|Institutional Source||Beutler Lab|
|Gene Name||B cell CLL/lymphoma 7A|
|Is this an essential gene?||Essential (E-score: 1.000)|
|Stock #||R6964 (G1)|
|Chromosomal Location||123343834-123374992 bp(+) (GRCm38)|
|Type of Mutation||critical splice donor site (2 bp from exon)|
|DNA Base Change (assembly)||T to C at 123369456 bp|
|Amino Acid Change|
|Ref Sequence||ENSEMBL: ENSMUSP00000031391 (fasta)|
|Gene Model||predicted gene model for transcript(s): [ENSMUST00000031391]|
|Predicted Effect||probably null
|Coding Region Coverage||
|MGI Phenotype||FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene is directly involved, with Myc and IgH, in a three-way gene translocation in a Burkitt lymphoma cell line. As a result of the gene translocation, the N-terminal region of the gene product is disrupted, which is thought to be related to the pathogenesis of a subset of high-grade B cell non-Hodgkin lymphoma. The N-terminal segment involved in the translocation includes the region that shares a strong sequence similarity with those of BCL7B and BCL7C. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]|
|Allele List at MGI|
|Other mutations in this stock||
|Other mutations in Bcl7a||
(F):5'- TGCAGCTTCTCATGTGTCTG -3'
(R):5'- CTTAACCTTAAGGATGTGGGGTC -3'
(F):5'- GCTTCTCATGTGTCTGAAAAACAGC -3'
(R):5'- TTTAATCCCAGCACTTGAGAGGC -3'