved in the neonatal adaptation of circulatory system, osteoporosis, as well as initiation of skin immune responses. [provided by RefSeq, Jul 2008]
PHENOTYPE: Most homozygous targeted null mutants die shortly after birth due to failed closure of the ductus arteriosis. Survivors show decreased migration of Langerhans cells to lymph nodes, contact hypersensitivity and decreased incidence of induced arthritis. [provided by MGI curators]
Allele List at MGI
Other mutations in this stock
Total: 51 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Abca1 T C 4: 53,072,924 (GRCm39) D1170G probably benign Het
Ak7 A T 12: 105,676,503 (GRCm39) T68S probably benign Het
Arhgap12 A T 18: 6,111,901 (GRCm39) N26K probably damaging Het
B3galt1 A T 2: 67,949,033 (GRCm39) E249D probably damaging Het
Catsper4 T A 4: 133,954,648 (GRCm39) M1L probably benign Het
Cc2d2b T C 19: 40,773,506 (GRCm39) V523A possibly damaging Het
Ccn4 C T 15: 66,791,047 (GRCm39) T283M probably benign Het
Cyp11a1 T C 9: 57,925,659 (GRCm39) F98S probably damaging Het
Cyp2d26 T C 15: 82,674,446 (GRCm39) S479G probably damaging Het
Dclre1a T G 19: 56,531,141 (GRCm39) Y735S probably damaging Het
Dio2 C T 12: 90,696,671 (GRCm39) G106R probably damaging Het
Efcab12 T C 6: 115,815,273 (GRCm39) probably benign Het
Ehhadh C A 16: 21,581,028 (GRCm39) V655L probably benign Het
Ercc2 G A 7: 19,127,615 (GRCm39) R379Q probably damaging Het
Fabp4 A G 3: 10,273,537 (GRCm39) V12A probably benign Het
Fbn1 T C 2: 125,223,980 (GRCm39) I590V probably benign Het
Grm8 C A 6: 27,981,281 (GRCm39) V210L probably damaging Het
Jakmip3 A G 7: 138,625,065 (GRCm39) D359G probably damaging Het
Lrit1 G C 14: 36,782,052 (GRCm39) V242L probably damaging Het
Ly75 A T 2: 60,136,749 (GRCm39) Y1493N probably benign Het
Lyst A G 13: 13,808,663 (GRCm39) N111S probably benign Het
Lyz2 G C 10: 117,114,607 (GRCm39) I107M possibly damaging Het
Mgat5 A T 1: 127,248,371 (GRCm39) D91V possibly damaging Het
Mical3 T A 6: 120,935,504 (GRCm39) D1674V probably damaging Het
Myom2 G A 8: 15,167,741 (GRCm39) A1109T probably null Het
Naa16 A G 14: 79,596,911 (GRCm39) Y358H possibly damaging Het
Nktr T A 9: 121,571,758 (GRCm39) H226Q probably damaging Het
Ocln T G 13: 100,635,380 (GRCm39) K503T possibly damaging Het
Olfm4 T C 14: 80,258,754 (GRCm39) L301S probably damaging Het
Or4f4b G A 2: 111,314,071 (GRCm39) V127I possibly damaging Het
Or6c74 T C 10: 129,869,972 (GRCm39) L159P probably benign Het
Paqr4 G A 17: 23,956,697 (GRCm39) A222V probably benign Het
Pcdhb13 A G 18: 37,576,509 (GRCm39) T296A probably benign Het
Phka2 G A X: 159,316,044 (GRCm39) V230I probably damaging Het
Pigg T C 5: 108,474,707 (GRCm39) V309A probably damaging Het
Ptprc C T 1: 138,006,183 (GRCm39) probably null Het
Rabggta A C 14: 55,959,299 (GRCm39) probably null Het
Rnf25 A G 1: 74,634,403 (GRCm39) S207P possibly damaging Het
Rsf1 G GACGGCGGCC 7: 97,229,116 (GRCm39) probably benign Het
Rtf1 A G 2: 119,541,559 (GRCm39) Q264R probably damaging Het
Ryr2 A G 13: 11,816,129 (GRCm39) V619A probably benign Het
Serpinb6d A G 13: 33,855,181 (GRCm39) N285S probably benign Het
Slamf6 A G 1: 171,745,320 (GRCm39) M16V probably damaging Het
Slc22a23 A G 13: 34,528,140 (GRCm39) probably null Het
Slc23a2 T C 2: 131,933,173 (GRCm39) D95G probably damaging Het
Smc3 T C 19: 53,617,802 (GRCm39) Y600H probably damaging Het
Tarbp1 G A 8: 127,155,778 (GRCm39) T1320M possibly damaging Het
Tigd4 A T 3: 84,501,423 (GRCm39) K113N probably damaging Het
Tjp1 A T 7: 64,952,763 (GRCm39) F1444I possibly damaging Het
Tstd3 A T 4: 21,767,118 (GRCm39) M1K probably null Het
Zbtb46 T C 2: 181,065,217 (GRCm39) D311G probably damaging Het
Other mutations in Ptger4
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00562:Ptger4 APN 15 5,272,614 (GRCm39) missense probably benign 0.00
IGL00848:Ptger4 APN 15 5,264,589 (GRCm39) missense probably benign 0.16
IGL01309:Ptger4 APN 15 5,272,239 (GRCm39) missense probably damaging 1.00
IGL02083:Ptger4 APN 15 5,272,655 (GRCm39) missense probably benign 0.00
IGL03245:Ptger4 APN 15 5,264,588 (GRCm39) missense probably damaging 1.00
R0369:Ptger4 UTSW 15 5,272,491 (GRCm39) missense probably benign 0.06
R0427:Ptger4 UTSW 15 5,272,382 (GRCm39) missense probably benign 0.25
R1399:Ptger4 UTSW 15 5,264,412 (GRCm39) missense possibly damaging 0.81
R1778:Ptger4 UTSW 15 5,264,576 (GRCm39) missense probably damaging 1.00
R1801:Ptger4 UTSW 15 5,272,281 (GRCm39) missense possibly damaging 0.95
R2089:Ptger4 UTSW 15 5,272,326 (GRCm39) missense possibly damaging 0.80
R2091:Ptger4 UTSW 15 5,272,326 (GRCm39) missense possibly damaging 0.80
R2091:Ptger4 UTSW 15 5,272,326 (GRCm39) missense possibly damaging 0.80
R2484:Ptger4 UTSW 15 5,264,654 (GRCm39) missense probably benign 0.06
R2873:Ptger4 UTSW 15 5,264,286 (GRCm39) missense probably benign 0.02
R4515:Ptger4 UTSW 15 5,271,860 (GRCm39) missense probably damaging 1.00
R4572:Ptger4 UTSW 15 5,272,614 (GRCm39) missense probably benign 0.00
R4655:Ptger4 UTSW 15 5,272,545 (GRCm39) missense probably benign 0.06
R4860:Ptger4 UTSW 15 5,272,087 (GRCm39) missense probably benign 0.02
R4860:Ptger4 UTSW 15 5,272,087 (GRCm39) missense probably benign 0.02
R6429:Ptger4 UTSW 15 5,272,478 (GRCm39) missense possibly damaging 0.76
R7992:Ptger4 UTSW 15 5,264,381 (GRCm39) missense probably damaging 0.99
R8471:Ptger4 UTSW 15 5,271,800 (GRCm39) missense probably damaging 1.00
R8768:Ptger4 UTSW 15 5,272,138 (GRCm39) missense probably benign 0.00
R9245:Ptger4 UTSW 15 5,273,193 (GRCm39) start gained probably benign
R9638:Ptger4 UTSW 15 5,264,693 (GRCm39) missense probably damaging 1.00
R9790:Ptger4 UTSW 15 5,273,178 (GRCm39) start codon destroyed probably null 0.00
R9791:Ptger4 UTSW 15 5,273,178 (GRCm39) start codon destroyed probably null 0.00
Predicted Primers PCR Primer
(F):5'- ACTCAAGGACCTCAGTCTGC -3'
(R):5'- TACCTGCCAGACCTGACTGAAAG -3'

Sequencing Primer
(F):5'- AGGAGCTCGCCTGTTCTCTAG -3'
(R):5'- TGACTGAAAGCAGCCTCG -3'
Posted On 2018-11-28